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https://www.readbyqxmd.com/read/30339264/effects-of-brimonidine-on-retinal-pigment-epithelial-cells-and-m%C3%A3-ller-cells-exposed-to-amyloid-beta-1-42-peptide-in-vitro
#1
Sean W Tsao, Rami Gabriel, Kunal Thaker, Baruch D Kuppermann, M Cristina Kenney
BACKGROUND AND OBJECTIVE: To evaluate whether brimonidine can prevent cytotoxicity in human retinal pigment epithelial (RPE) and Müller (MIO) cells after exposure to amyloid-beta 1-42 (Aβ42). MATERIALS AND METHODS: An in vitro model of geographic atrophy (GA), which is an end-stage complication of age-related macular degeneration (AMD), simulated with the application of Aβ42 in cell culture. RPE and MIO cells were pretreated with brimonidine for 6 hours, then exposed to 10μM Aβ42 for 24 hours...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30338926/advanced-glycation-end-products-related-modulation-of-cathepsin-l-and-nf-%C3%AE%C2%BAb-signalling-effectors-in-retinal-pigment-epithelium-lead-to-augmented-response-to-tnf%C3%AE
#2
Umar Sharif, Nur Musfirah Mahmud, Paul Kay, Yit C Yang, Simon P Harding, Ian Grierson, Tengku Ain Kamalden, Malcolm J Jackson, Luminita Paraoan
The retinal pigment epithelium (RPE) plays a central role in neuroretinal homoeostasis throughout life. Altered proteolysis and inflammatory processes involving RPE contribute to the pathophysiology of age-related macular degeneration (AMD), but the link between these remains elusive. We report for the first time the effect of advanced glycation end products (AGE)-known to accumulate on the ageing RPE's underlying Bruch's membrane in situ-on both key lysosomal cathepsins and NF-κB signalling in RPE. Cathepsin L activity and NF-κB effector levels decreased significantly following 2-week AGE exposure...
October 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30334924/effectiveness-of-en-bloc-removal-of-fibrinogen-rich-component-of-cystoid-lesion-for-the-treatment-of-cystoid-macular-edema
#3
Hisanori Imai, Keiko Otsuka, Akira Tetsumoto, Akiko Miki, Makoto Nakamura
PURPOSE: To introduce the methodology and outcomes of en bloc removal of the component of cystoid lesion during pars plana vitrectomy as a novel approach for the treatment of cystoid macular edema and show evidence that the component is an aggregation of fibrinogen by mass spectrometry analysis. METHODS: The surgical en bloc extraction of the component of cystoid lesion was performed for cystoid macular edemas secondary to diabetic retinopathy and retinal vein occlusion...
October 16, 2018: Retina
https://www.readbyqxmd.com/read/30332547/demographic-and-clinical-features-of-pediatric-uveitis-in-israel
#4
Zohar Habot-Wilner, Liran Tiosano, Juan M Sanchez, Shiri Shulman, Dana Barequet, Ori Rahat, Gil Amarilyo, Radgonde Amer
PURPOSE: To report the epidemiology, etiology, ocular characteristics, treatment and visual outcome of pediatric uveitis in Israel. METHODS: Retrospective study from two tertiary uveitis centers. RESULTS: Included were 107 patients (182 eyes), 55% females. Mean age at diagnosis 8.8 years. Uveitis was predominantly anterior, idiopathic, bilateral, and chronic. Systemic associations were seen in 36% of patients of which the most common disease was juvenile idiopathic arthritis...
October 17, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/30326539/-long-term-outcome-after-autologous-free-internal-limiting-membrane-flap-for-the-treatment-of-refractory-macular-holes
#5
Josef Guber, Max Vieregge, Hendrik P N Scholl, Christophe Valmaggia
PURPOSE: To evaluate the technique and the long-term outcomes after autologous internal limiting membrane flap surgery for refractory macular holes. METHODS: The free ILM flap technique was used as a secondary procedure for non-closing macular holes after failed initial standard procedure. SD-OCT images were taken to assess the anatomical outcome of surgery while best corrected visual acuity (BCVA) was used to evaluate the functional outcome during a one-year follow-up...
