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https://www.readbyqxmd.com/read/30547492/-introduction-in-2014-a-symposium-focusing-on-access-to-healthcare-was-organized-with-input-from-socially-excluded-people-using-the-atd-fourth-world-guidelines-for-the-merging-of-knowledge-and-practices-as-the-ethical-framework-can-this-approach-be-transferred
#1
Bruno de Goer, Jean Vanoye, Corinne Bernati
INTRODUCTION: In 2014, a symposium focusing on access to healthcare was organized with input from socially excluded people, using the ATD Fourth World Guidelines for the Merging of Knowledge and Practices as the ethical framework. Can this approach be transferred to other settings? METHODS: Prospective assessment of a participatory approach in the context of a symposium. RESULTS: Strict conditions are required to ensure effective participation of extremely vulnerable people...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547488/comment-les-m%C3%A3-decins-g%C3%A3-n%C3%A3-ralistes-favorisent-ils-l-%C3%A3-quit%C3%A3-d-acc%C3%A3-s-%C3%A3-l-%C3%A3-ducation-th%C3%A3-rapeutique-pour-leurs-patients
#2
Cécile Fournier, Marie-Odile Frattini, Michel Naiditch, Pierre-Yves Traynard, Rémi Gagnayre, Pierre Lombrail
Our research is designed to understand how and under what conditions general practitioners contribute to equitable access to patient education (PE).We conducted a survey based on interactionist sociology in a sample of 32 doctors. These practitioners worked in the context of health networks and health care centres and were also involved in the PE resource centre for the Île-de-France region, thereby providing a favourable setting for our study, also reflected by the fact that one-half of practitioners were aware of the importance of or had been trained in PE...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547487/-introduction-the-city-of-villeurbanne-has-made-the-political-choice-to-reduce-social-inequalities-in-health-sih-the-public-health-department-wanted-to-assess-the-health-impact-in-the-context-of-this-project-the-main-objective-was-to-analyse-the-links-between
#3
[Introduction: The city of Villeurbanne has made the political choice to reduce social inequalities in health (SIH). The Public Health Department wanted to assess the health impact in the context of this project. The main objective was to analyse the links between urban development and health in order to identify the impact of the urban project on health and to make recommendations to reduce physical inactivity of children. Attention was focused on a neighbourhood of 6,000 inhabitants in the process of urban renewal. A high rate of adults on antidiabetic treatment was observed in this relatively deprived neighbourhood. School medicine also noted a high proportion of overweight children in schools in the neighbourhood, higher than in all schools of the city. The objective of this HIA was therefore to identify the impact of the renovation project on children’s mobility and to make recommendations in order to combat their physical inactivity by encouraging spontaneous physical activity.Methods: The selected determinants were grouped into four categories: outdoor environment, use of open spaces, adapted sports facilities/equipment, roads. The evaluation was based on analysis of urban planning documents, environmental analysis reports, ad hoc surveys, individual interviews with the various partners and target actors. A bibliographic review confirmed the positive or negative impacts of various aspects of the project on health.Results: Although some aspects of the project had a positive impact on the health of the inhabitants, others have a negative impact on children’s mobility, well-being and social capital. About 30 recommendations were proposed and prioritized according to their political support and their technical, economic and temporal feasibility.Discussion].
Lucie Anzivino, Carole Martin de Champs, Pascale Colom, Géraldine Ollivier, Fabienne Beynel-Melinand, Natacha Litzistorf, Damien Regenass
INTRODUCTION: The city of Villeurbanne has made the political choice to reduce social inequalities in health (SIH). The Public Health Department wanted to assess the health impact in the context of this project. The main objective was to analyse the links between urban development and health in order to identify the impact of the urban project on health and to make recommendations to reduce physical inactivity of children. Attention was focused on a neighbourhood of 6,000 inhabitants in the process of urban renewal...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547484/-introduction-reduction-of-social-inequalities-in-health-has-been-one-of-the-main-political-pillars-of-regional-health-agencies-in-france-since-their-creation-in-2009-this-paper-presents-a-contextual-analysis-of-the-effects-on-social-inequalities-in-health
#4
[Introduction: Reduction of social inequalities in health has been one of the main political pillars of Regional Health Agencies in France since their creation in 2009. This paper presents a contextual analysis of the effects on social inequalities in health of a hospital-based health promotion and disease prevention programme in terms of overall health policy and scope.Methods: Qualitative analysis was used to describe the impact on social inequalities in health according to the classification proposed by Diderichsen et al. Carey’s framework was used to apply proportionate universalism in order to analyse its action on these inequalities, adopting a contextualised and holistic approach with regard to regional and national public policy. The results showed that the intervention focused on targeted actions, but may have broader applications. The intervention strategy shifts between closing the inequality gap and levelling up the social gradient. However, analysis of this type of intervention using the proportionate universalism framework may lead to a revised view of the effects of the intervention on social inequalities in health.Results: Implementing health-equity focused interventions remains a challenge for each institution, including Regional Health Agencies. However, research on hospital-based preventive interventions highlights contrasting results in terms of social gradient, depending on whether the intervention is considered in isolation or in its broader context.Discussion].
