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https://www.readbyqxmd.com/read/30315154/harnessing-copper-palladium-alloy-tetrapod-nanoparticle-induced-pro-survival-autophagy-for-optimized-photothermal-therapy-of-drug-resistant-cancer
#1
Yunjiao Zhang, Rui Sha, Lan Zhang, Wenbin Zhang, Peipei Jin, Weiguo Xu, Jianxun Ding, Jun Lin, Jing Qian, Guangyu Yao, Rui Zhang, Fanchen Luo, Jie Zeng, Jie Cao, Long-Ping Wen
Chemo-PTT, which combines chemotherapy with photothermal therapy, offers a viable approach for the complete tumor eradication but would likely fail in drug-resistant situations if conventional chemotherapeutic agents are used. Here we show that a type of copper (Cu)-palladium (Pd) alloy tetrapod nanoparticles (TNP-1) presents an ideal solution to the chemo-PTT challenges. TNP-1 exhibit superior near-infrared photothermal conversion efficiency, thanks to their special sharp-tip structure, and induce pro-survival autophagy in a shape- and composition-dependent manner...
October 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/30314732/normalized-glandular-dose-coefficients-in-mammography-digital-breast-tomosynthesis-and-dedicated-breast-ct
#2
A Sarno, G Mettivier, F Di Lillo, R M Tucciariello, K Bliznakova, P Russo
PURPOSE: To provide mean glandular dose (MGD) estimates via Monte Carlo (MC) simulations as a function of the breast models and scan parameters in mammography, digital breast tomosynthesis (DBT) and dedicated breast CT (BCT). METHODS: The MC code was based on GEANT4 toolkit. The simulated compressed breast was either a cylinder with a semi-circular section or ad hoc shaped for oblique view (MLO). In DBT we studied the influence of breast models and exam parameters on the T-factors (i...
October 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/30305612/bap1-acts-as-a-tumor-suppressor-in-intrahepatic-cholangiocarcinoma-by-modulating-the-erk1-2-and-jnk-c-jun-pathways
#3
Xu-Xiao Chen, Yue Yin, Jian-Wen Cheng, Ao Huang, Bo Hu, Xin Zhang, Yun-Fan Sun, Jian Wang, Yu-Peng Wang, Yuan Ji, Shuang-Jian Qiu, Jia Fan, Jian Zhou, Xin-Rong Yang
Current therapeutic options for intrahepatic cholangiocarcinoma (ICC) are very limited, which is largely attributed to poor understanding of molecular pathogenesis of ICC. Breast cancer type 1 susceptibility protein-associated protein-1 (BAP1) has been reported to be a broad-spectrum tumor suppressor in many tumor types, yet its role in ICC remains unknown. The aim of this study was to investigate the clinical implications and biological function of BAP1 in ICC. Our results showed that the messenger RNA and protein levels of BAP1 were significantly downregulated in ICC versus paired non-tumor tissues...
October 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30300062/atorvastatin-induces-autophagy-in-mda-mb-231-breast-cancer-cells
#4
Ming-Bai Hu, Jing-Wei Zhang, Jing-Bo Gao, Yu-Wen Qi, Yang Gao, Liu Xu, Yanbing Ma, Zheng-Zhuan Wei
This article explores the effects of atorvastatin on cultured breast cancer cells. Our experiment demonstrated that atorvastatin triggered autophagy and inhibited proliferation in breast cancer cells. A CCK8 assay indicated that atorvastatin can inhibit the activity of MDA-MB-231 breast cancer cells. Western blotting results showed that atorvastatin increased the conversion of light chain 3 (LC3)-I to LC3-phosphatidylethanolamine conjugate (LC3-II). Confocal microscopy was used to reveal the appearance of a punctate structure in the cytoplasm, and electron microscopy was used to reveal the formation of double-membrane autophagosome...
October 9, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/30295111/evaluation-of-a-crosswalk-between-the-european-quality-of-life-five-dimension-five-level-and-the-menopause-specific-quality-of-life-questionnaire
#5
C Coon, A Bushmakin, S Tatlock, N Williamson, M Moffatt, R Arbuckle, L Abraham
OBJECTIVES: Postmenopausal (PM) women taking therapies using estrogens plus progestogens (EPTs) can experience side effects (breast pain, vaginal spotting/bleeding). Sensitivity of the European Quality of Life Five Dimension Five Level (EQ-5D-5L) in measuring quality of life of PM women experiencing side effects of EPTs is unknown. A crosswalk between the Menopause-Specific Quality of Life (MENQOL) questionnaire and the EQ-5D-5L was assessed. METHODS: The measures were administered to 352 PM women (side effects = 202; control = 75; untreated = 75) in a non-interventional study...