October 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/30325876/10-year-follow-up-of-a-subclinical-choroidal-neovascular-membrane-in-a-patient-with-age-related-macular-degeneration
#6
Katherine G Chen, Panos G Christakis, Emily Y Chew
PURPOSE: To provide long-term, natural history data of a case of a subclinical choroidal neovascular membrane (CNVM) in the setting of age-related macular degeneration. METHODS: Retrospective review of the 10-year clinical course of a patient including multimodal imaging. RESULTS: A 75-year-old white female with macular degeneration presented with visual acuity of 20/25 in the right eye and 20/40 in the left eye. In the left eye, a retinal pigment epithelial detachment with associated subretinal and intraretinal fluid was found on spectral domain optical coherence tomography...
October 15, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30315261/asian-age-related-macular-degeneration-from-basic-science-research-perspective
#7
REVIEW
Yasuo Yanagi, Valencia Hui Xian Foo, Akitoshi Yoshida
In Asian populations, polypoidal choroidal vasculopathy (PCV), a distinct phenotype of neovascular age-related macular degeneration (AMD), is more prevalent than Caucasians. Recently, there has been significant focus on how PCV differs from typical AMD. Although typical AMD and PCV share a variety of mechanisms by which abnormal angiogenic process occurs at the retinochoroidal interface, PCV has different clinical characteristics such as aneurysm-like dilation at the terminal of choroidal neovascular membranes, less frequent drusen and inner choroidal degeneration due to the thickened choroid...
October 12, 2018: Eye
https://www.readbyqxmd.com/read/30314435/development-of-a-full-thickness-macular-hole-after-vitrectomy-for-rhegmatogenous-retinal-detachment-a-sequential-study-via-optical-coherence-tomography
#8
Hsin-Yu Yang, Chang-Sue Yang
BACKGROUND: To demonstrate a full thickness macular hole (MH) development after vitrectomy (VT) for rhegmatogenous retinal detachment (RRD) and to investigate the possible disease mechanism with optical coherence tomography (OCT). CASE PRESENTATION: A 47-year-old female underwent 23G vitrectomy surgery to repair the macula-detached RRD successfully. However, intraretinal cysts initially developed two months after surgery. Cysts gradually increased in number and size, and cystoid macular edema was noted at the 5th month...
October 11, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/30312261/a-human-amniotic-membrane-plug-to-promote-retinal-breaks-repair-and-recurrent-macular-hole-closure
#9
Stanislao Rizzo, Tomaso Caporossi, Ruggero Tartaro, Lucia Finocchio, Fabrizio Franco, Francesco Barca, Fabrizio Giansanti
No abstract text is available yet for this article.
October 3, 2018: Retina
https://www.readbyqxmd.com/read/30312258/internal-limiting-membrane-peeling-and-air-tamponade-for-stage-iii-and-stage-iv-idiopathic-macular-hole
#10
Yanping Yu, Xida Liang, Zengyi Wang, Jing Wang, Xinxin Liu, Jinqiu Chen, Wu Liu
PURPOSE: To evaluate the effect of internal limiting membrane peeling and air tamponade for idiopathic macular hole, and explore reasons and interventions for persistent holes. METHODS: One hundred and thirty-five eyes with Stage III and IV idiopathic macular hole that underwent 23-gauge vitrectomy, internal limiting membrane peeling, and air tamponade were reviewed. Eyes with persistent holes underwent a second surgery. Outcome-related factors and interventions treating persistent holes were discussed...
October 3, 2018: Retina
https://www.readbyqxmd.com/read/30312255/pars-plana-vitrectomy-for-the-treatment-of-tractional-and-degenerative-lamellar-macular-holes-functional-and-anatomical-results
#11
Marta S Figueroa, Andrea Govetto, David H Steel, J Sebag, Gianni Virgili, Jean Pierre Hubschman
PURPOSE: Functional and anatomical outcomes of vitrectomy with membrane peeling were compared in tractional lamellar macular holes (LMH)/macular pseudoholes (MPH) versus degenerative LMH. METHODS: This multicenter retrospective study enrolled patients with a minimum follow-up of 6 months. The association of spectral domain optical coherence tomography parameters with preoperative and postoperative best-corrected visual acuity was analyzed. RESULTS: Seventy-seven (74...
