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Skin dermatologic treatment

B Llombart, C Serra, C Requena, M Alsina, D Morgado-Carrasco, V Través, O Sanmartín
Sarcomas comprise a broad group of tumors, many of whose biological behavior and aggressiveness differ from one type to another. The therapeutic approach is generally multidisciplinary and often complex. Developments in surgical and oncological dermatology during the last few decades have positioned dermatologists as specialists in the diagnosis and treatment of skin cancer. The aim of this article is to review the main soft tissue sarcomas that typically affect the skin. Dermatofibrosarcoma protuberans is a low-grade malignant sarcoma...
December 2018: Actas Dermo-sifiliográficas
David E Castillo, Sonali Nanda, Jonette E Keri
Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. A delicate balance of these microorganisms is essential for the barrier function of the skin. Propionibacterium acnes represents nearly 90% of the human skin microbiome of healthy adults...
December 11, 2018: Dermatology and Therapy
Kam Lun Hon, Kin Fon Leong, Theresa Nh Leung, Alexander Kc Leung
Background: Eczema or atopic dermatitis (AD) is a common relapsing childhood dermatologic illness. Treatment of AD is primarily topical with emollients and corticosteroid/calcineurin inhibitor, which is efficacious for the majority of patients. However, AD is often complicated and difficult to manage in many Asian cities. Effective therapy is impeded by fallacies in the following aspects: (1) mistrust and unrealistic expectations about Western medicine, (2) skin care and allergy treatment, (3) ambiguity about optimal bathing and moisturizing, (4) hesitation and phobias about the usage of adequate topical corticosteroid and immunomodulatory therapies, (5) food and aeroallergen avoidance and dietary supplementation, and (6) complementary and alternative therapies...
2018: Drugs in Context
Jochen Schmitt, Toni Lange, Jan Kottner, Cecilia A C Prinsen, Tobias Weberschock, Elisabeth Hahnel, Christian Apfelbacher, Susanne Brandstetter, Andreas Dreher, Giles Stevens, Esther Burden-Teh, Natasha Rogers, Phyllis Spuls, Matthew J Grainge, Hywel C Williams, Lena Jacobi
Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Currently, no gold standard of outcome choice for dermatology trials and reviews exists. We systematically assessed concordance between efficacy outcomes in a random sample of 10 Cochrane Skin systematic reviews and the 220 dermatology trials included. Reviews did not include 742 (68%) of the 1,086 trial outcomes...
December 5, 2018: Journal of Investigative Dermatology
Yasuhiro Fujisawa, Takeru Funakoshi, Yoshiyuki Nakamura, Maki Ishii, Jun Asai, Takatoshi Shimauchi, Kazuyasu Fujii, Manabu Fujimoto, Norito Katoh, Hironobu Ihn
BACKGROUND: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan. OBJECTIVE: To investigate the actual number of advanced NMSC patients in Japan. METHODS: A questionnaire survey was sent to 668 institutes to educe information on: 1) the numbers of patients with squamous cell carcinoma (SCC), extramammary Paget disease (EMPD), other skin origin carcinomas, and cutaneous angiosarcoma (CAS) admitted in 2016 and 2017; 2) the preferred first- and second-line chemotherapies; and 3) the anticipated for future development...
November 3, 2018: Journal of Dermatological Science
Naomi Chuchu, Yemisi Takwoingi, Jacqueline Dinnes, Rubeta N Matin, Oliver Bassett, Jacqueline F Moreau, Susan E Bayliss, Clare Davenport, Kathie Godfrey, Susan O'Connell, Abhilash Jain, Fiona M Walter, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for most skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and potentially offer an instant risk assessment of the likelihood of malignancy so that the right people seek further medical attention from a clinician for more detailed assessment of the lesion. There is, however, a risk that melanomas will be missed and treatment delayed if the application reassures the user that their lesion is low risk...
