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https://www.readbyqxmd.com/read/30296276/adolescent-binge-ethanol-induced-loss-of-basal-forebrain-cholinergic-neurons-and-neuroimmune-activation-are-prevented-by-exercise-and-indomethacin
#1
Ryan P Vetreno, Fulton T Crews
Basal forebrain cholinergic neurons mature in adolescence coinciding with development of adult cognitive function. Preclinical studies using the rodent model of adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2-days on/2-days off from postnatal day [P]25 to P55) reveal persistent increases of brain neuroimmune genes that are associated with cognitive dysfunction. Adolescent intermittent ethanol exposure also reduces basal forebrain expression of choline acetyltransferase (ChAT), an enzyme critical for acetylcholine synthesis in cholinergic neurons similar to findings in the post-mortem human alcoholic basal forebrain...
2018: PloS One
https://www.readbyqxmd.com/read/30131506/deletion-of-p75-ntr-prevents-vaso-obliteration-and-retinal-neovascularization-via-activation-of-trk-a-receptor-in-ischemic-retinopathy-model
#2
Sally L Elshaer, Azza B El-Remessy
Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the neurotrophin receptor; p75NTR can overcome retinal ischemia using oxygen-induced retinopathy (OIR) mouse model. Wildtype (WT) or p75NTR-/- mice pups were subjected to hyperoxia (70% O2 , p7-p12) then returned to normal air (relative hypoxia, p12-p17). Vascular alterations were assessed at p12 and p17 time-points...
August 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30076938/long-term-effects-of-cigarette-smoke-extract-or-nicotine-on-nerve-growth-factor-and-its-receptors-in-a-bronchial-epithelial-cell-line
#3
A M Stabile, L Marinucci, S Balloni, A Giuliani, A Pistilli, M Bodo, M Rende
Long-term exposure to cigarette smoke induces severe injuries to respiratory system through several mechanisms, some of them are well defined, but many others are not yet elucidated. Beside its classical role in nervous system, we have previously shown that Nerve Growth Factor (NGF) and its receptors have a crucial role in airway inflammatory diseases, such as Chronic Obstructive Pulmonary Disease. To expand our knowledge about the relevance of NGF and its receptors in airway diseases induced by cigarette smoking, we exposed for 16 weeks the bronchial epithelial cell line BEAS-2B to sub-toxic concentrations of whole cigarette smoke extract or pure nicotine...
August 1, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/30030957/nerve-growth-factor-as-an-important-possible-component-of-novel-therapy-for-cancer-diabetes-and-cardiovascular-diseases
#4
Karol P Steckiewicz, Ewelina Barcińska, Michał Woźniak
Nerve growth factor (NGF) is protein discovered by Rita Levi Montalcini in the 1950s. It plays a crucial role in the development of nervous system. NGF may be produced by a variety of cells even beyond nervous system. NGF modulate cell metabolism by binding to p75NTR and TrkA receptors. NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and cardiovascular diseases, which will be described in the article.
June 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/30006508/effects-of-bnn27-a-novel-c17-spiroepoxy-steroid-derivative-on-experimental-retinal-detachment-induced-photoreceptor-cell-death
#5
Pavlina Tsoka, Hidetaka Matsumoto, Daniel E Maidana, Keiko Kataoka, Irene Naoumidi, Achille Gravanis, Demetrios G Vavvas, Miltiadis K Tsilimbaris
Retinal detachment (RD) leads to photoreceptor cell death secondary to the physical separation of the retina from the underlying retinal pigment epithelium. Intensifying photoreceptor survival in the detached retina could be remarkably favorable for many retinopathies in which RD can be seen. BNN27, a blood-brain barrier (BBB)-permeable, C17-spiroepoxy derivative of dehydroepiandrosterone (DHEA) has shown promising neuroprotective activity through interaction with nerve growth factor receptors, TrkA and p75NTR ...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29869196/nerve-growth-factor-role-on-retinal-ganglion-cell-survival-and-axon-regrowth-effects-of-ocular-administration-in-experimental-model-of-optic-nerve-injury
#6
Louise A Mesentier-Louro, Pamela Rosso, Valentina Carito, Rosalia Mendez-Otero, Marcelo F Santiago, Paolo Rama, Alessandro Lambiase, Paola Tirassa
Retinal ganglion cell (RGC) degeneration occurs within 2 weeks following optic nerve crush (ONC) as a consequence of reduced retro-transport of growth factors including nerve growth factor (NGF). The hypothesis that intravitreal (ivt) and eye drop (ed) administration of recombinant human NGF (rhNGF) might counteract ONC in adult rats is explored in this study. We found that both ivt- and ed-rhNGF reduced RGC loss and stimulated axonal regrowth. Chiefly, survival and regenerative effects of rhNGF were associated with a reduction of cells co-expressing Nogo-A/p75NTR at crush site borders, which contribute to glia scar formation following nerve injury, and induce further degeneration...
