keyword
MENU ▼
Read by QxMD icon Read
search

DBS microelectrode

keyword
https://www.readbyqxmd.com/read/30532732/deep-brain-stimulation-surgery-for-parkinson-disease-coexisting-with-communicating-hydrocephalus-a-case-report
#1
Carlos Guevara, Jose de Grazia, Pedro Vazquez, Pablo Baabor, Cristián Garrido, Melissa Martinez, Jaime Fuentes, Fabian Piedimonte, Marcos Baabor
We report a successful bilateral globus pallidus internus-deep brain stimulation (GPi-DBS) for a Parkinson disease (PD) patient with idiopathic normal pressure hydrocephalus (INPH) and an unusually long anterior commissure-posterior commissure (AC-PC) line. A 54-year-old man presented with a history of 3 months of severe shuffling gait, rigidity, slow movements of the left side limbs, and difficulty managing finances. A brain MRI revealed marked ventriculomegaly (Evans index = 0.42). The patient was diagnosed with INPH and a ventriculoperitoneal shunt was placed...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30445556/identification-of-somatotopic-organization-and-optimal-stimulation-site-within-the-subthalamic-nucleus-for-parkinson-s-disease
#2
Tatsuya Sasaki, Ken Kuwahara, Ittetsu Kin, Mihoko Okazaki, Susumu Sasada, Aiko Shinko, Masahiro Kameda, Takao Yasuhara, Takashi Agari, Isao Date
BACKGROUND: Details of the somatotopy within the subthalamic nucleus (STN) are still poorly understood; however, the STN is a common target of deep brain stimulation (DBS) for Parkinson disease. OBJECTIVE: To examine somatotopic organization within the STN and identify optimal stimulation sites from 77 surgical cases with microelectrode recording. METHODS: STN-DBS was performed for 77 patients with Parkinson disease between 2010 and 2014. We performed passive movements of each joint and captured single neuronal activities to identify movement-related cells (MRCs)...
November 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30424443/integrity-assessment-of-a-hybrid-dbs-probe-that-enables-neurotransmitter-detection-simultaneously-to-electrical-stimulation-and-recording
#3
Danesh Ashouri Vajari, Maria Vomero, Johannes B Erhardt, Ali Sadr, Juan S Ordonez, Volker A Coenen, Thomas Stieglitz
Deep brain stimulation (DBS) is a successful medical therapy for many treatment resistant neuropsychiatric disorders such as movement disorders; e.g., Parkinson's disease, Tremor, and dystonia. Moreover, DBS is becoming more and more appealing for a rapidly growing number of patients with other neuropsychiatric diseases such as depression and obsessive compulsive disorder. In spite of the promising outcomes, the current clinical hardware used in DBS does not match the technological standards of other medical applications and as a result could possibly lead to side effects such as high energy consumption and others...
October 10, 2018: Micromachines
https://www.readbyqxmd.com/read/30391540/modulation-of-inhibitory-plasticity-in-basal-ganglia-output-nuclei-of-patients-with-parkinson-s-disease
#4
Luka Milosevic, Robert Gramer, Tae Hyun Kim, Musleh Algarni, Alfonso Fasano, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Milos R Popovic, William D Hutchison
Deep brain stimulation of certain target structures within the basal ganglia is an effective therapy for the management of the motor symptoms of Parkinson's disease. However, its mechanisms, as well as the pathophysiology of Parkinson's disease, are varied and complex. The classical model of Parkinson's disease states that symptoms may arise as a result of increased neuronal activity in the basal ganglia output nuclei due to downregulated GABAergic striato-nigral/-pallidal projections. We sought to investigate the stimulation and levodopa induced effects on inhibitory synaptic plasticity in these basal ganglia output nuclei, and to determine the clinical relevance of altered plasticity with respect to patients' symptoms...
