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https://www.readbyqxmd.com/read/30116628/peripheral-cone-dystrophy-expanded-clinical-spectrum-multimodal-and-ultrawide-field-imaging-and-genomic-analysis
#1
Robert A Sisk, Robert B Hufnagel, Ailee Laham, Elizabeth S Wohler, Nara Sobreira, Zubair M Ahmed
Purpose: To present new clinical features, multimodal and ultrawide-field imaging characteristics of peripheral cone dystrophy (PCD), and results of laboratory and genetic investigation to decipher the etiology. Methods: Retrospective observational case-series. Results: Three patients with PCD presented with bilateral paracentral scotomas and a mean visual acuity of 20/25. All exhibited confluent macular hyperautofluorescence with a central bull's eye lesion...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/30115644/retinal-cholesterol-content-is-reduced-in-simvastatin-treated-mice-due-to-inhibited-local-biosynthesis-albeit-increased-uptake-of-serum-cholesterol
#2
Natalia Mast, Ilya R Bederman, Irina A Pikuleva
Statins, a class of cholesterol-lowering drugs, are currently investigated for treatment of age-related macular degeneration, a retinal disease. Herein, retinal and serum concentrations of four statins (atorvastatin, simvastatin, pravastatin, and rosuvastatin) were evaluated after mice were given a single drug dose of 60 mg/kg body weight. All statins, except rosuvastatin, were detected in the retina: atorvastatin and pravastatin at 1.6 pmols and simvastatin at 4.1 pmols. Serum statin concentrations (pmol/ml) were 223 (simvastatin), 1,401 (atorvastatin), 2,792 (pravastatin), and 9,050 (rosuvastatin)...
August 16, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/30114306/repeat-surgery-in-failed-primary-vitrectomy-for-macular-holes-operated-with-the-inverted-ilm-flap-technique
#3
Zofia Michalewska, Jerzy Nawrocki
BACKGROUND AND OBJECTIVE: Effects of repeat surgery in failed primary full-thickness macular hole (FTMH) closure with the inverted internal limiting membrane (ILM) flap technique. PATIENTS AND METHODS: Retrospective analysis of patients operated with the inverted ILM flap technique. Optical coherence tomography was performed before initial and secondary surgeries and then at up to 12 months post-surgery. RESULTS: During the second surgery, the inverted ILM flap created at the first attempt had returned to its original position, instead of covering the FTMH...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30114303/prediction-of-visual-acuity-after-cataract-surgery-using-optical-coherence-tomography-findings-in-eyes-with-retinitis-pigmentosa
#4
Jianbo Mao, Dong Fang, Yiqi Chen, Jiwei Tao, Mengai Wu, Sulan Wu, Pengfei Wang, Yun Zhang, Lijun Shen
BACKGROUND AND OBJECTIVE: To investigate the predictive factors of visual acuity (VA) after cataract surgery in patients with retinitis pigmentosa (RP). PATIENTS AND METHODS: Retrospective, observational study. The authors reviewed a consecutive series of 70 patients (109 eyes) with RP who underwent cataract surgery. The changes in best-corrected visual acuity (BCVA) before and 3 months after surgery were measured. The relationship between preoperative ellipsoid zone (EZ) conditions, external limiting membrane (ELM) conditions, central macular thickness (CMT), and postoperative BCVA were investigated...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30114301/first-operated-and-fellow-eyes-with-bilateral-idiopathic-macular-hole-comparison-of-anatomical-and-functional-postoperative-outcomes
#5
Mumin Hocaoglu, Isil Sayman Muslubas, M Giray Ersoz, Serra Arf, Murat Karacorlu
BACKGROUND AND OBJECTIVE: To report anatomical and functional outcomes of surgery in each of the eyes in cases of bilateral macular hole (MH). PATIENTS AND METHODS: The anatomical and functional results for 42 patients with bilateral idiopathic MH were evaluated retrospectively. First-operated and fellow eyes were compared at various time points for preoperative characteristics and postoperative outcomes. RESULTS: Anatomical success was achieved in all patients after a single operation, and no reopening of an initially closed MH was observed during the follow-up period...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30105564/-vitrectomy-and-ioct-assisted-inverted-ilm-flap-technique-in-patients-with-full-thickness-macular-holes
#6
M Maier, S Bohnacker, J Klein, J Klaas, N Feucht, A Nasseri, C P Lohmann
BACKGROUND: In large full thickness macular holes (FTMH) the closure rate after vitrectomy and conventional internal limiting membrane (ILM) peeling is less than 90%. The aim of this study was to examine the visual acuity and anatomical success rate with high-resolution optical coherence tomography (OCT) after transconjunctival sutureless 23-gauge pars plana vitrectomy as well as intraoperative OCT (iOCT) and Brilliant Peel (BP)-assisted ILM peeling using the inverted ILM flap technique in patients with large FTMHs...
