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Skin dermatologic treatment

Thierry Olivry, Emmanuel Bensignor, Claude Favrot, Craig E Griffin, Peter B Hill, Ralf S Mueller, Jon D Plant, Hywel C Williams
BACKGROUND: For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clinical signs were validated later, there was little impact on standardizing outcome measures resulting in difficulties in comparing treatment efficacy between trials and impeding meta-analyses. RESULTS: Participants in the Outcome Measures subcommittee of the International Committee of Allergic Diseases of Animals (ICADA) collaborated for two years to develop a core outcome set (COS) for canine AD, the COSCAD...
August 16, 2018: BMC Veterinary Research
William D Shipman, Susan Chyou, Anusha Ramanathan, Peter M Izmirly, Sneh Sharma, Tania Pannellini, Dragos C Dasoveanu, Xiaoping Qing, Cynthia M Magro, Richard D Granstein, Michelle A Lowes, Eric G Pamer, Daniel H Kaplan, Jane E Salmon, Babak J Mehrara, James W Young, Robert M Clancy, Carl P Blobel, Theresa T Lu
Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus and other autoimmune and dermatologic conditions, but the mechanistic underpinnings are poorly understood. We identify a Langerhans cell (LC)-keratinocyte axis that limits UVR-induced keratinocyte apoptosis and skin injury via keratinocyte epidermal growth factor receptor (EGFR) stimulation. We show that the absence of LCs in Langerin-diphtheria toxin subunit A (DTA) mice leads to photosensitivity and that, in vitro, mouse and human LCs can directly protect keratinocytes from UVR-induced apoptosis...
August 15, 2018: Science Translational Medicine
Amy E Mitchell
Dermatological conditions are common among children. They are a frequent cause of presentation to health care services and a leading contributor to burden of disease. Evidence supports the notion that bidirectional relationships exist between children's physical and psychological health, whereby the child's dermatological condition can impact their psychological health and well-being, while, in the reverse direction, psychological factors (eg, stress) can impact the severity and course of the child's skin disease...
2018: Psychology Research and Behavior Management
Yogesh Sharma, Karen Humphreys, Campbell Thompson
BACKGROUND: Antiphospholipid syndrome is an autoimmune disorder characterized by the presence of antiphospholipid antibodies and commonly presents with vascular thromboembolic phenomena, thrombocytopenia, and obstetric complications. Antiphospholipid syndrome can be classified as either primary or secondary to other connective tissue diseases. Dermatologic manifestations are common; however, non-vasculitic skin ulceration is an uncommon manifestation of antiphospholipid syndrome with limited treatment options...
August 14, 2018: Journal of Medical Case Reports
Bridget E Shields, Misha Rosenbach, Zoe Brown-Joel, Anthony Berger, Bradley A Ford, Karolyn A Wanat
Angioinvasive fungal infections cause significant morbidity and mortality due to their propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia, infarct, and necrosis. While occasionally seen in immunocompetent hosts, opportunistic fungi are emerging in immunosuppressed hosts, including patients with hematologic malignancy, acquired immunodeficiency syndrome (AIDS), organ transplant, and poorly controlled diabetes mellitus. The widespread use of antifungal prophylaxis has led to an "arms race" of emerging fungal resistance patterns...
August 10, 2018: Journal of the American Academy of Dermatology
Mari Kishibe, Hiroyoshi Nozaki, Mizue Fujii, Shin Iinuma, Sawa Ohtsubo, Satomi Igawa, Kyoko Kanno, Masaru Honma, Kan Kishibe, Kensaku Okamoto, Akemi Ishida-Yamamoto
Azathioprine (AZA)-metabolizing enzyme gene polymorphism is strongly related to thiopurine-induced leukocytopenia, which has not been well recognized in dermatological practice. We tried to see whether NUDT15 gene polymorphism can be the most susceptible genetic factor for AZA toxicity and the gene screening is beneficial to avoid the adverse events of AZA for the treatment of skin diseases. A retrospective study was carried out on 15 adult Japanese patients who were treated with AZA. Gene polymorphism of thiopurine-metabolizing enzymes NUDT15 R139C, ITPA 94C>A, TPMT*2, TPMT*3B and TPMT*3C was analyzed...
August 13, 2018: Journal of Dermatology
S Holowacz, I Guinobert, A Guilbot, S Hidalgo, J F Bisson
BACKGROUND: There is a growing interest in the effects of probiotics for the prevention and treatment of skin diseases due to their immunomodulatory and anti-inflammatory properties. OBJECTIVE: To assess a mixture of five bacterial strains in the prevention of chronic skin inflammation in mice. METHOD: Hairless SKH-1 mice received daily oral treatment with the probiotic mixture at the dose of 1x109 colony-forming unit (CFU)/day (or vehicle) for three weeks...
