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https://www.readbyqxmd.com/read/30450224/predictive-factors-for-hyperglycaemic-progression-in-patients-with-schizophrenia-or-bipolar-disorder
#1
Ichiro Kusumi, Yuki Arai, Ryo Okubo, Minoru Honda, Yasuhiro Matsuda, Yukihiko Matsuda, Akihiko Tochigi, Yoshiteru Takekita, Hiroyoshi Yamanaka, Keiichi Uemura, Koichi Ito, Kiyoshi Tsuchiya, Jun Yamada, Bunta Yoshimura, Nobuyuki Mitsui, Sigehiro Matsubara, Takayuki Segawa, Nobuyuki Nishi, Yasufumi Sugawara, Yuki Kako, Ikuta Shinkawa, Kaoru Shinohara, Akiko Konishi, Junichi Iga, Naoki Hashimoto, Shinsaku Inomata, Noriko Tsukamoto, Hiroto Ito, Yoichi M Ito, Norihiro Sato
Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression...
November 2018: BJPsych Open
https://www.readbyqxmd.com/read/30443006/the-relationship-between-repeated-measurement-of-casual-and-24-h-urinary-sodium-to-potassium-ratio-in-patients-with-chronic-kidney-disease
#2
Yuka Okuyama, Haruhito A Uchida, Toshiyuki Iwahori, Hiroyoshi Segawa, Ayako Kato, Hidemi Takeuchi, Yuki Kakio, Ryoko Umebayashi, Masashi Kitagawa, Hitoshi Sugiyama, Katsuyuki Miura, Hirotsugu Ueshima, Jun Wada
This study aimed to clarify the relationship between repeated measurements of casual (spot) and 24-h urinary sodium-to-potassium (Na/K) ratios in patients with chronic kidney disease (CKD). A total of 61 inpatients with CKD, 31 in stage 1-3 (eGFR [estimated glomerular filtration rate] ≥ 30 ml/min/1.73 m2 ) and 30 in stage 4-5 (eGFR < 30 ml/min/1.73 m2 ), aged 20-85 consuming a low-sodium diet (NaCl [sodium chloride] 6 g/day) were recruited. Urinary Na, K, and Na/K ratios were measured in both casual urine samples and 2-day, 24 h urine samples, and then analyzed by correlation and Bland-Altman analyses...
November 15, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/30404814/placenta-specific-8-suppresses-il-18-production-through-regulation-of-autophagy-and-is-associated-with-adult-still-disease
#3
Seiji Segawa, Yuya Kondo, Yuji Nakai, Akira Iizuka, Shunta Kaneko, Masahiro Yokosawa, Kotona Furuyama, Hiroto Tsuboi, Daisuke Goto, Isao Matsumoto, Takayuki Sumida
Adult Still disease (ASD) is a systemic disorder of unknown etiology characterized by high spiking fever, rash, and arthritis. The purpose of this study was to identify genes specifically associated with the active phase of the disease. In this study, we have reported that placenta specific 8 (PLAC8) was a newly specific gene involved in ASD. DNA microarray and validation analysis using human monocytes revealed that the expression of PLAC8 was significantly higher in active-ASD patients than in inactive-ASD patients and healthy controls...
November 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30389435/elamipretide-promotes-mitophagosome-formation-and-prevents-its-reduction-induced-by-nutrient-excess-in-ins1-%C3%AE-cells
#4
Anton Petcherski, Kyle M Trudeau, Dane M Wolf, Mayuko Segawa, Jennifer Lee, Evan P Taddeo, Jude T Deeney, Marc Liesa
Elamipretide is a tetrapeptide that restores defects in mitochondrial function, binds to cardiolipin, and is being tested in clinical trials for mitochondria-related diseases. However, whether elamipretide modulates mitochondrial quality control and dynamics, processes essential to preserve mitochondrial function, is unclear. Thus, we tested the effects of elamipretide on mitochondrial morphology, mitophagosome formation, and their early disruption induced by excess nutrients in INS1 β-cells. Elamipretide treatment was sufficient to increase engulfment of mitochondria into autophagosomes in control INS1 β-cells, without inducing widespread changes in mitochondrial morphology or membrane potential...