Marion Porcherie, Blanche Le Bihan-Youinou, Jeanine Pommier
INTRODUCTION: Reduction of social inequalities in health has been one of the main political pillars of Regional Health Agencies in France since their creation in 2009. This paper presents a contextual analysis of the effects on social inequalities in health of a hospital-based health promotion and disease prevention programme in terms of overall health policy and scope. METHODS: Qualitative analysis was used to describe the impact on social inequalities in health according to the classification proposed by Diderichsen et al...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547482/parcours-de-soins-en-situation-de-pr%C3%A3-carit%C3%A3-%C3%A2-entre-d%C3%A3-termination-et-individualisation
#5
Caroline Desprès
The purpose of this article is to analyse healthcare pathways for precarious people, based on the results of a field study conducted in 2011 and 2012 in the north of France and Burgundy. About 40 semi-directed interviews were conducted in order to collect healthcare pathways narratives revolving around various health events during the subject's life, and putting them in perspective with individual, familial stories as well as their environment (social environment, healthcare organization, etc.).The results indicate various types of determinants, firstly concerning norms and rules determining access to health insurance and health services...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547481/-introduction-health-literacy-refers-to-the-competences-and-resources-required-by-individuals-to-meet-the-complex-demands-of-health-in-modern-society-this-paper-describes-and-analyses-the-health-literacy-profiles-of-type-160-2-diabetic-patients-included-in
#6
Xavier Debussche, Maryvette Balcou-Debussche
INTRODUCTION: Health literacy refers to the competences and resources required by individuals to meet the complex demands of health in modern society. This paper describes and analyses the health literacy profiles of type 2 diabetic patients included in a 2-year long self-management education programme. METHODS: Nested in the ERMIES randomized controlled trial conducted in Reunion island, the ERMIES Ethnosocio study explored health literacy by means of two complementary approaches: description of health literacy profiles via the French version of the multidimensional ?Health Literacy Questionnaire?, and a socio-anthropological perspective based on 40 semi-structured interviews carried out in 2012 and then in 2015...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547477/adaptation-et-conditions-d-utilisation-d-un-outil-d-analyse-des-interventions-au-regard-des-in%C3%A3-galit%C3%A3-s-sociales-de-sant%C3%A3
#7
Anne Guichard, Catherine Hébert, Kareen Nour, Ginette Lafontaine, Émilie Tardieu, Valery Ridde
Although actions to reduce social inequalities in health cannot be considered the exclusive responsibility of public health actors, they should at least make sure their interventions account for these inequalities. However, the actors involved in these interventions have few tools to support them in this process. Therefore, building on a study conducted in France, we have adapted, tested, and developed in Quebec a tool intended to help actors take into account social inequalities in health. The article presents the approach that led to the adaptation of the tool to the Quebec context, to describe the tool, and then to discuss some issues for inclusion in professional practices...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547474/r%C3%A3-duire-les-in%C3%A3-galit%C3%A3-s-subies-par-une-communaut%C3%A3-am%C3%A3-rindienne-au-br%C3%A3-sil%C3%A2-le-r%C3%A3-le-social-de-l-universit%C3%A3
#8
David Ramos da Silva Rios, Maria Constantina Caputo, Christine Quélier
The objective of this article is to describe and analyse the actions developed by a health promotion programme between 2013 and 2014 in an indigenous Kiriri community in Bahia, Brazil. One of the specificities of the programme was that it was conducted in the context of the extension activities of Brazilian universities. This programme illustrates the actions of extension, a longstanding social function of Brazilian universities and the value of involving the university in community health actions.Based on the action research methodology, the project was designed to stimulate reflection on the broader concept of health and its social determinants, developing the link between the various languages and cultures based on social mobilization around health promotion and to promote respect for cultural diversity...