June 4, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29859871/pretangle-pathology-within-cholinergic-nucleus-basalis-neurons-coincides-with-neurotrophic-and-neurotransmitter-receptor-gene-dysregulation-during-the-progression-of-alzheimer-s-disease
#7
Chelsea T Tiernan, Stephen D Ginsberg, Bin He, Sarah M Ward, Angela L Guillozet-Bongaarts, Nicholas M Kanaan, Elliott J Mufson, Scott E Counts
Cholinergic basal forebrain neurons of the nucleus basalis of Meynert (nbM) regulate attentional and memory function and are exquisitely prone to tau pathology and neurofibrillary tangle (NFT) formation during the progression of Alzheimer's disease (AD). nbM neurons require the neurotrophin nerve growth factor (NGF), its cognate receptor TrkA, and the pan-neurotrophin receptor p75NTR for their maintenance and survival. Additionally, nbM neuronal activity and cholinergic tone are regulated by the expression of nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors as well as receptors modulating glutamatergic and catecholaminergic afferent signaling...
September 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29802376/the-neurotrophic-tyrosine-kinase-receptor-trka-and-its-ligand-ngf-are-increased-in-squamous-cell-carcinomas-of-the-lung
#8
Fangfang Gao, Nathan Griffin, Sam Faulkner, Christopher W Rowe, Lily Williams, Severine Roselli, Rick F Thorne, Aysha Ferdoushi, Phillip Jobling, Marjorie M Walker, Hubert Hondermarck
The neurotrophic tyrosine kinase receptor TrkA (NTRK1) and its ligand nerve growth factor (NGF) are emerging promoters of tumor progression. In lung cancer, drugs targeting TrkA are in clinical trials, but the clinicopathological significance of TrkA and NGF, as well as that of the precursor proNGF, the neurotrophin co-receptor p75NTR and the proneurotrophin co-receptor sortilin, remains unclear. In the present study, analysis of these proteins was conducted by immunohistochemistry and digital quantification in a series of 204 lung cancers of different histological subtypes versus 121 normal lung tissues...
May 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789375/neurotrophin-responsiveness-of-sympathetic-neurons-is-regulated-by-rapid-mobilization-of-the-p75-receptor-to-the-cell-surface-through-trka-activation-of-arf6
#9
F Edward Hickman, Emily M Stanley, Bruce D Carter
The p75 neurotrophin receptor (p75NTR) plays an integral role in patterning the sympathetic nervous system during development. Initially, p75NTR is expressed at low levels as sympathetic axons project toward their targets, which enables neurotrophin-3 (NT3) to activate TrkA receptors and promote growth. Upon reaching nerve growth factor (NGF) producing tissues, p75NTR is upregulated, resulting in formation of TrkA-p75 complexes, which are high-affinity binding sites selective for NGF, thereby blunting NT3 signaling...
