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https://www.readbyqxmd.com/read/30517101/prevalence-and-type-of-artefact-with-spectral-domain-optical-coherence-tomography-macular-ganglion-cell-imaging-in-glaucoma-surveillance
#1
Mona S Awadalla, Jude Fitzgerald, Nicholas H Andrew, Tiger Zhou, Henry Marshall, Ayub Qassim, Mark Hassall, Robert J Casson, Stuart L Graham, Paul R Healey, Ashish Agar, Anna Galanopoulos, Simon Phipps, Angela Chappell, John Landers, Jamie E Craig
PURPOSE: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. METHOD: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment...
2018: PloS One
https://www.readbyqxmd.com/read/30511035/association-of-disorganization-of-retinal-inner-layers-with-ischemic-index-and-visual-acuity-in-central-retinal-vein-occlusion
#2
Duncan Berry, Akshay S Thomas, Sharon Fekrat, Dilraj S Grewal
Purpose: To determine whether disorganization of retinal inner layers (DRIL) on optical coherence tomography (OCT) is associated with ischemia on ultra-widefield fluorescein angiography (UWFFA) and with visual outcomes in eyes with acute, treatment-naïve central retinal vein occlusion (CRVO). Design: Retrospective, single-institution, longitudinal cohort study. Participants: Twenty-five consecutive patients with treatment-naïve CRVO and ≥ 1 year follow-up...
November 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/30505990/short-term-effect-of-intravitreal-bevacizumab-for-diabetic-macular-edema-associated-with-epiretinal-membrane
#3
Ashraf Khorasani Maryam, Mohammadi Tafgeh, Motallebi Mahmoud, Anvari Pasha, Sedaghat Ahad, Ghasemi Falavarjani Khalil
Purpose: To evaluate the effect of intravitreal bevacizumab (IVB) injection on central macular thickness (CMT) in patients with diabetic macular edema (DME) associated with epiretinal membrane (ERM) and compare the results to those with DME without ERM. Methods: 54 eyes of 54 patients with DME were included in this prospective comparative case series. Twenty-eight patients had ERM. All patients received 2.5 mg/ 0.1 ml IVB. The primary outcome measure was the change in central macular thickness (CMT) and the secondary outcome measure was the change in best corrected visual acuity (BCVA), one month after the IVB injection...
July 2018: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/30502990/triamcinolone-in-small-gauge-vitrectomy-for-epiretinal-membrane-peeling
#4
Reinhard Angermann, Claus Zehetner, Patrick Sidoroff, Inga Waltl, Gerhard Kieselbach, Martina Kralinger
OBJECTIVE: We compared visual and macular morphological outcomes after epiretinal membrane (ERM) peeling, with and without IVTA treatment. DESIGN: Interventional, retrospective, consecutive case-control study. PARTICIPANTS: Forty-one eyes of 41 participants (17 men, 24 women) were included. Twenty-one were treated by standard vitrectomy and peeling (controls) and 20 patients received intravitreal triamcinolone after vitrectomy and peeling...
December 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/30496729/up-regulation-of-p-gp-via-nf-%C3%AE%C2%BAb-activation-confers-protection-against-oxidative-damage-in-the-retinal-pigment-epithelium-cells
#5
Qiting Feng, Weizhong Yang, Zongyin Gao, Xiangcai Ruan, Yuehong Zhang
Dysfunction of retinal pigment epithelial (RPE) cells has been associated with the pathogenesis of age-related macular degeneration in relation to increased oxidative stress, subsequent mitochondrial dysfunction and cell death. Permeability-glycoprotein (P-gp), encoded by the multidrug resistance 1 gene (MDR1), is an active efflux pump involved in cell homeostasis and nuclear factor κB (NF-κB) shows potential involvement in P-gp regulation due to its binding to the promoter domains of MDR1 gene. This study sought to determine the role of P-gp expression regulated by NF-κB in RPE cells during oxidative stress...
November 26, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30496406/emerging-roles-of-transforming-growth-factor-%C3%AE-signaling-in-wet-age-related-macular-degeneration
#6
Kai Wang, Haoran Li, Ruipu Sun, Chaxian Liu, Yunfei Luo, Shuhua Fu, Ying Ying
Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness among aging populations in developed countries and can be classified as dry or wet according to its progression. Wet AMD, which is characterized by angiogenesis on the choroidal membrane, is uncommonly seen but more severe. Controlling or completely inhibiting the factors that contribute to the progression of events that lead to angiogenesis may be an effective strategy for treating wet AMD. Emerging evidence has shown that transforming growth factor-β (TGF-β) signaling plays a significant role in the progression of wet AMD...
November 29, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/30481134/use-of-telehealth-screening-to-detect-diabetic-retinopathy-and-other-ocular-findings-in-primary-care-settings
#7
Xinxiao Gao, Carl H Park, Krista Dedrick, Durga S Borkar, Anthony Obeid, Shae Reber, Jay Federman
PURPOSE: To determine the incidence of diabetic retinopathy (DR) and other ocular findings in previously diagnosed diabetes using telehealth retinal screening with nonmydriatic fundus photography (nFP) in primary care physicians' offices. METHODS: A retrospective study based on electronic chart review was performed. All diabetic patients who participated in the Wills Eye Hospital (WEH) telehealth retinal screening program from July 1, 2012 to February 20, 2017 were included...
