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Marina Garcia-Prat, Daniel Álvarez-Sierra, Aina Aguiló-Cucurull, Sandra Salgado-Perandrés, Sara Briongos-Sebastian, Clara Franco-Jarava, Andrea Martin-Nalda, Roger Colobran, Isabel Montserrat, Manuel Hernández-González, Ricardo Pujol-Borrell, Pere Soler-Palacin, Mónica Martínez-Gallo
BACKGROUND: For the accurate diagnosis of immunodeficiencies is crucial to compare patients' immunology laboratory values with age-sex matched controls, yet there is a paucity of normal values for most populations. OBJECTIVES: To define appropriate reference values of extended lymphocyte subpopulations and T-cell receptor excision circle (TRECs) levels in healthy pediatric donors between 1 month and 18 years of age. METHODS: Extended immunophenotyping values were obtained by analysis of multiparameter flow cytometry panels for the following subpopulations: CD4+ and CD8+ Naive, Effector, Effector Memory and Central Memory, T helper subpopulations and their degrees of activation, T Regulatory cells, Recent Thymic Emigrants (RTE), B Lymphocyte subpopulations (Transitional, Naive, Preswitch-Memory, Switch-Memory, Plasmablasts, CD21low, and Exhausted), and subpopulations for Monocytes, NK cells and Dendritic Cells...
October 17, 2018: Cytometry. Part B, Clinical Cytometry
Vasilios Karageorgiou, Theodoros G Papaioannou, Ioannis Bellos, Krystallenia Alexandraki, Nikolaos Tentolouris, Christodoulos Stefanadis, George P Chrousos, Dimitrios Tousoulis
OBJECTIVE: Artificial pancreas is a technology that minimizes user input by bridging continuous glucose monitoring and insulin pump treatment, and has proven safety in the adult population. The purpose of this meta-analysis is to evaluate the efficacy of closed-loop (CL) systems in the glycemic control of non-adult type 1 diabetes patients in both a pairwise and network meta-analysis (NMA) context and investigate various parameters potentially affecting the outcome. METHODS: Literature was systematically searched using the MEDLINE (1966-2018), Scopus (2004-2018), Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2018), Clinicaltrials...
October 12, 2018: Metabolism: Clinical and Experimental
Cem Onat
PID controllers are still widely practiced in the industrial systems. In the literature, many publications can be found considering PID controller design for unstable processes. However, owing to the structural limitations of PID controllers, generally, good closed loop performance cannot be achieved with a PID for controlling unstable processes and usually a step response with a high overshoot and oscillation is obtained. On the other hand, PI-PD controllers are proved to give very satisfactory closed loop performances for unstable processes...
October 6, 2018: ISA Transactions
Daisuke Shigemi, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Background: Pelvic inflammatory disease is common among women of reproductive age and can be complicated by tubo-ovarian abscess, which is a serious and potentially life-threatening disease. However, recent mortality rates from pelvic inflammatory disease on hospital admission and the short-term therapeutic usefulness of initial treatment for Chlamydia trachomatis remain unknown. Methods: Using the Diagnosis Procedure Combination database, we identified patients who were diagnosed with pelvic inflammatory disease on admission from July 2010 to March 2016 in Japan...
October 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Caroline Y Kuo
PURPOSE OF REVIEW: Conventional gene therapy has been a successful, curative treatment modality for many primary immune deficiencies with significant improvements in the last decade. However, the risk of leukemic transformation with viral-mediated gene addition still remains, and unregulated gene addition is not an option for certain diseases in which the target gene is closely controlled. The recent bloom in genome modification platforms has created the opportunity to site-specifically correct mutated DNA base pairs or insert a corrective cDNA minigene while maintaining gene expression under control of endogenous regulatory elements...
October 6, 2018: Current Opinion in Allergy and Clinical Immunology
Wonjun Choi, Hideki Kikumoto, Ryozo Ooka
The presented thermal performance test (TPT) datasets were related to the research article "New perspectives in thermal performance test: Cost-effective apparatus and extended data analysis" (Choi et al., 2018), where a new TPT apparatus was developed by adding a solid-state-relay and a proportional-integral-derivative (PID) controller to a thermal response test apparatus. Using the developed apparatus connected to a 50-m-long vertical ground heat exchanger, two TPTs were conducted for 144 h with inlet setpoint temperatures of 30 °C and 40 °C...