October 30, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/30355768/phospholipid-flippases-enable-precursor-b-cells-to-flee-engulfment-by-macrophages
#5
Katsumori Segawa, Yuichi Yanagihashi, Kyoko Yamada, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata
ATP11A and ATP11C, members of the P4-ATPases, are flippases that translocate phosphatidylserine (PtdSer) from the outer to inner leaflet of the plasma membrane. Using the W3 T lymphoma cell line, we found that Ca2+ ionophore-induced phospholipid scrambling caused prolonged PtdSer exposure in cells lacking both the ATP11A and ATP11C genes. ATP11C -null ( ATP11C -/y ) mutant mice exhibit severe B-cell deficiency. In wild-type mice, ATP11C was expressed at all B-cell developmental stages, while ATP11A was not expressed after pro-B-cell stages, indicating that ATP11C -/y early B-cell progenitors lacked plasma membrane flippases...
November 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30329028/advanced-glycation-end-product-accumulation-is-associated-with-low-skeletal-muscle-mass-weak-muscle-strength-and-reduced-bone-density-the-nagahama-study
#6
Yasuharu Tabara, Tome Ikezoe, Mikihiro Yamanaka, Kazuya Setoh, Hiroaki Segawa, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda
Background: The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods: This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and lower limbs and usual gait speed were measured in a portion of older (≥60 years of age) participants (n = 1,934)...
October 11, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/30326272/engineering-a-bispecific-antibody-with-a-common-light-chain-identification-and-optimization-of-an-anti-cd3-epsilon-and-anti-gpc3-bispecific-antibody-ery974
#7
Hirotake Shiraiwa, Atsushi Narita, Mika Kamata-Sakurai, Takahiro Ishiguro, Yuji Sano, Naoka Hironiwa, Takashi Tsushima, Hiroaki Segawa, Toshiaki Tsunenari, Yosuke Ikeda, Yoko Kayukawa, Mizuho Noguchi, Tetsuya Wakabayashi, Akihisa Sakamoto, Hiroko Konishi, Taichi Kuramochi, Mika Endo, Kunihiro Hattori, Junichi Nezu, Tomoyuki Igawa
The antibody drug market is rapidly expanding, and various antibody engineering technologies are being developed to create antibodies that can provide better benefit to patients. Although bispecific antibody drugs have been researched for more than 30 years, currently only a limited number of bispecific antibodies have achieved regulatory approval. Of the few successful examples of industrially manufacturing a bispecific antibody, the "common light chain format" is an elegant technology that simplifies the purification of a whole IgG-type bispecific antibody...
October 13, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/30319559/high-throughput-flaa-short-variable-region-sequencing-to-assess-campylobacter-diversity-in-fecal-samples-from-birds
#8
Qian Zhang, Gabriel A Al-Ghalith, Mayumi Kobayashi, Takahiro Segawa, Mitsuto Maeda, Satoshi Okabe, Dan Knights, Satoshi Ishii
Current approach to identify sources of human pathogens is largely dependent on the cultivation and isolation of target bacteria. For rapid pathogen source identification, culture-independent strain typing method is necessary. In this study, we designed new primer set that broadly covers flaA short variable region (SVR) of various Campylobacter species, and applied the flaA SVR sequencing method to examine the diversity of Campylobacter spp. in geese fecal samples ( n = 16) with and without bacteria cultivation...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30317447/analysis-of-opossum-kidney-napi-iic-sodium-dependent-phosphate-transporter-to-understand-pi-handling-in-human-kidney
#9
Toru Fujii, Yuji Shiozaki, Hiroko Segawa, Shiori Nishiguchi, Ai Hanazaki, Miwa Noguchi, Ruri Kirino, Sumire Sasaki, Kazuya Tanifuji, Megumi Koike, Mizuki Yokoyama, Yuki Arima, Ichiro Kaneko, Sawako Tatsumi, Mikiko Ito, Ken-Ichi Miyamoto
BACKGROUND: The role of Na+ -dependent inorganic phosphate (Pi) transporters in the human kidney is not fully clarified. Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is caused by loss-of-function mutations in the IIc Na+ -dependent Pi transporter (NPT2c/Npt2c/NaPi-IIc) gene. Another Na+ -dependent type II transporter, (NPT2A/Npt2a/NaPi-IIa), is also important for renal Pi reabsorption in humans. In mice, Npt2c deletion does not lead to hypophosphatemia and rickets because Npt2a compensates for the impaired Pi reabsorption...