August 13, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/30105447/cell-specific-gene-therapy-driven-by-an-optimized-hypoxia-regulated-vector-reduces-choroidal-neovascularization
#7
Manas R Biswal, Howard M Prentice, George W Smith, Ping Zhu, Yao Tong, C Kathleen Dorey, Alfred S Lewin, Janet C Blanks
Aberrant growth of blood vessels in the choroid layer of the eye, termed choroidal neovascularization (CNV), is the pathological hallmark of exudative age-related macular degeneration (AMD), causing irreversible blindness among the elderly. Co-localization of proangiogenic factors and hypoxia inducible factors (HIF) in neovascular membranes from AMD eyes suggests the role of hypoxia in pathogenesis of CNV. In order to utilize hypoxic conditions in RPE for therapeutic purposes, we developed an optimized hypoxia regulated, RPE cell-specific gene therapy to inhibit choroidal neovascularization...
August 13, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/30098011/p2x7-as-a-scavenger-receptor-for-innate-phagocytosis-in-the-brain
#8
REVIEW
Ben J Gu, James S Wiley
The P2X7 receptor (P2X7 or P2X7R) has been widely studied for ATP-induced proinflammation, but in the absence of ligand, P2X7 has a second function as a scavenger receptor which is active in the development of human brain. The scavenger activity of P2X7 is only evident in the absence of serum but is fully active in cerebrospinal fluid. P2X7 on the cell surface is present as a membrane complex and an attachment to nonmuscle myosin of the cytoskeleton is required for particle engulfment. Selective antagonists of P2X7 proinflammatory function have little effect on phagocytosis but coinheritance of a haplotype spanning in P2RX7 and P2RX4 genes has been associated with loss of P2X7 mediated phagocytosis...
August 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30097785/incidence-and-risk-factors-for-neovascular-age-related-macular-degeneration-in-the-fellow-eye
#9
Toke Bek, Sidsel Ehlers Klug
PURPOSE: The epidemiology, risk factors, and the effect of anti-VEGF treatment on neovascular age-related macular degeneration (nAMD) have primarily been studied in the first eye developing the disease. The understanding of pathophysiology and planning of follow-up examinations can be improved by knowledge of incidence and risk factors for development of the disease in the fellow eye. METHODS: In a prospective observational cohort study, epidemiological and clinical risk factors for the development of nAMD in the fellow eye among 2516 patients consecutively diagnosed with the disease from a population of 0...
August 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30096403/osmotic-and-electroosmotic-fluid-transport-across-the-retinal-pigment-epithelium-a-mathematical-model
#10
Mariia Dvoriashyna, Alexander J E Foss, Eamonn A Gaffney, Oliver E Jensen, Rodolfo Repetto
The retinal pigment epithelium (RPE) is the outermost cell layer of the retina. It has several important physiological functions, among which is removal of excess fluid from the sub-retinal space by pumping it isotonically towards the choroid. Failure of this pumping leads to fluid accumulation, which is closely associated with several pathological conditions, such as age-related macular degeneration, macular oedema and retinal detachment. In the present work we study mechanisms responsible for fluid transport across the RPE with the aim of understanding how fluid accumulation can be prevented...