August 13, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
A K S Silva, T R N Silva, J R Nicoli, L M C Vasquez-Pinto, F S Martins
A healthy skin provides a protective barrier against pathogenic microorganisms. Recent studies have shown that probiotics, as those of Bifidobacterium genus, could act beneficially in dermatology, both when ingested and by topical use. In the present study, we evaluated by in vitro antagonism assays and using two skin cell lines the potential of four strains of Bifidobacterium spp. Among the four bifidobacteria, Bifidobacterium longum 51A was the only one able to inhibit the growth of the eight pathogenic indicators tested...
August 12, 2018: Letters in Applied Microbiology
Michele Antonelli, Davide Donelli
Recent findings highlight the role of skin microbiome in modulating immune function and inflammatory response. This systematic review aims to investigate the effects of muds, already used for the treatment of several rheumatic and dermatologic conditions, on skin microbiome. Medline via PubMed, Embase, Cochrane Library, and Google Scholar were searched for articles about the effects of therapeutic muds on microorganisms of skin microbiome. Five studies were included in the review and critically appraised. Limited data suggest that muds have various properties that may explain their action on skin microbiome, with different effects on commensal and pathogenic microorganisms...
August 8, 2018: International Journal of Biometeorology
Sarah G K Engel, Sonal Bhatia
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder characterized by dermatologic manifestations and growth of multiple benign tumors often involving the brain, skin, kidneys, heart, lungs, and liver. It exhibits wide phenotypic variation, ranging from the most severe cases with intellectual disability and intractable epilepsy to the mildest, clinically silent forms of the disease. The incidence of TSC is reported to be 1/6000; however, this does not account for those with milder forms of the disease, of which forme fruste is the mildest...
April 2018: Journal of Pediatric Neurosciences
Rubén Cebrián, Sergio Arévalo, Susana Rubiño, Salvador Arias-Santiago, María Dolores Rojo, Manuel Montalbán-López, Manuel Martínez-Bueno, Eva Valdivia, Mercedes Maqueda
We report the high susceptibility of several clinical isolates of Propionibacterium acnes from different sources (skin, bone, wound exudates, abscess or blood contamination) to the head-to-tail cyclized bacteriocin AS-48. This peptide is a feasible candidate for further pharmacological development against this bacterium, due to its physicochemical and biological characteristics, even when it is growing in a biofilm. Thus, the treatment of pre-formed biofilms with AS-48 resulted in a dose- and time-dependent disruption of the biofilm architecture beside the decrease of bacterial viability...
August 6, 2018: Scientific Reports
Rungsima Wanitphakdeedecha, Thanawan Iamphonrat, Weeranut Phothong, Sasima Eimpunth, Woraphong Manuskiatti
Therapy with light-emitting diodes (LED) has been associated with the reduction of erythema and accelerated wound healing. LED phototherapy has been used in various clinical practices including post-laser wound healing enhancement. Fractional laser resurfacing is one of the popular dermatological procedures; however, the duration and degree of downtime may limit daily life activity and studies on the effect of LED low-level light therapy (LED-LLLT) on post-ablative laser wound care are still limited. To evaluate local and systemic effects of LED-LLLT on post-ablative laser erythema and wound healing acceleration after fractional ablative laser resurfacing...
August 3, 2018: Lasers in Medical Science
Maria Isabel Ramos Saraiva, Larissa Karine Leite Portocarrero, Marcella Amaral Horta Barbosa Vieira, Bethania Cabral Cavalli Swiczar, Andrezza Telles Westin
BACKGROUND: Actinic keratoses are benign intraepithelial skin neoplasms that develop in photoexposed areas and can progress to invasive carcinoma. They are seen frequently in dermatological practice, occurring in 5.1% of consultations. Ingenol mebutate (IM) was recently approved in Brazil as a topical therapy for field cancerization in actinic keratosis. OBJECTIVE: To evaluate the clearance rate and adverse events in the treatment of actinic keratoses with ingenol mebutate...
July 2018: Anais Brasileiros de Dermatologia
Tatiana Ţăranu, Mirela Grigorovici, Magda Constantin, Mihaela Paula Toader
Dear Editor, Subcutaneous granuloma annulare (SGA) is considered a rare clinical variant of granuloma annulare, a common self-healing chronic inflammatory disorder that may appear in childhood as well as in adult age (1-3). A 29-year-old female patient reported the onset of several small subcutaneous nodules on the dorsal aspect of the second interphalangeal joint of the left medius finger and the left elbow, accompanied by vague joint pain, had occurred 13 years ago. Specific markers for rheumatoid arthritis were negative, leading to a diagnosis of sero-negative rheumatoid arthritis, for which treatment with methotrexate was initiated...