June 13, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29715758/ngf-and-pi3k-akt-signaling-participate-in-the-ventral-motor-neuronal-protection-of-curcumin-in-sciatic-nerve-injury-rat-models
#10
Qiuling Sang, Daju Sun, Zonghan Chen, Weijia Zhao
OBJECTIVE: It has been reported that sciatic nerve injury (SNI) leads to degeneration, damage, and apoptosis of motor neurons. Nerve growth factor (NGF) plays a pivotal role in regeneration and reestablishment of neuronal function via activating PI3K/Akt survival signaling pathways. Curcumin owns neuroprotective effect following brain injury. In the present study, we attempt to investigate underlying mechanism of neuroprotective effect of curcumin through elucidating its correlation with NGF and PI3K/Akt signaling pathways in vitro and in vivo...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29569362/temporally-restricted-death-and-the-role-of-p75ntr-as-a-survival-receptor-in-the-developing-sensory-nervous-system
#11
Irene Cheng, Lucy Jin, Lucy C Rose, Christopher D Deppmann
The peripheral somatosensory system overproduces neurons early in development followed by a period of cell death during final target innervation. The decision to survive or die in somatosensory neurons of the dorsal root ganglion (DRG) is mediated by target-derived neurotrophic factors and their cognate receptors. Subsets of peripheral somatosensory neurons can be crudely defined by the neurotrophic receptors that they express: peptidergic nociceptors (TrkA+), nonpeptidergic nociceptors (Ret+), mechanoreceptors (Ret+ or TrkB+), and proprioceptors (TrkC+)...
July 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29483280/swedish-nerve-growth-factor-mutation-ngf-r100w-defines-a-role-for-trka-and-p75-ntr-in-nociception
#12
Kijung Sung, Luiz F Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L Pearn, Michael T Maloney, William C Mobley, Jon D Levine, Chengbiao Wu
Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to a change from arginine to tryptophan at residue 100 in the mature NGFβ sequence (NGFR100W ) in patients with hereditary sensory and autonomic neuropathy type V (HSAN V) made it possible to distinguish the signaling mechanisms that lead to two functionally different outcomes of NGF: trophic versus nociceptive. We performed extensive biochemical, cellular, and live-imaging experiments to examine the binding and signaling properties of NGFR100W Our results show that, similar to the wild-type NGF (wtNGF), the naturally occurring NGFR100W mutant was capable of binding to and activating the TrkA receptor and its downstream signaling pathways to support neuronal survival and differentiation...
April 4, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29407470/anticarcinogenic-activities-of-sulforaphane-are-influenced-by-nerve-growth-factor-in-human-melanoma-a375-cells
#13
Paola Arcidiacono, Anna Maria Stabile, Francesco Ragonese, Alessandra Pistilli, Stefano Calvieri, Ugo Bottoni, Andrea Crisanti, Roberta Spaccapelo, Mario Rende
Melanoma is a severe form of cancer, resistant to conventional therapies. According to in vitro studies, sulforaphane, a dietary component, has been considered a promising antineoplastic candidate. The present study analyzes the in vitro biological effects of sulforaphane in A375 melanoma cell line with or without the addition of Nerve Growth Factor. For the first time, our results show that a supplementation of Nerve Growth Factor partially reverses the sulforaphane-induced: i) inhibition of cell migration, ii) pro apoptotic changes in cell cycle and iii) modulation of active caspase-3...
March 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29374092/-mycn-amplified-neuroblastoma-maintains-an-aggressive-and-undifferentiated-phenotype-by-deregulation-of-estrogen-and-ngf-signaling
#14
Johanna Dzieran, Aida Rodriguez Garcia, Ulrica Kristina Westermark, Aine Brigette Henley, Elena Eyre Sánchez, Catarina Träger, Henrik Johan Johansson, Janne Lehtiö, Marie Arsenian-Henriksson
Neuroblastoma (NB) is a remarkably heterogenic childhood tumor of the sympathetic nervous system with clinical behavior ranging from spontaneous regression to poorly differentiated tumors and metastasis. MYCN is amplified in 20% of cases and correlates with an undifferentiated, aggressive phenotype and poor prognosis. Estrogen receptor alpha (ERα) and the nerve growth factor (NGF) receptors TrkA and p75NTR are involved in neuronal differentiation and survival. We have previously shown that MYCN, via miR-18a, targets ERα in NB cells...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29328070/nerve-growth-factor-upregulates-sirtuin-1-expression-in-cholestasis-a-potential-therapeutic-target
#15
Ming-Shian Tsai, Po-Huang Lee, Cheuk-Kwan Sun, Ting-Chia Chiu, Yu-Chun Lin, I-Wei Chang, Po-Han Chen, Ying-Hsien Kao
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers...