August 7, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/30096103/spontaneous-closure-of-macular-hole-in-a-patient-with-macular-telangiectasia-type-2
#11
Hilal Nalcı, Figen Batıoğlu, Sibel Demirel, Emin Özmert
PURPOSE: To present a case of macular hole associated with macular telangiectasia Type 2 (Mac-Tel 2) which underwent spontaneous closure. METHODS: A 58-year-old woman is admitted with complaints of blurred and distorted vision. Optical coherence tomography, fundus autofluorescence, and optical coherence tomography angiography were performed for diagnosis and follow-up. RESULTS: Optical coherence tomography revealed hyporeflective cavitations in both eyes, and full-thickness macular hole covered with internal limiting membrane drape in the left eye...
August 9, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30095597/surgical-management-of-full-thickness-macular-hole-superimposed-on-exudative-age-related-macular-degeneration
#12
Olga A Shif, Matthew S J Katz
BACKGROUND/PURPOSE: We describe a case of full-thickness macular hole formation in a patient with exudative age-related macular degeneration after an intravitreal ranibizumab injection and its surgical management. METHODS: This case is a retrospective, interventional case report. RESULTS: A 77-year-old woman with bilateral exudative age-related macular degeneration and pre-existing retinal pigment epithelium tear developed a full-thickness macular hole after intravitreal ranibizumab...
August 7, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30091308/effectiveness-of-intravitreal-ranibizumab-for-diabetic-macular-edema-with-serous-retinal-detachment
#13
Mahmut Kaya, Eyyup Karahan, Taylan Ozturk, Nilufer Kocak, Suleyman Kaynak
PURPOSE: To evaluate the effectiveness of intravitreal injection of ranibizumab (IVR) in treating diabetic macular edema (DME) with serous retinal detachment (SRD) based on spectral domain optical coherence tomography (SD-OCT) patterns. METHODS: One hundred thirty-four eyes of 134 patients with DME who underwent SD-OCT evaluation were included in this study. We retrospectively analyzed the medical records of patients who received IVR for the treatment of DME. Their eyes were classified into three groups according to the following SD-OCT features: SRD, diffuse retinal thickness and cystoid macular edema...
August 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/30090180/early-macular-changes-after-phacoemulsification-in-eyes-with-high-myopia
#14
Hossein Ashraf, Samaneh Koohestani, M Hossein Nowroozzadeh
Purpose: To evaluate macular changes after cataract surgery in eyes with high myopia. Methods: This prospective cohort enrolled patients with high myopia (axial length ≥26 mm) who underwent phacoemulsification with intraocular lens implantation. Spectral-domain optical coherence tomography (OCT) scans were obtained at baseline and 2 and 6 months after the operation. Postoperative macular changes on OCT scans were regarded as the main outcome measure. Results: Thirty-four eyes of 31 patients with high myopia were included (age, 60 ± 10 years [mean ± SD]); of these, 14 patients (45...
July 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/30086105/macular-vortex-vein-in-a-highly-myopic-eye-imaged-by-optical-coherence-tomography-angiography
#15
Richard I Kaplan, Joseph B Walsh, Richard B Rosen, Meenakashi Gupta
PURPOSE: To report a case of macular vortex vein imaged with indocyanine green angiography, spectral domain optical coherence tomography, and optical coherence tomography angiography. METHODS: Observational case report. RESULTS: A 51-year-old myopic man presented with the complaint of a floater in his left eye for the previous 2 weeks. His visual acuity was 20/25 in the right eye and 20/40 in the left eye. Biomicroscopy was normal. Retinoscopy revealed lattice degeneration and posterior vitreous detachment of both eyes with dilated submacular vasculature in the right eye and submacular hemorrhage in the left eye...