December 2017: Acta Dermatovenerologica Croatica: ADC
Hidehisa Sekijima, Kenji Goto, Keiichi Hiramoto, Rio Komori, Kazuya Ooi
PURPOSE: Type 2 diabetes mellitus (DM) induces various dermatological conditions that can affect patient quality of life, including increased susceptibility to skin infections and dry skin. While the mechanisms that underlie the causes of dry skin in type 1 DM have been widely studied, how type 2 DM elicits similar effects is unclear. The purpose of this study was therefore to evaluate skin barrier and hydration function using a KK-Ay /TaJcl mouse model of type 2 DM. MATERIALS AND METHODS: KK-Ay /TaJcl and control mice were housed separately for 4 weeks and then body weight, water intake, urine production, and blood glucose levels were measured...
July 31, 2018: Cutaneous and Ocular Toxicology
Tse-Hung Huang, Pei-Wen Wang, Shih-Chun Yang, Wei-Ling Chou, Jia-You Fang
Fish oil has been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. There has been increasing interest in the relationship of fish oil with skin protection and homeostasis, especially with respect to the omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The other PUFAs, such as α-linolenic acid (ALA) and linoleic acid (LA), also show a beneficial effect on the skin...
July 30, 2018: Marine Drugs
Pavel V Chernyshov, Anastasiia Petrenko, Victoria Kopylova
Background: Acne is a common dermatologic disease that can have a profound negative impact on a patient's health-related quality of life (HRQoL). HRQoL correlates with acne severity in some, but not all, studies. In other words, patients with the same level of acne severity might experience different levels of impact on their HRQoL. Objective: We aimed to determine which HRQoL factors are negatively affected most in patients with acne who seek dermatologic consultation and treatment for their acne. Methods: One hundred patients with acne who sought treatment from a dermatologist ("active" patients) and 159 students with a confirmed diagnosis of acne ("passive" patients) who had not sought treatment from a dermatologist were assessed for HRQoL...
July 2018: Journal of Clinical and Aesthetic Dermatology
Mohammad Shahidi-Dadras, Fahimeh Abdollahimajd, Razieh Jahangard, Ali Javinani, Amir Ashraf-Ganjouei, Parviz Toossi
Background: Morphea is an inflammatory disease of the connective tissue that may lead to thickening and hardening of the skin due to fibrosis. The aim of this study was to document magnetic resonance imaging (MRI) changes in patients with linear morphea who were treated with methotrexate (MTX) and high-dose corticosteroid. Methods: This study was conducted on 33 patients from the outpatient's dermatology clinic of our institute, who fulfilled the inclusion criteria...
2018: Dermatology Research and Practice
Michele Maria Luchetti, Devis Benfaremo, Anna Campanati, Elisa Molinelli, Monia Ciferri, Serena Cataldi, William Capeci, Marco Di Carlo, Anna Maria Offidani, Fausto Salaffi, Armando Gabrielli
Psoriatic arthritis (PsA) is a chronic inflammatory autoimmune arthritis, occurring in patients with psoriasis (Pso), that may affect the whole musculoskeletal system but also nails, eye, and gastrointestinal tract. Dermatologists and rheumatologists usually manage Pso and PsA separately, but early diagnosis and integrated management could achieve better outcomes of both skin and musculoskeletal manifestations, thus improving the health-related quality of life (HRQoL) of patients. In this work, we have described a model of integrated dermo-rheumatologic approach for the early diagnosis of PsA and to present the outcomes of the multidisciplinary management of PsA patients after 48 weeks of follow-up...
July 29, 2018: Clinical Rheumatology
Aakash Desai, Anand Krishnan, Ahmed Zaghloul, Mitchell McClure
Mohs micrographic surgery (MMS) is a specialised micrographic technique used for the treatment of locally invasive skin cancers. Despite being a relatively low risk surgery, the overall complication rates range between 1.6% and 3%. Common complications include postoperative haemorrhage, haematoma formation, wound infection, wound dehiscence and flap/graft necrosis. Osteomyelitis after dermatological cancer surgery is exceedingly rare. There have only been two cases of osteomyelitis in association with Mohs surgery reported in the literature to date...
July 26, 2018: BMJ Case Reports
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