October 2018: Data in Brief
Xiaojing Zheng, Catherine M O'Connell, Wujuan Zhong, Taylor B Poston, Harold C Wiesenfeld, Sharon L Hillier, Maria Trent, Charlotte Gaydos, George Tseng, Brandie D Taylor, Toni Darville
Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment increases risk of sequelae. Blood mRNA from 111 women from three cohorts was profiled using microarray. Unsupervised analysis revealed a transcriptional profile that distinguished 9 cases of STI-induced endometritis from 18 with cervical STI or uninfected controls. Using a hybrid feature selection algorithm we identified 21 genes that yielded maximal classification accuracy within our training dataset...
2018: Frontiers in Cellular and Infection Microbiology
Mayuko Hida, Takatoshi Anno, Fumiko Kawasaki, Hideaki Kaneto, Kohei Kaku, Niro Okimoto
BACKGROUND: Pyosalpinx, which is one of the pelvic inflammatory diseases, is usually observed in young women; it is rarely found in older women. Possible causative agents are thought to be Chlamydia trachomatis and Neisseria gonorrhea in addition to some Enterobacteriaceae. On the other hand, type 2 diabetes is a disease with a lot of complications such as hyperglycemia, inflammation, and immune disorders. Therefore, patients with type 2 diabetes mellitus have an increased susceptibility to infection especially when glycemic control is poor...
October 6, 2018: Journal of Medical Case Reports
A Alavudeen Basha, S Vivekanandan, P Parthasarathy
The blood pressure disparity is the major problem in post-operative surgery especially diabetic patients, because there is substantial interrelation between diabetic and hypertension and this abnormality creates complicated problems and needs to be controlled by continuous monitoring based on the severity. To overcome this problem, implementation of automatic drug infusion is required for critical patients, by which workload of the clinical staffs are reduced. Most commonly the sodium nitroprusside (SNP) is used to reduce the blood pressure in fast action based on the prescribed level...
December 2018: Health Information Science and Systems
Yu Sun, Jing Zhang, Wenpei Bai
STUDY OBJECTIVE: To study the association between endometrial polyps and fallopian tube patency diagnosed by hysteroscopy, conventional histology, and four-dimensional hysterosalpingo contrast sonography (4D-HyCoSy). DESIGN: Case-control study (Canadian Task Force classification II-2). SETTING: University hospital. PATIENTS: A total of 323 women of reproductive age underwent 4D-HyCoSy and hysteroscopy between January 2015 and December 2017...
September 28, 2018: Journal of Minimally Invasive Gynecology
Hyo K Park, Joellen M Schildkraut, Anthony J Alberg, Elisa V Bandera, Jill S Barnholtz-Sloan, Melissa Bondy, Sydnee Crankshaw, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Paul Terry, Frances Wang, Julie J Ruterbusch, Ann G Schwartz, Michele L Cote
BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women. METHODS: Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer...
September 29, 2018: Cancer Causes & Control: CCC
Shamyla Farrukh, Adam B Sivitz, Bilgehan Onogul, Kavita Patel, Cena Tejani
STUDY OBJECTIVE: We evaluate the additive value of pelvic examinations in predicting sexually transmitted infection for young female patients with suspected cervicitis or pelvic inflammatory disease in a pediatric emergency department (ED). METHODS: This was a prospective observational study of female patients aged 14 to 20 years who presented to an urban academic pediatric ED with a complaint of vaginal discharge or lower abdominal pain. Enrolled patients provided a urine sample for chlamydia, gonorrhea, and trichomonas testing, which served as the criterion standard for diagnosis...
July 2, 2018: Annals of Emergency Medicine
Tahereh Babaie Janvier, Peter A Robinson
Neural field theory is used to model and analyze realistic corticothalamic responses to simple visual stimuli. This yields system transfer functions that embody key features in common with those of engineering control systems, which enables interpretation of brain dynamics in terms of data filters. In particular, these features assist in finding internal signals that represent input stimuli and their changes, which are exactly the types of quantities used in control systems to enable prediction of future input signals, and adjustment of gains which is argued to be the analog of attention in control theory...
2018: Frontiers in Human Neuroscience
Lisa Tabacco, Shang-En Chung, Jamie Perin, Steven Huettner, Arlene Butz, Maria Trent
Adolescent and young adult women disproportionately experience Pelvic Inflammatory Disease (PID) as a complication of Sexually Transmitted Infections (STIs). This study seeks to understand the relationship context, changes in sexual behavior, and impact of partner sexual behavior on recurrent STI diagnoses at 3-months post-diagnosis. Adolescents and young adult women 13-25 were recruited from an outpatient disposition from an outpatient clinic, and pediatric and adult emergency rooms. Participants received treatment at baseline and follow-up at 2-weeks, 1-month and 3-month post-diagnosis, including interviews about personal and partner sexual behaviors and STI screening (n = 94)...
