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https://www.readbyqxmd.com/read/30531144/-primary-immunodeficiencies-and-hematological-malignancies
#1
Hirokazu Kanegane, Akihiro Hoshino, Masatoshi Takagi
Primary immunodeficiency disease (PID) is characterized by an impaired immune system along with recurrent and severe and/or opportunistic infections; these infections are frequently associated with malignancies and autoimmune disorders. Dysregulation of the adaptive immune system leads to an increased risk of malignancies. Various mechanisms contribute to increased tumor susceptibility in patients with PIDs, which are as follows: defective cell-mediated tumor surveillance, defective apoptosis, specific susceptibility to carcinogens, decreased pathogen clearance and over-active inflammatory responses, defects in cytokinesis, impaired control of virus-infected cells, defects in cell cycle control, and impaired cellular response to genotoxic agents...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/30527669/the-generalized-forced-oscillation-method-for-tuning-pid-controllers
#2
Charles Lorenzini, Alexandre Sanfelice Bazanella, Luís Fernando Alves Pereira, Gustavo R Gonçalves da Silva
In this paper a generalized tuning methodology for proportional-integral-derivative (PID) controllers is proposed. The methodology is akin to the Ziegler-Nichols forced oscillation method, inheriting fully its practical appeal, but can be applied to much more general classes of plants. This generalization is achieved by employing a relay with adjustable phase (RAP) in a relay feedback experiment, and the tuning consists of formulas based on measurements obtained from this experiment. Experimental results in a liquid processing plant with of-the-shelf industrial equipments illustrate the performance of the methodology and the practical procedures involved in its application, which can be fully automated...
November 19, 2018: ISA Transactions
https://www.readbyqxmd.com/read/30509895/epigenetic-deregulation-in-human-primary-immunodeficiencies
#3
REVIEW
Elena Campos-Sanchez, Jorge Martínez-Cano, Lucía Del Pino Molina, Eduardo López-Granados, Cesar Cobaleda
Primary immunodeficiencies (PIDs) are immune disorders resulting from defects in genes involved in immune regulation, and manifesting as an increased susceptibility to infections, autoimmunity, and cancer. However, the molecular basis of some prevalent entities remains poorly understood. Epigenetic control is essential for immune functions, and epigenetic alterations have been identified in different PIDs, including syndromes such as immunodeficiency-centromeric-instability-facial-anomalies, Kabuki, or Wolf-Hirschhorn, among others...
November 30, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/30496205/predicting-the-mean-first-passage-time-mfpt-to-reach-any-state-for-a-passive-dynamic-walker-with-steady-state-variability
#4
Isuri Wijesundera, Malka N Halgamuge, Ampalavanapillai Nirmalathas, Thrishantha Nanayakkara
Idealized passive dynamic walkers (PDW) exhibit limit cycle stability at steady state. Yet in reality, uncertainty in ground interaction forces result in variability in limit cycles even for a simple walker known as the Rimless Wheel (RW) on seemingly even slopes. This class of walkers is called metastable walkers in that they usually walk in a stable limit cycle, though guaranteed to eventually fail. Thus, control action is only needed if a failure state (i.e. RW stopping down the ramp) is imminent. Therefore, efficiency of estimating the time to reach a failure state is key to develop a minimal intervention controller to inject just enough energy to overcome a failure state when required...
2018: PloS One
https://www.readbyqxmd.com/read/30481107/ethnic-minority-status-and-experiences-of-infertility-in-female-veterans
#5
Rachel P Goossen, Karen M Summers, Ginny L Ryan, Michelle A Mengeling, Brenda M Booth, James C Torner, Craig H Syrop, Anne G Sadler
BACKGROUND: In the general population, infertility is increasingly prevalent in ethnic minority women; these women suffer longer and are less likely to access care. There is a paucity of data regarding the issue of race and infertility in the growing female military veteran population. MATERIALS AND METHODS: This cross-sectional observational study involved computer-assisted telephone interviews of 1,004 Veterans Administration (VA)-enrolled women aged ≤52 years...