October 13, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/30275242/tumor-sidedness-and-enriched-gene-groups-for-efficacy-of-first-line-cetuximab-treatment-in-metastatic-colorectal-cancer
#10
Yu Sunakawa, Kaoru Mogushi, Heinz-Josef Lenz, Wu Zhang, Akihito Tsuji, Takehiro Takahashi, Tadamichi Denda, Ken Shimada, Mitsugu Kochi, Masato Nakamura, Masahito Kotaka, Yoshihiko Segawa, Hiroaki Tanioka, Yuji Negoro, Miriana Moran, Stephanie H Astrow, Jack Hsiang, Craig Stephens, Masashi Fujii, Wataru Ichikawa
Molecular differences in tumor locations may contribute to the sidedness-specific response to cetuximab in metastatic colorectal cancer (mCRC). We investigated genes associated with the response to cetuximab treatment depending on tumor sidedness. Our study included 77 mCRC patients (13/63, right/left) with KRAS exon2 wild-type tumors from phase II trials of first-line therapy with cetuximab. Expression levels of 2551 genes were measured in tissue samples by HTG EdgeSeq Oncology Biomarker Panel. Univariate Cox regression analysis using log2 values of counts per million (CPM) was conducted in each sidedness to assess associations with clinical outcomes, and to define the optimal cutoff-point for clinically significant genes...
October 1, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/30246365/metagenomic-analyses-highlight-the-symbiotic-association-between-the-glacier-stonefly-andiperla-willinki-and-its-bacterial-gut-community
#11
Takumi Murakami, Takahiro Segawa, Nozomu Takeuchi, Gonzalo Barcaza Sepúlveda, Pedro Labarca, Shiro Kohshima, Yuichi Hongoh
The glacier stonefly Andiperla willinki is the largest metazoan inhabiting the Patagonian glaciers. In this study, we analysed the gut microbiome of the aquatic nymphs by 16S rRNA gene amplicon and metagenomic sequencing. The bacterial gut community was consistently dominated by taxa typical of animal digestive tracts, such as Dysgonomonadaceae and Lachnospiraceae, as well as those generally indigenous to glacier environments, such as Polaromonas. Interestingly, the dominant Polaromonas phylotypes detected in the stonefly gut were almost never detected in the glacier surface habitat...
September 24, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/30243533/two-nadh-dependent-s-3-hydroxyacyl-coa-dehydrogenases-from-polyhydroxyalkanoate-producing-ralstonia-eutropha
#12
Mutsumi Segawa, Cheng Wen, Izumi Orita, Satoshi Nakamura, Toshiaki Fukui
Ralstonia eutropha H16 contains both NADH- and NADPH-dependent reduction activities to acetoacetyl-CoA, and the NADPH-dependent activity is mediated by PhaB paralogs with (R)-stereospecificity providing (R)-3-hydroxybutyryl (3HB)-CoA monomer for poly((R)-3-hydroxybutyrate) synthesis. In contrast, the gene encoding the NADH-dependent enzyme has not been identified to date. This study focused on the NADH-dependent dehydrogenase with (S)-stereospecificity in R. eutropha, as the (S)-specific reduction of acetoacetyl-CoA potentially competed with the polyester biosynthesis via (R)-3HB-CoA...
