Read by QxMD icon Read


Brian Lee, Stephan A Schug, Girish P Joshi, Henrik Kehlet
Post-operative pain management protocols may be optimised by examining procedure-specific evidence and outcomes. This recognition led to the formation of the PROcedure-SPECific Pain ManagemenT (PROSPECT) collaboration of anaesthesiologists and surgeons. The aim of PROSPECT is to provide practical and evidence-based recommendations to prevent and treat post-operative pain after specific surgical procedures, thereby overcoming the limitations of generic, non-specific guidelines. Updates in the methodology of PROSPECT in 2017 have placed an increased emphasis on the clinical relevance of studies, including a focus on interventions in the context of multimodal analgesia strategies and consideration of risks and benefits of interventions in specific surgical settings...
June 2018: Best Practice & Research. Clinical Anaesthesiology
Dolors Mateo-Ortega, Joaquín T Limonero, Jorge Maté-Méndez, Elba Beas, Jesús González-Barboteo, Elisabeth Barbero, Sara Ela, Xavier Gómez-Batiste
OBJECTIVE: The goal of this study is to describe the development of a new tool, the Psychosocial and Spiritual Needs Evaluation scale Instrumento de Evaluación de Necesidades Psicosociales y Espirituales del Enfermo al Final de Vida (ENP-E), designed to assess the psychosocial needs of end-of-life (EOL) patients. And, secondarily, to describe the face validity and psychometric properties of this instrument in the Spanish-speaking context. METHOD: The scale was developed through a seven-stage process: (1) literature review; (2) expert panel establishment; (3) discussion and agreement on the most relevant dimensions of psychosocial care; (4) description of key indicators and consensus-based questions to evaluate such dimensions; (5) assessment of the scale by external palliative care (PC) professionals; (6) evaluation by patients; and (7) analysis of scale's psychometrics properties...
October 16, 2018: Palliative & Supportive Care
Courtney M Schaal, Namrata Bora-Singhal, Durairaj Mohan Kumar, Srikumar P Chellappan
BACKGROUND: Lung cancer is the leading cause of cancer related deaths and its incidence is highly correlated with cigarette smoking. Nicotine, the addictive component of tobacco smoke, cannot initiate tumors, but can promote proliferation, migration, and invasion of cells in vitro and promote tumor growth and metastasis in vivo. This nicotine-mediated tumor promotion is facilitated through the activation of nicotinic acetylcholine receptors (nAChRs), specifically the α7 subunit. More recently, nicotine has been implicated in promoting self-renewal of stem-like side-population cells from lung cancers...
October 15, 2018: Molecular Cancer
Niccolò Tempini, Sabina Leonelli
This paper analyses the role of information security (IS) in shaping the dissemination and re-use of biomedical data, as well as the embedding of such data in material, social and regulatory landscapes of research. We consider data management practices adopted by two UK-based data linkage infrastructures: the Secure Anonymised Information Linkage, a Welsh databank that facilitates appropriate re-use of health data derived from research and routine medical practice in the region, and the Medical and Environmental Data Mash-up Infrastructure, a project bringing together researchers to link and analyse complex meteorological, environmental and epidemiological data...
October 2018: Social Studies of Science
Brittany Jamieson
Inadequate prenatal care utilization has been proposed as a mechanism between exposure to violence during pregnancy and adverse maternal and fetal obstetric outcomes. Adequate prenatal care is important for identifying and treating obstetric complications as they arise and connecting pregnant women to supports and interventions as needed. There is some evidence that pregnant women experiencing relational violence may delay or never enter prenatal care, though this association has not been systematically or quantitatively synthesized...
October 15, 2018: Trauma, Violence & Abuse
Ivano Iavarone, Carlotta Buzzoni, Giorgia Stoppa, Eva Steliarova-Foucher
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Children's environmental health is on the 2030 Agenda for Sustainable Development. The incidence of childhood cancer is increasing worldwide and in Europe. Yet, the aetiology of most childhood cancers, including the role of environmental carcinogens, is still largely unknown. Contaminated areas, especially of industrial origin, are of high concern due to complex mix of hazardous pollutants and their potential health impacts on human populations, notably in children...
