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https://www.readbyqxmd.com/read/30544196/smyd3-promotes-the-epithelial-mesenchymal-transition-in-breast-cancer
#1
Claudio Fenizia, Cinzia Bottino, Silvia Corbetta, Raffaella Fittipaldi, Pamela Floris, Germano Gaudenzi, Silvia Carra, Franco Cotelli, Giovanni Vitale, Giuseppina Caretti
SMYD3 is a methylase previously linked to cancer cell invasion and migration. Here we show that SMYD3 favors TGFβ-induced epithelial-mesenchymal transition (EMT) in mammary epithelial cells, promoting mesenchymal and EMT transcription factors expression. SMYD3 directly interacts with SMAD3 but it is unnecessary for SMAD2/3 phosphorylation and nuclear translocation. Conversely, SMYD3 is indispensable for SMAD3 direct association to EMT genes regulatory regions. Accordingly, SMYD3 knockdown or its pharmacological blockade with the BCI121 inhibitor dramatically reduce TGFβ-induced SMAD3 association to the chromatin...
December 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30541574/stemness-marker-aldh1a1-promotes-tumor-angiogenesis-via-retinoic-acid-hif-1%C3%AE-vegf-signalling-in-mcf-7-breast-cancer-cells
#2
Valerio Ciccone, Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Lucia Morbidelli, Marina Ziche
BACKGROUND: Aldehyde dehydrogenase 1A1 (ALDH1A1), a member of aldehyde dehydrogenase family, is a marker of stemness in breast cancer. During tumor progression cancer stem cells (CSCs) have been reported to secrete angiogenic factors to orchestrate the formation of pathological angiogenesis. This vasculature can represent the source of self-renewal of CSCs and the route for further tumor spreading. The aim of the present study has been to assess whether ALDH1A1 controls the output of angiogenic factors in breast cancer cells and regulates tumor angiogenesis in a panel of in vitro and in vivo models...
December 12, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30538109/tumor-microenvironment-remodeling-by-intratumoral-oncolytic-vaccinia-virus-enhances-the-efficacy-of-immune-checkpoint-blockade
#3
Hong Jae Chon, Won Suk Lee, Hannah Yang, So Jung Kong, Na Keum Lee, Eun Sang Moon, Jiwon Choi, Eun Chun Han, Joo Hoon Kim, Joong Bae Ahn, Joo-Hang Kim, Chan Kim
PURPOSE: Cancer immunotherapy is a potent treatment modality, but its clinical benefit depends on the tumor's immune profile. Here, we employed mJX-594 (JX), a targeted and GM-CSF-armed oncolytic vaccinia virus, as a strategy to remodel the tumor microenvironment (TME) and subsequently increase sensitivity to αPD-1 and/or αCTLA-4 immunotherapy. EXPERIMENTAL DESIGN: The remodeling of TME was determined using histologic, flow cytometric, and NanoString immune profiling analyses...
December 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30532072/s100a3-a-partner-protein-regulating-the-stability-activity-of-rar%C3%AE-and-pml-rar%C3%AE-in-cellular-models-of-breast-lung-cancer-and-acute-myeloid-leukemia
#4
Maurizio Gianni, Mineko Terao, Mami Kurosaki, Gabriela Paroni, Laura Brunelli, Roberta Pastorelli, Adriana Zanetti, Monica Lupi, Andrea Acquavita, Marco Bolis, Maddalena Fratelli, Cecile Rochette-Egly, Enrico Garattini
All trans-retinoic acid (ATRA) is used in the treatment of acute promyelocytic leukemia (APL) and it is a promising agent also in solid tumors. The pharmacological activity of ATRA is mediated by the ligand-activated RAR and RXR transcription factors. In the present study, we define the basal and ATRA dependent RARα interactome in a RARα-overexpressing breast cancer cellular model, identifying 28 nuclear proteins. We focus our attention on the S100A3 calcium-binding protein, which interacts with RARα constitutively...