September 19, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/30242469/estimation-of-day-of-death-using-micro-segmental-hair-analysis-based-on-drug-use-history-a-case-of-lidocaine-use-as-a-marker
#13
Kenji Kuwayama, Maika Nariai, Hajime Miyaguchi, Yuko T Iwata, Tatsuyuki Kanamori, Kenji Tsujikawa, Tadashi Yamamuro, Hiroki Segawa, Hiroko Abe, Hirotaro Iwase, Hiroyuki Inoue
During investigations of unnatural death, the time of death is generally estimated using anatomical examinations. However, it can be difficult to accurately determine the day of death, because postmortem changes in the body tissues can be greatly affected by the circumstances of the location of the corpse. We recently developed a method to estimate the day of drug ingestion, using micro-segmental hair analysis based on internal temporal markers (ITMs). In this method, ITMs are ingested at a specific time interval before hair collection to mark timescales within individual hair strands...
September 21, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/30232165/complete-genome-sequence-of-a-bla-kpc-2-positive-klebsiella-pneumoniae-strain-isolated-from-the-effluent-of-an-urban-sewage-treatment-plant-in-japan
#14
Tsuyoshi Sekizuka, Koji Yatsu, Yuba Inamine, Takaya Segawa, Miho Nishio, Norimi Kishi, Makoto Kuroda
Antimicrobial resistance genes (ARGs) and the bacteria that harbor them are widely distributed in the environment, especially in surface water, sewage treatment plant effluent, soil, and animal waste. In this study, we isolated a KPC-2-producing Klebsiella pneumoniae strain (GSU10-3) from a sampling site in Tokyo Bay, Japan, near a wastewater treatment plant (WWTP) and determined its complete genome sequence. Strain GSU10-3 is resistant to most β-lactam antibiotics and other antimicrobial agents (quinolones and aminoglycosides)...
September 19, 2018: MSphere
https://www.readbyqxmd.com/read/30229126/scattering-angle-dependent-christiansen-color-spectra-data-of-poly-vinyl-chloride-pvc-suspended-in-styrene-liquid-and-a-comprehensive-data-list-of-wavelength-dependent-refractive-indices-of-pvc
#15
Sadaki Samitsu, Hideki T Miyazaki, Hiroyo Segawa
This paper reports transmission and scattering spectra of poly(vinyl chloride) (PVC) in styrene liquid, which is derived from Christiansen effect. The spectra were measured by varying scattering angles. Further discussion on Christiansen color was provided in the paper entitled "Transmitting and scattering colors of porous particles of poly(vinyl chloride) based on Christiansen effect" (Samitsu et al., 2018) [1]. The paper additionally provides refractive indices of PVC reported in literatures because Christiansen effect has close relationship with wavelength-dependent refractive index, i...
October 2018: Data in Brief
https://www.readbyqxmd.com/read/30221812/comparison-of-the-gut-microbiota-of-captive-common-bottlenose-dolphins-tursiops-truncatus-in-three-aquaria
#16
A Suzuki, T Segawa, S Sawa, C Nishitani, K Ueda, T Itou, K Asahina, M Suzuki
AIMS: This study was conducted to assess the presence and extent of differences in the gut microbiota of common bottlenose dolphins depending on rearing facilities. METHODS AND RESULTS: Faecal samples were collected from 16 common bottlenose dolphins at three aquaria in Japan. After extracting DNA from the faeces, the V3-V4 region of bacterial 16S rRNA was amplified and sequenced using Illumina MiSeq platform. The constituent phyla of the gut microbiota were similar among aquaria; however, the most dominant phylum differed depending on the facility, and the compositions of microbiota were remarkably varied at the family level among aquaria...
