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https://www.readbyqxmd.com/read/28230291/therapeutic-potentials-of-bdnf-trkb-in-breast-cancer-current-status-and-perspectives
#1
Amir Tajbakhsh, Amin Mokhtari-Zaer, Mehdi Rezaee, Fahimeh Afzaljavan, Mehdi Rivandi, Seyed Mahdi Hassanian, Gordon A Ferns, Alireza Pasdar, Amir Avan
Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to stimulate breast cancer cell growth and metastasis via tyrosine kinase receptors TrkA, TrkB and the p75(NTR) death receptor. The aberrant activation of BDNF/TrkB pathways can modulate several signaling pathways, including Akt/PI3K, Jak/STAT, NF-kB, UPAR/UPA, Wnt/β-catenin and VEGF pathways as well as the ER receptor. Several microRNAs have been identified that are involved in the modulation of BDNF/TrkB pathways...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28229962/overexpression-of-hsa-mir-939-follows-by-ngfr-down-regulation-and-apoptosis-reduction
#2
Fahimeh Hosseini Aghdaei, Bahram M Soltani, Sadat Dokanehiifard, Seyed Javad Mowla, Masoud Soleimani
Neurotrophin receptors play a crucial role in neuronal survival, differentiation and regeneration. Nerve growth factor receptor (NGFR) or P75(NTR) is a neurotrophin receptor that is involved in many pathological conditions including cancers. Genetic factors that are involved in regulation of neurotrophin receptors are under intense investigation. MiRNAs are novel regulators of signalling pathways that are candidates for regulation of neurotrophin receptors. Computational programs predicted that NGFR gene is a bona fide target for hsa-miR- 939...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28215307/structural-characterization-of-the-p75-neurotrophin-receptor-a-stranger-in-the-tnfr-superfamily
#3
M Vilar
Although p75 neurotrophin receptor (p75(NTR)) was the founding member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF), it is an atypical TNFRSF protein. p75(NTR) like TNF-R1 and Fas-R contain an extracellular domain with four cysteine-rich domains (CRD) and a death domain (DD) in the intracellular region. While TNFRSF proteins are activated by trimeric TNFSF ligands, p75(NTR) forms dimers activated by dimeric neurotrophins that are structurally unrelated to TNFSF proteins. In addition, although p75(NTR) shares with other members the interaction with the TNF receptor-associated factors to activate the NF-κB and cell death pathways, p75(NTR) does not interact with the DD-containing proteins FADD, TRADD, or MyD88...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28215302/the-role-of-neurotrophin-signaling-in-gliomagenesis-a-focus-on-the-p75-neurotrophin-receptor-p75-ntr-cd271
#4
M M Alshehri, S M Robbins, D L Senger
The p75 neurotrophin receptor (p75(NTR), a.k.a. CD271), a transmembrane glycoprotein and a member of the tumor necrosis family (TNF) of receptors, was originally identified as a nerve growth factor receptor in the mid-1980s. While p75(NTR) is recognized to have important roles during neural development, its presence in both neural and nonneural tissues clearly supports the potential to mediate a broad range of functions depending on cellular context. Using an unbiased in vivo selection paradigm for genes underlying the invasive behavior of glioma, a critical characteristic that contributes to poor clinical outcome for glioma patients, we identified p75(NTR) as a central regulator of glioma invasion...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28215294/bdnf-and-hippocampal-synaptic-plasticity
#5
G Leal, C R Bramham, C B Duarte
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out among all neurotrophins by its high expression levels in the brain and its potent effects at synapses. Several aspects of BDNF biology such as transcription, processing, and secretion are regulated by synaptic activity. Such observations prompted the suggestion that BDNF may regulate activity-dependent forms of synaptic plasticity such as long-term potentiation (LTP), a sustained enhancement of excitatory synaptic efficacy thought to underlie learning and memory...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28208669/the-role-of-nerve-growth-factor-ngf-and-its-precursor-forms-in-oral-wound-healing
#6
REVIEW
Karl Schenck, Olav Schreurs, Katsuhiko Hayashi, Kristen Helgeland
Nerve growth factor (NGF) and its different precursor forms are secreted into human saliva by salivary glands and are also produced by an array of cells in the tissues of the oral cavity. The major forms of NGF in human saliva are forms of pro-nerve growth factor (pro-NGF) and not mature NGF. The NGF receptors tropomyosin-related kinase A (TrkA) and p75 neurotrophin receptor (p75(NTR)) are widely expressed on cells in the soft tissues of the human oral cavity, including keratinocytes, endothelial cells, fibroblasts and leukocytes, and in ductal and acinar cells of all types of salivary glands...
