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Vitamin D3 and Breast Cancer

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https://www.readbyqxmd.com/read/30314996/vitamin-d-induced-vitamin-d-receptor-expression-induces-tamoxifen-sensitivity-in-mcf-7-stem-cells-via-the-suppression-of-wnt-%C3%AE-catenin-signaling
#1
Wei Zheng, Bofeng Duan, Qian Zhang, Linna Ouyang, Wei Peng, Fuyong Qian, Yibin Wang, Shiting Huang
OBJECTIVE: Cancer stem cells (CSCs) are responsible for the drug resistance of breast cancers. Vitamin D deficiency promotes tumor resistance. This study examined the effect of vitamin D and vitamin D receptor (VDR) expression on the tamoxifen resistance of CSCs. METHODS: MCF-7 cells were treated with 1,25(OH)2 D3 and their levels of VDR expression, viability, and apoptosis were detected. CD133+ MCF-7 stem cells were identified and transfected with a VDR-overexpression plasmid...
October 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30232176/calcitriol-and-calcipotriol-modulate-transport-activity-of-abc-transporters-and-exhibit-selective-cytotoxicity-in-mrp1-overexpressing-cells
#2
Kee Wee Tan, Angelina Sampson, Bremansu Osa-Andrews, Surtaj Hussain Iram
Efflux transporters P-glycoprotein (P-gp/ABCB1), multidrug resistance protein 1 (MRP1/ABCC1), and breast cancer resistance protein (BCRP/ABCG2) can affect the efficacy and toxicity of a wide variety of drugs and are implicated in multidrug resistance (MDR). Eight test compounds, recently identified from an intramolecular FRET-based high throughput screening, were characterized for their interaction with MRP1. We report that the active metabolite of vitamin D3, calcitriol, and its analog calcipotriol are selectively cytotoxic to MRP1-overexpressing cells, besides inhibiting transport function of P-gp, MRP1, and BCRP...
September 19, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/30181873/activation-of-pro-survival-metabolic-networks-by-1-25-oh-2-d-3-does-not-hamper-the-sensitivity-of-breast-cancer-cells-to-chemotherapeutics
#3
Mohamed A Abu El Maaty, Yasamin Dabiri, Fadi Almouhanna, Biljana Blagojevic, Jannick Theobald, Michael Büttner, Stefan Wölfl
Background: We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], the bioactive form of vitamin D3 , as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the current study, we investigated the effects of 1,25(OH)2 D3 on breast cancer (BCa) cell metabolism using cell lines representing distinct molecular subtypes, luminal (MCF-7 and T-47D), and triple-negative BCa (MDA-MB-231, MDA-MB-468, and HCC-1143). Methods: 1,25(OH)2 D3 's effect on BCa cell metabolism was evaluated by employing a combination of real-time measurements of glycolysis/oxygen consumption rates using a biosensor chip system, GC/MS-based metabolomics, gene expression analysis, and assessment of overall energy levels...
2018: Cancer & Metabolism
https://www.readbyqxmd.com/read/30125657/synthesis-of-a-novel-analog-of-calcitriol-and-its-biological-evaluation-as-antitumor-agent
#4
María Julia Ferronato, Diego Javier Obiol, Eliana Noelia Alonso, Josefina Alejandra Guevara, Silvina Mariela Grioli, Marilina Mascaró, Marcos Lois Rivadulla, Andrea Martínez, Generosa Gómez, Yagamare Fall, Mario Alfredo Quevedo, Alejandro Carlos Curino, María Marta Facchinetti
Calcitriol analogs have shown promising potential as compounds to be used in cancer chemotherapy. This report presents the synthesis of a novel vitamin D3 derivative with an amide and a carboxyl group in its side chain, called ML-344. In addition, we report its in vitro antitumor activity and its in vivo calcemic effects. We demonstrate that the analog decreases cell viability and retards cell migration of different breast, glioblastoma and head and neck cancer cell lines. Additionally, unlike calcitriol, ML-344 does not display citotoxicity to the murine non-malignant mammary cells and human astrocytes...