September 2018: Epidemiologia e Prevenzione
Manuela De Sario, Roberto Pasetto, Simona Vecchi, Ariana Zeka, Gerard Hoek, Paola Michelozzi, Ivano Iavarone, Tony Fletcher, Lisa Bauleo, Carla Ancona
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Industrial contaminated sites (ICSs) are of high concern since industrial plants have produced widespread contamination potentially affecting the health of local population OBJECTIVES: to assess the types of epidemiological designs applied in studies of health effects related to ICSs according to time periods, type of ICS, and geography. METHODS: a literature search was conducted in Medline (OVID) through June 30th, 2018, using MeSH and customized terms, and no restrictions on publication year or language...
September 2018: Epidemiologia e Prevenzione
Dimosthenis A Sarigiannis, Spyros P Karakitsios
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Assessment of the health impacts related to industrially contaminated sites (ICSs) is a major scientific challenge with multiple societal implications. Most studies related to associations between ICSs and public health do not provide established mechanistic links between environmental exposure and disease burden, potentially resulting in suboptimal risk management measures. OBJECTIVES: to assess the potential of the exposome paradigm to overhaul ICS risk assessment and management leading to precision prevention and targeted interventions...
September 2018: Epidemiologia e Prevenzione
Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina
Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers. In particular, peculiar biological and therapeutic functions are associated with the sigma-2 (σ₂) receptor. The σ ₂ receptor ligands determine tumor cell death through apoptotic and non-apoptotic pathways, and the overexpression of σ ₂ receptors in several tumor cell lines has been well documented, with significantly higher levels in proliferating tumor cells compared to quiescent ones...
October 14, 2018: Marine Drugs
Li Yan Chan, Joshua Ding Wei Teo, Kevin Shyong-Wei Tan, Keitaro Sou, Wei Lek Kwan, Chi-Lik Ken Lee
Chloroquine was among the first of several effective drug treatments against malaria until the onset of chloroquine resistance. In light of diminished clinical efficacy of chloroquine as an antimalarial therapeutic, there is potential in efforts to adapt chloroquine for other clinical applications, such as in combination therapies and in diagnostics. In this context, we designed and synthesized a novel asymmetrical squaraine dye coupled with chloroquine (SQR1-CQ). In this study, SQR1-CQ was used to label live Plasmodium falciparum ( P...
October 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Wenyu Miao, Katsuya Sakai, Ryu Imamura, Kenichiro Ito, Hiroaki Suga, Tetsushi Sakuma, Takashi Yamamoto, Kunio Matsumoto
Non-native ligands for growth factor receptors with distinct chemical properties and different biological activities have the potential to become therapeutic applications. We previously generated MET/hepatocyte growth factor (HGF) receptor agonists using bivalent macrocyclic peptides. The highest MET-activating agonists exhibited biological activity that was indistinguishable from the effects of HGF. In this study, we investigated MET activation, signal characteristics, and biological responses induced by a macrocyclic peptide partial agonist known as aML5-PEG11...
October 12, 2018: International Journal of Molecular Sciences
Erika Klassen, Karl-Ruediger Wiebelitz, André-Michael Beer
BACKGROUND: Currently, there is a need for scientific evidence on the efficacy of classical massage therapy for chronic, unspecific back pain, especially for the improvement in functional impairment and long-term pain reduction. According to the National Health Care Guidelines, classical massage for nonspecific low back pain may only be prescribed in combination with exercise therapy and a share of the remuneration. Acupuncture, on the other hand, is recognised in the guidelines as an independent treatment for chronic back pain and is remunerated by health insurance companies...
