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https://www.readbyqxmd.com/read/30341725/clinical-sleep-wake-disorders-i-focus-on-hypersomnias-and-movement-disorders-during-sleep
#1
Christian R Baumann
Central disorders of hypersomnolence are characterized by daily periods of irrepressible need to sleep or daytime lapses into sleep, as defined in the current version of the International Criteria of Sleep Disorders. Thus, the unifying symptom is excessive daytime sleepiness which is not caused by any other sleep-wake disorder. Relevant disorders including narcolepsy type 1 and 2, idiopathic hypersomnia, Kleine-Levin syndrome, and insufficient sleep syndrome will be discussed. Other central disorders of hypersomnolence include hypersomnias due to medical or psychiatric disorders or because of medication or substance use...
October 20, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/30317200/sleeping-beauty-syndrome-presenting-with-insomnia
#2
Sara Hussain, Khulood Al Jarman, Sahar Hussain
A young man previously diagnosed with Kleine-Levin syndrome (KLS) presented with abnormal behaviour over the last 8 days. This included decreased sleeping hours and appetite, hypersexuality, aggressiveness and visual hallucinations. All blood tests and investigations in the emergency department yielded normal results. A preliminary diagnosis of a KLS episode with psychosis was made and the patient was started on a regimen of aripiprazole 10 mg once daily along with lorazepam 2 mg intravenously in two divided doses in the event of agitation or insomnia...
October 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30030664/neuroimaging-in-the-kleine-levin-syndrome
#3
REVIEW
Maria Engström, Francesco Latini, Anne-Marie Landtblom
PURPOSE OF REVIEW: The purpose was to review the most recent literature on neuroimaging in the Kleine-Levin syndrome (KLS). We aimed to investigate if frontotemporal and thalamic dysfunction are key KLS signatures, and if recent research indicates other brain networks of interest that elucidate KLS symptomatology and aetiology. RECENT FINDINGS: In a comprehensive literature search, we found 12 original articles published 2013-2018. Most studies report deviations related to cerebral perfusion, glucose metabolism, or blood-oxygen-level-dependent responses in frontotemporal areas and/or the thalamus...
July 21, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29923248/kleine-levin-syndrome-is-associated-with-lmod3-variants
#4
Saad M Al Shareef, Sulman Basit, Sha Li, Corinne Pfister, Sylvain Pradervand, Michel Lecendreux, Geert Mayer, Yves Dauvilliers, Vincenzo Salpietro, Henry Houlden, Ahmed S BaHammam, Mehdi Tafti
Kleine-Levin syndrome (KLS) is a rare periodic hypersomnia with associated behavioural abnormalities but with often favourable prognosis. There is excess risk of KLS in first-degree relatives, suggesting a strong genetic contribution. So far, no mutation is identified in KLS and comprehensive genetic analysis of affected individuals is lacking. Here we performed whole genome single-nucleotide polymorphism (SNP) genotyping and exome sequencing in a large family with seven affected members. The identified gene with a mutation was resequenced in 38 sporadic KLS patients and the expression of the gene product was mapped in the mouse brain...
June 19, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29773218/kleine-levin-syndrome-the-contribution-of-pet-scan-and-hydrogen-breath-test-for-small-intestinal-bacterial-overgrowth
#5
Andrea Melpignano, Giulia Milioli, Anna Bertelè, Anna Elisabetta Vaudano, Caterina Ghetti, Liborio Parrino, Livia Ruffini
No abstract text is available yet for this article.
