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Plasma Sodium

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https://www.readbyqxmd.com/read/30542707/emodin-attenuated-severe-acute-pancreatitis-via-the-p2x-ligand%C3%A2-gated-ion-channel-7-nod%C3%A2-like-receptor-protein-3-signaling-pathway
#1
Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang
Acute pancreatitis (AP) is an aseptic inflammation characterized with an annual incidence rate, and ~20% patients progressing to severe AP (SAP) with a high mortality rate. Although Qingyi decoction has been frequently used for SAP treatment over the past 3 decades in clinic, the actual mechanism of its protective effects remains unknown. As the major active ingredient of Qingyi decoction, emodin was selected in the present study to investigate the effect of emodin against severe acute pancreatitis (SAP) in rats through NOD‑like receptor protein 3 (NLRP3) inflammasomes...
November 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30539816/sodium-valproate-suppresses-abnormal-neurogenesis-induced-by-convulsive-status-epilepticus
#2
Peng Wu, Yue Hu, Xiu-Juan Li, Min Cheng, Li Jiang
Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. However, whether neurogenesis can play a role in the antiepileptic effect of sodium valproate remains unknown...
March 2019: Neural Regeneration Research
https://www.readbyqxmd.com/read/30539707/montelukast-sodium-formulation-containing-green-tea-extract-to-reduce-the-oxidative-stress-in-guinea-pig-model-of-chronic-allergic-asthma
#3
Neelam Singh, Giriraj T Kulkarni, Yatendra Kumar
AIM AND BACKGROUND: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and green tea extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2)...
December 11, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/30538486/the-possible-effect-of-scn1a-and-scn2a-genetic-variants-on-carbamazepine-response-among-khyber-pakhtunkhwa-epileptic-patients-pakistan
#4
Haleema Rehana Nazish, Niaz Ali, Shakir Ullah
Purpose: SCN1A (3184 A > G) and SCN2A (56G > A) gene encodes α subunit of the neuronal voltage-gated sodium channel, which is a target for carbamazepine (CBZ). Recent studies have demonstrated that polymorphism of SCN1A (3184 A > G) and SCN2A (56G > A) was associated with use of CBZ. However, it has not been determined whether the polymorphism affects CBZ or other antiepileptic drug responsiveness. The aim of the study was to establish whether the SCN1A (3184 A > G) and SCN2A (56G > A) polymorphisms of the SCN1A and SCN2A genes affect responsiveness to CBZ...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30537611/orchestration-of-cu-zn-sod-and-class-iii-peroxidase-with-upstream-interplay-between-nadph-oxidase-and-pm-h-atpase-mediates-root-growth-in-vigna-radiata-l-wilczek
#5
Arkajo Majumdar, Rup Kumar Kar
Post-germination plant growth depends on the regulation of reactive oxygen species (ROS) metabolism, spatiotemporal pH changes and Ca+2 homeostasis, whose potential integration has been studied during Vigna radiata (L.) Wilczek root growth. The dissipation of proton (H+ ) gradients across plasma membrane (PM) by CCCP (protonophore) and the inhibition of PM H+ -ATPase by sodium orthovanadate repressed SOD (superoxide dismutase; EC 1.15.1.1) activity as revealed by spectrophotometric and native PAGE assay results...
November 8, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/30537048/population-pharmacokinetics-and-bayesian-estimation-of-mycophenolic-acid-exposure-in-chinese-renal-allograft-recipients-after-administration-of-ec-mps
#6
Bing Chen, Kun Shao, Hui-Min An, Hao-Qiang Shi, Jia-Qian Lu, Xiao-Hui Zhai, Xiao-Xue Liu, Xiang-Hui Wang, Da Xu, Pei-Jun Zhou
The aim of the present study is to establish a population pharmacokinetic (PPK) model of mycophenolic acid (MPA) and limited sampling strategy models for the estimation of MPA exposure in Chinese adult renal allograft recipients following oral administration of enteric coated mycophenolate sodium (EC-MPS). A total of 74 sets of full pharmacokinetic profiles and 47 sets of MPA-sparing samples were collected from 102 renal transplant recipients who received oral EC-MPS. The MPA concentration was determined by an enzyme-multiplied immunoassay technique, and the pathophysiologic data were recorded...
December 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30535158/infusion-of-sodium-butyrate-promotes-rumen-papillae-growth-and-enhances-expression-of-genes-related-to-rumen-epithelial-vfa-uptake-and-metabolism-in-neonatal-twin-lambs
#7
Lixiang Liu, Daming Sun, Shengyong Mao, Weiyun Zhu, Junhua Liu
The objective of this study was to evaluate the effect of sodium butyrate (SB) infusion on rumen papillae growth and volatile fatty acids (VFA) uptake and metabolism in neonatal lambs. Seven pairs of newborn twin lambs were used. Within each pair, lambs were assigned to receive an oral infusion of SB at 0.36 g/kg body weight (BW) (SB, n = 7) or the same volume of saline (Con, n = 7). Treatments were administered from 10 to 49 d of age, when all lambs were slaughtered. Results showed that the average daily feed intake (ADFI) of starter, average daily gain (ADG), BW of lambs at ages of 5 and 6 wks in SB group were greater (P < 0...