September 6, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/30547435/repurposing-drugs-based-on-evolutionary-relationships-between-targets-of-approved-drugs-and-proteins-of-interest
#9
Sohini Chakraborti, Gayatri Ramakrishnan, Narayanaswamy Srinivasan
Drug repurposing has garnered much interest as an effective method for drug development among biopharmaceutical companies. The availability of information on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of small molecules offers opportunities to explore the repurpose-able potential of existing pharmacopoeia. This method gains further importance, especially, in the context of development of drugs against infectious diseases, some of which pose serious complications due to emergence of drug-resistant pathogens...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30547404/inferring-gene-regulatory-networks-from-multiple-datasets
#10
Christopher A Penfold, Iulia Gherman, Anastasiya Sybirna, David L Wild
Gaussian process dynamical systems (GPDS) represent Bayesian nonparametric approaches to inference of nonlinear dynamical systems, and provide a principled framework for the learning of biological networks from multiple perturbed time series measurements of gene or protein expression. Such approaches are able to capture the full richness of complex ODE models, and can be scaled for inference in moderately large systems containing hundreds of genes. Related hierarchical approaches allow for inference from multiple datasets in which the underlying generative networks are assumed to have been rewired, either by context-dependent changes in network structure, evolutionary processes, or synthetic manipulation...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30547400/integrative-approaches-for-inference-of-genome-scale-gene-regulatory-networks
#11
Alireza Fotuhi Siahpirani, Deborah Chasman, Sushmita Roy
Transcriptional regulatory networks specify the regulatory proteins of target genes that control the context-specific expression levels of genes. With our ability to profile the different types of molecular components of cells under different conditions, we are now uniquely positioned to infer regulatory networks in diverse biological contexts such as different cell types, tissues, and time points. In this chapter, we cover two main classes of computational methods to integrate different types of information to infer genome-scale transcriptional regulatory networks...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30547398/causal-queries-from-observational-data-in-biological-systems-via-bayesian-networks-an-empirical-study-in-small-networks
#12
Alex White, Matthieu Vignes
Biological networks are a very convenient modeling and visualization tool to discover knowledge from modern high-throughput genomics and post-genomics data sets. Indeed, biological entities are not isolated but are components of complex multilevel systems. We go one step further and advocate for the consideration of causal representations of the interactions in living systems. We present the causal formalism and bring it out in the context of biological networks, when the data is observational. We also discuss its ability to decipher the causal information flow as observed in gene expression...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30547381/implicit-associations-between-individual-properties-of-color-and-sound
#13
Andrey Anikin, N Johansson
We report a series of 22 experiments in which the implicit associations test (IAT) was used to investigate cross-modal correspondences between visual (luminance, hue [R-G, B-Y], saturation) and acoustic (loudness, pitch, formants [F1, F2], spectral centroid, trill) dimensions. Colors were sampled from the perceptually accurate CIE-Lab space, and the complex, vowel-like sounds were created with a formant synthesizer capable of separately manipulating individual acoustic properties. In line with previous reports, the loudness and pitch of acoustic stimuli were associated with both luminance and saturation of the presented colors...
December 13, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/30547350/insomnia-and-cardiorespiratory-fitness-in-a-middle-aged-population-the-scapis-pilot-study
#14
Ding Zou, Heini Wennman, Örjan Ekblom, Ludger Grote, Daniel Arvidsson, Anders Blomberg, Kjell Torén, Göran Bergström, Mats Börjesson, Jan Hedner
BACKGROUND: The relationship between insomnia and cardiorespiratory fitness (CRF), a well-established risk factor for cardiovascular disease, has not been extensively studied. We aimed to assess the independent association between insomnia and CRF in a population-based cohort of subjects aged 50 to 64 years. METHODS: Subjects participating in the Swedish CArdioPulmonary bioImaging Study (SCAPIS) pilot cohort (n = 603, men 47.9%) underwent a submaximal cycle ergometer test for estimation of maximal oxygen consumption (VO2 max)...
