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hyperplasia of prostate

Yoshihisa Matsukawa, Shun Takai, Tsuyoshi Majima, Yasuhito Funahashi, Naoto Sassa, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
PURPOSE: To investigate the 1-year effects of tadalafil on storage and voiding function in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (LUTS/BPH) based on a urodynamic study. METHODS: In a one-armed, prospective study, 105 untreated outpatients with LUTS/BPH received 5 mg tadalafil every day for 12 months. Subjective symptoms and objective findings on voiding and storage functions, obtained through urodynamic studies that included cystometry and pressure flow study, were evaluated before, at 3 months, and at 12 months of treatment...
August 18, 2018: World Journal of Urology
Xue Wang, Baijun Dong, Kai Zhang, Zhongzhong Ji, Chaping Cheng, Huifang Zhao, Yaru Sheng, Xiaoxia Li, Liancheng Fan, Wei Xue, Wei-Qiang Gao, Helen He Zhu
Cell polarity and correct mitotic spindle positioning are essential for the maintenance of a proper prostate epithelial architecture, and disruption of the two biological features occurs at early stages in prostate tumorigenesis. However, whether and how these two epithelial attributes are connected in vivo is largely unknown. We herein report that conditional genetic deletion of E-cadherin, a key component of adherens junctions, in a mouse model results in loss of prostate luminal cell polarity and randomization of spindle orientations...
August 17, 2018: PLoS Genetics
Stefan Aufderklamm, Jörg Hennenlotter, Phillip Leidenberger, Steffen Rausch, Andrea Hohneder, Ursula Kühs, Moritz Maas, Christian Schwentner, Jens Bedke, Arnulf Stenzl, Tilman Todenhöfer
Purpose: Dickkopf-1 (DKK-1) and sclerostin seem to inhibit osteoblast activity by blocking the Wnt pathway, which leads to progression of metastatic prostate cancer (PC). However, it is unknown whether serum levels of these proteins are altered in PC patients with or without metastasis. The aim of this study was to assess DKK-1 and sclerostin serum levels in PC patients, including patients with bone metastases. Methods: The study cohort ( N = 143) consisted of 53 controls with benign prostatic hyperplasia (BPH), 43 with localized PC (PC cM0), and 47 had PC with metastasis (PC cM1)...
2018: Disease Markers
Yoshihisa Matsukawa, Shun Takai, Tsuyoshi Majima, Yasuhito Funahashi, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
Background: The aim of this research was to investigate intermediate-term effects of silodosin on lower urinary tract functions and symptoms in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) according to prostate size, using urodynamics. Methods: A total of 70 untreated outpatients with a prostate volume <40 ml [small prostate (SP) group] and 70 with prostate volume ⩾40 ml [large prostate (LP) group] were prospectively enrolled and treated by monotherapy with silodosin for 24 months...
September 2018: Therapeutic Advances in Urology
Mahmoud Ahmed, Trang Huyen Lai, Sahib Zada, Jin Seok Hwang, Trang Minh Pham, Miyong Yun, Deok Ryong Kim
Raf kinase inhibitor protein (RKIP) plays a critical role in many signaling pathways as a multi-functional adapter protein. In particular, the loss of RKIP's function in certain types of cancer cells results in epithelial to mesenchymal transition (EMT) and the promotion of cancer metastasis. In addition, RKIP inhibits autophagy by modulating LC3-lipidation and mTORC1. How the RKIP-dependent inhibition of autophagy is linked to EMT and cancer progression is still under investigation. In this study, we investigated the ways by which RKIP interacts with key gene products in EMT and autophagy during the progression of prostate cancer...
August 16, 2018: Cancers
Manasi Jiwrajka, William Yaxley, Marlon Perera, Matt Roberts, Nigel Dunglison, John Yaxley, Rachel Esler
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common benign tumour in men. Although men with BPH often need medical or surgical management from a urologist at some point throughout the timeline of their disease, most men are initially assessed and managed by a general practitioner (GP) in the primary healthcare setting. OBJECTIVE: The aim of this article is to highlight the principles of the pathogenesis, presentation, assessment and management of BPH in a primary care setting...
July 2018: Australian journal of general practice
Zhi-Hua Zhang, Fei Luo, Yan-Hui Su, Jian Li
The study is aiming to evaluate the treatment safety and efficacy of greenlight laser photovaporization of the prostate (PVP) combined with transurethral electrovaporization resection (TUVP) for elderly (≥ 70 years) men with lower urinary tract symptoms due to benign prostatic hyperplasia (BPH/LUTS) with a large prostate volume (≥ 80 mL). One hundred twelve BPH/LUTS patients treated with PVP were divided into 2 groups according to prostate volume (PV), the outcomes of the 2 groups were assessed at 12 months after the operation...