February 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28140833/nanoparticles-induced-apoptosis-of-human-airway-epithelium-is-mediated-by-prongf-p75-ntr-signaling
#7
Sreeparna Chakraborty, Vincent Castranova, Miriam K Perez, Giovanni Piedimonte
Environmental and occupational exposures to respirable ultrafine fractions of particulate matter (PM) have been implicated in the initiation and exacerbation of lung diseases. However, the precise mechanisms underlying production of cell damage and death attributed to nanoparticles (NP) on human airway epithelium are not fully understood. This study examined the role of neurotrophic pathways in NP-induced airway toxicity. Size and agglomeration of TiO2 nanoparticles (TiO2-NP) and fine (TiO2-FP) particles were measured by dynamic light scattering...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28119091/functional-interaction-between-bdnf-and-mglur-ii-in-vitro-bdnf-down-regulated-mglur-ii-gene-expression-and-an-mglur-ii-agonist-enhanced-bdnf-induced-bdnf-gene-expression-in-rat-cerebral-cortical-neurons
#8
Shingo Suzuki, Hisatsugu Koshimizu, Naoki Adachi, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken-Ichi Ohta, Takanori Miki
Accumulating evidence suggests functional interaction between brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor (mGluR) signaling pathways in the central nervous system (CNS). To date, eight subtypes of mGluRs, mGluR1-8, have been identified, and a previous study suggested that BDNF leads to down-regulation of GluR2 mRNA in rat cerebral cortical cultures. However, precise transcriptomic effects of BDNF on other mGluRs and their cellular significance on the BDNF signaling pathway remain largely unknown...
March 2017: Peptides
https://www.readbyqxmd.com/read/28074534/depolarizing-gaba-contributes-to-glutamatergic-network-rewiring-in-epilepsy
#9
Nazim Kourdougli, Christophe Pellegrino, Juho-Matti Renko, Stanislav Khirug, Geneviève Chazal, Tiina-Kaisa Kukko-Lukjanov, Sari E Lauri, Jean-Luc Gaiarsa, Liang Zhou, Angélique Peret, Eero Castrén, Raimo Kalevi Tuominen, Valérie Crépel, Claudio Rivera
OBJECTIVE: Rewiring of excitatory glutamatergic neuronal circuits is a major abnormality in epilepsy. Besides the rewiring of excitatory circuit, an abnormal depolarizing GABAergic drive has been hypothesized to participate in the epileptogenic processes. However, a remaining clinically relevant question is whether early post Status Epilepticus (SE) evoked chloride dysregulation is important for the remodeling of aberrant glutamatergic neuronal circuit. METHODS: Osmotic mini-pumps were used to infuse intracerebrally a specific inhibitor of depolarizing GABAergic transmission as well as a functionally blocking antibody towards the pan-neurotrophin receptor p75 (p75(NTR) )...
January 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28067793/time-dependent-nerve-growth-factor-signaling-changes-in-the-rat-retina-during-optic-nerve-crush-induced-degeneration-of-retinal-ganglion-cells
#10
Louise A Mesentier-Louro, Sara De Nicolò, Pamela Rosso, Luigi A De Vitis, Valerio Castoldi, Letizia Leocani, Rosalia Mendez-Otero, Marcelo F Santiago, Paola Tirassa, Paolo Rama, Alessandro Lambiase
Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the presence of increased levels of endogenous NGF. To further investigate this apparently paradoxical condition, a time-course study was performed to evaluate the effects of unilateral ONC on NGF expression and signaling in the adult retina. Visually evoked potential and immunofluorescence staining were used to assess axonal damage and RGC loss...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28060678/canine-central-nervous-system-neoplasm-phenotyping-using-tissue-microarray-technique
#11
I Spitzbarth, F Heinrich, V Herder, T Recker, P Wohlsein, W Baumgärtner
Tissue microarrays (TMAs) represent a useful technique for the simultaneous phenotyping of large sample numbers and are particularly suitable for histopathologic tumor research. In this study, TMAs were used to evaluate semiquantitatively the expression of multiple antigens in various canine central nervous system (CNS) neoplasms and to identify markers with potential discriminative diagnostic relevance. Ninety-seven canine CNS neoplasms, previously diagnosed on hematoxylin and eosin sections according to the World Health Organization classification, were investigated on TMAs, with each tumor consisting of 2 cylindrical samples from the center and the periphery of the neoplasm...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28034674/combination-of-exogenous-cell-transplantation-and-5-ht4-receptor-agonism-induce-endogenous-enteric-neural-crest-derived-cells-in-a-rat-hypoganglionosis-model
#12
Hui Yu, Bai-Jun Zheng, Wei-Kang Pan, Huai-Jie Wang, Chong Xie, Yu-Ying Zhao, Xin-Lin Chen, Yong Liu, Ya Gao
Enteric neural crest-derived cells (ENCCs) can migrate into endogenous ganglia and differentiate into progeny cells, and have even partially rescued bowel function; however, poor reliability and limited functional recovery after ENCC transplantation have yet to be addressed. Here, we investigated the induction of endogenous ENCCs by combining exogenous ENCC transplantation with a 5-HT4 receptor agonist mosapride in a rat model of hypoganglionosis, established by benzalkonium chloride treatment. ENCCs, isolated from the gut of newborn rats, were labeled with a lentiviral eGFP reporter...