December 7, 2018: Oncogene
https://www.readbyqxmd.com/read/30528546/-current-situation-of-breast-reconstruction-after-breast-cancer-in-reunion-island
#5
C Lembrouck, G Nicolet, A Nguyen, C Tunon de Lara
OBJECTIVES: The aim of this study is to describe the current trends of breast reconstruction (BR) and breast oncoplasty (BO) for breast cancer patients in Reunion Island. METHODS: This is a multicenter retrospective descriptive study of all BR and BO surgeries in 2016. We studied the first stage of BR that corresponds to the choice of surgical technique. Patient's age, care center, technique and duration of surgery, complications and their risk factors were reviewed...
December 5, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/30525207/technical-challenges-in-generalizing-calibration-techniques-for-breast-density-measurements
#6
E Fowler, A Smallwood, N Khan, K Kilpatrick, T A Sellers, J Heine
PURPOSE: We are developing a calibration methodology for full field digital mammography (FFDM). Calibration compensates for the image acquisition technique influences on this pixel representation, ideally producing improved inter-image breast density estimates. This approach relies on establishing references with rigid breast tissue equivalent phantoms (BTEs) and requires an accurate estimate of the compressed breast thickness because the system readout is nominal. There is also an attenuation mismatch between adipose breast tissue and the adipose BTE that was noted in our previous work...
December 7, 2018: Medical Physics
https://www.readbyqxmd.com/read/30525025/anticancer-activity-and-cisplatin-binding-ability-of-bis-quinoline-and-bis-isoquinoline-derived-pd-2-l-4-4-metallosupramolecular-cages
#7
Roan A S Vasdev, Lachlan F Gaudin, Dan Preston, Jackmil P Jogy, Gregory I Giles, James D Crowley
New bis- quinoline ( L q ) and bis- isoquinoline-based ( L iq ) ligands have been synthesized, along with their respective homoleptic [Pd2 ( L q or L iq )4 ]4+ cages ( C q and C iq ). The ligands and cages were characterized by 1 H, 13 C and diffusion ordered (DOSY) NMR spectroscopies, high resolution electrospray ionization mass spectrometry (HR-ESIMS) and in the case of the bis -quinoline cage, X-ray crystallography. The crystal structure of the C q architecture showed that the [Pd2 ( L q )4 ]4+ cage formed a twisted meso isomer where the [Pd( quinoline )4 ]2+ units at either end of the cage architecture adopt the opposite twists (left and right handed)...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/30523916/cascaded-systems-analysis-of-a-se-a-si-and-a-ingazno-tft-passive-and-active-pixel-sensors-for-tomosynthesis
#8
Aunnasha Sengupta, Chumin Zhao, Anastasios C Konstantinidis, Jerzy Kanicki
Medical imaging systems like full field digital mammography (FFDM) and digital breast tomosynthesis (DBT) commonly use amorphous selenium (a-Se) based passive pixel sensor (PPS) direct conversion x-ray detectors. On one hand, direct conversion detectors inherently offer better resolution characteristics in terms of a higher modulation transfer function (MTF), in comparison to the indirect CsI:Tl PPS x-ray imager. On the other hand, especially at lower doses, this superior performance of the direct imager is seldom retained in its detective quantum efficiency (DQE) curves...
December 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/30523909/generalized-breast-density-metrics
#9
Erin E E Fowler, Autumn Smallwood, Cassandra Miltich, Jennifer Drukteinis, Thomas A Sellers, John J Heine
Mammograms represent data that can inform future risk of breast cancer. Data from two case-control study populations were analyzed. Population 1 included women (N = 180 age matched case-control pairs) with mammograms acquired with one indirect x-ray conversion mammography unit. Population 2 included women (N = 319 age matched case-control pairs) with mammograms acquired from 6 direct x-ray conversion units. The Fourier domain was decomposed into n concentric rings (radial spatial frequency bands). The power in each ring was summarized giving a set of measures...
November 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/30522454/a-contribution-to-the-validation-of-the-italian-version-of-the-body-image-scale-bis
#10
Maria Antonietta Annunziata, Barbara Muzzatti, Francesca Bomben, Cristiana Flaiban, Marika Piccinin, Valentina Solfrini
BACKGROUND: The Body Image Scale (BIS) is a 10-item mono-factorial scale, designed to capture distress and symptoms related to body image in cancer patients. This paper describes the conversion and psychometric evaluation of an Italian BIS version. METHODS: After the back-translation procedure, the Italian version of the BIS, together with the Hospital Anxiety and Depression Scale and the Short Form 36 Health Survey Questionnaire, have been administered to a sample of Italian adult females, surgically treated for a breast cancer at least one year before...