October 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30292425/-breast-cancer-won-t-kill-ya-in-the-breast-broaching-a-rationale-for-chemotherapy-during-the-surgical-consultation-for-early-stage-breast-cancer
#6
Virginia Teas Gill
OBJECTIVE: To examine how, and for what interactional purpose, a surgeon raises the risk of death with an early-stage breast cancer patient. METHOD: Single-case analysis of a recorded surgical consultation, using conversation analysis. RESULTS: The surgeon not only negotiates the surgical treatment decision with the patient, she provides an overview of what her non-surgical treatment is likely to entail. Analysis reveals how the surgeon addresses interactional challenges when providing this overview, including how to broach the rationale for administering chemotherapy, the possibility that cancer could spread to vital organs and prove fatal...
September 5, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/30289544/dietary-amino-acids-under-hypoxic-conditions-exacerbates-muscle-myopathies-including-wooden-breast-and-white-stripping
#7
M L Livingston, P R Ferket, J Brake, K A Livingston
The occurrence of wooden breast (WB) and white striping (WS) of broiler breast myopathies may be associated with least-cost feed formulations and the inclusion of greater amounts of synthetic amino acids. Two experiments were conducted to evaluate the effects of supplemental glutamine (Gln-/+, 0 and 1%) and arginine (Arg-/+, 0 and 0.25%) in a 2 × 2 factorial arrangement. Experiment 1 consisted of 8 replicates using 32 pens and focused on live performance to 44 d of age, carcass yield, and meat quality evaluations at 45 d of age...
October 5, 2018: Poultry Science
https://www.readbyqxmd.com/read/30289100/changes-in-body-composition-and-meat-quality-in-response-to-dietary-amino-acid-provision-in-finishing-broilers
#8
P Belloir, M Lessire, W Lambert, E Corrent, C Berri, S Tesseraud
In order to control and optimize chicken quality products, it is necessary to improve the description of the responses to dietary amino acid (AA) concentration in terms of carcass composition and meat quality, especially during the finishing period. The aim of this study was to investigate the effects of Lysine (Lys, i.e. a limiting AA used as reference in AA nutrition) and AA other than Lys (AA effect). In total, 12 experimental diets were formulated with four levels of digestible Lys content (7, 8.5, 10 and 11...
October 5, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/30287178/the-impact-of-breast-density-reporting-laws-on-women-s-awareness-of-density-associated-risks-and-conversations-regarding-supplemental-screening-with-providers
#9
Nancy M Cappello, Dorinda Richetelli, Christoph I Lee
OBJECTIVE: We conducted a national survey to understand the impact of state-level density reporting laws on women's level of density risk awareness and their engagement in conversations with providers regarding supplemental screening. METHODS: In all, 1,500 US women aged 40 to 74 years who obtained a mammogram within 2 years were surveyed in February 2018. The sampling design yielded 300 respondents in each of five groups categorized based on density reporting law features...
September 17, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/30285251/effect-of-vitamin-e-in-ovo-feeding-to-broiler-embryos-on-hatchability-chick-quality-oxidative-state-and-performance
#10
Itallo C S Araújo, Marcos B Café, Raiana A Noleto, Julyana M S Martins, Cirano J Ulhoa, Gabriela C Guareshi, Matheus M Reis, Nadja S M Leandro
The objective of the present study was to ascertain the effect of in ovo feeding of vitamin E (VE) on the incubation results, quality, and oxidative state of newborn chicks and on the initial performance results. The design consisted of randomized blocks with treatments at different levels of VE (0.0, 27.5, 38.5, 49.5, and 60.4 IU). On 17.5 d of embryonic development, 780 eggs underwent in ovo injection using a manual needle. VE supplementation of 60.4 IU provided the highest hatching rate (P < 0.05) and shortest hatch window (P < 0...
