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H Tsuchie, N Miyakoshi, K Iba, Y Kasukawa, K Nozaka, T Dohke, I Kosukegawa, T Aizawa, S Maekawa, H Abe, M Takeshima, T Tomite, T Segawa, K Ouchi, H Kinoshita, M Suzuki, T Yamashita, Y Shimada
We compared the effectiveness of promoting bone healing between two teriparatide preparations for atypical femoral fracture (AFF). A total of 45 AFFs were included in this study, and we compared the duration of bone union. Teriparatide administered by daily injection enhanced bone union more than weekly administration in complete AFFs. INTRODUCTION: The efficacy of teriparatide for atypical femoral fracture (AFF) has been recently reported. Although two different teriparatide preparations can be used to treat osteoporosis in Japan, daily or weekly injection, all previous reports on the effectiveness of teriparatide for AFF only examined daily injection formulations...
August 13, 2018: Osteoporosis International
Takahiro Segawa, Ryo Matsuzaki, Nozomu Takeuchi, Ayumi Akiyoshi, Francisco Navarro, Shin Sugiyama, Takahiro Yonezawa, Hiroshi Mori
Red-snow algae are red-pigmented unicellular algae that appear seasonally on the surface of thawing snow worldwide. Here, we analyse the distribution patterns of snow algae sampled from glaciers and snow patches in the Arctic and Antarctica based on nuclear ITS2 sequences, which evolve rapidly. The number of phylotypes is limited in both polar regions, and most are specific to either the Arctic or Antarctica. However, the bipolar phylotypes account for the largest share (37.3%) of all sequences, suggesting that red-algal blooms in polar regions may comprise mainly cosmopolitan phylotypes but also include endemic organisms, which are distributed either in the Arctic or Antarctica...
August 6, 2018: Nature Communications
Ryuji Nakamura, Hisao Kakuhara, Koyo Kikuchi, Takafumi Segawa, Hirobumi Oikawa, Kazuhiro Iwasaki, Wataru Obara, Hisanori Ariga
BACKGROUND/AIM: Secure dose escalation is required to compensate avoidance of concurrent chemotherapy in radiotherapy for increasing elderly bladder cancer. We aimed to evaluate the efficacy of lipiodol submucosally injected as a fiducial marker during image-guided radiotherapy (Lip-IGRT) for muscle invasive bladder cancer (BC). PATIENTS AND METHODS: Twenty-three patients with T2a-4aN0-1M0 BC underwent whole-bladder irradiation of 46 Gy and Lip-IGRT of 20 Gy, conventionally...
August 2018: Anticancer Research
Reiko Yamaguchi, Akimoto Nimura, Kentaro Amaha, Kumiko Yamaguchi, Yuko Segawa, Atsushi Okawa, Keiichi Akita
BACKGROUND: Anatomical knowledge of the tarsal canal and sinus is still unclear owing to the complexity of the ligamentous structures within them, particularly the relationship with the capsules of the subtalar joints. The aim of this study was to examine the anatomical relationship between the fibrous tissues of the tarsal canal and sinus and the articular capsules of the subtalar joint. METHODS: We conducted a descriptive anatomical study of 21 embalmed cadaveric ankles...
July 27, 2018: Foot & Ankle International
Yoshihisa Ishiura, Yasutaka Shiba, Yasushi Terasaki, Seiko Yoneyama, Kazutoshi Yamada, Yoshinobu Hinoue, Yoichi Ishida, Masataka Segawa, Yoshinori Doki, Kazuo Kasahara, Masaki Fujimura, Shinji Nakao, Takeshi Tamaki, Toshiki Shimizu, Shosaku Nomura
An increasing number of patients with lung cancer are undergoing outpatient chemotherapy, and thus, it is very important to maintain the quality of life(QOL)of these patients. Ninjin-Youei-To(TJ-108), a Japanese traditional medicine, has been reported to improve the QOL of patients with advanced cancer. However, the effect of TJ-108 in patients with lung cancer undergoing outpatient chemotherapy is unknown. Therefore, we conducted this study. To investigate factors influencing the QOL of these patients, we administered a QOL questionnaire,"The QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs"(QOL-ACD)to 15 patients with non-small cell lung cancer...