January 12, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29325876/nogo-a-interacts-with-trka-to-alter-nerve-growth-factor-signaling-in-nogo-a-overexpressing-pc12-cells
#16
Robert G Farrer, Gwendolyn L Kartje
The Nogo-A protein, originally discovered as a potent myelin-associated inhibitor of neurite outgrowth, is also expressed by certain neurons, especially during development and after injury, but its role in neuronal function is not completely known. In this report, we overexpressed Nogo-A in PC12 cells to use as a model to identify potential neuronal signaling pathways affected by endogenously expressed Nogo-A. Unexpectedly, our results show that viability of Nogo-A-overexpressing cells was reduced progressively due to apoptotic cell death following NGF treatment, but only after 24 h...
April 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29274773/nerve-growth-factor-plays-a-role-in-the-neurotherapeutic-effect-of-a-cd45-pan-hematopoietic-subpopulation-derived-from-human-umbilical-cord-blood-in-a-traumatic-brain-injury-model
#17
Galit Gincberg, Esther Shohami, Victoria Trembovler, Alexander G Alexandrovich, Philip Lazarovici, Uriel Elchalal
BACKGROUND AIMS: Human umbilical cord blood (HUCB) is an important source of stem cells for therapy of hematopoietic disorders and is a potential therapy for various neurological disorders, including traumatic brain injury (TBI). The expression of nerve growth factor (NGF) and its receptors TrkA, p75NTR and α9β1 integrin on an HUCB CD45+ pan-hematopoietic subpopulation was investigated in the context of its neurotherapeutic potential after TBI. METHODS: NGF and its receptors were detected on CD45+ cells by reverse transcriptase polymerase chain reaction, flow cytometry analysis and confocal microscopy...
February 2018: Cytotherapy
https://www.readbyqxmd.com/read/29222769/neurotrophic-factors-an-overview
#18
Stephen D Skaper
The neurotrophins are a family of closely related proteins that were first identified as survival factors for sympathetic and sensory neurons and have since been shown to control a number of aspects of survival, development, and function of neurons in both the central and peripheral nervous systems. Limiting quantities of neurotrophins during development control the numbers of surviving neurons to ensure a match between neurons and the requirement for a suitable density of target innervation. Biological effects of each of the four mammalian neurotrophins are mediated through activation of one or more of the three members of the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB, and TrkC)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29208634/the-synthetic-microneurotrophin-bnn27-affects-retinal-function-in-rats-with-streptozotocin-induced-diabetes
#19
Ruth Ibán-Arias, Silvia Lisa, Niki Mastrodimou, Despina Kokona, Emmanuil Koulakis, Panagiota Iordanidou, Antonis Kouvarakis, Myrto Fothiadaki, Sofia Papadogkonaki, Aggeliki Sotiriou, Haralambos E Katerinopoulos, Achille Gravanis, Ioannis Charalampopoulos, Kyriaki Thermos
BNN27, a C17-spiroepoxy derivative of DHEA, was shown to have antiapoptotic properties via mechanisms involving the nerve growth factor receptors (tropomyosin-related kinase A [TrkA]/neurotrophin receptor p75 [p75NTR ]). In this study, we examined the effects of BNN27 on neural/glial cell function, apoptosis, and inflammation in the experimental rat streptozotocin (STZ) model of diabetic retinopathy (DR). The ability of BNN27 to activate the TrkA receptor and regulate p75NTR expression was investigated. BNN27 (2,10, and 50 mg/kg i...
February 2018: Diabetes
https://www.readbyqxmd.com/read/29165617/selective-activation-of-striatal-ngf-trka-p75ntr-mapk-intracellular-signaling-in-rats-that-show-suppression-of-methamphetamine-intake-30-days-following-drug-abstinence
#20
Oscar V Torres, Subramaniam Jayanthi, Michael T McCoy, Jean Lud Cadet
Background: The continuing epidemic of methamphetamine addiction has prompted research aimed at understanding striatal dysfunctions potentially associated with long-term methamphetamine use. Methods: Here, we investigated transcriptional and translational alterations in the expression of neurotrophic factors in the rat striatum at 30 days following methamphetamine self-administration and footshock punishment. Male Sprague-Dawley rats were trained to self-administer methamphetamine (0...
March 1, 2018: International Journal of Neuropsychopharmacology
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