October 4, 2018: Poultry Science
https://www.readbyqxmd.com/read/30278461/mining-prognostic-significance-of-meg3-in-human-breast-cancer-using-bioinformatics-analysis
#11
Xiangrong Cui, Qin Yi, Xuan Jing, Yue Huang, Jie Tian, Chunlan Long, Zhongping Xiang, Jianping Liu, Chunmin Zhang, Bin Tan, Yasha Li, Jing Zhu
BACKGROUND/AIMS: Maternally expressed gene 3 (MEG3) is an imprinted gene with maternal expression, which may function as a tumor suppressor by inhibiting angiogenesis. To identify the prognostic value of MEG3 in breast cancer, systematic analysis was performed in this study. METHODS: To evaluate gene alteration during breast carcinogenesis, we explored MEG3 expression using the Serial Analysis of Gene Expression Genie suite and Oncomine analysis. The prognostic roles of MEG3 in breast cancer were investigated using the PrognoScan database...
October 2, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30277006/would-1-0-cm-be-a-more-suitable-cutoff-to-subdivide-pt1-tumors-in-hormone-receptor-negative-and-her2-positive-breast-cancer
#12
Changjun Wang, Yidong Zhou, Hanjiang Zhu, Wei Huang, Ziyuan Chen, Feng Mao, Yan Lin, Xiaohui Zhang, Songjie Shen, Ying Zhong, Yan Li, Qiang Sun
BACKGROUND: HER2+ and hormone receptor (HoR)-negative breast cancer usually associated with poor outcome. However, it remained elusive for the prognosis of small (T1a-T1c) HER2+/HoR- breast cancer. The present study retrospectively analyzed the Surveillance, Epidemiology, and End Results (SEER) database to explore the clinicopathological characteristics and prognosis of T1a-T1c HER2+/HoR- breast cancer. MATERIAL AND METHODS: Data for patients diagnosed with either HER2-/HoR+or HER2+/HoR- T1a-T1c breast cancer between 2010 and 2012 were obtained from SEER program...
October 1, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30274964/monitoring-twitter-conversations-for-targeted-recruitment-in-cancer-trials-in-los-angeles-county-protocol-for-a-mixed-methods-pilot-study
#13
Katja Reuter, Praveen Angyan, NamQuyen Le, Alicia MacLennan, Sarah Cole, Ricky N Bluthenthal, Christianne J Lane, Anthony B El-Khoueiry, Thomas A Buchanan
BACKGROUND: Insufficient recruitment of participants remains a critical roadblock to successful clinical research, particularly clinical trials. Social media provide new ways for connecting potential participants with research opportunities. Researchers suggest that the social network Twitter may serve as a rich avenue for exploring how patients communicate about their health issues and increasing enrollment in cancer clinical trials. However, there is a lack of evidence that Twitter offers practical utility and impact...
September 25, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30273870/functionalized-mos-2-nanosheets-for-targeted-drug-delivery-and-chemo-photothermal-therapy
#14
Xueyi Zhang, Jianrong Wu, Gareth R Williams, Shiwei Niu, Qianqian Qian, Li-Min Zhu
Molybdenum disulfide (MoS2 ) has been extensively explored for biomedical applications due to its excellent photothermal conversion ability. In this paper, we report a nanoplatform based on folic acid (FA) targeted dual-stimuli responsive MoS2 nanosheets and explore this for the treatment of FA-receptor positive human breast cancer. The nanocomposites generated had a uniform diameter (ca. 133 nm), and could be loaded with the anti-cancer drug doxorubicin (DOX) to a high capacity (151.4 mg/g). The release of DOX was greatly accelerated at pH 5...