December 13, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30547312/inhibitory-control-and-information-processing-in-adhd-comparing-the-dual-task-and-performance-adjustment-hypotheses
#15
Whitney D Fosco, Michael J Kofler, R Matt Alderson, Stephanie J Tarle, Joseph S Raiker, Dustin E Sarver
Inhibition is a key neurocognitive domain in ADHD that is commonly assessed with the stop-signal task. The stop-signal involves both "go" and "stop" trials; previous research indicates that response times are reliably slower to "go" trials during tasks with vs. without intermittent "stop" trials. However, it is unclear whether this pattern reflects deliberate slowing to maximize inhibitory success (performance adjustment hypothesis) and/or disrupted bottom-up information processing due to increased cognitive demands (dual-task hypothesis)...
December 13, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/30547281/an-examination-of-preterm-birth-and-residential-social-context-among-black-immigrant-women-in-california-2007-2010
#16
Bridgette E Blebu, Annie Ro, Jennifer B Kane, Tim A Bruckner
The foreign-born black population contributes a considerable amount of heterogeneity to the US black population. In 2005, black immigrants accounted for 20% of the US black population. Compared to native-born black women, black immigrant women are at lower risk for adverse birth outcomes, including preterm birth. Some scholars posit that differential exposures to socioeconomic disadvantage and structural racism in the residential context may account for this advantage. However, to date, few studies offer comprehensive examinations of the black immigrant residential social context, particularly in settlement regions beyond predominantly black and historically segregated regions...
December 13, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/30547244/glaucoma-next-generation-therapeutics-impossible-to-possible
#17
REVIEW
Christopher M Adams, Rebecca Stacy, Nalini Rangaswamy, Chad Bigelow, Cynthia L Grosskreutz, Ganesh Prasanna
The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first in over 20 years. However, these are still being administered as topical drops. Efforts are underway to increase patient compliance and greater therapeutic benefits with the development of sustained delivery technologies. Furthermore, innovations from biologics- and gene therapy-based therapeutics are being developed in the context of disease modification, which are expected to lead to more permanent therapies for patients...
December 13, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/30547212/race-ethnicity-nativity-and-lifetime-risk-of-mental-disorders-in-us-adults
#18
Kiara Alvarez, Mirko Fillbrunn, Jennifer Greif Green, James S Jackson, Ronald C Kessler, Katie A McLaughlin, Ekaterina Sadikova, Nancy A Sampson, Margarita Alegría
PURPOSE: There has been no comprehensive examination of how race/ethnicity and nativity intersect in explaining differences in lifetime prevalence of mental disorders among Asian, Black, Latino, and White adults. This study aims to estimate racial/ethnic differences in lifetime risk of mental disorders and examine how group differences vary by nativity. METHODS: Survival models were used to estimate racial/ethnic and nativity differences in lifetime risk of DSM-IV anxiety, mood, and substance use disorders in a nationally representative sample of over 20,000 respondents to four US surveys...
December 13, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/30547090/structure-and-dynamical-behavior-of-non-normal-networks
#19
Malbor Asllani, Renaud Lambiotte, Timoteo Carletti
We analyze a collection of empirical networks in a wide spectrum of disciplines and show that strong non-normality is ubiquitous in network science. Dynamical processes evolving on non-normal networks exhibit a peculiar behavior, as initial small disturbances may undergo a transient phase and be strongly amplified in linearly stable systems. In addition, eigenvalues may become extremely sensible to noise and have a diminished physical meaning. We identify structural properties of networks that are associated with non-normality and propose simple models to generate networks with a tunable level of non-normality...
December 2018: Science Advances
https://www.readbyqxmd.com/read/30546957/tumor-infiltrating-neutrophils-predict-therapeutic-benefit-of-tyrosine-kinase-inhibitors-in-metastatic-renal-cell-carcinoma
#20
Jiajun Wang, Li Liu, Qi Bai, Chenzhang Ou, Ying Xiong, Yang Qu, Zewei Wang, Yu Xia, Jianming Guo, Jiejie Xu
Tumor-infiltrating neutrophils (TINs) show diverse predictive effects in the context of different cancer types and therapeutic regimens. In this study we investigated their relevance with therapeutic effect of tyrosine kinase inhibitors (TKIs) in metastatic renal cell carcinoma (mRCC). Two independent datasets including 271 mRCC patients treated by TKIs or IL-2/IFN-α based immunotherapy were retrospective included, and TINs were detected by immunohistochemistry. The presence of TINs was observed in 50 (45...
2019: Oncoimmunology
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