November 27, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/30477893/cpaf-hsp60-and-momp-antigens-elicit-pro-inflammatory-cytokines-production-in-the-peripheral-blood-mononuclear-cells-from-genital-chlamydia-trachomatis-infected-patients
#6
Heng Choon Cheong, Chalystha Yie Qin Lee, Yi Ying Cheok, Esaki M Shankar, Negar S Sabet, Grace Min Yi Tan, Elaheh Movahed, Tee Cian Yeow, Sofiah Sulaiman, Won Fen Wong, Chung Yeng Looi, Rishein Gupta, Jamiyah Hassan, Bernard Arulanandam, Sazaly AbuBakar
BACKGROUND: Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. chlamydial protease-like factor (CPAF), heat shock protein 60 (HSP60) and major outer membrane protein (MOMP). METHODS: A total of 19 patients with genital C...
November 20, 2018: Immunobiology
https://www.readbyqxmd.com/read/30464884/pid-bfo-optimized-pid-and-pd-flc-control-of-a-two-wheeled-machine-with-two-direction-handling-mechanism-a-comparative-study
#7
K M Goher, S O Fadlallah
In this paper; three control approaches are utilized in order to control the stability of a novel five-degrees-of-freedom two-wheeled robotic machine designed for industrial applications that demand a limited-space working environment. Proportional-integral-derivative (PID) control scheme, bacterial foraging optimization of PID control method, and fuzzy logic control method are applied to the wheeled machine to obtain the optimum control strategy that provides the best system stabilization performance. According to simulation results, considering multiple motion scenarios, the PID controller optimized by bacterial foraging optimization method outperformed the other two control methods in terms of minimum overshoot, rise time, and applied input forces...
2018: Robotics and Biomimetics
https://www.readbyqxmd.com/read/30464035/phosphatidic-acid-directly-regulates-pinoid-dependent-phosphorylation-and-activation-of-the-pin-formed-2-auxin-efflux-transporter-in-response-to-salt-stress
#8
Peipei Wang, Like Shen, Jinhe Guo, Wen Jing, Yana Qu, Wenyu Li, Rongrong Bi, Wei Xuan, Qun Zhang, Wenhua Zhang
Remodeling of auxin distribution in the integration of plant growth responses with the environment requires the precise control of auxin influx and efflux transporters. The plasma membrane-localized PIN-FORMED (PIN) proteins facilitate auxin efflux from cells, and their activity is regulated by reversible phosphorylation. How PIN modulates plant cellular responses to external stresses, and whether its activity is coordinated by phospholipids, remains unclear. Here, we reveal that in Arabidopsis, the phosphatidic acid (PA)-regulated PINOID (PID) kinase is a crucial modulator of PIN2 activity and auxin redistribution in response to salt stress...
November 21, 2018: Plant Cell
https://www.readbyqxmd.com/read/30461271/subtle-changes-in-lipid-environment-have-profound-effects-on-membrane-oxidation-chemistry
#9
Xinxing Zhang, Kevin M Barraza, Kathleen T Upton, Jesse Lee Beauchamp
Nature carefully designs the components of amphiphile-composed monolayer and bilayer membranes to deliver specific functions. The compositions of these interfacial layered structures are so delicate that minute modifications can result in huge changes in function. Great efforts have been expended to understand membrane physical properties, with only minimum attention given to associated chemical properties. Here we report the first examples of the delicate chemistry associated with membrane amphiphilic components by studying OH mediated oxidation of six different unsaturated li-pids/surfactants and their mixtures at the air-water interface using field-induced droplet ionization mass spectrometry (FIDI-MS)...