September 21, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30271201/expressions-and-prognostic-values-of-the-e2f-transcription-factors-in-human-breast-carcinoma
#15
REVIEW
Ze-Long Liu, Xi-Wen Bi, Pan-Pan Liu, De-Xin Lei, Yu Wang, Zhi-Ming Li, Wen-Qi Jiang, Yi Xia
E2F transcription factors ( E2Fs ) are a family of transcription factors involved in cell proliferation, differentiation, and apoptosis. Their important roles in the development and metastasis of breast carcinoma (BC) have been discovered by previous in vitro and in vivo studies. Yet, expressions and distinct prognostic values of these eight E2Fs in human BC remain unclear in many respects. In this study, we aimed to reveal their roles in BC through analyzing the transcription and survival data of the E2Fs in BC patients from four online databases including ONCOMINE, Breast Cancer Gene-Expression Miner v4...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30267745/nrf1-is-paved-as-a-new-strategic-avenue-to-prevent-and-treat-cancer-neurodegenerative-and-other-diseases
#16
REVIEW
Jianxin Yuan, Shuwei Zhang, Yiguo Zhang
Transcription factor Nrf1 acts as a unique vital player in maintaining cellular homeostasis and organ integrity during normal development and growth throughout the life process. Loss-of-function of Nrf1 results in severe oxidative stress, genomic instability, embryonic lethality, developmental disorders, and adult diseases such as non-alcoholic steatohepatitis, hepatocellular carcinoma, diabetes and neurogenerative diseases. Thereby, Nrf1 is critically implicated in a variety of important physio-pathological processes by governing robust target genes in order to reinforce antioxidant, detoxification and cytoprotective responses to cellular stress...
September 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30264514/the-effects-of-supplemental-threonine-on-performance-carcass-characteristics-immune-response-and-gut-health-of-broilers-in-subtropics-during-pre-starter-and-starter-period
#17
Bikas C Debnath, Purnendu Biswas, Barun Roy
Three hundred thirty-day-old unsexed commercial broiler chicks (Vencobb-400) with initial average body weight of 44.04 ± 0.42 g were allocated into five experimental groups, in a completely randomized design (CRD) with 21-day experiment. Groups were formed according to dose of supplemental L-threonine in various rations i.e., 100% NRC specification, 100% threonine of Vencobb-400 strain specification, 110% threonine of Vencobb-400 strain specification, 120% of threonine of Vencobb-400 strain specification and 130% threonine of Vencobb-400 strain specification...
September 28, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/30257985/cd151-regulates-expression-of-fgfr2-in-breast-cancer-cells-via-pkc-dependent-pathways
#18
Rafal Sadej, Xiaohong Lu, Lukasz Turczyk, Vera Novitskaya, Andrea F Lopez-Clavijo, Radzisław Kordek, Piotr Potemski, Michael J O Wakelam, Hanna Romanska, Fedor Berditchevski
Expression of the tetraspanin CD151 is frequently upregulated in epithelial malignancies and correlates with poor prognosis. Here we report that CD151 is involved in regulation of the expression of fibroblast growth factor receptor 2 (FGFR2). Depletion of CD151 in breast cancer cells resulted in an increased level of FGFR2. Accordingly, an inverse correlation between CD151 and FGFR2 was observed in breast cancer tissues. CD151-dependent regulation of the FGFR2 expression relies on post-transcriptional mechanisms involving HuR/ELAVL1, a multifunctional RNA binding protein, and the assembly of processing bodies (P-bodies)...
September 26, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/30257522/betaine-and-antioxidants-improve-growth-performance-breast-muscle-development-and-ameliorate-thermoregulatory-responses-to-cyclic-heat-exposure-in-broiler-chickens
#19
Majid Shakeri, Jeremy James Cottrell, Stuart Wilkinson, Mitchell Ringuet, John Barton Furness, Frank Rowland Dunshea
Heat stress (HS) is an environmental stressor challenging poultry production and requires a strategy to cope with it. A total of 288-day-old male broiler chicks were fed with one of the following diets: basal diet, basal with betaine (BET), or with selenium and vitamin E (AOX), or with a combination of BET and AOX, under thermoneutral and cyclic HS. Results showed that HS reduced average daily feed intake (ADFI) ( p = 0.01) and average daily gain (ADG) ( p < 0.001), and impaired feed conversion ratio (FCR) ( p = 0...
September 25, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/30255294/p21-waf1-cip1-its-paradoxical-effect-in-the-regulation-of-breast-cancer
#20
REVIEW
Samir F Zohny, Abdulrahman L Al-Malki, Mazin A Zamzami, Hani Choudhry
p21Waf1/Cip1 , the cyclin-dependent kinase (CDK) inhibitor belonging to the KIP/CIP family, was initially regarded as a tumor suppressor protein because it was recognized as the chief mediator of p53-dependent cell cycle arrest elicited by DNA damage. Conversely, it has been proposed that p21Waf1/Cip1 may also function as an oncogene because it can inhibit apoptosis. Thus, p21Waf1/Cip1 is regarded as a protein with a dual behavior, as its expression might cause potential benefits or dangerous effects in breast cancer...
September 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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