July 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Guillaume Povie, Yasutomo Segawa, Taishi Nishihara, Yuhei Miyauchi, Kenichiro Itami
The synthesis and X-ray crystal structure of the first member of the carbon nanobelt family is reported. [12]Carbon nanobelt ([12]CNB) was originally obtained from a nickel-mediated reductive coupling reaction of a dodecabrominated macrocyclic precursor, albeit only in 1% yield. The present article reports on the development of this synthetic strategy and its extension to the preparation of the [16] and [24]CNB analogues. In particular, our extensive investigations on the final belt-forming, nickel-mediated reaction led to the development of a new ligand system that provides [12]CNB in up to 7% yield, contributing to the commercialization of [12]CNB...
August 8, 2018: Journal of the American Chemical Society
Tatsuyuki Kanamori, Yuko Togawa-Iwata, Hiroki Segawa, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Hiroyuki Inoue
Purpose: The usefulness of hepatocytes isolated from a liver-humanized mouse (PXB-cells) as a model in vitro system for the prediction of the in vivo metabolism of new drugs of abuse was evaluated. Methods: For the drug metabolism study, fentanyl, a powerful synthetic opioid, and acetylfentanyl, an N -acetyl analog of fentanyl, were selected as model drugs. PXB-cells were cultured with the drug for 24-48 h and then the media were collected and analyzed by liquid chromatography/mass spectrometry after deproteinization with acetonitrile...
2018: Forensic Toxicology
Ichiro Kaneko, Hiroko Segawa, Kayo Ikuta, Ai Hanazaki, Toru Fujii, Sawako Tatsumi, Shinsuke Kido, Tomoka Hasegawa, Norio Amizuka, Hitoshi Saito, Ken-Ichi Miyamoto
X-linked hypophosphatemia (XLH), the most common form of inheritable rickets, is caused by inactivation of phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and leads to fibroblast growth factor (FGF) 23-dependent renal inorganic phosphate (Pi) wasting. In the present study, we investigated whether maintaining Pi homeostasis with a potent vitamin D3 analog, eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropyloxy) vitamin D3; ED71], could improve hypophosphatemic rickets in a murine model of XLH, the Hyp mouse...
July 1, 2018: Endocrinology
W-W Wang, J-S Dang, R Jono, H Segawa, M Sugimoto
We herein report that surface modification of metal halide perovskites using graphene would be beneficial to improving the energy conversion efficiencies of perovskite solar cells. The present first-principles calculations on MAPbI3 with a single vacancy created by removing either I, Pb or MA show that the I and Pb vacancies near the surface result in the formation of Pb-Pb and I-I dimers, respectively. They are predicted to yield mid-gap levels, and would degrade the energy conversion efficiency of perovskite solar cells through carrier trapping...
April 7, 2018: Chemical Science
Mamoru Oshiki, Takayuki Miura, Shinobu Kazama, Takahiro Segawa, Satoshi Ishii, Masashi Hatamoto, Takashi Yamaguchi, Kengo Kubota, Akinori Iguchi, Tadashi Tagawa, Tsutomu Okubo, Shigeki Uemura, Hideki Harada, Naohiro Kobayashi, Nobuo Araki, Daisuke Sano
Detection and genotyping of pathogenic RNA viruses in human and environmental samples are useful for monitoring the circulation and prevalence of these pathogens, whereas a conventional PCR assay followed by Sanger sequencing is time-consuming and laborious. The present study aimed to develop a high-throughput detection-and-genotyping tool for 11 human RNA viruses [Aichi virus; astrovirus; enterovirus; norovirus genogroup I (GI), GII, and GIV; hepatitis A virus; hepatitis E virus; rotavirus; sapovirus; and human parechovirus] using a microfluidic device and next-generation sequencer...
2018: Frontiers in Microbiology
Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito
Troglitazone, a member of the thiazolidinedione class of antidiabetic drugs, was withdrawn from the market because it causes severe liver injury. One of the mechanisms for this adverse effect is thought to be mitochondrial toxicity. To investigate the characteristics of troglitazone-induced liver toxicity in more depth, the toxicological effects of troglitazone on hepatocytes and liver mitochondria were investigated using a rat model of type 2 diabetes mellitus (T2DM). Troglitazone was found to increase mitochondrial permeability transition (MPT) in the liver mitochondria of diabetic rats to a greater extent than in control rats, whereas mitochondrial membrane potential and oxidative phosphorylation were not affected...
