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Federica Pollastro, Diego Caprioglio, Patrizia Marotta, Aniello Schiano Moriello, Luciano De Petrocellis, Orazio Taglialatela-Scafati, Giovanni Appendino
Treatment with iodine cleanly converts various p-menthane-type phytocannabinoids and their carboxylated precursors into cannabinol (CBN, 1a). The reaction is superior to previously reported protocols in terms of simplicity and substrate range, which includes not only tricyclic tetrahydrocannabinols such as Δ9 -THC (2a) but also bicyclic phytocannabinoids such as cannabidiol (CBD, 3a). Lower homologues from the viridin series (2c and 3c, respectively) afforded cannabivarin (CBV), a non-narcotic compound that, when investigated against a series of ionotropic (thermo-TRPs) biological end-points of phytocannabinoids, retained the submicromolar TRPA1-activating and TRPM8-inhibiting properties of CBN, while also potently activating TRPV2...
March 23, 2018: Journal of Natural Products
Aurelia Tubaro, Anna Giangaspero, Silvio Sosa, Roberto Negri, Gianpaolo Grassi, Salvatore Casano, Roberto Della Loggia, Giovanni Appendino
A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids...
October 2010: Fitoterapia
F W Merkus
No abstract text is available yet for this article.
February 26, 1971: Pharmaceutisch Weekblad
T B Vree, D D Breimer, C A van Ginneken, J M van Rossum, R A de Zeeuw, A H Witte
No abstract text is available yet for this article.
September 1971: Clinica Chimica Acta; International Journal of Clinical Chemistry
F W Merkus, M G Jaspers, J F Roovers
No abstract text is available yet for this article.
1972: Beiträge Zur Gerichtlichen Medizin
F W Merkus
No abstract text is available yet for this article.
August 20, 1971: Nature
K Bailey, D Gagné
The on-column flash methylation of synthetic cannabidiol, cannabichromene, and cannabivarin by trimethylanillinium hydroxide offers a rapid, simple GLC method for their distinction. The phenolic groups of other cannabinoids are methylated by the procedure described.
October 1975: Journal of Pharmaceutical Sciences
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