November 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30448815/-physicians-induced-demand-in-the-primary-health-care-level
#10
Valentyn Bakhnivskyi, Filip Furman
Spending on health care in developed countries with the market economics has been growing over the past few years. Health care economists, along with other professionals, are constantly looking for new ways to control these costs. In this publication, an analysis of the theory of physicians induced demand (PID) at the primary level of medical care in Denmark, France and the Netherlands is presented the analysis of available literature data. Also we discussed the possibilities of conducting this study in the countries of Eastern Europe, taking Ukraine as an example...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/30448252/rapid-estimation-of-pid-minimum-variance
#11
Farzam Shahni, Wei Yu, Brent Young
PID controllers are the most common type of controllers used in industry. However, to find the best PID performance is a challenging task. Assessment of the best PID performance leads to the minimization of the deviation from set point as indicated by closed loop transfer function. This is a non-convex optimization problem and there is no direct solution for finding this benchmark. Solving this problem iteratively as proposed in literature requires long calculation times. Furthermore, iterative methods are not guaranteed to find the minimum value...
November 9, 2018: ISA Transactions
https://www.readbyqxmd.com/read/30428836/quality-of-life-and-paracetamol-in-advanced-dementia-q-pid-protocol-of-a-randomised-double-blind-placebo-controlled-crossover-trial
#12
Paulien H van Dam, Wilco P Achterberg, Jacobijn Gussekloo, Bettina S Husebo, Monique A A Caljouw
BACKGROUND: No proven effective interventions on quality of life (QoL) are available for persons with dementia in a long-term care facility (LTCF). However, several interventions are effective in diminishing mediators of QoL (i.e. challenging behaviour, depressed mood, sleeping disorders), including pain treatment. Un(der)diagnosed and un(der)treated pain is a serious and frequent problem in persons with dementia. Also, although pain is difficult to assess in this group, the impact on QoL is probably considerable...
November 14, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/30424420/development-of-a-contactless-air-conveyor-system-for-transporting-and-positioning-planar-objects
#13
Xirui Chen, Wei Zhong, Chong Li, Jiwen Fang, Fanghua Liu
In this study, we developed a completely contactless air conveyor system for transporting and positioning planar objects. The air conveyor forms a thin film underneath the object for support and simultaneously generates a controlled airflow that results in viscous traction. It is potentially applicable in the manufacturing process for semiconductor wafer or flat foodstuffs, where mechanical contact is expected to be avoided during transportation of the products to minimize contamination. The air conveyor employs duplicated arrays of actuating cells that are square pockets with a surrounding dam...
September 24, 2018: Micromachines
https://www.readbyqxmd.com/read/30424174/hysteresis-compensation-and-sliding-mode-control-with-perturbation-estimation-for-piezoelectric-actuators
#14
Bingxiao Ding, Yangmin Li
Based on the background of atomic force microscope (AFM) driven by piezoelectric actuators (PEAs), this paper proposes a sliding mode control coupled with an inverse Bouc⁻Wen (BW) hysteresis compensator to improve the positioning performance of PEAs. The intrinsic hysteresis and creep characteristics degrade the performance of the PEA and cause accuracy loss. Although creep effect can be eliminated by the closed-loop control approach, hysteresis effects need to be compensated and alleviated by hysteresis compensators...
May 16, 2018: Micromachines
https://www.readbyqxmd.com/read/30424103/stretchable-tattoo-like-heater-with-on-site-temperature-feedback-control
#15
Andrew Stier, Eshan Halekote, Andrew Mark, Shutao Qiao, Shixuan Yang, Kenneth Diller, Nanshu Lu
Wearable tissue heaters can play many important roles in the medical field. They may be used for heat therapy, perioperative warming and controlled transdermal drug delivery, among other applications. State-of-the-art heaters are too bulky, rigid, or difficult to control to be able to maintain long-term wearability and safety. Recently, there has been progress in the development of stretchable heaters that may be attached directly to the skin surface, but they often use expensive materials or processes and take significant time to fabricate...