August 2018: Medicine (Baltimore)
Aysegul Erman, Lisa Masucci, Murray D Krahn, Dean S Elterman
OBJECTIVE: To evaluate the cost-effectiveness of using a surgery such as transurethral resection of the prostate (TURP) or photoselective vaporization of the prostate using greenlight laser (GL-PVP) as initial treatment for men with moderate-to-severe benign prostate hyperplasia (BPH) compared to the standard practice of using pharmacotherapy as initial treatment followed by surgery if symptoms do not resolve. PATIENTS AND METHODS: We compared a combination of eight strategies involving upfront pharmacotherapy (i...
August 16, 2018: BJU International
Shinji Ohtake, Takashi Kawahara, Yukari Ishiguro, Teppei Takeshima, Shinnosuke Kuroda, Koji Izumi, Hiroshi Miyamoto, Hiroji Uemura
Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG...
September 2018: Molecular and Clinical Oncology
Ruan Yuan, Yang Boyu, Zhao Fujun, Jiang Chengyi, Jing Yifeng, Wang Xiaohai, Cui Di, Xia Shujie, Han Bangmin
This study aimed to compare the clinical outcomes between transurethral thulium laser enucleation of the prostate (ThuLEP) and transurethral thulium laser resection of the prostate (ThuLRP) for treating benign prostatic hyperplasia (BPH). From May 2014 to August 2015, 212 patients underwent ThuLRP and 188 patients underwent ThuLEP. The ThuLEP group was further divided into two subgroups according to the ways the prostate was taken out. The perioperative parameters were recorded and analyzed. The international prostate symptom score (IPSS), quality-of-life (QoL) score, maximum flow rate (Qmax), and postvoid residual urine volume (PVR) in both groups were estimated and compared 3, 6, and 12 months after surgery...
August 14, 2018: Lasers in Medical Science
Jihun Jang, Jin Ho Chang
Although transrectal ultrasound (TRUS) imaging is widely used for screening and diagnosing prostate cancer, prostate cancer is often not found on TRUS images, depending on its stage, size, and location. Additionally, due to the weak echo signal and the low contrast of TRUS images, it is difficult to diagnose early-stage prostate cancers and distinguish malignant tumors from benign prostatic hyperplasia. For this reason, TRUS image-guided biopsy is mandatory to confirm the malignancy of the suspicious tumor, but the diagnostic accuracy of initial biopsy is only 20 to 30%, so that the patients inevitably undergo repeated biopsies...
August 10, 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Satheesh Krishna, Nicola Schieda, Matthew Df McInnes, Trevor A Flood, Rebecca E Thornhill
PURPOSE: To assess T2-weighted (T2W) MRI to differentiate transition zone (TZ) prostate cancer (PCa) from benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: With IRB approval, 22 consecutive TZ PCa were retrospectively compared with 30 consecutive BPH (15 stromal, 15 glandular) nodules diagnosed using radical prostatectomy MRI maps. Two blinded radiologists (R1/R2) subjectively assessed the shape (round/oval vs. lenticular) and margin (circumscribed vs. blurred/indistinct) and for a T2W hypointense rim...
August 13, 2018: European Radiology
Ersin Koseoglu, Altug Tuncel, Melih Balci, Oguzhan Kaya, Yilmaz Aslan, Ozer Guzel, Fatma Meric Yilmaz, Ali Atan
Objectives: To investigate serum and urine levels of Alpha-methylacyl-CoA-racemase (AMACR) and Netrin 1 in patients with and without prostate cancer and to determine whether these markers could be used as alternatives in diagnosis of prostate cancer instead of serum prostate specific antigen (PSA) levels. Methods: One hundred and seventy five patients between 45-75 years to whom transrectal ultrasound guided biopsies were performed for abnormal serum PSA levels or digital rectal examinations were included...