December 26, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27964967/expression-and-signaling-of-ngf-in-the-healthy-and-injured-retina
#13
REVIEW
Tarcyane Barata Garcia, Margrit Hollborn, Andreas Bringmann
This review summarizes the present knowledge concerning the retinal localization of the nerve growth factor (NGF), its precursor proNGF, and the receptors TrkA and p75(NTR) in the developing and mature rodent retina. We further discuss the changes in the expression of NGF and the receptors in experimental models of retinal disorders and diseases like inherited retinitis pigmentosa, retinal detachment, glaucoma, and diabetic retinopathy. Since proNGF is now recognized as a bioactive signaling molecule which induces cell death through p75(NTR) activation, the role of proNGF in the induction of retinal cell loss under neurodegenerative conditions is also highlighted...
December 2, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27943583/human-dental-pulp-stem-cells-expressing-stro-1-c-kit-and-cd34-markers-in-peripheral-nerve-regeneration
#14
Gianluca Carnevale, Alessandra Pisciotta, Massimo Riccio, Laura Bertoni, Sara De Biasi, Lara Gibellini, Alessio Zordani, Gian Maria Cavallini, Giovanni Battista La Sala, Giacomo Bruzzesi, Adriano Ferrari, Andrea Cossarizza, Anto de Pol
Peripheral nerve injuries are a commonly encountered clinical problem and often result in long-term functional defects. The application of stem cells able to differentiate in Schwann cells-like cells in vitro and in vivo, could represent an attractive therapeutic approach for the treatment of nerve injuries. Further, stem cells sources sharing the same embryological origin of Schwann cells might be considered a suitable tool. The aim of this study was to demonstrate the ability of a neuroectodermal subpopulation of human STRO-1+/c-Kit+/CD34+ DPSCs, expressing P75(NTR) , Nestin and SOX-10, to differentiate into Schwann cells-like cells in vitro and to promote axonal regeneration in vivo, which led to functional recovery as measured by sustained gait improvement, in animal rat model of peripheral nerve injury...
December 11, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27913431/pro-brain-derived-neurotrophic-factor-probdnf-mediated-p75ntr-activation-promotes-depolarizing-actions-of-gaba-and-increases-susceptibility-to-epileptic-seizures
#15
Baptiste Riffault, Nazim Kourdougli, Camille Dumon, Nadine Ferrand, Emmanuelle Buhler, Fabienne Schaller, Caroline Chambon, Claudio Rivera, Jean-Luc Gaiarsa, Christophe Porcher
The brain-derived neurotrophic factor (BDNF) is synthesized as a precursor, namely proBDNF, which can be processed into mature BDNF (mBDNF). Evidences suggest that proBDNF signaling through p75(NTR) may account for the emergence of neurological disorders. These findings support the view that the relative availability of mBDNF and proBDNF forms is an important mechanism underlying brain circuit formation and cognitive functions. Here we describe novel insights into the proBDNF/p75(NTR) mechanisms and function in vivo in modulating neuronal circuit and synaptic plasticity during the first postnatal weeks in rats...
