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Plasma Sodium

Noriko Kuramoto, Tatsuya Wakahara, Yuichi Tamagawa, Takahiro Uchino, Masahiro Koseto, Manabu Kawakami, Michio Otsuki, Yoshimasa Aoki, Midori Ishibashi, Soji Kasayama, Satoru Sumitani, Masafumi Koga
BACKGROUND: It is known that an immunoglobulin abnormality affects various clinical laboratory measurements and leads to abnormal values. We experienced a case of monoclonal gammopathy of undetermined significance (MGUS) showing a falsely low plasma glycated albumin (GA) level. CASE REPORT: The patient was a 75-y-old male who visited our hospital for thrombocytosis identified during a medical checkup. Based on further examinations, he was diagnosed with MGUS (IgM-κ type)...
October 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Duc Ninh Nguyen, Thomas Thymann, Sandra K Goericke-Pesch, Shuqiang Ren, Wei Wei, Kerstin Skovgaard, Peter Damborg, Anders Brunse, Charlotte van Gorp, Boris W Kramer, Tim G Wolfs, Per T Sangild
Prenatal inflammation is a major risk for preterm birth and neonatal morbidity, but its effects on postnatal immunity and organ functions remain unclear. Using preterm pigs as a model for preterm infants, we investigated whether prenatal intra-amniotic (IA) inflammation modulates postnatal systemic immune status and organ functions. Preterm pigs exposed to IA lipopolysaccharide (LPS) for 3 days were compared with controls at birth and postnatal day 5 after formula feeding. IA LPS induced mild chorioamnionitis but extensive intra-amniotic inflammation...
October 4, 2018: American Journal of Pathology
Hong Xu, Ali Hashem, Anna Witasp, Rik Mencke, David Goldsmith, Peter Barany, Annette Bruchfeld, Annika Wernerson, Juan-Jesus Carrero, Hannes Olauson
Background: Recent studies suggest that the phosphaturic hormone fibroblast growth factor 23 (FGF23) is involved in regulation of renal sodium excretion and blood pressure. There is evidence of both direct effects via regulation of the sodium-chloride symporter (NCC) in the distal tubule, and indirect effects through interactions with the renin-angiotensin-aldosterone system. However, clinical data on the association between FGF23 and renal sodium regulation is lacking. Herein, we investigated the associations of FGF23 with renal sodium handling and blood pressure in non-dialysis CKD patients...
October 11, 2018: Nephrology, Dialysis, Transplantation
G Decaux
The differential diagnosis between hypertonic, isotonic and hypotonic hyponatremia are presented. The help of some usual serum (urea, uric acid and TCO2 ) and urine parameters (mainly osmolality and sodium concentration) are discussed and help to determine the best treatment. Morbidity associated with untreated hyponatremia and with the different treatment available is also discussed. Who to prevent and treat ODS (osmotic demyelating syndrome) is recalled. The pathophysiology and treatment of hypernatremia are also discussed...
October 12, 2018: Acta Clinica Belgica
Gamze Akkus, Mehtap Evran, Murat Sert, Tamer Tetiker
OBJECTIVE: Adrenal incidentalomas are diagnosed incidentally during radiological screenings and requires endocrinological investigations for hormonal activity and malignancy. In certain studies, it has been reported that non-functional incidentalomas can be associated with high adipocytokines levels affecting the insulin resistance just like the adipose tissue with metabolic syndrome. Here, we studied serum adipocytokine levels including leptin, resistin, visfatin, omentin 1 and adiponectin in subjects with non-functional adrenal incidentaloma...
October 9, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Lara Hessels, Annemieke Oude Lansink-Hartgring, Miriam Zeillemaker-Hoekstra, Maarten W Nijsten
BACKGROUND: Nonosmotic sodium storage has been reported in animals, healthy individuals and patients with hypertension, hyperaldosteronism and end-stage kidney disease. Sodium storage has not been studied in ICU patients, who frequently receive large amounts of sodium chloride-containing fluids. The objective of our study was to estimate sodium that cannot be accounted for by balance studies in critically ill patients. Chloride was also studied. We used multiple scenarios and assumptions for estimating sodium and chloride balances...
October 11, 2018: Annals of Intensive Care
Zhong-Shi Xu, Feng Dai, Ji Chen, Meng Lv, Ji-Wu Cheng, Xiao-Ming Zhang, Bo-Wen Lin
Background: Evidence has shown that endogenous H2 S plays an important role in the physiological and pathophysiological processes of many organs. The study aimed to explore whether exogenous H2 S has a potential therapeutic effect on a rat ovariectomy-induced model of osteoporosis. Methods: The OVX osteoporosis model was established in female Sprague-Dawley rats by full bilateral ovariectomy. The rats were randomly divided into four groups, with the two experimental groups receiving an intraperitoneal injection of GYY4137 or sodium alendronate...
