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Skin dermatologic treatment

Jean-François Stalder, Joachim W Fluhr, Tim Foster, Martin Glatz, Ehrhardt Proksch
In recent years, the importance of the microbiome in maintaining healthy skin has become apparent. Both the classic microbiology cultivation techniques used since the early 1970s and the next-generation sequencing procedures refined in the past decade reveal the importance of skin microbiome in healthy and diseased skin. To strengthen and eventually restore a healthy microbiome in patients with dermatological conditions like atopic dermatitis (AD), it is important to consider the factors that influence the composition of the microbiome, such as skin pH and skin barrier integrity...
October 16, 2018: Journal of Dermatological Treatment
Ramiz N Hamid, Christine S Ahn, William W Huang
Neratinib is a tyrosine kinase inhibitor that was FDA-approved for extended adjuvant treatment in adults with HER-2 positive breast cancer in 2017. Due to the novelty of the drug, there are no current reports in the literature of adverse cutaneous effects associated with neratinib therapy. We present a case of a woman on neratinib for HER-2 positive infiltrating ductal carcinoma of the right breast who presented to the dermatology clinic with changes to the fingernails, acne, and a rash on the face. Physical examination revealed erythema, induration, and some serum crust along the lateral nail folds of the right 4th and left 3rd digits as well as monomorphic acneiform papules and pustules on the face...
October 15, 2018: Journal of Dermatological Treatment
Mara Weinstein Velez, Omer Ibrahim, Kathleen Petrell, Jeffrey S Dover
Objective: Noninvasive fat reduction has become increasingly popular. This study evaluated the outcomes of multiple treatments with a nonthermal focused ultrasound device for the noninvasive removal of excess abdominal fat. Design: Participants underwent a total of three pulsed, focused ultrasound treatments spaced two weeks apart. Setting: This study took place in an outpatient dermatology office in a suburb of a major city. Participants: Ten healthy female subjects between 18 and 60 years of age with an abdominal thickness of at least 0...
September 2018: Journal of Clinical and Aesthetic Dermatology
Robert J Barry, Ulises Zanetto, Sai Kolli, Rupal Morjaria
A 38-year-old woman presented to casualty with bilateral red eyes associated with a recent upper respiratory tract infection. This was initially diagnosed as conjunctivitis, however systemic review revealed an erythematous facial and skin rash, mildly swollen lips and mild swallowing difficulties. The patient was referred for an urgent medical assessment, by which time she was found to have erythema affecting 54% of her body surface area and diagnosed with suspected toxic epidermal necrolysis (TEN). She rapidly deteriorated over 24 hours with a spreading blistering skin rash and airway compromise requiring urgent intubation and admission to the intensive treatment unit (ITU)...
October 12, 2018: BMJ Case Reports
A Cuellar-Barboza, J Ocampo-Candiani, M E Herz-Ruelas
Erythroderma is an inflammatory skin syndrome that involves desquamation and erythema of more than 90% of the body surface area. It represents a final clinical endpoint for many adult dermatological conditions. The most frequent cause of erythroderma is psoriasis followed by eczematous conditions, drug-induced reactions, pityriasis rubra pilaris and cutaneous T-cell lymphomas. Diagnostic approach must include a thorough history and clinical examination. If the etiology of erythroderma is uncertain multiple skin biopsies may enhance diagnostic accuracy...
October 10, 2018: Actas Dermo-sifiliográficas
Or Friedman, Amir Koren, Roni Niv, Joseph N Mehrabi, Ofir Artzi
PURPOSE: Rosacea is a common, chronic facial skin disease that affects the quality of life. Treatment of facial erythema with intradermal botulinum toxin injection has previously been reported. The primary objective of the study was the safety and efficacy of thermal decomposition of the stratum corneum using a novel non-laser thermomechanical system (Tixel, Novoxel, Israel) to increase skin permeability for Botulinum toxin in the treatment of facial flushing of rosacea. METHODS: A retrospective review of16 patients aged 23-45 years with Fitzpatrick Skin Types II to IV and facial erythematotelangiectatic rosacea treated by Tixel followed by topical application of 100 U of abobotulinumtoxin...
October 12, 2018: Lasers in Surgery and Medicine
Sukhjot Kaur, Jatinder Singh Goraya
BACKGROUND/OBJECTIVES: Vitamin B12 deficiency in infants is uncommonly reported from developed countries and generally lacks dermatologic manifestations. On the contrary, infantile vitamin B12 deficiency is common in India and cutaneous manifestations are a constant feature, although often overshadowed by neurologic and hematological manifestations. The aim of this study was to describe the skin changes of vitamin B12 deficiency in infants. MATERIALS AND METHODS: A retrospective chart review of vitamin B12 deficient infants for clinical and laboratory parameters was performed and data analyzed...