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29615884/central-disorders-of-hypersomnolence-restless-legs-syndrome-and-surgery-with-general-anesthesia-patient-perceptions
#6
Vincent LaBarbera, Paul S García, Donald L Bliwise, Lynn M Trotti
Introduction: The importance of obstructive sleep apnea in patients undergoing surgery with general anesthesia is well-defined, but the surgical and anesthetic implications of other sleep disorders are less clear. We sought to evaluate response to surgery with general anesthesia in patients with central disorders of hypersomnolence or restless legs syndrome. Methods: We surveyed patients on their most recent surgical procedure with general anesthesia, querying about procedure, recovery, and any changes in sleep disorder symptomatology following the procedure...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29606318/kleine-levin-syndrome-a-neuropsychiatric-disorder
#7
REVIEW
I Arnulf, E Groos, P Dodet
Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy). Some psychiatric symptoms (megaphagia, hypersexuality, anxiety, depressed mood, hallucinations, delusions) arise during episodes, albeit less frequently, while patients are normal between episodes. However, sudden severe (>18h/day of sleep) and recurrent hypersomnia helps to differentiate KLS from other psychiatric mimics...
April 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29572278/iv-steroids-during-long-episodes-of-kleine-levin-syndrome
#8
Antoine Léotard, Elisabeth Groos, Charlotte Chaumereuil, Laure Peter-Derex, Andrea O Rossetti, Smaranda Leu-Semenescu, Isabelle Arnulf
OBJECTIVE: To retrospectively compare the benefits (episode cessation) and risks of IV methylprednisolone (IV-MP) vs abstention during prolonged Kleine-Levin syndrome (KLS) episodes. METHODS: A total of 26 patients with KLS received 1 g/d IV-MP for 3 days during 1 to 6 episodes each (totaling 43 IV-MP sessions). The change of episode duration with IV-MP (vs previous episode duration) was compared with the change duration between 2 consecutive episodes in 48 untreated patients matched for age, sex, age at KLS onset, number of episodes, and disease duration (more treated than untreated patients had long episodes)...
April 24, 2018: Neurology
https://www.readbyqxmd.com/read/29553974/breathing-abnormalities-during-sleep-in-kleine-levin-syndrome-fact-or-coincidence
#9
Natan Gadoth
PURPOSE OF REVIEW: To highlight and critically discuss the possibility that breathing abnormalities during hypersomnolent episodes are an additional clinical feature of Kleine-Levin Syndrome (KLS). RECENT FINDINGS: A computerized literature search of breathing abnormalities in patients with KLS disclosed two old and a single recent publication describing a total of six patients with sleep apnea during hypersomnolent episodes. SUMMARY: Owing to scarce reports on complete polysomnography during and in-between hypersomnic episodes of KLS, the possibility that breathing abnormalities are an additional clinical feature of this unique episodic sleep syndrome should be further studied...
July 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29532411/kleine-levin-syndrome-clues-to-aetiology
#10
REVIEW
Saad Mohammed AlShareef, Richard Mark Smith, Ahmed Salem BaHammam
Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1-2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected...
September 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29436797/a-case-of-kleine-levin-syndrome-diagnostic-and-therapeutic-challenge
#11
Marino Marčić, Ljiljana Marčić, Marina Titlić
Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hyper sexuality. Etiology is unknown, and there is no specific clinical or imaging test for this syndrome even though the illness has well-defined clinical features. Also, there is no effective treatment for KLS. KLS is self-limited, so the prognosis for these patients is not so bad. This study presents our case report and comprehensive workout that led to diagnosis which is primarily clinical...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29397778/the-clinical-characteristics-of-kleine-levin-syndrome-according-to-ethnicity-and-geographic-location
#12
Saad M Al Shareef, Aljohara S Almeneessier, Richard M Smith, Ahmed S BaHammam
PURPOSE: Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting, debilitating sleep disorder. Examining KLS characteristics in different ethnic populations may help elucidate the genetic basis of the disorder. No studies have examined KLS in Arabs. Therefore, we compared the clinical characteristics of Saudi Arabian KLS patients to those in other published cohorts to determine whether Arab patients have a distinct phenotype. METHODS: This study included all patients who were diagnosed with KLS at our center between June 2003 and July 2016 (P = 12; Six familial cases)...