August 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29970508/mart-10-a-1%C3%AE-25-oh-2-d-3-analog-potently-represses-metastasis-of-er-breast-cancer-cells-with-vegf-a-overexpression
#5
Kun-Chun Chiang, Chun-Nan Yeh, Ta-Sen Yeh, Horng-Heng Juang, Li-Wei Chen, Sheng-Fong Kuo, Ming-Huang Chen, Tai C Chen, Masashi Takano, Atsushi Kittaka, Jong-Hwei S Pang
BACKGROUND: Breast cancer ranks second in the list of cancer-related deaths for women. Even under multidisciplinary treatment, 25-50% of patients with breast cancer still ultimately develop metastasis, leading to poor prognosis. In addition to inducing angiogenesis, vascular endothelial growth factor-A (VEGF-A) is believed to directly increase cancer cell metastatic potential and overexpression of VEGF-A is associated with higher invasiveness of breast cancer. 1α,25(OH)2 D3 , the active form of vitamin D, and its analogs have been widely applied as anticancer agents in the past...
July 2018: Anticancer Research
https://www.readbyqxmd.com/read/29559791/significant-improvement-of-bone-mineral-density-by-denosumab-treatment-in-japanese-osteoporotic-patients-following-breast-cancer-treatment
#6
Yukio Nakamura, Mikio Kamimura, Akio Morikawa, Akira Taguchi, Takako Suzuki, Hiroyuki Kato
Background: The aim of this study was to evaluate the effects of denosumab in patients with osteoporosis (OP) and non-metastatic breast cancer following treatment of 1) surgery, 2) surgery and aromatase inhibitors, and 3) surgery, aromatase inhibitors, and anti-cancer agents, compared with those in primary OP patients. Patients and methods: In this retrospective 24-month study, patients were divided into the primary OP group (34 cases) or OP receiving breast cancer treatment group (breast cancer group; 17 cases)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29518319/further-developments-of-the-phenyl-pyrrolyl-pentane-series-of-nonsteroidal-vitamin-d-receptor-modulators-as-anticancer-agents
#7
Meixi Hao, Siyuan Hou, Lingjing Xue, Haoliang Yuan, Lulu Zhu, Cong Wang, Bin Wang, Chunming Tang, Can Zhang
The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential molecular target for anticancer-drug discovery. In this study, a series of nonsteroidal vitamin D mimics with phenyl-pyrrolyl pentane skeletons with therapeutic potentials in cancer treatment were synthesized. Among them, 11b and 11g were identified as the most effective agents in reducing the viability of four cancer-cell lines, particularly those of breast-cancer cells, with IC50 values in the submicromolar-concentration range...
April 12, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29376548/vitamin-d-levels-in-swiss-breast-cancer-survivors
#8
Michael Baumann, Sergio Ulhoa Dani, Daniel Dietrich, Andreas Hochstrasser, Dirk Klingbiel, Michael Thomas Mark, Walter F Riesen, Thomas Ruhstaller, Arnoud J Templeton, Beat Thürlimann
BACKGROUND: Cholecalciferol (vitamin D3) is widely supplemented in breast cancer survivors because of the role of vitamin D in multiple health outcomes. METHODS: We conducted an observational study in 332 women in Eastern Switzerland with early, i.e., nonmetastatic breast cancer. Tumour-, patient-related and sociodemographic variables were recorded. Cholecalciferol intake and serum 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were measured at the first visit (baseline) and during a follow-up visit in a median of 210 days (range 87-857) after the first visit...
2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29298280/complete-objective-response-stable-for-5-years-with-the-di-bella-method-of-multiple-metastatic-carcinoma-of-the-breast
#9
Giuseppe Di Bella, Biagio Colori, Rosilde Toscano
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof...
December 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29216499/vitamin-d-3-decreases-glycolysis-and-invasiveness-and-increases-cellular-stiffness-in-breast-cancer-cells
#10
Julianna Maria Santos, Zeina Shereen Khan, Maliha Tabassum Munir, Kaiser Tarafdar, Shaikh Mizanoor Rahman, Fazle Hussain
Breast cancer is one of the major causes of death in the USA. Cancer cells, including breast, have high glycolysis rates to meet their energy demands for survival and growth. Vitamin D3 (VD3 ) is important for many important physiological processes such as bone mineralization, but its anticancer role is yet to be proven. We find that VD3 treatment significantly down-regulates glycolytic enzymes and genes and decreases glucose uptake - for both lowly metastatic MCF-7 and highly metastatic MDA-MB-231 (MB231) breast cancer cells...