October 3, 2018: Retina
https://www.readbyqxmd.com/read/30310161/changes-in-volume-of-various-retinal-layers-over-time-in-early-and-intermediate-age-related-macular-degeneration
#12
Ali Lamin, Jonathan D Oakley, Adam M Dubis, Daniel B Russakoff, Sobha Sivaprasad
PURPOSE: To evaluate longitudinally volume changes in inner and outer retinal layers in early and intermediate age-related macular degeneration (AMD) compared to healthy control eyes using optical coherence tomography (OCT). METHODS: 71 eyes with AMD and 31 control eyes were imaged at two time points: baseline and after 2 years. Automated OCT layer segmentation was performed using OrionTM . This software is able to measure volumes of retinal layers with distinct boundaries including Retinal Nerve Fibre Layer (RNFL), Ganglion Cell-Inner Plexiform Layer (GCIPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptors (PR) and Retinal Pigment Epithelium-Bruch's Membrane complex (RPE-BM)...
October 11, 2018: Eye
https://www.readbyqxmd.com/read/30310136/sodium-tanshinone-iia-sulfonate-protects-arpe-19-cells-against-oxidative-stress-by-inhibiting-autophagy-and-apoptosis
#13
Dongmei Han, Xingwei Wu, Libin Liu, Wanting Shu, Zhenping Huang
Oxidative stress in retinal pigment epithelium (RPE) is considered to be a major contributor to the development and progression of age-related macular degeneration (AMD). Previous investigations have shown that sodium tanshinone IIA sulfonate (STS) can alleviate oxidative stress in haemorrhagic shock-induced organ damage and cigarette smoke-induced chronic obstructive pulmonary disease in mice. However, whether STS has a protective effect in ARPE-19 cells under oxidative stress and its exact mechanisms have not yet been fully elucidated...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30309772/accuracy-of-ss-oct-biometry-compared-with-partial-coherence-interferometry-biometry-for-combined-phacovitrectomy-with-internal-limiting-membrane-peeling
#14
Efstathios Vounotrypidis, Velina Haralanova, Daniel R Muth, Christian Wertheimer, Mehdi Shajari, Armin Wolf, Siegfried Priglinger, Wolfgang J Mayer
PURPOSE: To evaluate the accuracy of a swept-source optical coherence tomography (SS-OCT) biometer compared with a standard partial coherence interferometry (PCI) biometer in terms of phacovitrectomy for vitreomacular pathology and cataract. SETTING: Department of Ophthalmology, Ludwig-Maximilians-University Munich, Germany. DESIGN: Prospective, nonrandomized, single center consecutive case series. METHODS: Patients with age-related cataract, regular corneal astigmatism less than 1...
October 8, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/30308558/assessment-of-anatomical-and-functional-outcomes-with-ocriplasmin-treatment-in-patients-with-vitreomacular-traction-with-or-without-macular-holes-results-of-oviid-1-trial
#15
Ramin Tadayoni, Frank G Holz, Christophe Zech, Xin Liu, Claudio Spera, Peter Stalmans
PURPOSE: To evaluate the anatomical and functional outcomes with ocriplasmin in patients with vitreomacular traction (VMT) with or without macular hole (MH). METHODS: In a Phase 4, multicenter, single-arm, open-label study, eligible patients (VMT with focal adhesion, without epiretinal membrane, and with MH ≤400 µm [if present]) received a single intravitreal injection of ocriplasmin. Nonsurgical resolution of VMT (Day 28 [primary endpoint]), best-corrected visual acuity, MH closure, vitrectomy rate, and safety were assessed through Day 180...