December 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30522116/potential-role-of-microrna-183-as-a-tumor-suppressor-in-hepatocellular-carcinoma
#11
Wei Bian, Hongfei Zhang, Miao Tang, Shaojun Zhang, Lichao Wang, Longlong Liu, Wenyao Wang
BACKGROUND/AIMS: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30514558/calculating-individual-lifetime-effective-risk-from-initial-mean-glandular-dose-arising-from-the-first-screening-mammogram
#12
Raed M Ali, Andrew England, Claire E Mercer, Andrew Tootell, Peter Hogg
OBJECTIVES: The objective of the study was to use the initial mean glandular dose (MGD) arising from the first screening mammogram to estimate the individual total screening lifetime effective risk. METHODS: Organ doses from full-field digital mammography (FFDM) screening exposures (craniocaudal and mediolateral oblique for each breast) were measured using a simulated approach, with average breast thickness and adult ATOM phantoms, on 16 FFDM machines. Doses were measured using thermoluminescent dosimeters accommodated inside the ATOM phantom; examined breast MGD was calculated...
December 2018: Journal of Medical Imaging and Radiation Sciences
https://www.readbyqxmd.com/read/30511408/single-incision-for-oncologic-breast-conserving-surgery-and-sentinel-node-biopsy-in-early-stage-breast-cancer-a-minimally-invasive-approach
#13
Brendan P Lovasik, Rebecca L Seidel, Matteo Novello, Mylin A Torres, Albert Losken, Monica Rizzo
INTRODUCTION: Breast conserving surgery (BCS) has a postoperative morbidity up to 30%. We report the feasibility of a single-incision approach for tumor excision and axillary sentinel node biopsy (SNB) sampling intended to minimize patient morbidity and complications. MATERIALS AND METHODS: A tertiary surgical oncology single surgeon database was retrospectively reviewed for all patients undergoing BCS and SNB between January 2013 and December 2015. The single-incision approach used a single breast incision to resect the tumor and the Lymphazurin-tagged SNB...
December 3, 2018: Breast Journal
https://www.readbyqxmd.com/read/30510420/fabricating-polydopamine-coated-mose-2-wrapped-hollow-mesoporous-silica-nanoplatform-for-controlled-drug-release-and-chemo-photothermal-therapy
#14
Song Chai, Shifeng Kan, Ran Sun, Ruijuan Zhou, Yi Sun, Wenhua Chen, Bo Yu
Background: Integration of several types of therapeutic agents into one nanoplatform to enhance treatment efficacy is being more widely used for cancer therapy. Methods: Herein, a biocompatible polydopamine (PDA)-coated MoSe2 -wrapped doxorubicin (DOX)-loaded hollow mesoporous silica nanoparticles (HMSNs) nanoplatform (PM@HMSNs-DOX) was fabricated for dual-sensitive drug release and chemo-photothermal therapy for enhancing the therapeutic effects on breast cancer...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30506398/communication-about-hereditary-cancers-on-social-media-a-content-analysis-of-tweets-about-hereditary-breast-and-ovarian-cancer-and-lynch-syndrome
#15
Caitlin G Allen, Megan Roberts, Brittany Andersen, Muin J Khoury
Social media is increasingly being used as an information source and tool for individuals and organizations to share resources and engage in conversations about health topics. Because the public tends to learn about health topics and genetics from online social media sources, it is imperative to understand the amount, type, and quality of information being shared. We performed a retrospective analysis of tweets related to hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) between January 1, 2017 and December 31, 2017...