2018: Journal of Toxicological Sciences
Hisao Osada, Shokichi Teramoto, Hirotsune Kaijima, Tomoya Segawa, Osamu Miyauchi, Masaji Nagaishi, Makio Shozu, Keiichi Kato, Victor Gomel
STUDY OBJECTIVE: To evaluate the efficacy of a nonsurgical treatment for cervical pregnancy (CP) and cesarean section scar pregnancy (CSP). DESIGN: Retrospective clinical study (Canadian Task Force classification III). SETTING: Private assisted reproductive technology practice. PATIENTS: Nineteen women with CP (n = 16) or CSP (n = 3), including 6 patients with positive fetal heartbeat. INTERVENTION: Transvaginal local injection of absolute ethanol (AE) into the hyperechoic ring (lacunar space) around the gestational sac under ultrasound guidance...
April 30, 2018: Journal of Minimally Invasive Gynecology
Samy Almosni, Amaury Delamarre, Zacharie Jehl, Daniel Suchet, Ludmila Cojocaru, Maxime Giteau, Benoit Behaghel, Anatole Julian, Camille Ibrahim, Léa Tatry, Haibin Wang, Takaya Kubo, Satoshi Uchida, Hiroshi Segawa, Naoya Miyashita, Ryo Tamaki, Yasushi Shoji, Katsuhisa Yoshida, Nazmul Ahsan, Kentaro Watanabe, Tomoyuki Inoue, Masakazu Sugiyama, Yoshiaki Nakano, Tomofumi Hamamura, Thierry Toupance, Céline Olivier, Sylvain Chambon, Laurence Vignau, Camille Geffroy, Eric Cloutet, Georges Hadziioannou, Nicolas Cavassilas, Pierre Rale, Andrea Cattoni, Stéphane Collin, François Gibelli, Myriam Paire, Laurent Lombez, Damien Aureau, Muriel Bouttemy, Arnaud Etcheberry, Yoshitaka Okada, Jean-François Guillemoles
Photovoltaic generation has stepped up within the last decade from outsider status to one of the important contributors of the ongoing energy transition, with about 1.7% of world electricity provided by solar cells. Progress in materials and production processes has played an important part in this development. Yet, there are many challenges before photovoltaics could provide clean, abundant, and cheap energy. Here, we review this research direction, with a focus on the results obtained within a Japan-French cooperation program, NextPV, working on promising solar cell technologies...
2018: Science and Technology of Advanced Materials
Kenji Kuwayama, Maika Nariai, Hajime Miyaguchi, Yuko T Iwata, Tatsuyuki Kanamori, Kenji Tsujikawa, Tadashi Yamamuro, Hiroki Segawa, Hiroko Abe, Hirotaro Iwase, Hiroyuki Inoue
Sleeping aids are often abused in the commission of drug-facilitated crimes. Generally, there is little evidence that a victim ingested a spiked drink unknowingly because the unconscious victim cannot report the situation to the police immediately after the crime occurred. Although conventional segmental hair analysis can estimate the number of months since a targeted drug was ingested, this analysis cannot determine the specific day of ingestion. We recently developed a method of micro-segmental hair analysis using internal temporal markers (ITMs) to estimate the day of drug ingestion...
July 2018: Forensic Science International
Toshiaki Kudo, Atsushi Kobiyama, Jonaira Rashid, Md Shaheed Reza, Yuichiro Yamada, Yuri Ikeda, Daisuke Ikeda, Nanami Mizusawa, Kazuho Ikeo, Shigeru Sato, Takehiko Ogata, Mitsuru Jimbo, Shinnosuke Kaga, Shiho Watanabe, Kimiaki Naiki, Yoshimasa Kaga, Satoshi Segawa, Katsuhiko Mineta, Vladimir Bajic, Takashi Gojobori, Shugo Watabe
Ofunato Bay is located in the northeastern Pacific Ocean area of Japan, and it has the highest biodiversity of marine organisms in the world, primarily due to tidal influences from the cold Oyashio and warm Kuroshio Currents. Our previous results from performing shotgun metagenomics indicated that Candidatus Pelagibacter ubique and Planktomarina temperata were the dominant bacteria (Reza et al., 2018a, 2018b). These bacteria are reportedly able to catabolize dimethylsulfoniopropionate (DMSP) produced from phytoplankton into dimethyl sulfide (DMS) or methanethiol (MeSH)...