August 6, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30082277/in-vitro-drusen-model-three-dimensional-spheroid-culture-of-retinal-pigment-epithelial-cells
#16
Hideaki Usui, Akiko Nishiwaki, Lanors Landiev, Johannes Kacza, Wolfram Eichler, Rina Wako, Aki Kato, Noriaki Takase, Soichiro Kuwayama, Kazuki Ohashi, Yousef Yafai, Andreas Bringmann, Ayae Kubota, Yuichiro Ogura, Johannes Seeger, Peter Wiedemann, Tsutomu Yasukawa
Age-related macular degeneration (AMD) is a leading cause of legal blindness in people over 50 years of age in many developed countries. Drusen are yellowish extracellular deposits beneath retinal pigment epithelium (RPE) found in aging eyes and considered as a biomarker of AMD. However, the biogenesis of drusen has not been elucidated. We reported previously that multicellular spheroids comprised of human RPE cells constructed a well-differentiated monolayer of RPE with Bruch's membrane. We determined that RPE spheroids exhibited drusen formation between RPE and Bruch's membrane with expression of many drusen-associated proteins such as amyloid ß and complement components, the expression of which was altered by a challenge with oxidative stress...
August 6, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/30074572/spectral-domain-optical-coherence-tomography-findings-in-a-case-of-whiplash-maculopathy-with-incomplete-resolution
#17
Ezio Cappello, Chiara Della Guardia, Elisa Cecchin, Simonetta Morselli
PURPOSE: To report spectral domain optical coherence tomography (OCT) findings of a patient who experienced bilateral visual loss after a motorcycle accident. METHODS: A 51-year-old man presented to the emergency department complaining of bilateral visual loss after a motorcycle falling down. A complete ophthalmologic examination and OCT testing were made on the same day of the accident. Follow-up was made at 2 days, 2 weeks, 5 months, and 12 months adding central visual field assessment using Humphrey automated perimetry...
August 1, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30074568/optical-coherence-tomography-angiography-imaging-of-a-congenital-simple-hamartoma-of-the-retinal-pigment-epithelium
#18
Marta Zola, Aude Ambresin, Leonidas Zografos
PURPOSE: To report the case of a small pigmented tumor in the macular region investigated using optical coherence tomography angiography (OCT-A) in the context of a multimodal approach. METHODS: Case report RESULTS:: A 24-year-old man was referred for evaluation of an asymptomatic unilateral round comma-shaped pigmented tumor located in the macular region of his right eye. Spectral-domain OCT revealed an irregular hyperreflective mass within the retina, with a thickened hyaloid membrane and abrupt margins, and a complete posterior shadowing effect...
August 1, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/30066485/swept-source-optical-coherence-tomography-angiography-features-of-subretinal-fibrosis-in-neovascular-age-related-macular-degeneration
#19
Konstantinos Balaskas, Zaria C Ali, Tarik Saddik, Maria Gemenetzi, Praveen Patel, Tariq M Aslam
IMPORTANCE: The study highlights the role of Optical Coherence Angiography in the management of patients with neovascular age-related macular degeneration who have developed subretinal fibrosis. BACKGROUND: Development of subretinal fibrosis in the context of neovascular age-related macular degeneration is known to adversely affect visual function. The aim of this study is to assess structure and flow features obtained through swept-source optical coherence tomography angiography in patients with subretinal fibrosis and associate these with visual acuity...
August 1, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/30061650/long-term-surgical-outcomes-of-multiple-parfoveolar-curvilinear-internal-limiting-membrane-peeling-for-myopic-foveoschisis
#20
Tian Tian, Haiying Jin, Qi Zhang, Xiang Zhang, Hongtao Zhang, Peiquan Zhao
PURPOSE: To investigate the long-term results of a modified technique for parafoveal multiple curvilinear internal limiting membrane (ILM) peeling to preserve the epi-foveal ILM in myopic foveoschisis surgery. METHODS: Thirty-two consecutive patients (36 eyes) were retrospectively reviewed. Patients were divided into two groups according to the extent of ILM peeled: the fovea-sparing ILM peeling group (FS) (18 eyes) and total ILM peeling group (TP) (18 eyes). Patients were followed up for at least 12 months...
July 30, 2018: Eye
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