March 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29159099/cancer-sunlight-and-vitamin-d
#11
REVIEW
Michael F Holick
The sunshine vitamin has been associated with reduced risk for many chronic illnesses including cancer and cancer mortality. Epidemiologic and ecological studies have suggested that living at higher latitudes and having lower blood levels of 25-hydroxyvitamin D are associated with increased risk for up to 15 cancers including breast, colon, lung, lymphoma, pancreatic, ovarian and prostate cancer. Most randomized controlled trials using appropriate doses of vitamin D have suggested that improvement in vitamin D status reduces risk for several cancers...
December 2014: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29064397/association-of-vitamin-d3-level-with-breast-cancer-risk-and-prognosis-in-african-american-and-hispanic-women
#12
Yanyuan Wu, Marianna Sarkissyan, Sheilah Clayton, Rowan Chlebowski, Jaydutt V Vadgama
Background : This study investigated the association of vitamin D3 levels with breast cancer risk and progression in African-Americans and Hispanics. Methods : A total of 237 African-American (Cases = 119, Control = 118) and 423 Hispanic women (Cases = 124, Control = 299) were recruited in the study. Blood samples were collected at the time of breast cancer screening and prior to cancer treatment for 4 weeks on average for the cases. The serum 25-hydroxyvitamin D (25(OH)D3) was measured at a Quest-Diagnostics facility...
October 24, 2017: Cancers
https://www.readbyqxmd.com/read/28770449/randomized-trial-of-vitamin-d3-to-prevent-worsening-of-musculoskeletal-symptoms-in-women-with-breast-cancer-receiving-adjuvant-letrozole-the-vital-trial
#13
RANDOMIZED CONTROLLED TRIAL
Qamar J Khan, Bruce F Kimler, Pavan S Reddy, Priyanka Sharma, Jennifer R Klemp, Jennifer L Nydegger, Hung-Wen Yeh, Carol J Fabian
PURPOSE: Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) frequently occur in women being treated for breast cancer. Prior studies suggest high prevalence of vitamin D deficiency in breast cancer patients with musculoskeletal (MS) pain. We conducted a randomized, placebo-controlled trial to determine if 30,000 IU vitamin D3 per week (VitD3) would prevent worsening of AIMSS in women starting adjuvant letrozole for breast cancer. METHODS: Women with stage I-III breast cancer starting adjuvant letrozole and 25(OH)D level ≤40 ng/ml were eligible...
November 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28749628/circulating-25-hydroxy-vitamin-d-relative-to-vitamin-d-receptor-polymorphism-after-vitamin-d3-supplementation-in-breast-cancer-women-a-randomized-double-blind-controlled-clinical-trial
#14
Houra Mohseni, Seyed Ahmad Hosseini, Reza Amani, Alireza Ekrami, Ahmad Ahmadzadeh, Seyed Mahmoud Latifi
Objective: The influence of vitamin D receptor (VDR) genetic variation on serum 25-hydroxyvitamin D levels [25(OH)D] after vitamin D3 supplementation remains unclear. We aimed to investigate changes of 25(OH)D in a randomized, double-blind, placebo-controlled clinical trial, according to VDR genotype, after provision of vitamin D3 to breast cancer cases for a 2-month period. Methods: Participants were assigned to two treatment arms: placebo (n = 28) and vitamin D3 supplementation (n =28). The supplementation group received 50,000 IU of vitamin D every week for 2 months...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28742387/vitamin-d-loaded-nanostructured-lipid-carrier-nlc-a-new-strategy-for-enhancing-efficacy-of-doxorubicin-in-breast-cancer-treatment
#15
Mehdi Sabzichi, Jamal Mohammadian, Maryam Mohammadi, Farhad Jahanfar, Ali Akbar Movassagh Pour, Hamed Hamishehkar, Alireza Ostad-Rahimi
The dangerous dose-dependent side effects of anticancer agents triggered the finding of new approaches for elevated chemotherapy efficacy. This study investigated the potential application of nanostructured lipid careers (NLCs) in increasing vitamin D3 (VitD) effectiveness in breast cancer cell (MCF-7) in concurrent administration with doxorubicin (Dox). VitD-loaded NLCs were characterized by particle size, zeta potential, Fourier transform infrared spectroscopy, and scanning electron microscope. Cytotoxicity and molecular effects of formulation were evaluated by MTT, DAPI staining, flow cytometry, and real-time quantitative PCR assays...
