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Barber Safety

Robert Howard, Elizabeth Cort, Rosie Bradley, Emma Harper, Linda Kelly, Peter Bentham, Craig Ritchie, Suzanne Reeves, Waleed Fawzi, Gill Livingston, Andrew Sommerlad, Sabu Oomman, Ejaz Nazir, Ramin Nilforooshan, Robert Barber, Chris Fox, Ajay Macharouthu, Pranathi Ramachandra, Vivek Pattan, John Sykes, Valerie Curran, Cornelius Katona, Tom Dening, Martin Knapp, Renee Romeo, Richard Gray
BACKGROUND: Very late-onset (aged ≥ 60 years) schizophrenia-like psychosis (VLOSLP) occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy or risks of antipsychotic treatment. Most patients are not prescribed treatment. OBJECTIVES: The study investigated whether or not low-dose amisulpride is superior to placebo in reducing psychosis symptoms over 12 weeks and if any benefit is maintained by continuing treatment thereafter...
November 2018: Health Technology Assessment: HTA
Katie E Barber, Alison M Bell, Mary Joyce B Wingler, Jamie L Wagner, Kayla R Stover
Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and current progress with omadacycline in clinical trials. Omadacycline inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome at the tetracycline-binding site with an affinity similar to glycylcyclines...
October 5, 2018: Pharmacotherapy
Matthew A Miller, Douglas N Fish, Gerard R Barber, Michelle A Barron, Tiffany A Goolsby, Pierre Moine, Scott W Mueller
BACKGROUND: Methicillin-susceptible Staphylococcus aureus (MSSA) is a frequent cause of bloodstream infections (BSI). Treatment with nafcillin (NAF) has been preferred to cefazolin (CFZ). However, comparable outcomes have been found with CFZ with possibly lower risk for side-effects. This study compared safety and effectiveness of NAF versus CFZ for MSSA BSI. METHODS: This single center retrospective study evaluated adults admitted with MSSA BSI who received NAF or CFZ...
August 18, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Michael P Leiter, Lois Jackson, Ivy Bourgeault, Sheri Price, Audrey Kruisselbrink, Pauline Gardiner Barber, Shiva Nourpanah
OBJECTIVE: The study examined the relationship of occupational safety with job burnout. DESIGN: The study used a cross-sectional survey design. SETTING: The setting was Nova Scotia, Canada. PARTICIPANTS: Mobile health employees ( N = 156) completed surveys on road safety, workload, burnout and supervisor incivility. MAIN OUTCOME MEASURE: The main outcome measure was the Maslach Burnout Inventory...
July 11, 2018: International Journal of Environmental Research and Public Health
Jesmin Antony, Wasifa Zarin, Ba' Pham, Vera Nincic, Roberta Cardoso, John D Ivory, Marco Ghassemi, Sarah Louise Barber, Sharon E Straus, Andrea C Tricco
OBJECTIVES: This review was commissioned by WHO, South Africa-Country office because of an exponential increase in medical litigation claims related to patient safety in obstetrical care in the country. A rapid review was conducted to examine the effectiveness of quality improvement (QI) strategies on maternal and newborn patient safety outcomes, risk of litigation and burden of associated costs. DESIGN: A rapid review of the literature was conducted to provide decision-makers with timely evidence...
July 6, 2018: BMJ Open
Geraud Souteyrand, Louis Viallard, Nicolas Combaret, Bruno Pereira, Guillaume Clerfond, Guilhem Malcles, Nicolas Barber Chamoux, Francesco Prati, Pascal Motreff
BACKGROUND: A two-step strategy of invasive management without stenting, guided by optical coherence tomography (OCT), in selected patients with acute coronary syndrome (ACS), might avoid systematic stent implantation and allow medical therapy alone. AIMS: To assess the feasibility and safety of such a procedure, and to define coronary imaging characteristics in a specific population. METHODS: This single-centre proof-of-concept study included all patients with ACS who benefited from a two-step revascularization procedure with optimal reperfusion during primary percutaneous coronary intervention followed by delayed angiography and OCT...
June 19, 2018: Archives of Cardiovascular Diseases
Robert Howard, Elizabeth Cort, Rosie Bradley, Emma Harper, Linda Kelly, Peter Bentham, Craig Ritchie, Suzanne Reeves, Waleed Fawzi, Gill Livingston, Andrew Sommerlad, Sabu Oomman, Ejaz Nazir, Ramin Nilforooshan, Robert Barber, Chris Fox, Ajay Verma Macharouthu, Pranathi Ramachandra, Vivek Pattan, John Sykes, Val Curran, Cornelius Katona, Tom Dening, Martin Knapp, Richard Gray
BACKGROUND: Very late (aged ≥60 years) onset schizophrenia-like psychosis occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy and risks of antipsychotic treatment. We investigated whether low-dose amisulpride (100 mg daily) is superior to placebo in reducing psychosis symptoms over 12 weeks and whether any benefit is maintained by continuing treatment after 12 weeks. METHODS: The ATLAS double-blind controlled trial enrolled participants from 25 old age psychiatry services in the UK...