December 3, 2018: Cochrane Database of Systematic Reviews
Morgan M McNeil, Amanda F Nahhas, Taylor L Braunberger, Iltefat H Hamzavi
Afamelanotide, an α-melanocyte stimulating hormone analogue, has become an emerging therapeutic option for a variety of skin conditions previously refractory to other treatments. Its efficacy has been demonstrated in several dermatologic conditions, including erythropoietic protoporphyria (EPP), solar urticaria, polymorphic light eruption (PMLE), vitiligo, acne, and Hailey-Hailey disease. Its relatively low risk side effect profile makes it an attractive treatment option and also paves the way for innovative use in other disorders...
November 2018: Skin Therapy Letter
Dustin H. Marks, Adam Friedman
Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic conditions. This review thus assesses the therapeutic potential of phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids in the management of cutaneous disease. The PubMed® and Scopus® databases were subsequently reviewed in December 2017 using MeSH and keywords, such as cannabinoid, THC, dermatitis, pruritus, and skin cancer...
November 2018: Skin Therapy Letter
S Metekoglu, T Oral, C Ucar Psy, M A Akalin
BACKGROUND: Acne is the most common skin disease, and isotretinoin is the most powerful drug amongst the various drugs used for its treatment. A causal relationship has not yet been established between isotretinoin use and depression. OBJECTIVES: The aim of this study is to research the effect of isotretinoin treatment on depression in a group of patients undergoing isotretinoin therapy. METHODS: Behavioral tests measuring anxiety and depression, and the measures assessing acne severity and quality of life were applied to 112 acne patients consulted at Dermatology Clinic of Beyazit Medico Social Center of Istanbul University...
December 5, 2018: Dermatologic Therapy
Kumutnart Chanprapaph, Wimolsiri Iamsumang, Penpun Wattanakrai, Vasanop Vachiramon
Background: Chronic spontaneous urticaria (CSU) is autoimmune in nature and associated with thyroid autoimmunity (TA), but evidence on autoimmunity in relation to CSU progression and prognosis is limited. We evaluated whether TA and autoimmunity in CSU are correlated with disease severity, therapeutic response, and time to remission and establish an association between CSU characteristics linked to thyroid autoantibody. Methods: Medical records of patients diagnosed with urticaria attending outpatient dermatology clinic at a university-based hospital from 2013 to 2017 were retrospectively reviewed...
2018: BioMed Research International
Chandra S Sirka, Swetalina Pradhan, Debadatta Mohapatra, Biswa R Mishra
Munchausen syndrome by proxy (MSBP) is a rare psychiatric disorder of a caregiver (commonly mother) who induces injury or symptoms on victim because of his or her psychiatry illness. The victims are usually under 6 years of age who cannot complain regarding inflicted injury. Diagnosis is challenging to the physician. We came across a 15-month-old girl child, who had consulted various specialists for episodes of blister followed by erosions on body since 6 months of age. Dermatological examination revealed blisters and healed leaf-shaped scars of different sizes which were suggestive of scalds...
November 2018: Indian Dermatology Online Journal
Shweta Arora, Bikash R Kar
Introduction: Psoriasis is a chronic inflammatory and proliferative condition of the skin which is well-known to impair the patients' quality of life (QoL). Of the various treatment modalities, narrowband UVB (NBUVB) phototherapy is one of the standard treatments for moderate to severe plaque psoriasis with minimal side-effects compared to other systemic therapies. Objectives: To study whether NBUVB phototherapy administration improves QoL in plaque-type psoriasis and to find the correlation between clinical severity of psoriasis and patients' QoL by using psoriasis area severity index (PASI), dermatology life quality index (DLQI), and psoriasis disability index (PDI) tools before and after NBUVB phototherapy...
November 2018: Indian Dermatology Online Journal
Chen Peng, Chen Fuchao, Zhou Benhong
BACKGROUND: This meta-analysis was conducted to assess the risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients. METHODS: We considered relevant prospective randomized Phase I, II and III trials of melanoma patients on the combined BRAF and MEK inhibition versus BRAF inhibition, describing events of rash, photosensitivity reaction (PR), hyperkeratosis (HK), alopecia, cutaneous squamous-cell carcinom(cSCC), skin papilloma(SP), pruritus and hand-foot syndrome(HFS), as eligible for inclusion...