2018: International archives of nursing and health care
Hong Zhang, Chuansheng Wang, Xiaorui Li, Boyan Sun, Dong Jiang
A novel way to measure humidity through testing the emissivity of an area radiant source is presented in this paper. The method can be applied in the environment at near room temperature (5~95 °C) across the relative humidity (RH) range of 20~90% RH. The source, with a grooved radiant surface, works in the far infrared wavelength band of 8~12 μm. The Monte-Carlo model for thermal radiation was set up to analyze the V-grooved radiant surface. Heat pipe technology is used to maintain an isothermal radiant surface...
September 13, 2018: Sensors
Luai R Khoury, Joel Nowitzke, Narayan Dahal, Kirill Shmilovich, Annie Eis, Ionel Popa
Here, we describe a force-clamp rheometry method to characterize the biomechanical properties of protein-based hydrogels. This method uses an analog proportional-integral-derivative (PID) system to apply controlled-force protocols on cylindrical protein-based hydrogel samples, which are tethered between a linear voice-coil motor and a force transducer. During operation, the PID system adjusts the extension of the hydrogel sample to follow a predefined force protocol by minimizing the difference between the measured and set-point forces...
August 21, 2018: Journal of Visualized Experiments: JoVE
G Azizi, Y Bagheri, R Yazdani, M Zaki-Dizaji, M Jamee, F Jadidi-Niaragh, A N Kamali, H Abolhassani, A Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiency (PID). LPS-responsive beige-like anchor protein (LRBA) deficiency is an autosomal recessive disease characterized by a CVID-like phenotype. T cell abnormality was reported in patients with CVID and LRBA deficiency. The study's aim was to evaluate IL-4, IL-5, IL-10 and GATA3 expression in patients with LRBA deficiency and CVID with no known monogenic disease, and further evaluate its relevance with immunological futures and clinical complications of patients...
September 4, 2018: Allergologia et Immunopathologia
Mehran Rahmani, Mohammad Habibur Rahman
This paper proposes a novel robust control method for the control of a 7-DOF exoskeleton robot. The external disturbances and unknown dynamics in the form of friction forces, different upper-limb's mass, backlash, and input saturation make robot unstable, which prevents the robot from correctly following the defined path. A new fractional sliding mode controller (NFSMC) is designed, which is robust against unknown dynamic and external disturbances. Fractional PID controller (FPID) has high trajectory tracking, but it is not robust against external disturbances...
2018: PloS One
Noé Amir Rodríguez-Olivares, José Vicente Cruz-Cruz, Alejandro Gómez-Hernández, Rodrigo Hernández-Alvarado, Luciano Nava-Balanzar, Tomás Salgado-Jiménez, Jorge Alberto Soto-Cajiga
This paper presents the improvement of an ultrasonic pulse generator for a pipeline inspection gauge (PIG), which uses 64 transducers for inspecting distances up to 100 km with an axial resolution fixed at 3 mm and variable speeds between 0 and 2 m/s. An ultrasonic pulse generator is composed of a high-voltage (HV) MOSFETs, driver logic and an HV power supply. We used a DC-HV DC converter device as the HV power supply because it reduces the size of the ultrasound system considerably. However, pipeline geometry and inspection effects such as hammer and shock cause a variable pulse repetition frequency (PRF), producing voltage drops, poor quality of the HV pulse generated, failures in the dimensioning of defects and damage to devices by over-voltage...
September 5, 2018: Sensors
Martin J Wilby, Carolyn Hopkins, Emma Bedson, Sue Howlin, Girvan Burnside, Elizabeth J Conroy, Dyfrig A Hughes, Manohar Sharma, Anthony Marson, Simon R Clark, Paula Williamson
BACKGROUND: Sciatica is a common condition reported to affect over 3% of the UK population at any time and is often caused by a prolapsed intervertebral disc (PID). Although the duration and severity of symptoms can vary, pain persisting beyond 6 weeks is unlikely to recover spontaneously and may require investigation and treatment. Currently, there is no specific care pathway for sciatica in the National Health Service (NHS), and no direct comparison exists between surgical microdiscectomy and transforaminal epidural steroid injection (TFESI)...
September 5, 2018: Trials
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