November 2, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/30373767/long-lasting-electrophysiological-after-effects-of-high-frequency-stimulation-in-the-globus-pallidus-human-and-rodent-slice-studies
#5
Feng Luo, Linda H Kim, Philippe Magown, M Sohail Noor, Zelma Ht Kiss
Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is a highly effective therapy for movement disorders, yet its mechanism of action remains controversial. Inhibition of local neurons due to release of GABA from afferents to the GPi is a proposed mechanism in patients. Yet, high frequency stimulation (HFS) produces prolonged membrane depolarization mediated by cholinergic neurotransmission in endopeduncular neurons (EP, GPi-equivalent in rodent). We applied HFS while recording neuronal firing from an adjacent electrode during microelectrode mapping of GPi in awake patients (both male and female) with Parkinson disease (PD) and dystonia...
October 29, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/30339204/procedural-variables-influencing-stereotactic-accuracy-and-efficiency-in-deep-brain-stimulation-surgery
#6
Zaman Mirzadeh, Tsinsue Chen, Kristina M Chapple, Margaret Lambert, John P Karis, Rohit Dhall, Francisco A Ponce
BACKGROUND: Deep brain stimulation (DBS) is well-established, evidence-based therapy for Parkinson disease, essential tremor, and primary dystonia. Clinical outcome studies have recently shown that "asleep" DBS lead placement, performed using intraoperative imaging with stereotactic accuracy as the surgical endpoint, has motor outcomes comparable to traditional "awake" DBS using microelectrode recording (MER), but with shorter case times and improved speech fluency...
October 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30305788/passive-limb-movement-test-facilitates-subthalamic-deep-brain-stimulation-under-general-anesthesia-without-influencing-awareness
#7
Sheng-Tzung Tsai, Shee-Ping Chen, Sheng-Huang Lin, Shinn-Zong Lin, Shin-Yuan Chen
Objectives: We have shown that neuronal activity in the subthalamic nucleus (STN) in patients with Parkinson's disease can be accurately recorded during deep brain stimulation (DBS) with general anesthesia (GA). However, a vigorous passive range of motion (PROM) test might exert awakening effects on patients who are lightly anesthetized. We will explore the effects of PROM on the heart rate (HR) and mean arterial pressure (MAP) during microelectrode recording (MER) and confirm whether it facilitates identifying the sensory motor portion of the STN under GA...
October 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/30293864/a-review-on-microelectrode-recording-selection-of-features-for-machine-learning-in-deep-brain-stimulation-surgery-for-parkinson-s-disease
#8
Kai Rui Wan, Tomasz Maszczyk, Angela An Qi See, Justin Dauwels, Nicolas Kon Kam King
OBJECTIVE: This study seeks to systematically review the selection of features and algorithms for machine learning and automation in deep brain stimulation surgery (DBS) for Parkinson's disease. This will assist in consolidating current knowledge and accuracy levels to allow greater understanding and research to be performed in automating this process, which could lead to improved clinical outcomes. METHODS: A systematic literature review search was conducted for all studies that utilized machine learning and DBS in Parkinson's disease...
September 25, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/30282063/accuracy-of-different-three-dimensional-subcortical-human-brain-atlases-for-dbs-lead-localisation
#9
Andreas Nowacki, T A-K Nguyen, Gerd Tinkhauser, Katrin Petermann, Ines Debove, Roland Wiest, Claudio Pollo
BACKGROUND: Accurate interindividual comparability of deep brain stimulation (DBS) lead locations in relation to the surrounding anatomical structures is of eminent importance to define and understand effective stimulation areas. The objective of the current work is to compare the accuracy of the DBS lead localisation relative to the STN in native space with four recently developed three-dimensional subcortical brain atlases in the MNI template space. Accuracy is reviewed by anatomical and volumetric analysis as well as intraoperative electrophysiological data...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30196280/propofol-anesthesia-precludes-lfp-based-functional-mapping-of-pallidum-during-dbs-implantation
#10
Mahsa Malekmohammadi, Hiro Sparks, Nicholas AuYong, Andrew Hudson, Nader Pouratian