2018: Cellular & Molecular Biology Letters
Julio Rosenstock, Chantal Mathieu, Hungta Chen, Ricardo Garcia-Sanchez, Gabriela Luporini Saraiva
OBJECTIVE: This analysis compared the efficacy and safety of the sodium-glucose cotransporter-2 (SGLT2) inhibitor, dapagliflozin, and the dipeptidyl peptidase-4 (DPP4) inhibitor, saxagliptin, both added on to metformin. MATERIALS AND METHODS: This was a post-hoc analysis from a double-blind, randomized, 24-week clinical trial (NCT01606007) of patients with type 2 diabetes (T2D) inadequately controlled with metformin. We compared the dapagliflozin 10 mg (n = 179) and saxagliptin 5 mg (n = 176) treatment arms...
August 2018: Archives of Endocrinology and Metabolism
Carolina C Rennó, Juliana Z B Papini, Cintia Maria Saia Cereda, Elizabeth Martinez, Victor Angelo Montalli, Eneida de Paula, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Giovana Radomille Tofoli
BACKGROUND: Our research group has recently developed liposomes with ionic gradient and in a combined manner as donor and acceptor vesicles containing ropivacaine (RVC; at 2% or 0.75%). Looking for applications of such novel formulations for postoperative pain control, we evaluated the duration of anesthesia, pharmacokinetics, and tissue reaction evoked by these new RVC formulations. METHODS: The formulations used in this study were large multivesicular vesicle (LMVV) containing sodium acetate buffer at pH 5...
October 9, 2018: Anesthesia and Analgesia
Dongliang Chao, Bo Ouyang, Pei Liang, Tran Thi Thu Huong, Guichong Jia, Hui Huang, Xinhui Xia, Rajdeep Singh Rawat, Hong Jin Fan
Tin and its derivatives have provoked tremendous progress of high-capacity sodium-ion anode materials. However, achieving high areal and volumetric capability with maintained long-term stability in a single electrode remains challenging. Here, an elegant and versatile strategy is developed to significantly extend the lifespan and rate capability of tin sulfide nanobelt electrodes while maintaining high areal and volumetric capacities. In this strategy, in situ bundles of robust hierarchical graphene (hG) are grown uniformly on tin sulfide nanobelt networks through a rapid (5 min) carbon-plasma method with sustainable oil as the carbon source and the partially reduced Sn as the catalyst...
October 9, 2018: Advanced Materials
F Abeni, F Petrera, Y Le Cozler
Puberty attainment in dairy heifers has been widely studied from a hormonal point of view, but few studies have focussed on puberty-blood profile relationships during growth. We led experiments to determine the effects of feeding treatments on growth parameters, age at puberty and plasma biochemical profiles, and the relationships between age at puberty and metabolic profiles at 6, 9, 12 and 15 months (mo) of age. Blood samples were collected from 67 Holstein heifers, born between September 2011 and February 2012, every 10 days from 5...
October 10, 2018: Animal: An International Journal of Animal Bioscience
Kristin L Jonvik, Kaatje Lenaerts, Joey Sj Smeets, Jeroen J Kolkman, Luc Jc van Loon, Lex B Verdijk
PURPOSE: Strenuous exercise induces intestinal injury, which is likely related to splanchnic hypoperfusion and may be associated with gastrointestinal complaints commonly reported during certain exercise modalities. Increasing circulating nitric oxide (NO) levels or inducing postprandial hyperemia may improve splanchnic perfusion, thereby attenuating intestinal injury during exercise. Therefore, we investigated the effects of both dietary nitrate ingestion and sucrose ingestion on splanchnic perfusion and intestinal injury induced by prolonged strenuous cycling...
October 5, 2018: Medicine and Science in Sports and Exercise
Heather Edgell, Anna Grinberg, Keith R Beavers, Nathalie Gagné, Richard L Hughson
After exposure to microgravity, or head-down bed rest (HDBR), fluid loading is often used with the intent of increasing plasma volume and maintaining mean arterial pressure during orthostatic stress. Nine men (aged 18-32 years) underwent three randomized trials with lower body negative pressure (LBNP) before and after: (1) 4-h of sitting with fluid loading (1 g sodium chloride/125 mL of water starting 2.5-h before LBNP), (2) 28-h of 6-degree HDBR without fluid loading, and (3) 28-h of 6-degree HDBR with fluid loading...