October 11, 2018: Pediatric Dermatology
Janine Topp, Matthias Augustin, Kathrin von Usslar, Ramona Gosau, Kristian Reich, Michael Reusch, Christine Blome
This study investigated the validity and feasibility of the Patient Benefit Index 2.0 (PBI 2.0), a short instrument to assess patient-relevant treatment benefit. In a cross-sectional study, patients with skin diseases completed the PBI 2.0 alongside instruments on quality of life and disease-specific PBI long versions to assess convergent validity. Feasibility questions appraise comprehensibility, completeness, length, and readability. Data from a longitudinal study were used to explore responsiveness and test-retest reliability...
October 11, 2018: Acta Dermato-venereologica
Lindsey M LePoidevin, Dylan E Lee, Vivian Y Shi
BACKGROUND/OBJECTIVES: Atopic dermatitis (AD) is a chronic condition that is predominantly found in pediatric patients and commonly presents therapeutic challenges. The management of AD encompasses a variety of factors, and the pillars of optimal management revolve around skin barrier repair and antiinflammatory, antimicrobial, and antipruritic treatment. AD management guidelines exist in various geographic regions globally. The purpose of this review was to compare international guidelines to highlight the similarities and variances among populations and skin types...
October 10, 2018: Pediatric Dermatology
Sarah Asch, Diana L Vork, Josiane Joseph, Brittny Major-Elechi, Megha M Tollefson
BACKGROUND/OBJECTIVES: Skin infection is common in atopic dermatitis (AD), often necessitating treatment with systemic antibiotics. Topical adjunctive therapies such as dilute bleach baths are increasingly recommended, and topical dilute acetic acid (AA) has not been widely studied. The objective of this study was to evaluate whether various topical anti-infective bathing recommendations were associated with decreased systemic antibiotic exposure in pediatric AD, as well as evaluate topical anti-infective recommendations over time within our institution...
October 10, 2018: Pediatric Dermatology
Akimichi Morita, Fumikazu Yamazaki, Takashi Matsuyama, Kenzo Takahashi, Satoru Arai, Akihiko Asahina, Shinichi Imafuku, Hidemi Nakagawa, Yuichi Hasegawa, David Williams, Naoto Matsuda, Susumu Kitamura
A phase 3, multicenter, open-label, 52-week study investigated the efficacy and safety of adalimumab 80 mg at week 0 followed by adalimumab 40 mg every other week (option to escalate to 80 mg when necessary) in Japanese patients with generalized pustular psoriasis (GPP). Adults (aged 15-75 years) with GPP, total skin score (overall erythema area, erythema area with pustules, and edema area) of 3 or more, and erythema with pustules (skin score, ≥1) based on the 2014 Japanese Dermatological Association severity index of GPP were enrolled...
October 10, 2018: Journal of Dermatology
Amandine André, Joanna Wdzieczak-Bakala, Alexis Kaatio Touré, Didier Stien, Véronique Eparvier
Glycation is a common non-enzymatic reaction between proteins and sugars, which gives rise in the human body to the formation of advanced glycation end products (AGEs). These modifications impacts both extra and intracellular proteins, leading to cells and tissues dysfunctions. In the skin, accumulation of AGEs leads to aesthetic consequences, wrinkles, dark spots and yellowish skin tone, as it can be seen in diabetic patients. Consequently, there is a growing dermatological interest to find compounds able to eliminate AGEs accumulated in skin...
October 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Cynthia X Wang, Milan J Anadkat, Amy C Musiek
Hematopoietic stem cell transplants (HSCTs) are used to treat a variety of conditions, including hematologic malignancies, bone marrow failure syndromes, and immunodeficiencies. Over 60,000 HSCTs are performed annually worldwide, and the numbers continue to increase. Indeed, as new conditioning regimens develop, more and more individuals, including those of older age, will be eligible for transplants. Nevertheless, although HSCTs are clearly a life-saving and necessary treatment for thousands of patients per year, there is still substantial morbidity and mortality associated with the procedure...
October 8, 2018: American Journal of Clinical Dermatology
Jae Eun Choi, Dong Won Lee, Soo Hong Seo, Hyo Hyun Ahn, Young Chul Kye
BACKGROUND: Melasma is a common acquired facial pigmentary disorder that is resistant to various modalities of treatment. Recently, the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser (QSNY) has emerged as the new gold standard of melasma treatment in Asia. OBJECTIVE: To evaluate the efficacy and safety of low-fluence 1064-nm QSNY in Asian patients with melasma. METHODS: Data of patients with melasma treated with low-fluence QSNY in the department of dermatology at the Korea University Anam Hospital were reviewed retrospectively...