December 7, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30533986/comparative-quantitative-and-qualitative-analysis-of-three-different-reagents-for-preparation-of-platelet-rich-plasma-for-hair-rejuvenation
#8
Sukhbir Singh
Objective: The aim of this study was to compare the quantity and quality of platelets in platelet-rich plasma (PRP) samples prepared using three different reagents, namely, ethylenediaminetetraacetic acid (EDTA), sodium citrate, and acid citrate dextrose-A (ACD-A) solution. Materials and Methods: A prospective study was carried out in which all the 50 patients who attended the outpatient department for hair rejuvenation were enrolled for the study. All the patients had a history of hair fall with diffuse thinning of hair, Norwood Grades 2 and 3...
July 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/30532032/inhibitor-binding-mode-and-allosteric-regulation-of-na-glucose-symporters
#9
Paola Bisignano, Chiara Ghezzi, Hyunil Jo, Nicholas F Polizzi, Thorsten Althoff, Chakrapani Kalyanaraman, Rosmarie Friemann, Matthew P Jacobson, Ernest M Wright, Michael Grabe
Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bound to an aromatic aglycon tail. Here, we develop structural models of human SGLT1/2 in complex with inhibitors by combining computational and functional studies. Inhibitors bind with the sugar moiety in the sugar pocket and the aglycon tail in the extracellular vestibule...
December 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/30531137/-syndrome-of-inappropriate-secretion-of-antidiuretic-hormone-in-multiple-myeloma-patients-treated-with-bortezomib-lenalidomide-and-dexamethasone-combination-therapy
#10
Yuta Baba, Hiroshi Harada, Shotaro Shimada, Yohei Sasaki, So Murai, Maasa Abe, Shun Fujiwara, Nana Arai, Yukiko Kawaguchi, Nobuyuki Kabasawa, Hiroyuki Tsukamoto, Yui Uto, Hirotsugu Ariizumi, Kouji Yanagisawa, Norimichi Hattori, Bungo Saito, Tsuyoshi Nakamaki
Hyponatremia occurs while receiving bortezomib-containing combination therapy in multiple myeloma (MM) ; however, the mechanism of hyponatremia remains unclear. A 65-year-old female with MM was treated with bortezomib, lenalidomide, and dexamethasone. Fourteen days after chemotherapy initiation, she developed hyponatremia (serum sodium, 127 mEq/l, compared with 136 mEq/l before chemotherapy) with plasma hypo-osmolality and urine hyper-osmolality. She exhibited neither dehydration nor adrenal insufficiency. Her serum arginine vasopressin peptide (AVP) level was 1...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/30530977/central-diabetes-insipidus-a-rare-complication-of-ivh-in-a-very-low-birth-weight-preterm-infant
#11
P Thakore, A E Dunbar, E B Lindsay
A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. On the day of life 29, a gradual increase in serum sodium level refractory to increasing total fluid volume was noted...
December 1, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/30529264/rna-seq-analysis-of-the-scn1a-ko-model-based-on-crispr-cas9-genome-editing-technology
#12
Xiaoguang Shi, Wenxin He, Shanshan Guo, Bingying Zhang, Shuanglai Ren, Kunmei Liu, Tao Sun, Jianqi Cui
Dravet syndrome (DS) is a disease that is primarily caused by the inactivation of the SCN1A-encoded voltage-gated sodium channel alpha subunit (Nav1.1). In this study, we constructed an SCN1A gene knockout model using CRISPR/Cas9 genome editing technology to deprive the Nav1.1 function in vitro. With mRNA-seq analysis we found abundant gene changes after SCN1A knockout, which associated with various signaling pathways, such as cancer pathways, the PI3K-AKT signaling pathway, the MAPK signaling pathway, and pathways involved in HTLV-I infection...
December 7, 2018: Neuroscience
https://www.readbyqxmd.com/read/30525015/monozygotic-twins-suffering-from-sodium-taurocholate-cotransporting-polypeptide-deficiency-a-case-report
#13
Hui-Jun Tan, Mei Deng, Jian-Wu Qiu, Jun-Feng Wu, Yuan-Zong Song
Sodium taurocholate cotransporting polypeptide (NTCP) is a carrier protein encoded by the human SLC10A1 gene, acting as the principal transporter of conjugated bile salts from the plasma into hepatocytes. Although NTCP was cloned as early as in 1994 and its function has been studied extensively, clinical description of NTCP deficiency remains rather limited thus far. The patients in this paper were 2 female monozygotic twins, who were referred to our hospital at the age 2 years with the complaint of persistently-raised total bile acids (TBA) for 21 months...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30522145/effect-of-sodium-glucose-co-transporter-2-inhibition-on-the-aldosterone-renin-ratio-in-type-2-diabetes-mellitus
#14
Tomás P Griffin, Md Nahidul Islam, Liam Blake, Marcia Bell, Matthew D Griffin, Paula M O'Shea
The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of Sodium Glucose Co-Transporter-2 Inhibition on the ARR in patients with type 2 diabetes mellitus (T2DM) who were prescribed a Sodium Glucose Co-Transporter-2 Inhibitor (SGLT-2i) as part of routine clinical care. The primary outcomes were intra-individual changes in aldosterone, renin and ARR...