November 27, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/30480705/morphologic-biomechanical-and-compositional-features-of-the-internal-limiting-membrane-in-pathologic-myopic-foveoschisis
#8
Lu Chen, Yantao Wei, Xuezhi Zhou, Zhaotian Zhang, Wei Chi, Li Gong, Xintong Jiang, Shaochong Zhang
Purpose: To investigate alterations in the morphologic, compositional, and biomechanical properties of the internal limiting membrane (ILM) in pathologic myopic foveoschisis (MF) eyes. Methods: ILM specimens were peeled from 61 eyes with MF and 56 eyes with stage III/IV idiopathic macular hole (IMH) as a control. Samples were analyzed for transmission electron microscopy (TEM), scanning electron microscopy, immunofluorescence, Western blotting, and atomic force microscopy...
November 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30477223/tspo-ligands-promote-cholesterol-efflux-and-suppress-oxidative-stress-and-inflammation-in-choroidal-endothelial-cells
#9
Lincoln Biswas, Fahad Farhan, James Reilly, Chris Bartholomew, Xinhua Shu
Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation. Death of the endothelial cells of the choroid may cause abnormal deposits including unesterified and esterified cholesterol beneath RPE cells and within Bruch's membrane that contribute to the progression of age-related macular degeneration (AMD), the most prevalent cause of blindness in older people...
November 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30475289/ridge-shaped-macula-in-young-myopic-patients-and-its-differentiation-from-typical-dome-shaped-macula-in-elderly-myopic-patients
#10
Xian Xu, Yuxin Fang, Jost B Jonas, Ran Du, Kosei Shinohara, Noriko Tanaka, Tae Yokoi, Yuka Onishi, Kengo Uramoto, Koju Kamoi, Takeshi Yoshida, Kyoko Ohno-Matsui
PURPOSE: To assess and compare clinical features of a ridge-shaped macula (defined as macular elevation only in one meridian across the fovea) in individuals younger than 20 years with those of a dome-shaped macula (DSM) in patients aged 20+ years. METHODS: The retrospective observational case series study included 185 highly myopic eyes of 100 consecutive patients younger than 20 years, who were compared with highly myopic patients with DSMs, aged 20+ years and examined in previous studies...
November 20, 2018: Retina
https://www.readbyqxmd.com/read/30470714/foveal-microstructure-and-visual-outcomes-of-myopic-macular-hole-surgery-with-or-without-the-inverted-internal-limiting-membrane-flap-technique
#11
Xu-Ting Hu, Qin-Tuo Pan, Jing-Wei Zheng, Zong-Duan Zhang
PURPOSE: The aim of this study was to determine the effect of the inverted internal limiting membrane (ILM) flap technique on the macular hole (MH) closure and foveal microstructure recovery of patients with highly myopic MH. METHODS: Pars plana vitrectomy and gas tamponade with the inverted ILM flap technique (19 eyes) or with the ILM peeling technique (21 eyes) were performed in patients with highly myopic MH with or without retinal detachment. The rate of MH closure and retinal reattachment, the reconstructive anatomical change of the foveal microstructure and the best-corrected visual acuities (BCVA) of the two groups were compared...
November 23, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/30468870/nanofluidic-microsystem-for-sustained-intraocular-delivery-of-therapeutics
#12
Nicola Di Trani, Priya Jain, Corrine Ying Xuan Chua, Jeremy S Ho, Giacomo Bruno, Antonia Susnjar, Fernanda Paola Pons-Faudoa, Antons Sizovs, R Lyle Hood, Zachary W Smith, Andrea Ballerini, Carly S Filgueira, Alessandro Grattoni
Globally, 145.2 million people suffer from moderate to severe vision impairment or blindness due to preventable or treatable causes. However, patient adherence to topical or intravitreal treatment is a leading cause of poor outcomes. To address this issue, we designed an intraocularly implantable device called the nanofluidic Vitreal System for Therapeutic Administration (nViSTA) for continuous and controlled drug release based on a nanochannel membrane that obviates the need for pumps or actuation. In vitro release analysis demonstrated that our device achieves sustained release of bimatoprost (BIM) and dexamethasone (DEX) at concentrations within clinically relevant therapeutic window...
November 20, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30468719/bruch-s-membrane-allows-unhindered-passage-of-up-to-2-%C3%AE-m-latex-beads-in-an-in-vivo-porcine-model
#13
Nina Buus Sørensen, Anders Tolstrup Christiansen, Troels Wesenberg Kjær, Kristian Klemp, Morten la Cour, Steffen Heegaard, Jens Folke Kiilgaard
PURPOSE: It has been proposed that changes in the permeability of Bruch's membrane play a role in the pathogenesis of age-related macular degeneration (AMD). This paper investigates, in an in vivo porcine model, the migration of fluorescent latex beads across the Bruch's membrane after subretinal injection. METHODS: Forty-one healthy eyes of 33 three-month-old domestic pigs received a subretinal injection of 0.5, 1.0, 2.0, or 4.0 μm fluorescent latex beads. Between three hours and five weeks after injection evaluations were performed with fundus photographs and histology...