October 2, 2018: Journal of Cosmetic Dermatology
P Chen, F Chen, B Zhou
BACKGROUND: Vemurafenib has been linked to dermatological adverse events in patients with melanoma, including an increased risk of rash, cutaneous squamous cell carcinoma, photosensitivity reaction and keratoacanthoma. However, there has been no systematic attempt to assess the dermatological toxicity data of vemurafenib associated with melanoma treatment. AIM: To evaluate the point prevalence of dermatological toxicities associated with vemurafenib treatment in patients with melanoma...
October 2, 2018: Clinical and Experimental Dermatology
Ming-Yeh Yang, Kai-Chih Chang, Liang-Yü Chen, Anren Hu
Propionibacterium acnes (P. acnes) is an opportunistic infection in human skin that causes acne vulgaris. Antibiotic agents provide the effective eradication of microbes until the development of drug-resistant microbes. Photodynamic inactivation (PDI) is a non-antibiotic therapy for microbial eradication. In this study, the visible blue light (BL, λmax  = 462 nm) was used to enhance the antimicrobial activities of curcumin, a natural phenolic compound. Individual exposure to curcumin or BL irradiation does not generate cytotoxicity on P...
September 26, 2018: Journal of Photochemistry and Photobiology. B, Biology
Katsuhiro Masago, Fumiko Imamichi, Yoshio Masuda, Noriko Ariga, Kiyomi Fujitomi, Yoko Fukumine, Kana Hatakenaka, Shiro Fujita, Nobuyuki Katakami
Objective: The aim of this study was to evaluate the effectiveness of a rash team management intervention designed by certified nurses, medical physicians, and certified pharmacists. The quality of life (QOL) of patients administered epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) was assessed using the dermatology life quality index (DLQI) and Skindex-29 QOL questionnaires. Methods: A total of 51 patients with nonsmall cell lung cancer who were treated using EGFR-TKIs were examined between November 1, 2014, and October 31, 2015, at the Institute of Biomedical Research and Innovation in Kobe city, Japan...
October 2018: Asia-Pacific Journal of Oncology Nursing
Craig A Bauman, Peter Emary, Tyler Damen, Heather Dixon
Introduction: Melanoma can be a fatal form of skin cancer. The prognosis rapidly deteriorates from the in situ stage (stage 0) to stage 4. As such, early detection and treatment are key. Case Presentation: A middle-aged patient, who was also a chiropractor, self-identified a small skin lesion using the Chiropractors Guide to Skin Cancer. The primary care physician made a dermatology referral, and biopsy identified melanoma. Surgery was subsequently booked and the lesion was excised with a 5 mm margin...
April 2018: Journal of the Canadian Chiropractic Association
Barbara Algiert-Zielińska, Paulina Mucha, Helena Rotsztejn
BACKGROUND: Recently more attention has been drawn to alpha hydroxy and polyhydroxy acids (AHA and PHA) due to their excellent moisturizing and antioxidant properties. These compounds are very beneficial in terms of both cosmetic and dermatological treatments. OBJECTIVE: The aim of this study was an assessment of moisturizing properties of lactobionic and lactic acids based on available literature. METHODS: Literature review using scientific databases: PubMed, Medline (EBSCO), Medline Complete, Karger, Springer/ICM, SpringerLink/online, Wiley Online Library...
September 30, 2018: International Journal of Dermatology
Michiko Kurosawa, Ritei Uehara, Atsushi Takagi, Yumi Aoyama, Keiji Iwatsuki, Masayuki Amagai, Masaki Nagai, Yosikazu Nakamura, Yutaka Inaba, Kazuhito Yokoyama, Shigaku Ikeda
BACKGROUND: Autosomal recessive congenital ichthyosis (ARCI) and ichthyosis syndrome (IS) are rare genetic skin disorders. OBJECTIVE: To estimate the number of patients with ARCI and IS in Japan and clarify the clinicoepidemiologic features of these diseases. METHODS: We performed a nationwide survey of patients treated for ARCI or IS during January 2005-December 2009. We developed diagnostic criteria and conducted a primary survey in a stratified random sample of Japanese hospitals to quantify the number of outpatients and inpatients with ARCI or IS...
September 26, 2018: Journal of the American Academy of Dermatology
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