September 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29332107/the-sleep-architecture-of-saudi-arabian-patients-with-kleine-levin-syndrome
#13
Saad M Al Shareef, Aljohara S Almeneessier, Omeima Hammad, Richard M Smith, Ahmed S BaHammam
To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. Methods: This was a retrospective cohort study of the polysomnographic characteristics of 10 typical symptomatic Saudi Arabian KLS patients attending the University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia between 2002 and 2015. Data were captured by nocturnal polysomnography during an acute attack of hypersomnia and compared with other published cohorts identified via a systematic literature search...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29033645/kleine-levine-syndrome-co-occuring-with-bipolar-disorder
#14
COMMENT
Ahmet Tiryaki, Filiz Civil Arslan, Mihriban Yildirim
No abstract text is available yet for this article.
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29026774/atypical-kleine-levin-syndrome-an-elusive-entity
#15
Swarndeep Singh, Saurabh Kumar, Rohit Verma, Nand Kumar
Kleine-Levin syndrome (KLS) is a rare disorder (around 1.5 cases per million population), often presenting with triad of recurrent episodes of hypersomnia, hyperphagia, and hypersexuality. However, cases of atypical KLS with features opposite to that being commonly reported are often misdiagnosed as psychosis and present as a diagnostic challenge for the physicians, psychiatrists, and neurologists. We describe a case of atypical KLS which was misdiagnosed as unspecified nonorganic psychosis previously, highlighting the various points which would be helpful in identifying and diagnosing cases of atypical KLS in future...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28880359/-a-young-boy-with-periodic-strange-behavior-and-hypersomnia-kleine-levin-syndrome
#16
F Dauwe, L Imeraj, K Dhondt
Kleine-Levin syndrome is a rare neuro-psychiatric disease. Most of the young patients are males who present with hypersomnia, cognitive dysfunction, altered perception, eating disorder (e.g. hyperphagia) or disinhibited behaviour (e.g. hypersexuality). Psychiatric symptoms such as apathy, delusions and hallucinations, depressed mood and compulsive behaviours also appear often and result frequently in a psychiatric referral. These symptoms, however, should be distinguished from those of psychiatric diseases as early as possible in order to ensure that patients do not receive the wrong treatment...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28852256/successful-long-term-management-of-a-child-with-kleine-levin-syndrome-with-low-dose-lithium
#17
Arpit Parmar, Priyanka Yadav, Bichitra Nanda Patra, Rajesh Sagar
Kleine-Levin syndrome (KLS) is a rare disorder characterized by episodic hypersomnia along with cognitive and behavioral disturbances (i.e., hyperphagia and hypersexuality). It is commonly seen in a young male. Not much is known about its long-term management; however, many reports suggest the usefulness of anticonvulsants and lithium for the same. We hereby report a case of childhood KLS from India who was successfully treated with low-dose lithium and discuss the relevant literature.
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28804979/kleine-levin-syndrome-elicited-by-encephalopathy-with-reversible-splenial-lesion
#18
Masaru Takayanagi, Shinichi Okabe, Katsuya Yamamoto, Juri Komatsu, Rikio Suzuki, Taro Kitamura, Toshihiro Ohura
Kleine-Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13-year-old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5-10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode...
August 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28790559/kleine-levin-syndrome-a-case-report
#19
Msvk Raju
A 30 year old male soldier suffered from five episodes of hypersomnia. Each episode was associated with megaphagia, mental confusion, irritability, coenesthopathic hallucinations and sexual disinhibition. The average duration of each episode was ten weeks with symptomfree intervals ranging from two weeks to one year. The patient responded well to treatment with carbamazepine and fenfluramine.
July 1994: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28778238/sleepiness-in-children-an-update
#20
REVIEW
Gustavo Antonio Moreira, Marcia Pradella-Hallinan
Sleep is essential for children's learning, memory processes, school performance, and general well-being. The prevalence of sleepiness in children is approximately 4%. Reductions of sleep duration have daytime consequences, including sleepiness, behavior problems, cognitive deficits, poor school performance, inflammation, and metabolic dysfunction. Chronic pain, movement disorders, and sleep-disordered breathing also may lead to daytime somnolence, inattention, hyperactivity, oppositional behaviors, and mood dysregulation...
September 2017: Sleep Medicine Clinics
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