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Breast conversing

Hans-Ullrich Voelker, Lea Frey, Annette Strehl, Michael Weigel
During the multidisciplinary planning of postoperative therapy after breast cancer, borderline cases can arise with no clear rationale for or against adjuvant chemotherapy. In 50 hormone- receptor-positive, Her2neu-negative carcinomas of the breast with no or only minimal lymph node involvement (max. pT1a) we initiated an Oncotype DX® multigene assay in addition to the evaluation of usual parameters. In the oncology conference a vote for or against chemotherapy was taken on the basis of the conventional criteria for decision-making before the test results were available...
2018: International Journal of Breast Cancer
Sarah Boughdad, Christophe Nioche, Fanny Orlhac, Laurine Jehl, Laurence Champion, Irène Buvat
Background: To help interpret measurements in breast tissue and breast tumors from 18 F-FDG PET scans, we studied the influence of age in measurements of PET parameters in normal breast tissue and in a breast cancer (BC) population. Results: 522 women were included: 331 pts without history of BC (B-VOI) and 191 patients with BC (T-VOI). In B-VOI, there were significant differences between all age groups for Standardized Uptake Values (SUVs) and for 12 textural indices (TI) whereas histogram-based indices (HBI) did not vary between age groups...
July 20, 2018: Oncotarget
Mariana F Fernández, Iris Reina-Pérez, Juan Manuel Astorga, Andrea Rodríguez-Carrillo, Julio Plaza-Díaz, Luis Fontana
The microorganisms that live symbiotically in human beings are increasingly recognized as important players in health and disease. The largest collection of these microorganisms is found in the gastrointestinal tract. Microbial composition reflects both genetic and lifestyle variables of the host. This microbiota is in a dynamic balance with the host, exerting local and distant effects. Microbial perturbation (dysbiosis) could contribute to the risk of developing health problems. Various bacterial genes capable of producing estrogen-metabolizing enzymes have been identified...
August 14, 2018: International Journal of Environmental Research and Public Health
Mohamed F A Farghly, Khalid M Mahrose, Ross G Cooper, Z Ullah, Z Rehman, C Ding
Floor type management is an important factor in turkey production in hot climates exceeding 30°C. In this study, a total of 360 turkeys aged 4 wk were randomly distributed to investigate growth performance, carcass characteristics, certain health aspects (breast blisters score, footpad burns, hock discoloration, and plumage condition), and airborne conditions. Birds in the first group were raised on a littered floor (control; C), whereas birds in the other groups (T1, T2, T3, T4, and T5) were raised on cement, wire net, rubber mat, plastic and wooden slatted floors, respectively...
August 13, 2018: Poultry Science
Reni Butler, Philip T Lavin, F Lee Tucker, Lora D Barke, Marcela Böhm-Vélez, Stamatia Destounis, Stephen R Grobmyer, Janine Katzen, Kenneth A Kist, Erini V Makariou, Kathy J Schilling, Catherine A Young, Basak E Dogan, Erin I Neuschler
OBJECTIVE: Optoacoustic ultrasound breast imaging is a fused anatomic and functional modality that shows morphologic features, as well as hemoglobin amount and relative oxygenation within and around breast masses. The purpose of this study is to investigate the positive predictive value (PPV) of optoacoustic ultrasound features in benign and malignant masses. SUBJECTS AND METHODS: In this study, 92 masses assessed as BI-RADS category 3, 4, or 5 in 94 subjects were imaged with optoacoustic ultrasound...
August 14, 2018: AJR. American Journal of Roentgenology
Khaldoon Alsamman, Omar S El-Masry
Cancer is one of the leading causes of mortality worldwide. Platinum‑based chemotherapeutic agents such as cisplatin are the first line of treatment for many types of cancers. However, the development of cisplatin resistance after prolonged treatment is a common cause of cancer recurrence. In the present study, we investigated an approach designed to overcome resistance to cisplatin involving co‑treatment with a second chemotherapeutic agent, staurosporine, and examined the role of sequestosome 1 (SQSTM1/p62) in enhancing cellular sensitivity to cisplatin...
August 1, 2018: Oncology Reports
Martuza Sarwar, Azharuddin Sajid Syed Khaja, Mohammed Aleskandarany, Richard Karlsson, Maryam Althobiti, Niels Ødum, Nigel P Mongan, Nisthman Dizeyi, Heather Johnson, Andrew R Green, Ian O Ellis, Emad A Rakha, Jenny L Persson
Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1α and its association with survivals were analyzed using three BC cohorts from Nottingham (n = 913), KM plotter (n = 112) and TCGA (n = 817)...
August 13, 2018: Oncogene
Matthew L Livingston, C Landon, H J Barnes, J Brake
The effects of time-limited feeding, genetic background, and egg storage on white striping (WS) and wooden breast (WB) in broilers were studied. Male chicks (240) from 2 genetic backgrounds and 2 egg storage periods were fed on either an ad libitum (AL) or time-limited (TL) program from 7 d of age. A rapid growth strain (Growth) and an enhanced yield strain (Yield) of broiler breeder males were mated to a single female line and eggs were stored for periods of either 1 to 7 d or 8 to 14 d. Body weight (BW), feed consumption, and feed conversion ratio (FCR) were determined weekly...