October 15, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
Mackenzie Graham, Colin P Doherty, Lorina Naci
Robust prognostic indicators of neurological recovery are urgently needed for acutely comatose patients. Functional neuroimaging is a highly sensitive tool for uncovering covert cognition and awareness in behaviorally nonresponsive patients with prolonged disorders of consciousness, and may be applicable to acutely comatose patients. Establishing a link between early detection of covert awareness in acutely comatose patients and eventual recovery of function could have significant implications for patient prognosis, treatment, and end-of-life decisions...
October 2018: Seminars in Neurology
Neil H Vaishnav, Winston Chiong
The doctrine of informed consent sits at the intersection of law, ethics, and neuroscience, posing unique challenges for human subject research involving neurological patients. These challenges are compounded by the variegated nature of both neurological injury and the law governing research consent. This article provides a framework for investigators likely to encounter subjects with some degree of neurological impairment, whose capacity to consent requires scrupulous assessment prior to enrollment in research trials...
October 2018: Seminars in Neurology
Abigail Lang, Erin Talati Paquette
When caring for minors, the clinician-patient relationship becomes more ethically complex by the inclusion of parents in the clinician-parent-patient triad. As they age, children become more capable of participating in the decision-making process. This involvement may lead them to either accept or refuse proposed care, both of which are ethically acceptable positions when the minor's capacity to participate in decision making is carefully considered in the context of their age, development, and overall health...
October 2018: Seminars in Neurology
Yvonne Lehmann, Michael Ewers
INTRODUCTION: There is an increasing number of ventilated and other technology-dependent patients, cared for in their own homes or in shared apartments in Germany. Issues of patient safety have hardly been examined in this context. In this follow-up of a survey of patients and their relatives, the perspective of professional players on the subject of safety in intensive home care is explored. METHODS: Professional players in 6 heterogeneous, non-natural focus groups were faced with experiences and perspectives of ventilated patients and their relatives in a qualitative health care services research...
October 15, 2018: Das Gesundheitswesen
Ines Georg, Manfred Wildner
The German National Action Plan for the implementation of the WHO goal of measles elimination still faces considerable challenges regarding reaching its goal of increasing adult's vaccination rates and better outbreak management. METHODS: The description of the target population group -adults born after 1970 - as well as other potentially vulnerable groups was carried out by means of a systematic literature review. A further systematic review outlines options for the prevention of new infections...
October 15, 2018: Das Gesundheitswesen
Lea-Sophie Borgmann, Petra Rattay, Thomas Lampert
The lives of single mothers and fathers are associated with specific demands, which may result in higher psychosocial and physical strain compared to parents sharing their household with a partner. In this context, social support is known to function as a protective resource. The present article examines how different levels of social support interrelate with levels of mental health in single mothers and fathers in Germany. The data is drawn from the surveys 2009, 2010 and 2012 of the study "German Health Update" (GEDA) by the Robert Koch Institute...
October 15, 2018: Das Gesundheitswesen
Maya K Gislason, Vanessa Sloan Morgan, Kendra Mitchell-Foster, Margot W Parkes
The 'Ecohealth and Watersheds in Northern BC'' project, situated in a resource rich, settler colonial context, generated three digital stories at the request of the project's Steering Committee members that sought to connect health, environment, and community. Three Steering Committee members championed these stories from their distinct watersheds, resulting in emergent counter-narratives that respond directly to their social-ecological contexts. Nested in literature on blue and green spaces, we present and examine the process of storytelling as emergent counter-narrative and how these narratives challenge us to think of blue and green spaces in interconnected and nuanced ways...
October 12, 2018: Health & Place
Mengtuan Ge, Dengjun Wang, Junwei Yang, Qiang Jin, Zongyuan Chen, Wangsuo Wu, Zhijun Guo
Remediating uranium contamination becomes a worldwide interest because of increasing uranium release from mining activities. Due to ubiquitous presence of pyrite and the application of iron-based technology, colloidal iron oxy-hydroxides such as akaganéite colloid (AKC) extensively exist in uranium polluted water at uranium tailing sites. In this context, we studied individual and co-transport of U(VI) and AKC in water-saturated sand columns at 50 mg/L AKC and environmentally relevant U(VI) concentrations (5...
October 5, 2018: Water Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"