September 17, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/30219084/detection-of-specific-gene-rearrangements-by-fluorescence-in-situ-hybridization-in-16-cases-of-clear-cell-sarcoma-of-soft-tissue-and-6-cases-of-clear-cell-sarcoma-like-gastrointestinal-tumor
#17
Keiko Segawa, Shintaro Sugita, Tomoyuki Aoyama, Terufumi Kubo, Hiroko Asanuma, Taro Sugawara, Yumika Ito, Mitsuhiro Tsujiwaki, Hiromi Fujita, Makoto Emori, Tadashi Hasegawa
BACKGROUND: Clear cell sarcoma of soft tissue (CCSST) and clear cell sarcoma-like gastrointestinal tumor (CCSLGT) are malignant mesenchymal tumors that share some pathological features, but they also have several different characteristics. They are well known to express chimeric fusions of Ewing sarcoma breakpoint region 1 (EWSR1) and cAMP response element-binding protein (CREB) family members; namely, EWSR1-activating transcription factor 1 (ATF1) and EWSR1-CREB1. In addition, recent studies have suggested the presence of other fusions...
September 15, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/30218374/nad-metabolism-and-the-slc34-family-evidence-for-a-liver-kidney-axis-regulating-inorganic-phosphate
#18
REVIEW
Sawako Tatsumi, Kanako Katai, Ichiro Kaneko, Hiroko Segawa, Ken-Ichi Miyamoto
The solute carrier 34 (SLC34) family of membrane transporters is a major contributor to Pi homeostasis. Many factors are involved in regulating the SLC34 family. The roles of the bone mineral metabolism factors parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) in Pi homeostasis are well studied. Intracellular Pi is thought to be involved in energy metabolism, such as ATP production. Under certain conditions of altered energy metabolism, plasma Pi concentrations are affected by the regulation of a Pi shift into cells or release from the tissues...
September 14, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30212831/a-role-of-intestinal-alkaline-phosphatase-3-akp3-in-inorganic-phosphate-homeostasis
#19
Shohei Sasaki, Hiroko Segawa, Ai Hanazaki, Ruri Kirino, Toru Fujii, Kayo Ikuta, Miwa Noguchi, Sumire Sasaki, Megumi Koike, Kazuya Tanifuji, Yuji Shiozaki, Ichiro Kaneko, Sawako Tatsumi, Takaaki Shimohata, Yoshichika Kawai, Sonoko Narisawa, José Luis Millán, Ken-Ichi Miyamoto
BACKGROUND/AIMS: Hyperphosphatemia is a serious complication of late-stage chronic kidney disease (CKD). Intestinal inorganic phosphate (Pi) handling plays an important role in Pi homeostasis in CKD. We investigated whether intestinal alkaline phosphatase 3 (Akp3), the enzyme that hydrolyzes dietary Pi compounds, is a target for the treatment of hyperphosphatemia in CKD. METHODS: We investigated Pi homeostasis in Akp3 knockout mice (Akp3-/-). We also studied the progression of renal failure in an Akp3-/- mouse adenine treated renal failure model...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30149281/development-of-simple-and-accurate-detection-systems-for-cannabis-sativa-using-dna-chromatography
#20
Tadashi Yamamuro, Shigehiko Miyamoto, Masashi Kitamura, Tomonori Muro, Yuko T Iwata, Hiroki Segawa, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue
In recent years, the need for analyzing cannabis DNA has increased in order to accommodate the various types of cannabis samples encountered in forensic investigation. This study was aimed to establish a simple and accurate cannabis DNA detection system using DNA chromatography. Two chromatography chip systems with different features were successfully developed. One system (the "four-line version") involves tetraplex PCR amplification, which could be used to detect cannabis DNA and distinguish between drug-type and fiber-type cannabis using the tetrahydrocannabinolic acid synthase gene sequence...
October 2018: Forensic Science International
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