August 7, 2018: Poultry Science
Gerard A Tarulli, Geraldine Laven-Law, Mona Shehata, Kirsty A Walters, Iza M Denis, Md Mostafizur Rahman, David J Handelsman, Nicola R Dean, Wayne D Tilley, Theresa E Hickey
Androgens influence mammary gland development but the specific role of the androgen receptor (AR) in mammary function is largely unknown. We identified cell subsets that express AR in vivo and determined the effect of AR activation and transgenic AR inhibition on sub-populations of the normal mouse mammary epithelium by flow cytometry and immunohistochemistry. Immunolocalisation of AR with markers of lineage identity was also performed in human breast tissues. AR activation in vivo significantly decreased the proportion of basal cells, and caused an accumulation of cells that expressed a basal cell marker but exhibited morphological features of luminal identity...
August 12, 2018: Journal of Mammary Gland Biology and Neoplasia
Paola Bonetti, Montserrat Climent, Fabiana Panebianco, Chiara Tordonato, Angela Santoro, Matteo Jacopo Marzi, Pier Giuseppe Pelicci, Andrea Ventura, Francesco Nicassio
The role of the tumour-suppressor miR-34 family in breast physiology and in mammary stem cells (MaSCs) is largely unknown. Here, we revealed that miR-34 family, and miR-34a in particular, is implicated in mammary epithelium homoeostasis. Expression of miR-34a occurs upon luminal commitment and differentiation and serves to inhibit the expansion of the pool of MaSCs and early progenitor cells, likely in a p53-independent fashion. Mutant mice (miR34-KO) and loss-of-function approaches revealed two separate functions of miR-34a, controlling both proliferation and fate commitment in mammary progenitors by modulating several pathways involved in epithelial cell plasticity and luminal-to-basal conversion...
August 9, 2018: Oncogene
Heng Li, Zhufang Tian, Yiping Qu, Qi Yang, Haixia Guan, Bingyin Shi, Meiju Ji, Peng Hou
SIRT7 is an NAD+ -dependent histone/non-histone deacetylase, which is highly expressed in different types of cancer including thyroid cancer; however, its biological function in thyroid cancer is still undiscovered. In this study, we found that SIRT7 expression was elevated in papillary thyroid cancers (PTCs), and demonstrated that SIRT7 knockdown dramatically inhibited the proliferation, colony formation, migration and invasion of thyroid cancer cells, and induced thyroid cancer cell cycle arrest and apoptosis...
August 9, 2018: Oncogene
L Francisco Lorenzo-Martín, Carmen Citterio, Mauricio Menacho-Márquez, Javier Conde, Romain M Larive, Sonia Rodríguez-Fdez, Ramón García-Escudero, Javier Robles-Valero, Myriam Cuadrado, Isabel Fernández-Pisonero, Mercedes Dosil, María A Sevilla, María J Montero, Pedro M Fernández-Salguero, Jesús M Paramio, Xosé R Bustelo
The bidirectional regulation of epithelial-mesenchymal transitions (EMT) is key in tumorigenesis. Rho GTPases regulate this process via canonical pathways that impinge on the stability of cell-to-cell contacts, cytoskeletal dynamics, and cell invasiveness. Here, we report that the Rho GTPase activators Vav2 and Vav3 utilize a new Rac1-dependent and miR-200c-dependent mechanism that maintains the epithelial state by limiting the abundance of the Zeb2 transcriptional repressor in breast cancer cells. In parallel, Vav proteins engage a mir-200c-independent expression prometastatic program that maintains epithelial cell traits only under 3D culture conditions...
August 7, 2018: Oncogene
Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe Wang
BACKGROUND: Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS: We performed a transcriptome-wide screen to identify novel bounding mRNA of PCBP1. The bind regions between PCBP1 with target mRNA were investigated by using point mutation and luciferase assay...
August 7, 2018: Journal of Experimental & Clinical Cancer Research: CR
Yanan Kuang, Bilal Siddiqui, Jiani Hu, Matthew Pun, MacIntosh Cornwell, Gilles Buchwalter, Melissa E Hughes, Nikhil Wagle, Paul Kirschmeier, Pasi A Jänne, Cloud P Paweletz, Nancy U Lin, Ian E Krop, William T Barry, Eric P Winer, Myles Brown, Rinath Jeselsohn
ESR1 mutations were recently found to be an important mechanism of endocrine resistance in ER-positive (ER + ) metastatic breast cancer. To determine the clinicopathological features driving the emergence of the ESR1 mutations we studied plasma cfDNA and detailed clinical data collected from patients with metastatic breast cancer. Droplet Digital PCR was performed for the detection of the most common ESR1 mutations and PIK3CA mutations. Among the patients with ER + /HER2- disease, ESR1 mutations were detected in 30% of the patients...