July 2018: Lancet Psychiatry
Mark Plante, Peter Gilling, Neil Barber, Mohamed Bidair, Paul Anderson, Mark Sutton, Tev Aho, Eugene Kramolowsky, Andrew Thomas, Barrett Cowan, Ronald P Kaufman, Andrew Trainer, Andrew Arther, Gopal Badlani, Mihir Desai, Leo Doumanian, Alexis E Te, Mark DeGuenther, Claus Roehrborn
OBJECTIVE: To test the hypothesis that benign prostatic hyperplasia (BPH) robotic surgery with aquablation would have a more pronounced benefit in certain patient subgroups, such as men with more challenging anatomies (e.g. large prostates, large middle lobes) and men with moderate BPH. METHODS: We conducted prespecified and post hoc exploratory subgroup analyses from a double-blind, multicentre prospective randomized controlled trial that compared transurethral resection of the prostate (TURP) using either standard electrocautery vs surgery using robotic waterjet (aquablation) to determine whether certain baseline factors predicted more marked responses after aquablation as compared with TURP...
June 4, 2018: BJU International
Daniel J Cooper, Katherine Plewes, Matthew J Grigg, Giri S Rajahram, Kim A Piera, Timothy William, Mark D Chatfield, Tsin Wen Yeo, Arjen M Dondorp, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI...
April 24, 2018: Trials
Peter J Watkinson, Vicki S Barber, J Duncan Young
BACKGROUND: Observational and interventional studies in patients with both acute medical conditions and long-standing diabetes have shown that improved blood glucose control confers a survival advantage or reduces complication rates. Policies of "tight" glycaemic control were rapidly adopted by many general intensive care units (ICUs) worldwide in the mid 00's, even though the results of the studies were not generalizable to mixed medical/surgical ICUs with different intravenous feeding policies...
March 8, 2018: JMIR Research Protocols
Peter Gilling, Neil Barber, Mohamed Bidair, Paul Anderson, Mark Sutton, Tev Aho, Eugene Kramolowsky, Andrew Thomas, Barrett Cowan, Ronald P Kaufman, Andrew Trainer, Andrew Arther, Gopal Badlani, Mark Plante, Mihir Desai, Leo Doumanian, Alexis E Te, Mark DeGuenther, Claus Roehrborn
PURPOSE: We compared the safety and efficacy of Aquablation and transurethral prostate resection for the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia. MATERIALS AND METHODS: In a double-blind, multicenter, prospective, randomized, controlled trial 181 patients with moderate to severe lower urinary tract symptoms related to benign prostatic hyperplasia underwent transurethral prostate resection or Aquablation. The primary efficacy end point was the reduction in International Prostate Symptom Score at 6 months...
May 2018: Journal of Urology
Jo Howard, April E Slee, Simon Skene, Baba Inusa, Jamie Kawadler, Michelle Downes, Johanna Gavlak, Melanie Koelbel, Hanne Stotesbury, Maria Chorozoglou, Susan Tebbs, Subarna Chakravorty, Moji Awogbade, David C Rees, Atul Gupta, Patrick B Murphy, Nicholas Hart, Sati Sahota, Carol Nwosu, Maureen Gwam, Dawn Saunders, Vivek Muthurangu, Nathaniel Barber, Emmanuel Ako, Swee Lay Thein, Melanie Marshall, Isabel C Reading, Man Ying Edith Cheng, Fenella J Kirkham, Christina Liossi
BACKGROUND: In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties in attention and processing speed associated with low daytime and night-time oxygen saturation compounded by obstructive sleep apnoea (OSA). In the general population OSA is treated with continuous positive airways pressure (CPAP). The aim of this single-blind, randomised, controlled phase II trial is to compare auto-adjusting CPAP (APAP) with standard care to standard care alone in individuals with HbSS to determine whether the intervention improves attention and processing speed, brain structure, pain and quality of life...
January 22, 2018: Trials
Jo Bowen, Laurie Davies, Garry John Burdett, Christopher Michael Barber
The duty to manage asbestos in non-domestic premises is described in the Control of Asbestos Regulations 2012. Health and Safety Executive (HSE) policy and guidance on asbestos in the built environment in Great Britain is that asbestos-containing materials (ACMs) that are in good condition and unlikely to be disturbed can be managed in place. Where ACMs are in poor condition or likely to be disturbed they should be repaired, encapsulated or, if necessary, removed. HSE and Government Office for Science hosted a stakeholder workshop to consider evidence on the management of ACMs in public buildings...
