Osama A Mohammed, Sameh Saber, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S Alamri, Jaber Alfaifi, Masoud I E Adam, Muffarah Hamid Alharthi, Ali M S Eleragi, Hanan B Eltahir, Mohamed Osama Abdalla, Emad Bahashwan, Elwathiq Khalid Ibrahim, Assad Ali Rezigalla, Sameh Abdel-Ghany, Amany A Alzokaky, Ahmed S Doghish, Hussein M El-Husseiny, Mushabab Alghamdi, Mahmoud E Youssef
Ulcerative colitis (UC) is an inflammatory condition that affects the colon's lining and increases the risk of colon cancer. Despite ongoing research, there is no identified cure for UC. The recognition of NLRP3 inflammasome activation in the pathogenesis of UC has gained widespread acceptance. Notably, the ketone body β-hydroxybutyrate inhibits NLRP3 demonstrating its anti-inflammatory properties. Additionally, BD-AcAc 2 is ketone mono ester that increases β-hydroxybutyrate blood levels. It has the potential to address the constraints associated with exogenous β-hydroxybutyrate as a therapeutic agent, including issues related to stability and short duration of action...
April 25, 2024: Toxicology and Applied Pharmacology