November 20, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30467423/macular-microvasculature-features-before-and-after-vitrectomy-in-idiopathic-macular-epiretinal-membrane-an-oct-angiography-analysis
#14
Hui Chen, Wei Chi, Xiaojuan Cai, Yang Deng, Xintong Jiang, Yantao Wei, Shaochong Zhang
PURPOSE: To evaluate pre-operative and post-operative morphologic characteristics in idiopathic macular epiretinal membrane (ERM) by optical coherence tomography angiography (OCTA). METHODS: Thirty-three subjects with unilateral idiopathic ERM were enrolled and the contralateral eyes served as controls. Vascular parameters including superficial capillary plexus (SCP), deep capillary plexus (DCP), outer capillary plexus (OCP), and choroidal capillary plexus (CCP) were evaluated by OCTA...
November 22, 2018: Eye
https://www.readbyqxmd.com/read/30457651/successful-treatment-of-a-retinal-detachment-secondary-to-multiple-eccentric-macular-holes-with-autologous-lens-capsular-flap-transplantation
#15
Ignasi Jürgens, Roslyn Kathryn Manrique Lipa, Patricia Pera
The authors report a case of a retinal detachment secondary to multiple eccentric macular holes (MEMHs) following an uneventful pars plana vitrectomy and epiretinal membrane peel, successfully treated by autologous lens capsule graft. Anatomical and functional changes were also evaluated. Autologous lens capsule graft is a safe and effective treatment for MEMHs that may improve anatomical and functional results. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:901-903.].
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30457650/macular-hole-after-poppers-alkyl-nitrate-inhalation-in-a-child
#16
Agnieszka Dyrda, Jaume Català-Mora, Amanda Rey, Jesus Díaz-Cascajosa, Mariona Vidal-Santacana
The authors present the first case of macular hole (MH) after a single inhalation of poppers. A 13-year-old girl presented with vision loss in the left eye (OS). Pediatric and neurology exams were normal. Funduscopy revealed bilateral papilledema and yellow foveal spot OS. Optic neuritis was diagnosed and treated. Due to foveal alteration, optical coherence tomography was performed, and MH was diagnosed. Twenty-three-gauge pars plana vitrectomy, peeling of the internal limiting membrane, and SF6 exchange were performed...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30456418/outer-retinal-layers-as-predictors-of-visual-acuity-in-retinitis-pigmentosa-a-cross-sectional-study
#17
Keissy Sousa, Tiago Fernandes, Rita Gentil, Luís Mendonça, Manuel Falcão
PURPOSE: To evaluate the integrity of the outer retinal layers-outer nuclear layer (ONL), external limiting membrane (ELM), ellipsoid (EZ), and interdigitation band (IZ)-using spectral-domain optical coherence tomography and estimate their effect on visual acuity in retinitis pigmentosa (RP). METHODS: A cross-sectional study was performed in the Ophthalmology Department of Hospital de Braga, Portugal. Patients with RP followed in the Hospital de Braga during January to August 2017 were included...
November 19, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30451557/whole-genome-sequencing-reveals-novel-mutations-causing-autosomal-dominant-inherited-macular-degeneration
#18
Shyamanga Borooah, Chloe M Stanton, Joseph Marsh, Keren J Carss, Naushin Waseem, Pooja Biswas, Georgios Agorogiannis, Lucy Raymond, Gavin Arno, Andrew R Webster
BACKGROUND: Age-related macular degeneration (AMD) is a common sight threatening condition. However, there are a number of monogenic macular dystrophies that are clinically similar to AMD, which can potentially provide pathogenetic insights. METHODS: Three siblings from a non-consanguineous Greek-Cypriot family reported central visual disturbance and nyctalopia. The patients had full ophthalmic examinations and color fundus photography, spectral-domain ocular coherence tomography and scanning laser ophthalmoscopy...
December 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/30451206/secondary-paracentral-retinal-hole-following-internal-limiting-membrane-peeling-for-a-large-macular-hole
#19
Diva Kant Misra, Ronel Soibam, Awaneesh Upadhyay, Pushkar Dhir, Rammohan Paidi
No abstract text is available yet for this article.
December 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/30451186/comparison-of-clinical-outcomes-between-heads-up-3d-viewing-system-and-conventional-microscope-in-macular-hole-surgeries-a-pilot-study
#20
Atul Kumar, Nasiq Hasan, Prateek Kakkar, Vineet Mutha, R Karthikeya, Dheepak Sundar, Raghav Ravani
Purpose: To compare clinical outcomes of patients undergoing macular hole surgery with heads-up three-dimensional (3D) viewing system and conventional microscope. Methods: In all, 50 eyes of 50 patients with stage 3 or 4 macular hole were randomized and macular hole surgery [inverted internal limiting membrane (ILM) flap technique] was performed in 25 eyes using 3D viewing system and 25 eyes using conventional microscope. All surgeries were performed by a single surgeon...
December 2018: Indian Journal of Ophthalmology
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