September 2018: Physiological Reports
Maja Baretić, Vesna Kušec, Ivana Pavlić-Renar
INTRODUCTION: Glucagon-like peptide-1 (GLP-1) has many effects on the human body, but its glucose-lowering effect through its stimulation of insulin secretion is the most significant. GLP-1 also acts on renal function and hemodynamics. The antihypertensive and renoprotective effects of GLP-1 receptor agonists are partly explained by their vasoactive effect and increased natriuresis, but their positive influences on blood pressure and the development and progression of kidney disease are attributed to many effects beyond glycemic control...
October 8, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Muzaffer Akkoca, Suzan Emel Usanmaz, Serhat Tokgöz, Cüneyt Köksoy, Emine Demirel Yilmaz
OBJECTIVE: The aim of this long-term follow-up study was to investigate the association of local and systemic cardiovascular complications with endothelium-dependent and-independent microvascular relaxations and blood biomarkers and biochemicals in patients with peripheral arterial disease (PAD) caused by atherosclerosis. METHODS: This prospective study included 67 patients with PAD who had not undergone any endovascular intervention, peripheral arterial surgery, or major amputation...
October 2018: Anatolian Journal of Cardiology
Małgorzata Sochacka, Joanna Giebułtowicz, Małgorzata Remiszewska, Piotr Suchocki, Piotr Wroczyński
BACKGROUND: Selenium (Se) is an essential micronutrient for animals and humans used in the prevention or treatment of cancer. Selol is a mixture of selenitetriglycerides, containing Se(IV). It does not exhibit mutagenic activity and is less toxic than inorganic sodium selenite containing Se(IV). The antioxidant properties of the Selol were demonstrated using the blood of healthy animals. The aim of the study was to evaluate Selol as a Se supplement by determining the effect of its administration on the Se level and the antioxidant status in the tissues...
June 18, 2018: Pharmacological Reports: PR
Hajime Kataoka
BACKGROUND: Optimal vascular volume is required to avoid organ dysfunction during decongestive therapy for worsening heart failure (HF). The present study investigated the relation between changes in serum substance(s) and the vascular volume after diuresis in HF patients. METHODS AND RESULTS: Data from 47 patients with HF undergoing conventional diuretic therapy were analyzed. Blood tests included measurements of hemoglobin, hematocrit, and serum albumin/solutes...
October 5, 2018: Journal of Cardiac Failure
Naren Ramachandran, Rajesh Podar, Shishir Singh, Gaurav Kulkarni, Shifali Dadu
Background: Effective removal of smear layer ensures better penetration of irrigants ensuring root canal disinfection and has the potential of sealing dentinal tubules during obturation. Aim: The aim of this study is to evaluate the canal cleaning efficacy and calcium ion liberation with the use of demineralizing irrigants, namely, 17% ethylenediaminetetraacetic acid (EDTA), 7% maleic acid, and 10% citric acid with or without ultrasonic (US) activation. Materials and Methods: Crowns of 62 extracted maxillary central incisors were decoronated and root canals prepared...
September 2018: Journal of Conservative Dentistry: JCD
Ariana Maria Santos Lima, Liz Oliveira Dos Santos, Jorge Mauricio David, Sergio Luis Costa Ferreira
This work evaluated the influence of the cooking methods (cooked in a water bath, in a stove, and in a microwave oven) on the mineral composition of mustard leaves (Sinapis alba). So, raw and cooked samples were digested and afterward the elements calcium, magnesium, potassium, sodium, iron, zinc, phosphor, barium and sulfur were determined using inductively coupled plasma optical emission spectrometry (ICP OES). The experimental work involved a set of five samples from different locations, processed in triplicates...
February 1, 2019: Food Chemistry
Weiyi Zhang, Jun Yang, Jing Fan, Bin Wang, Yi Kang, Jin Liu, Wensheng Zhang, Tao Zhu
Water-soluble prodrugs of propofol often carry an excess of propofol at the effective dose and have a slower onset of action. Sustained release of the original drug can result in propofol accumulation in the body after administration, causing delays in wakefulness. This situation causes the prodrug to lose the benefits of rapid onset and recovery from the effects of propofol. In the present study, HX0921 (sodium 2-(2-(2,6-diisopropylphenoxy)-2-oxoethoxy)acetate), an improved prodrug of propofol with high utilization of propofol and fast onset of action, was studied...
October 2, 2018: European Journal of Pharmaceutical Sciences
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