July 30, 2018: Gene
Gaurav Kapil, Teresa S Ripolles, Kengo Hamada, Yuhei Ogomi, Takeru Bessho, Takumi Kinoshita, Jakapan Chantana, Kenji Yoshino, Qing Shen, Taro Toyoda, Takashi Minemoto, Takurou N Murakami, Hiroshi Segawa, Shuzi Hayase
Frequently observed high Voc loss in tin-lead mixed perovskite solar cells is considered to be one of the serious bottle-necks in spite of the high attainable Jsc due to wide wavelength photon harvesting. An amicable solution to minimize the Voc loss up to 0.50 V has been demonstrated by introducing an n-type interface with spike structure between the absorber and electron transport layer inspired by highly efficient Cu(In,Ga)Se2 solar cells. Introduction of a conduction band offset of ∼0.15 eV with a thin phenyl-C61-butyric acid methyl ester layer (∼25 nm) on the top of perovskite absorber resulted into improved Voc of 0...
June 13, 2018: Nano Letters
Rathnayake M L D Rathnayake, Mamoru Oshiki, Satoshi Ishii, Takahiro Segawa, Hisashi Satoh, Satoshi Okabe
Although nitric oxide (NO) emissions from anaerobic ammonium oxidation (anammox)-based processes were reported previously, the NO production pathways are poorly understood. Here, we investigated the NO production pathways in anammox granules in detail by combining 15 N-stable isotope tracer experiments with various inhibitors, microsensor measurements, and transcriptome analysis for key genes of NO2 - reduction. NO was emitted from the anammox granules, which account for 0.07% of the N2 emission. 15 N-stable isotope-tracer experiments indicated that most of the N2 was produced by anammox bacteria, whereas NO was produced from NO2 - reduction by anammox and denitrifying bacteria...
May 15, 2018: Environmental Science & Technology
Tadashi Yamamuro, Yuko T Iwata, Hiroki Segawa, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue
In recent years, analysis of cannabis DNA has been increasingly used in forensic drug tests. However, in the case of cannabis resin, a processed marijuana product, complicated procedures are required for the extraction of clean DNA, as the presence of various impurities inhibits PCR amplification. Therefore, in this study, we attempted to identify the factors that would allow quick and simple DNA extraction from cannabis resin with a commercially available kit. We also constructed a simple assay system for comparing relative amplification efficiencies by end-point PCR and used it to evaluate the purity of the obtained DNA solutions...
June 2018: Forensic Science International
Kazutaka Hirakawa, Dongyan Ouyang, Yuko Ibuki, Shiho Hirohara, Shigetoshi Okazaki, Eiji Kono, Naohiro Kanayama, Jotaro Nakazaki, Hiroshi Segawa
Photodynamic therapy (PDT) is a less-invasive treatment for cancer through the administration of less-toxic porphyrins and visible-light irradiation. Photosensitized damage of biomacromolecules through singlet oxygen (1 O2 ) generation induces cancer cell death. However, a large quantity of porphyrin photosensitizer is required, and the treatment effect is restricted under a hypoxic cellular condition. Here we report the phototoxic activity of P(V)porphyrins: dichloroP(V)tetrakis(4-methoxyphenyl)porphyrin (CLP(V)TMPP), dimethoxyP(V)tetrakis(4-methoxyphenyl)porphyrin (MEP(V)TMPP), and diethyleneglycoxyP(V)tetrakis(4-methoxyphenyl)porphyrin (EGP(V)TMPP)...
May 21, 2018: Chemical Research in Toxicology
Giacomo Giorgi, Koichi Yamashita, Hiroshi Segawa
We have here performed a campaign of ab initio calculations focusing on the anchoring mechanism and adduct formation of some Lewis bases, both aliphatic and aromatic, on a PbI2-rich flat (001) methylammonium lead iodide (MAPI) surface. Our goal is to provide theoretical support to the recently reported experimental techniques of MAPI surface passivation via Lewis acid-base neutralization and similarly of MAI·PbI2·(Lewis base) adduct formation. We tested several X-donor bases (X = :N, :O, :S), paying attention to the thermodynamic stability of the final MAPI·base adducts and to their electronic properties...
April 25, 2018: Physical Chemistry Chemical Physics: PCCP
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