BACKGROUND/AIMS: There are reports that microelectrode recording (MER) can be performed under certain anesthetized conditions for functional confirmation of the optimal deep brain stimulation (DBS) target. However, it is generally accepted that anesthesia affects MER. Due to a potential role of local field potentials (LFPs) in DBS functional mapping, we characterized the effect of propofol on globus pallidus interna (GPi) and externa (GPe) LFPs in Parkinson disease (PD) patients. METHODS: We collected LFPs in 12 awake and anesthetized PD patients undergoing DBS implantation...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/30186762/tractography-assisted-deep-brain-stimulation-of-the-superolateral-branch-of-the-medial-forebrain-bundle-slmfb-dbs-in-major-depression
#11
Volker A Coenen, Bastian Sajonz, Marco Reisert, Jan Bostroem, Bettina Bewernick, Horst Urbach, Carolin Jenkner, Peter C Reinacher, Thomas E Schlaepfer, Burkhard Mädler
Background: Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (slMFB) emerges as a - yet experimental - treatment for major depressive disorder (MDD) and other treatment refractory psychiatric diseases. First experiences have been reported from two open label pilot trials in major depression (MDD) and long-term effectiveness for MDD (50 months) has been reported. Objective: To give a detailed description of the surgical technique for DBS of the superolateral branch of the medial forebrain bundle (slMFB) in MDD...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30179717/lead-dbs-v2-towards-a-comprehensive-pipeline-for-deep-brain-stimulation-imaging
#12
Andreas Horn, Ningfei Li, Till A Dembek, Ari Kappel, Chadwick Boulay, Siobhan Ewert, Anna Tietze, Andreas Husch, Thushara Perera, Wolf-Julian Neumann, Marco Reisert, Hang Si, Robert Oostenveld, Christopher Rorden, Fang-Cheng Yeh, Qianqian Fang, Todd M Herrington, Johannes Vorwerk, Andrea A Kühn
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders and a growing number of other indications are investigated in clinical trials. To ensure optimal treatment outcome, exact electrode placement is required. Moreover, to analyze the relationship between electrode location and clinical results, a precise reconstruction of electrode placement is required, posing specific challenges to the field of neuroimaging. Since 2014 the open source toolbox Lead-DBS is available, which aims at facilitating this process...
January 1, 2019: NeuroImage
https://www.readbyqxmd.com/read/30145596/accuracy-of-microelectrode-trajectory-adjustments-during-dbs-assessed-by-intraoperative-ct
#13
Sander Bus, Gian Pal, Bichun Ouyang, Pepijn van den Munckhof, Maarten Bot, Sepehr Sani, Leo Verhagen Metman
BACKGROUND/AIMS: Microelectrode recording (MER)-guided deep brain stimulation (DBS) aims to place the DBS lead in the optimal electrophysiological target. When single-track MER or test stimulation yields suboptimal results, trajectory adjustments are made. The accuracy of these trajectory adjustments is unknown. Intraoperative computed tomography can visualize the microelectrode (ME) and verify ME adjustments. We aimed to determine the accuracy of ME movements in patients undergoing MER-guided DBS...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/30133472/patient-specific-anatomical-model-for-deep-brain-stimulation-based-on-7-tesla-mri
#14
Yuval Duchin, Reuben R Shamir, Remi Patriat, Jinyoung Kim, Jerrold L Vitek, Guillermo Sapiro, Noam Harel
OBJECTIVE: Deep brain stimulation (DBS) requires accurate localization of the anatomical target structure, and the precise placement of the DBS electrode within it. Ultra-high field 7 Tesla (T) MR images can be utilized to create patient-specific anatomical 3D models of the subthalamic nuclei (STN) to enhance pre-surgical DBS targeting as well as post-surgical visualization of the DBS lead position and orientation. We validated the accuracy of the 7T imaging-based patient-specific model of the STN and measured the variability of the location and dimensions across movement disorder patients...
2018: PloS One
https://www.readbyqxmd.com/read/30131429/local-field-potentials-of-subthalamic-nucleus-contain-electrophysiological-footprints-of-motor-subtypes-of-parkinson-s-disease
#15
MULTICENTER STUDY
Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, Nuri F Ince
Although motor subtypes of Parkinson's disease (PD), such as tremor dominant (TD) and postural instability and gait difficulty (PIGD), have been defined based on symptoms since the mid-1990s, no underlying neural correlates of these clinical subtypes have yet been identified. Very limited data exist regarding the electrophysiological abnormalities within the subthalamic nucleus (STN) that likely accompany the symptom severity or the phenotype of PD. Here, we show that activity in subbands of local field potentials (LFPs) recorded with multiple microelectrodes from subterritories of STN provide distinguishing neurophysiological information about the motor subtypes of PD...