December 3, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/30500680/protein-phosphatase-1-regulatory-subunit-sds22-inhibits-breast-cancer-cell-tumorigenesis-by-functioning-as-a-negative-regulator-of-the-akt-signaling-pathway
#16
Debasish Paul, Anil Bapu Bargale, Srikanth Rapole, Praveen Kumar Shetty, Manas Kumar Santra
Protein phosphatases play a crucial role in cell cycle progression, cell survival, cellular signaling, and genomic integrity. The protein phosphatase 1 (PP1) regulatory subunit SDS22 plays a significant role in cell cycle progression. A recent study showed that SDS22 plays a vital role in epithelial integrity and tumor suppression in Drosophila. However, its tumor suppressive activity remains obscure in the mammalian system. Here, for the first time, we show that SDS22 inhibits the growth of breast cancer cells through induction of apoptosis...
November 27, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/30500102/reframing-the-conversation-about-contralateral-prophylactic-mastectomy-preparing-women-for-post-surgical-realities
#17
Diane L Bloom, Brittany M Chapman, Stephanie B Wheeler, Kandace P McGuire, Clara N Lee, Kevin Weinfurt, Donald L Rosenstein, Jennifer K Plichta, Julie C Jacobson Vann, E Shelley Hwang
OBJECTIVE: Women with unilateral, early-stage breast cancer and low genetic risk are increasingly opting for contralateral prophylactic mastectomy (CPM), a concerning trend because CPM offers few clinical benefits while increasing risks of surgical complications. Few qualitative studies have analyzed factors motivating this irreversible decision. Using qualitative methods this study sought to understand women's decision-making and the impact of CPM on self-confidence, sense of femininity, sexual intimacy and peace of mind...
November 30, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/30499465/rho-gtpase-activating-protein-24-arhgap24-regulates-the-anti-cancer-activity-of-sorafenib-against-breast-cancer-mda-mb-231-cells-via-the-signal-transducer-and-activator-of-transcription-3-stat3-signaling-pathway
#18
Xianping Dai, Feng Geng, Jiale Dai, Mengshun Li, Ming Liu
BACKGROUND STAT3 has emerged as a novel potential target for sorafenib, a multikinase inhibitor, in the context of cancer therapy. ARHGAP24 is a Rac-specific Rho GTPase-activating protein (Rho GAP), which can convert Rho GTPases to an inactive state. It has been proved to be an oncosuppressor protein in renal cancer. In the present study, we investigated its anti-cancer effect in breast cancer (BC). MATERIAL AND METHODS Quantitative real-time PCR (qRT-PCR) and Western blot analysis were performed to detect the expression of ARHGAP24 in clinical tissue samples...
November 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30496504/effects-of-dietary-supplementation-of-alfalfa-meal-on-growth-performance-carcass-characteristics-meat-and-egg-quality-and-intestinal-microbiota-in-beijing-you-chicken
#19
Mingli Zheng, Peichun Mao, Xiaoxia Tian, Qiang Guo, Lin Meng
This study was conducted to investigate the effects of alfalfa meal supplementation on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in chickens. A total of 600 healthy 20-wk female Beijing-you chickens (a local Chinese chicken breed) were selected and randomly assigned into 4 dietary treatments: 0, 5, 8, and 10% alfalfa meal supplementation. Chickens were raised in a free-range system for 56 d. Microbiota inhabiting 3 different intestinal sections (duodenum, ileum, and cecum) was determined using high-throughput sequencing...
November 29, 2018: Poultry Science
https://www.readbyqxmd.com/read/30480453/mechanoregulation-of-cancer-associated-fibroblasts-phenotype-in-3d-interpenetrating-hydrogel-networks
#20
Huan Cao, Melissa Kao Hui Lee, Haibo Yang, Siu Kwan Sze, Nguan Soon Tan, Chor Yong Tay
Tumor stromal residing cancer-associated fibroblasts (CAFs) are significant accomplices in the growth and development of malignant neoplasm. As cancer progresses, the stroma undergoes a dramatic remodeling and stiffening of its extracellular matrix (ECM). However, exactly how these biomechanical changes influence CAF behavior and the functional paracrine crosstalk with the neighboring tumor cells in a 3-dimensional (3D) microenvironment remains elusive. Herein, a collagen and alginate interpenetrating network (CoAl-IPN) hydrogel system was employed as a 3D in vitro surrogate of the cancerous breast tissue stromal niche...
November 27, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
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