January 1, 2017: Annals of Work Exposures and Health
J W Evans, B R Graham, P Pordeli, F S Al-Ajlan, R Willinsky, W J Montanera, J L Rempel, A Shuaib, P Brennan, D Williams, D Roy, A Y Poppe, T G Jovin, T Devlin, B W Baxter, T Krings, F L Silver, D F Frei, C Fanale, D Tampieri, J Teitelbaum, D Iancu, J Shankar, P A Barber, A M Demchuk, M Goyal, M D Hill, B K Menon
BACKGROUND AND PURPOSE: The safety and efficacy of endovascular therapy for large-artery stroke in the extended time window is not yet well-established. We performed a subgroup analysis on subjects enrolled within an extended time window in the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) trial. MATERIALS AND METHODS: Fifty-nine of 315 subjects (33 in the intervention group and 26 in the control group) were randomized in the ESCAPE trial between 5...
January 2018: AJNR. American Journal of Neuroradiology
David Hemenway, Steven Rausher, Pina Violano, Toby A Raybould, Catherine W Barber
INTRODUCTION: Firearm safety instructors and public health professionals are natural allies in the quest to prevent firearm injuries. We audited basic firearm classes to provide information that can help familiarise public health professionals and others with the content covered. METHODS: With the advice of expert instructors, we created an audit form. Volunteers audited 20 basic firearm classes in seven north-eastern states. RESULTS: All trainers covered a wide variety of safety issues...
October 7, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Katharine Briggs, Chris Barber, Montserrat Cases, Philippe Marc, Thomas Steger-Hartmann
A first analysis of a database of shared preclinical safety data for 1214 small molecule drugs and drug candidates extracted from 3970 reports donated by thirteen pharmaceutical companies for the eTOX project ( is presented. Species, duration of exposure and administration route data were analysed to assess if large enough subsets of homogenous data are available for building in silico predictive models. Prevalence of treatment related effects for the different types of findings recorded were analysed...
2015: Toxicology Reports
Alexander Liede, Justyna Amelio, James Bennett, Helen Goodman, Pamela M Peters, Rebecca Barber, Elizabeth Kehler, J Michael Sprafka
BACKGROUND: Traditional methods for assessing prescriber knowledge can take several years to deliver results. This study was undertaken to obtain insights into the potential for using existing online communities to educate prescribers on therapy-related safety risks. OBJECTIVE: The aim of this study was to describe approaches to measuring prescribers' knowledge of safety risk (osteonecrosis of the jaw) outlined in the European Medicine Agency's summary of product characteristics for denosumab (XGEVA(®))...
2017: Pharmaceutical Medicine
Chris Barber, Vincent Antonucci, Jens-Christoph Baumann, Roland Brown, Elizabeth Covey-Crump, David Elder, Eric Elliott, Jared W Fennell, Fabrice Gallou, Nathan D Ide, Guido Jordine, Jeffrey M Kallemeyn, Dirk Lauwers, Adam R Looker, Lucie E Lovelle, Mark McLaughlin, Robert Molzahn, Martin Ott, Didier Schils, Rolf Schulte Oestrich, Neil Stevenson, Pere Talavera, Andrew Teasdale, Michael W Urquhart, David L Varie, Dennie Welch
The ICH M7 Option 4 control of (potentially) mutagenic impurities is based on the use of scientific principles in lieu of routine analytical testing. This approach can reduce the burden of analytical testing without compromising patient safety, provided a scientifically rigorous approach is taken which is backed up by sufficient theoretical and/or analytical data. This paper introduces a consortium-led initiative and offers a proposal on the supporting evidence that could be presented in regulatory submissions...
November 2017: Regulatory Toxicology and Pharmacology: RTP
Philip M Ahrens, Nicholas I Garlick, Julie Barber, Emily M Tims
BACKGROUND: The treatment of displaced midshaft clavicle fractures remains controversial. METHODS: We undertook a multicenter randomized controlled trial to compare effectiveness and safety between nonoperative management and ORIF (open reduction and internal fixation) for displaced midshaft clavicle fractures in adults. Three hundred and one eligible adult patients were randomized to 1 of the 2 treatment groups and followed at 6 weeks, 3 months, and 9 months after recruitment...
August 16, 2017: Journal of Bone and Joint Surgery. American Volume
K A Sauder, D Dabelea, R Bailey-Callahan, S Kanott Lambert, J Powell, R James, C Percy, B F Jenks, L Testaverde, J M Thomas, R Barber, J Smiley, C W Hockett, V W Zhong, L Letourneau, K Moore, A M Delamater, E Mayer-Davis
BACKGROUND: American Indian (AI) youth are at high risk for type 2 diabetes. OBJECTIVES: To partner with Eastern Band of Cherokee Indians and Navajo Nation to develop a culturally sensitive behavioural intervention for youth (Tribal Turning Point; TTP) and assess feasibility in an 8-month randomized pilot study. METHODS: We enrolled 62 overweight/obese AI children (7-10 years) who participated with ≥1 parent/primary caregiver. Intervention participants (n = 29) attended 12 group classes and five individual sessions...
May 2018: Pediatric Obesity
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