December 1, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27878552/strength-and-aerobic-exercises-improve-spatial-memory-in-aging-rats-through-stimulating-distinct-neuroplasticity-mechanisms
#16
Thais Ceresér Vilela, Alexandre Pastoris Muller, Adriani Paganini Damiani, Tamires Pavei Macan, Sabrina da Silva, Paula Bortoluzzi Canteiro, Alisson de Sena Casagrande, Giulia Dos Santos Pedroso, Renata Tiscoski Nesi, Vanessa Moraes de Andrade, Ricardo Aurino de Pinho
Aging is associated with impaired cognition and memory and increased susceptibility to neurodegenerative disorders. Physical exercise is neuroprotective; however, the major evidence of this effect involves studies of only aerobic training in young animals. The benefits of other exercise protocols such as strength training in aged animals remains unknown. Here, we investigated the effect of aerobic and strength training on spatial memory and hippocampal plasticity in aging rats. Aging Wistar rats performed aerobic or strength training for 50 min 3 to 4 days/week for 8 weeks...
November 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27834536/progression-of-tau-pathology-within-cholinergic-nucleus-basalis-neurons-in-chronic-traumatic-encephalopathy-a-chronic-effects-of-neurotrauma-consortium-study
#17
Elliott J Mufson, Sylvia E Perez, Muhammad Nadeem, Laura Mahady, Nicholas M Kanaan, Eric E Abrahamson, Milos D Ikonomovic, Fiona Crawford, Victor Alvarez, Thor Stein, Ann C McKee
OBJECTIVE: To test the hypothesis that the nucleus basalis of Meynert (nbM), a cholinergic basal forebrain (CBF) cortical projection system, develops neurofibrillary tangles (NFTs) during the progressive pathological stages of chronic traumatic encephalopathy (CTE) in the brain of athletes. METHOD: To characterize NFT pathology, tau-antibodies marking early, intermediate and late stages of NFT development in CBF tissue obtained at autopsy from eighteen former athletes and veterans with a history of repetitive mild traumatic brain injury (TBI) were used...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27826102/the-trka-receptor-mediates-experimental-thermal-hyperalgesia-produced-by-nerve-growth-factor-modulation-by-the-p75-neurotrophin-receptor
#18
Alla Khodorova, Grant D Nicol, Gary Strichartz
The p75 neurotrophin receptor (p75(NTR)) and its activation of the sphingomyelin signaling cascade are essential for mechanical hypersensitivity resulting from locally injected nerve growth factor (NGF). Here the roles of the same effectors, and of the tropomyosin receptor kinase A (TrkA) receptor, are evaluated for thermal hyperalgesia from NGF. Sensitivity of rat hind paw plantar skin to thermal stimulation after local sub-cutaneous injection of NGF (500ng) was measured by the latency for paw withdrawal (PWL) from a radiant heat source...
January 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/27824126/preservation-of-epithelial-progenitor-cells-from-collagenase-digested-oral-mucosa-during-ex-vivo-cultivation
#19
Yi-Jen Hsueh, Shiang-Fu Huang, Jui-Yang Lai, Shih-Chieh Ma, Hung-Chi Chen, Sung-En Wu, Tze-Kai Wang, Chi-Chin Sun, Kevin Sheng-Kai Ma, Jan-Kan Chen, Chyong-Huey Lai, David Hui-Kang Ma
To avoid xenogeneic infection, we report a novel protocol for producing animal-derived component-free oral mucosal epithelial cells (OMECs) sheet for transplantation, in which collagenase was used to replace dispase II/trypsin-EDTA for digesting oral mucosal tissue, and human platelet-derived PLTMax to replace fetal bovine serum. The resulting epithelial aggregates were expanded on de-epithelialized amniotic membranes without 3T3 feeder cells, and serum-free EpiLife was used to reduce contamination by submucosal mesenchymal cells...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817157/isoflurane-decreases-proliferation-and-differentiation-but-none-of-the-effects-persist-in-human-embryonic-stem-cell-derived-neural-progenitor-cells
#20
Hye-Min Sohn, Hye Young Kim, Seongjoo Park, Sung-Hee Han, Jin-Hee Kim
PURPOSE: Volatile anesthetics are a potential risk for cognitive impairment in the developing brain. Isoflurane causes cell death, reduces neurogenesis, and changes neuronal differentiation. In this study, the effects of a single isoflurane exposure on the developing human brain were evaluated using human embryonic stem cell (hESC)-derived neural progenitor cells (NPCs). METHODS: Multipotent NPCs were derived from hESCs and randomly exposed to either 5 vol% isoflurane (4 h) or no isoflurane (control group)...
November 5, 2016: Journal of Anesthesia
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