October 9, 2018: Retina
https://www.readbyqxmd.com/read/30308527/idiopathic-full-thickness-macular-hole-in-an-8-year-old-boy
#16
George J Manayath, Arvind Jain, Ratnesh Ranjan, Adarsh S Naik, Vekatapathy Narendran
PURPOSE: To report a case of idiopathic full-thickness macular hole in a young boy, which was managed surgically with good visual and anatomical outcomes. METHOD: Single case report. RESULTS: An 8-year-old boy presented for defective vision in the left eye noticed for the past 2 weeks with best-corrected visual acuity of 6/24. A large full-thickness macular hole was diagnosed clinically and was confirmed on optical coherence tomography. There was no clinical or tomographic findings suggestive of trauma or retinal degeneration...
October 9, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30308511/surgical-outcome-after-lamellar-macular-hole-associated-with-epiretinal-membrane
#17
Josef Guber, Hendrik P N Scholl, Christophe Valmaggia
PURPOSE: To evaluate functional and anatomical outcomes after pars plana vitrectomy (PPV) in patients with epiretinal membrane associated with lamellar hole (LH). PATIENTS AND METHODS: All patients who underwent PPV with epiretinal membrane peeling associated with an LH from January 2016 to December 2017 were included. Each patient received a complete ophthalmological examination including best-corrected visual acuity using Snellen charts (in decimal form; converted to logMAR) and spectral domain optical coherence tomography (SD-OCT) before surgery as well as 3 months after surgery...
October 11, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/30299988/use-of-ioct-in-vitreoretinal-surgery-for-dense-vitreous-hemorrhage-in-a-chinese-population
#18
Jiwei Tao, Hanfei Wu, Yiqi Chen, Jianbo Mao, Dan Cheng, Jingjing Lin, Lijun Shen
PURPOSE: To evaluate the feasibility and utility of intraoperative optical coherence tomography (iOCT) during pars plana vitrectomy (PPV) surgery for dense vitreous hemorrhage (VH). METHODS: A retrospective, consecutive, interventional case series. A total of 68 dense VH patients (71 eyes) were enrolled, and the patients were divided into two groups. The control group (43 eyes) did not receive iOCT and the experimental group (28 eyes) did. All patients with macular structures that could not be assessed by preoperative OCT underwent PPV for dense VH...
October 9, 2018: Current Eye Research
https://www.readbyqxmd.com/read/30296412/light-induced-generation-and-toxicity-of-docosahexaenoate-derived-oxidation-products-in-retinal-pigmented-epithelial-cells
#19
Yu-Shuian Cheng, Mikhail Linetsky, Xilin Gu, Naji Ayyash, Anthony Gardella, Robert G Salomon
Oxidative cleavage of docosahexaenoate (DHA) in retinal pigmented epithelial (RPE) cells produces 4-hydroxy-7-oxohept-5-enoic acid (HOHA) esters of 2-lysophosphatidylcholine (PC). HOHA-PC spontaneously releases a membrane-permeant HOHA lactone that modifies primary amino groups of proteins and ethanolamine phospholipids to produce 2-(ω-carboxyethyl)pyrrole (CEP) derivatives. CEPs have significant pathological relevance to age-related macular degeneration (AMD) including activation of CEP-specific T-cells leading to inflammatory M1 polarization of macrophages in the retina involved in "dry AMD" and TLR2-dependent induction of angiogenesis that characterizes "wet AMD"...
October 5, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30291136/prevalence-of-cystoid-macular-oedema-epiretinal-membrane-and-cataract-in-retinitis-pigmentosa
#20
Gerald Liew, Stacey Strong, Patrick Bradley, Philip Severn, Anthony T Moore, Andrew R Webster, Paul Mitchell, Annette Kifley, Michel Michaelides
BACKGROUND/AIMS: To report the prevalence of treatable complications (cystoid macular oedema, CME; epiretinal membrane, ERM and cataract) in patients with retinitis pigmentosa (RP). METHODS: Consecutive patients with RP attending a tertiary eye clinic in 2012. Spectral domain-optical coherence tomography was used to determine presence of CME and ERM. Clinic records were reviewed to identify cataract and pseudophakia. Multivariable analyses adjusted for age, gender and other confounders...
October 5, 2018: British Journal of Ophthalmology
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