December 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30521368/intra-articular-injection-of-hydrogen-sulfide-decreased-the-progression-of-gonarthrosis
#15
Kürşad Aytekin, Selma Şengiz Erhan, Züleyha Erişgin, Cem Zeki Esenyel, Selçuk Takır
Hydrogen sulfide (H2 S) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a H2 S donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Then, intra-articular injections of NaSH or methylprednisolone (1 mg/kg, 30 μL) were administered to rats. Half of each group was sacrificed at the end of the first day and the other half was sacrificed at the end of 4 weeks to evaluate early and later effects of injections on gonarthrosis...
December 6, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30514961/propionate-affects-insulin-signaling-and-progesterone-profiles-in-dairy-heifers
#16
A Bedford, L Beckett, K Hardin, N W Dias, T Davis, V R G Mercadante, A D Ealy, R R White
Emerging data highlighting gut microbiome influences on health support evaluation of how microbial fermentation end-products influence postabsorptive systems. This study aimed to investigate the effect of increased propionate status on progesterone profiles and insulin sensitivity in dairy heifers. Eleven Holstein heifers, synchronized in estrus, were assigned to one of two continuous, 5-day IV treatments: sodium propionate (PRO; n = 5) or saline (CON; n = 6). These infusions culminated in a hyperglycemic clamp with daily blood samples for an additional 7 days...
December 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30513832/effects-of-a-carbon-nanotube-additive-on-the-corrosion-resistance-and-heat-dissipation-properties-of-plasma-electrolytic-oxidation-on-az31-magnesium-alloy
#17
Myungwon Hwang, Wonsub Chung
Plasma electrolytic oxidation (PEO) coating was obtained on AZ31 Mg alloy using a direct current in a sodium silicate-based electrolyte with and without a carbon nanotube (CNT) additive. The surface morphology and phase composition of the PEO coatings were investigated through field emission scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The corrosion-resistance properties of the PEO coatings were evaluated using potentiodynamic polarization measurements and electrochemical impedance spectroscopy (EIS) in a 3...
December 2, 2018: Materials
https://www.readbyqxmd.com/read/30513547/effects-of-gut-bacteria-depletion-and-high-na-and-low-k-intake-on-circulating-levels-of-biogenic-amines
#18
Ivana Blaženović, Young Taek Oh, Fan Li, Jian Ji, Ahn-Khoi Nguyen, Benjamin Wancewicz, Jeffrey M Bender, Oliver Fiehn, Jang H Youn
SCOPE: High-sodium and low-potassium (HNaLK) content in Western diets increases the risk of hypertension and cardiovascular disease (CVD). We investigated if the dietary minerals interact with gut bacteria to modulate circulating levels of biogenic amines, which are implicated in various pathologies, including hypertension and CVD. METHODS AND RESULTS: Using a metabolomic approach to target biogenic amines, we examined the effects of gut-bacteria depletion and HNaLK intake on circulating levels of biogenic amines in rats...
December 4, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/30510439/nocturnal-blood-pressure-decrease-in-patients-with-chronic-kidney-disease-and-in-healthy-controls-significance-of-obstructive-sleep-apnea-and-renal-function
#19
Bodil G Hornstrup, Pia H Gjoerup, Jost Wessels, Thomas G Lauridsen, Erling B Pedersen, Jesper N Bech
Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-matched controls...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/30504697/parathyroid-hormone-related-protein-1-40-enhances-calcium-uptake-in-rat-enterocytes-through-pthr1-receptor-and-protein-kinase-c%C3%AE-%C3%AE-signaling
#20
Cuiping Liu, Guoli Shao, Yirong Lu, Minmin Xue, Fenfen Liang, Zhenshu Zhang, Lan Bai
BACKGROUND/AIMS: Parathyroid hormone-related protein (PTHrP) is implicated in regulating calcium homeostasis in vertebrates, including sea bream, chick, and mammals. However, the molecular mechanism underlying the function of PTHrP in regulating calcium transport is still not fully investigated. This study aimed to investigate the effect of PTHrP on the calcium uptake and its underlying molecular mechanism in rat enterocytes. METHODS: The rat intestinal epithelial cell line (IEC-6) was used...
2018: Cellular Physiology and Biochemistry
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