August 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28649655/gene-expression-in-breast-and-adipose-tissue-after-12-months-of-weight-loss-and-vitamin-d-supplementation-in-postmenopausal-women
#16
Caitlin Mason, Lei Wang, Catherine Duggan, Ikuyo Imayama, Sushma S Thomas, Ching-Yun Wang, Larissa A Korde, Anne McTiernan
Adipose tissue is involved in the etiology of postmenopausal breast cancer, possibly through increased sex steroid hormone production, inflammation, and altered adipokines. Vitamin D may affect these pathways but its effect on gene expression in different tissues has not been examined. Within a double-blind, 12-month placebo-controlled randomized trial, we compared 2000 IU/day oral vitamin D3 supplementation ( N  = 39) vs. placebo ( N  = 40) on the expression of 5 genes in breast and adipose tissue in overweight/obese postmenopausal women (50-75 years)...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28627723/vitamin-d-enhances-omega-3-polyunsaturated-fatty-acids-induced-apoptosis-in-breast-cancer-cells
#17
Jing Yang, Shenglong Zhu, Guangxiao Lin, Ci Song, Zhao He
Breast cancer is a leading type of cancer in women and generally classified into three subtypes of ER+ /PR+ , HER2+ and triple negative. Both omega-3 polyunsaturated fatty acids and vitamin D3 play positive role in the reduction of breast cancer incidence. However, whether combination of omega-3 polyunsaturated fatty acids and vitamin D3 has stronger protective effect on breast carcinogenesis still remains unknown. In this study, we show that the combination of ω-3 free fatty acids (ω-3 FFAs) and 1α, 25-dihydroxy-vitamin D3 (VD3 ) dramatically enhances cell apoptosis among three subtypes of breast cancer cell lines...
August 2017: Cell Biology International
https://www.readbyqxmd.com/read/28550626/combination-breast-cancer-chemotherapy-with-doxorubicin-and-cyclophosphamide-damages-bone-and-bone-marrow-in-a-female-rat-model
#18
Chiaming Fan, Kristen R Georgiou, Howard A Morris, Ross A McKinnon, Dorothy M K Keefe, Peter R Howe, Cory J Xian
PURPOSE: Anthracyclines (including doxorubicin) are still the backbone of commonly used breast cancer chemotherapy regimens. Despite increasing use of doxorubicin and cyclophosphamide (AC) combinations for treating breast cancer, their potential to cause adverse skeletal effects remains unclear. METHODS: This study examined the effects of treatments with the AC regimen on bone and bone marrow in adult female rats. RESULTS: AC treatment for four cycles (weekly intravenous injection of 2 mg/kg doxorubicin and 20 mg/kg cyclophosphamide) resulted in a reduced volume of trabecular bone at the metaphysis, which was associated with reduced serum levels of 25-hydroxy vitamin D3 and alkaline phosphatase...
August 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28480224/safety-feasibility-and-biomarker-effects-of-high-dose-vitamin-d-supplementation-among-women-at-high-risk-for-breast-cancer
#19
K D Crew, T Xiao, P S Thomas, M B Terry, M Maurer, K Kalinsky, S Feldman, L Brafman, S R Refice, D L Hershman
Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention. We examined the safety, feasibility, and biomarker effects of high-dose vitamin D among women at high risk for breast cancer. Forty high-risk women, defined as a 5-year breast cancer risk ≥1.67% per the Gail model, lobular or ductal carcinoma in situ , were assigned to a 1-year intervention of vitamin D3 20,000 IU or 30,000 IU weekly. Participants were monitored for toxicity every 3 months, underwent serial blood draws at baseline, 6 and 12 months, and a digital mammogram at baseline and 12 months...
2015: International Journal of Food Science, Nutrition and Dietetics
https://www.readbyqxmd.com/read/28440491/txnip-overexpression-suppresses-proliferation-and-induces-apoptosis-in-smmc7221-cells-through-ros-generation-and-mapk-pathway-activation
#20
Jian Li, Zhongyi Yue, Wancheng Xiong, Peisheng Sun, Kun You, Jianguo Wang
Thioredoxin binding protein (thioredoxin-interacting protein, TXNIP), known as vitamin D3 increase protein 1, has been identified as a tumor suppressor in various cancers such as pancreatic, breast, lung and thyroid cancer. However, the role of TXNIP in hepatocellular carcinoma cell proliferation and apoptosis remains unknown. In this study, we first used qRT-PCR, western blotting and immunohistochemistry to compare the expression of TXNIP between hepatocellular carcinoma tissues and tumor-adjacent normal liver tissues...
June 2017: Oncology Reports
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