September 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30105131/bilateral-stereotactic-lesions-and-chronic-stimulation-of-the-anterior-thalamic-nuclei-for-treatment-of-pharmacoresistant-epilepsy
#16
A R Sitnikov, Yu A Grigoryan, L P Mishnyakova
Background: The use of the anterior nucleus of thalamus (ANT) as a target for treatment of pharmacoresistant epilepsy is based on its crucial role in seizure propagation. We describe results of chronic bilateral ANT stimulation and bilateral ANT lesions in 31 patients with refractory epilepsy. Methods: ANT DBS was performed in 12 patients (group I) and bilateral stereotactic radiofrequency lesions of ANT were performed in 19 patients (group II). Targeting was based on stereotactic atlas information with correction of the final coordinates according to the location of anatomical landmarks and intraoperative microelectrode recording data...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30096492/intraoperative-stereotactic-magnetic-resonance-imaging-for-deep-brain-stimulation-electrode-planning-in-patients-with-movement-disorders
#17
Martin Jakobs, Erenik Krasniqi, Manja Kloß, Jan-Oliver Neumann, Benito Campos, Andreas W Unterberg, Karl L Kiening
OBJECTIVE: Implantation of deep brain stimulation (DBS) electrodes requires stereotactic imaging. Stereotactic magnetic resonance imaging (MRI) for DBS surgery has become more popular and intraoperative MRI scanners have become more available. We report on our cohort of movement disorder patients who underwent intraoperative stereotactic MRI-only DBS electrode implantation. METHODS: A review of our DBS database for eligible patients over a study period of 8 years was performed...
November 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30074454/imaging-alone-versus-microelectrode-recording-guided-targeting-of-the-stn-in-patients-with-parkinson-s-disease
#18
Christopher S Lozano, Manish Ranjan, Alexandre Boutet, David S Xu, Walter Kucharczyk, Alfonso Fasano, Andres M Lozano
OBJECTIVE The clinical results of deep brain stimulation (DBS) of the subthalamic nucleus (STN) are highly dependent on accurate targeting and target implantation. Several targeting tactics are in current use, including image-only and/or electrophysiologically guided approaches using microelectrode recordings (MERs). The purpose of the present study was to make an appraisal of imaging only-based versus imaging with the addition of intraoperative MER-guided STN electrode targeting. METHODS The authors evaluated 100 consecutive patients undergoing STN DBS...
August 3, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30065816/properties-of-oscillatory-neuronal-activity-in-the-basal-ganglia-and-thalamus-in-patients-with-parkinson-s-disease
#19
G Du, P Zhuang, M Hallett, Y-Q Zhang, J-Y Li, Y-J Li
Background: The cardinal features of Parkinson's disease (PD) are bradykinesia, rigidity and rest tremor. Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms. This study aims to characterize properties of oscillatory activity in the basal ganglia and motor thalamus in patients with PD. Methods: Twenty-nine patients with PD who underwent bilateral or unilateral electrode implantation for subthalamic nucleus (STN) DBS ( n  = 11), unilateral pallidotomy ( n  = 9) and unilateral thalamotomy (n = 9) were studied...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30018276/pediatric-deep-brain-stimulation-using-awake-recording-and-stimulation-for-target-selection-in-an-inpatient-neuromodulation-monitoring-unit
#20
Terence D Sanger, Mark Liker, Enrique Arguelles, Ruta Deshpande, Arash Maskooki, Diana Ferman, Aprille Tongol, Aaron Robison
Deep brain stimulation (DBS) for secondary (acquired, combined) dystonia does not reach the high degree of efficacy achieved in primary (genetic, isolated) dystonia. We hypothesize that this may be due to variability in the underlying injury, so that different children may require placement of electrodes in different regions of basal ganglia and thalamus. We describe a new targeting procedure in which temporary depth electrodes are placed at multiple possible targets in basal ganglia and thalamus, and probing for efficacy is performed using test stimulation and recording while children remain for one week in an inpatient Neuromodulation Monitoring Unit (NMU)...
July 17, 2018: Brain Sciences
keyword
keyword
168520
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"