December 2, 2018: Cutaneous and Ocular Toxicology
Rehab Nabil Shamma, Sinar Sayed, Nirmeen Ahmed Sabry, Solwan Ibrahim El-Samanoudy
Acne vulgaris is the most common dermatological disorder affecting millions of individuals. Acne therapeutic solutions include topical treatment with retinoic acid (RA) which showed a god efficacy in treatment of mild and moderate cases. However, the high prevalence of adverse events, such as skin dryness, shedding and skin irritation affects the patient convenience and obstruct the acne treatment. Thus, the objective of this paper was to produce Span 60 based elastic vesicles enriched with penetration enhancers, and study their influence on the delivery of RA and its skin irritation...
December 2, 2018: Journal of Liposome Research
Yu-Chiang Hung, Chieh-Ying Chin, Yi-Chiao Lee, Yen-Hao Chen, Ming-Yen Tsai
BACKGROUND: To summarize the clinical efficacy and safety of Chinese herbal medicine (CHM) in the treatment of dermatologic events resulting from epidermal growth factor receptor (EGFR) inhibitors according to our experience of ten patients. METHODS: Four males and six females, 35-73 years old, mainly with acneiform rash associated with EGFR inhibitors on the face, scalp, perineum, four limbs, and upper trunk, were treated at our traditional Chinese medicine (TCM) clinic in 2016 and 2017...
November 6, 2018: Explore: the Journal of Science and Healing
Chloe Ekelem, Margit Juhasz, Pooja Khera, Natasha Atanaskova Mesinkovska
Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4.0 mg/d. This phenomenon has piqued the interest of researchers and practitioners in regard to low-dose naltrexone's potential in the treatment of several autoimmune conditions...
November 28, 2018: JAMA Dermatology
Hélio Amante Miot, Gerson de Oliveira Penna, Andréa Machado Coelho Ramos, Maria Lúcia Fernandes Penna, Sílvia Maria Schmidt, Flávio Barbosa Luz, Maria Auxiliadora Jeunon Sousa, Sérgio Luiz Lira Palma, José Antonio Sanches Junior
BACKGROUND: Dermatological diseases are among the primary causes of the demand for basic health care. Studies on the frequency of dermatoses are important for the proper management of health planning. OBJECTIVES: To evaluate the nosological and behavioral profiles of dermatological consultations in Brazil. METHODS: The Brazilian Society of Dermatology invited all of its members to complete an online form on patients who sought consultations from March 21-26, 2018...
November 2018: Anais Brasileiros de Dermatologia
Caroline S Costa, Ediléia Bagatin, Ana Luiza C Martimbianco, Edina Mk da Silva, Marília M Lúcio, Parker Magin, Rachel Riera
BACKGROUND: Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit associated with socialisation and mental health problems, may affect more than 80% of teenagers. Isotretinoin is the only drug that targets all primary causal factors of acne; however, it may cause adverse effects. OBJECTIVES: To assess efficacy and safety of oral isotretinoin for acne vulgaris. SEARCH METHODS: We searched the following databases up to July 2017: the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase, PsycINFO and LILACS...
November 24, 2018: Cochrane Database of Systematic Reviews
Martin Ignacio Zapata Laguado, Jorge Enrique Aponte Monsalve, Jorge Hernan Santos, Javier Preciado, Andres Mosquera Zamudio, Cristina Garza Acosta
Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi's sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature...
September 2018: Case Reports in Oncology
M Kovacs, M Podda
Hidradenitis suppurativa (HS) is a chronic skin disease characterized by auto-inflammation resulting in abscesses, nodules, fistula and scaring in the affected areas. It is known as one of the most life restricting diseases in dermatology with highly negative effects regarding the DLQI. Despite the uprising therapeutic approaches available for HS, there is still a need for more effective medications to treat this auto-inflammational disease. This article is protected by copyright. All rights reserved.
November 27, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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