June 30, 2018: Colombia Médica: CM
Kim Orsel, Heidi Taipale, Sami Raatikainen, Pasi Lampela, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Helga Gardarsdottir, Sirpa Hartikainen
BACKGROUND: Antipsychotics (APs) are known to exacerbate symptoms of benign prostate hyperplasia (BPH) and may even cause urinary retention. The anticholinergic effects of APs and their dopamine D2- and α-receptor blockade may lead to voiding dysfunction of BPH patients. The objective of our study was to investigate whether the use of APs is associated with an increased risk of initiating medication for BPH in men with Alzheimer disease (AD). METHODS: Data from the nationwide MEDALZ (MEDication use and ALZheimer's disease) cohort, including all community-dwelling persons diagnosed with AD in Finland, were utilized...
August 10, 2018: Journal of Clinical Psychopharmacology
Kang Jun Cho, Jeong Zoo Lee, Yun Seob Song, Jong Bo Choi, Dae Kyung Kim, Yong Tae Kim, Joon Chul Kim
OBJECTIVE: To evaluate the efficacy and safety of silodosin on nocturia in patients with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: This was a 12-week, single-arm, open-label, prospective, multicenter study. The study included men 50 years or older with nocturia (≥2 events/night) based on a voiding diary, an International Prostate Symptom Score (IPSS) ≥8, and a quality of life score ≥3. Enrolled patients received 8 mg of silodosin once daily for 12 weeks...
August 8, 2018: Urology
R J Collins, L D Morgan, S Owen, F Ruge, W G Jiang, A J Sanders
EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumour suppressive function in cancer. EPLIN expression was evaluated in prostate cancer cell lines and tissues. PC-3 and LNCaP EPLINα overexpression models were generated through transfection with EPLINα sequence and EPLIN knockdown was achieved using shRNA in CA-HPV-10 cells...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
Tiannan Guo, Li Li, Qing Zhong, Niels J Rupp, Konstantina Charmpi, Christine E Wong, Ulrich Wagner, Jan H Rueschoff, Wolfram Jochum, Christian Daniel Fankhauser, Karim Saba, Cedric Poyet, Peter J Wild, Ruedi Aebersold, Andreas Beyer
It remains unclear to what extent tumor heterogeneity impacts on protein biomarker discovery. Here, we quantified proteome intra-tissue heterogeneity (ITH) based on a multi-region analysis of prostate tissues using pressure cycling technology and SWATH mass spectrometry. We quantified 6,873 proteins and analyzed the ITH of 3,700 proteins. The level of ITH varied depending on proteins and tissue types. Benign tissues exhibited more complex ITH patterns than malignant tissues. Spatial variability of ten prostate biomarkers was validated by immunohistochemistry in an independent cohort (n=83) using tissue microarrays...
May 29, 2018: Life science alliance
Shibao Li, Yao Zhao, Wenbai Chen, Lingyu Yin, Jie Zhu, Haoliang Zhang, Chenchen Cai, Pengpeng Li, Lingyan Huang, Ping Ma
Up-regulation of serum ephrinA2 is common in various malignancies and has been suggested as a potential biomarker for the diagnosis and prognosis of prostate cancer (PCa). However, the type of serum ephrinA2 expressed in PCa patients remains elusive. Furthermore, the level of exosomal ephrinA2 derived from serum is increased in patients with osteoporosis, a common complication of PCa patients undergoing androgen deprivation therapy. It is unknown whether exosomes derived from PCa patient serum contains ephrinA2...
2018: Journal of Cancer
Matthias Oelke, Bernhard Fangmeyer, Jörg Zinke, Jörn H Witt
Nocturia, defined as nocturnal micturition with a frequency of at least once per night, is one of the most frequent lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH) and often causes them to consult a physician. Nocturia is often bothersome and responsible for increased morbidity and mortality. Nocturia can be caused by increased fluid intake, increased diuresis or decreased bladder capacity, either alone or in combination. The underlying pathophysiology of nocturia can only be detected by methodical evaluation of the patient...
August 2018: Aktuelle Urologie
Xiangyu Wang, Ning Tu, Tao Qin, Fen Xing, Panying Wang, Guangyao Wu
OBJECTIVE: The objective of this study was to explore whether diffusion kurtosis imaging (DKI) combined with DWI can improve the performance of DWI in detection and assessment of aggressiveness of prostate cancer (PCa). MATERIALS AND METHODS: One hundred twenty patients with complete DK and MR images and diagnosis confirmed by prostate biopsy, including 67 patients with PCa and 53 patients with benign prostatic hyperplasia (BPH), were retrospectively analyzed. The patients with PCa were divided into a low-grade PCa group (Gleason score [GS] ≤ 3 + 3) and intermediate- and high-grade PCa group (GS ≥ 3 + 4)...
August 7, 2018: AJR. American Journal of Roentgenology
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