2018: NPJ Breast Cancer
Francisco Inesta-Vaquera, Viduth K Chaugule, Alison Galloway, Laurel Chandler, Alejandro Rojas-Fernandez, Simone Weidlich, Mark Peggie, Victoria H Cowling
CMTR1 contributes to mRNA cap formation by methylating the first transcribed nucleotide ribose at the O-2 position. mRNA cap O-2 methylation has roles in mRNA stabilisation and translation, and self-RNA tolerance in innate immunity. We report that CMTR1 is recruited to serine-5-phosphorylated RNA Pol II C-terminal domain, early in transcription. We isolated CMTR1 in a complex with DHX15, an RNA helicase functioning in splicing and ribosome biogenesis, and characterised it as a regulator of CMTR1. When DHX15 is bound, CMTR1 activity is repressed and the methyl-transferase does not bind to RNA pol II...
June 18, 2018: Life science alliance
Véronique Sirot, Thiema Traore, Thierry Guerin, Laurent Noël, Morgane Bachelot, Jean-Pierre Cravedi, André Mazur, Philippe Glorennec, Paule Vasseur, Julien Jean, Géraldine Carne, Sébastien Gorecki, Gilles Riviere, Marion Hulin
A total diet study (TDS) was conducted between 2010 and 2016 to assess the risk associated with chemicals in food of non-breast-fed children under three living in France. 291 composite food samples were prepared "as consumed" and analyzed for 16 trace elements: aluminium (Al), antimony (Sb), arsenic (As), barium (Ba), cobalt (Co), chromium (Cr), gallium (Ga), germanium (Ge), lead (Pb), mercury (Hg), nickel (Ni), silver (Ag), strontium (Sr), tellurium (Te), tin (Sn), vanadium (V). Dietary exposure was assessed for 705 representative children using food consumptions recorded through a 3-consecutive-days record...
August 2, 2018: Food and Chemical Toxicology
Mingzhu Tang, Zhe Chen, Di Wu, Linxi Chen
Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that specifically involves ferritin to release intracellular free iron. Ferritinophagy is implicated in maintaining efficient erythropoiesis. Notably, ferritinophagy also plays a central role in driving some pathological processes, including Parkinson's disease (PD) and urinary tract infections. Some evidence has demonstrated that ferritinophagy is critical to induce ferroptosis. Ferroptosis is a newly nonapoptotic form of cell death, characterized by the accumulation of iron-based lipid reactive oxygen species...
August 4, 2018: Journal of Cellular Physiology
Jian Liu, Xiang Li, Meng Wang, Guodong Xiao, Ganghua Yang, Huangzhen Wang, Yanbo Li, Xin Sun, Sida Qin, Ning Du, Hong Ren, Yamei Pang
Tamoxifen (TAM) resistance is a substantial challenge in the treatment of estrogen receptor (ER)-positive breast cancer. Previous studies have revealed an important role of microRNA (miRNA/miR)-26a in TAM resistance in breast cancer. However, the mechanism underlying the regulatory effects of miR-26a on TAM resistance remains to be elucidated. The expression levels of miR-26a in ER-positive breast cancer were detected by reverse transcription-quantitative polymerase chain reaction. E2F transcription factor 7 (E2F7) and MYC proto-oncogene, bHLH transcription factor (MYC) levels were detected by western blotting...
October 2018: International Journal of Oncology
Jieun Lee, Dong-Min Kim, Ahwon Lee
Purpose: Tumor-infiltrating lymphocyte (TIL), programmed death-ligand 1 (PD-L1) expression and neutrophil-to-lymphocyte ratio (NLR) is associated to immunogenicity and prognosis of breast cancer. We analyzed baseline NLR, changes of NLR, TIL, and PD-L1 during neoadjuvant chemotherapy (NAC) and their clinical implication in triple-negative breast cancer (TNBC). Materials and Methods: Between January 2008 to December 2015, 358 TNBC patients were analyzed. Baseline NLR, 50 paired NLR (initial diagnosis, after completion of NAC) and 34 paired tissues (initial diagnosis, surgical specimen after completion of NAC) were collected...
July 31, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Fangdi Sun, Alexander Hall, Megan P Tighe, Cheryl L Brunelle, Hoda E Sayegh, Tessa C Gillespie, Kayla M Daniell, Alphonse G Taghian
PURPOSE: Despite increasing emphasis on screening and early intervention for breast cancer-related lymphedema (BCRL), there is marked heterogeneity in diagnostic methodology, including for volumetric measures. This retrospective study compared two volumetric modalities, perometry and simulated circumferential tape measurement (anatomic- and interval-based), for BCRL detection. METHODS: Between 2005 and 2017, 287 female patients with unilateral breast cancer were prospectively screened for BCRL by perometry and the relative volume change (RVC) formula...
July 30, 2018: Breast Cancer Research and Treatment
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