April 8, 2018: Micromachines
https://www.readbyqxmd.com/read/30417838/comparison-of-the-prevalence-of-adhesions-at-the-time-of-diagnostic-laparoscopy-for-infertility-between-patient-who-had-open-myomectomy-and-those-who-had-no-previous-pelvic-abdominal-surgery-or-pelvic-inflammatory-disease
#16
J I Ikechebelu, G U Eleje, N N Joe-Ikechebelu, C D Okafor, A O Akintobi
Objective: The aim of this study is to determine the prevalence and patterns of adhesions in infertile women with prior open myomectomy compared with women without prior pelvic-abdominal surgery. Methods: A nested case-control study of infertile women who had diagnostic laparoscopy after open myomectomy between January 2008 and June 2015 in Life Institute for Endoscopy Limited, Nnewi Nigeria, was conducted. At diagnostic laparoscopy, the presence, site, and quality (density) of adhesions was noted and recorded...
November 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/30389246/tuning-of-linear-active-disturbance-rejection-controller-with-robustness-specification
#17
Binwen Zhang, Wen Tan, Jian Li
Active disturbance rejection control (ADRC) treats all the model uncertainties and all the external disturbances as a generalized disturbance. It uses an extended state observer (ESO) to estimate the generalized disturbance in real time, and compensate it using a state-feedback control law, thus can achieve good disturbance rejection performance. For linear ADRC (LADRC), the parameters can be tuned via the bandwidths of the ESO and the feedback control, thus an LADRC can be regarded as a fixed-structured controller with several parameters to tune, just like a PID controller...
October 24, 2018: ISA Transactions
https://www.readbyqxmd.com/read/30387716/automated-balloon-control-in-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa
#18
Cormac McCarthy, Ian Kanterman, Fabian Trauzettel, H Alexander Jaeger, Alice-Anne Goetz, Benjamin Colvard, Lee Swanstrom, Padraig Cantillon-Murphy
OBJECTIVE: The goal of this work was to demonstrate technical feasibility of automated balloon pressure management during REBOA in the pre-clinical setting. METHODS: This paper presents an intelligent balloon management device which automates the balloon inflation process, preventing the possibility of balloon over or under inflation, optimizes inflation pressure and if indicated, deflates automating partial REBOA to allow distal organ perfusion. Edwards TruWave pressure transducers are used to monitor the blood pressure proximal and distal to the balloon, as well as the internal balloon pressure...
November 1, 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/30356889/design-and-methodology-of-a-pilot-randomized-controlled-trial-of-transcranial-direct-current-stimulation-in-acute-middle-cerebral-artery-stroke-stica
#19
Estelle Pruvost-Robieux, David Calvet, Wagih Ben Hassen, Guillaume Turc, Angela Marchi, Nicolas Mélé, Pierre Seners, Catherine Oppenheim, Jean-Claude Baron, Jean-Louis Mas, Martine Gavaret
Background: Stroke is a major cause of death and disability worldwide. The related burden is expected to further increase due to aging populations, calling for more efficient treatment. Ischemic stroke results from a focal reduction in cerebral blood flow due to the sudden occlusion of a brain artery. Ischemic brain injury results from a sequence of pathophysiological events that evolve over time and space. This cascade includes excitotoxicity and peri-infarct depolarizations (PIDs). Focal impairment of cerebral blood flow restricts the delivery of energetics substrates and impairs ionic gradients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30352985/association-of-pelvic-inflammatory-disease-with-risk-of-endometriosis-a-nationwide-cohort-study-involving-141-460-individuals
#20
Fei-Wu Tai, Cherry Yin-Yi Chang, Jen-Huai Chiang, Wu-Chou Lin, Lei Wan
Endometriosis occurs when endometrial tissue exists outside the uterine cavity. The presence of ectopic endometrial tissue and resultant inflammation cause serious symptoms, including chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Pelvic inflammatory disease is caused by the ascension of pathogenic bacteria from the vagina to the uterus, Fallopian tubes, and ovaries. The factors involved in the pathogenesis of the two conditions are not clearly understood, but recent studies have suggested that disturbances of the female reproductive tract microbiota and inflammatory processes influence the development of both diseases...
October 24, 2018: Journal of Clinical Medicine
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