Saad Bakrim, Nasreddine El Omari, Eman Jamil Khan, Asaad Khalid, Ashraf N Abdalla, Jack Bee Chook, Khang Wen Goh, Long Chiau Ming, Sara Aboulaghras, Abdelhakim Bouyahya
Nuclear receptors (NRs) represent intracellular proteins that function as a signaling network of transcriptional factors to control genes in response to a variety of environmental, dietary, and hormonal stimulations or serve as orphan receptors lacking a recognized ligand. They also play an essential role in normal development, metabolism, cell growth, cell division, physiology, reproduction, and homeostasis and function as biological markers for tumor subclassification and as targets for hormone therapy. NRs, including steroid hormone receptors (SHRs), have been studied as tools to examine the fundamentals of transcriptional regulation within the development of mammals and human physiology, in addition to their links to disturbances...
November 7, 2023: Biomedicine & Pharmacotherapy