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Aryl hydrocarbon receptor

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https://www.readbyqxmd.com/read/29034060/activation-of-the-aryl-hydrocarbon-receptor-and-risk-of-lymphoma-subtypes
#1
Sonia Sanna, Giannina Satta, Marina Padoan, Sara Piro, Angela Gambelunghe, Lucia Miligi, Giovanni Maria Ferri, Corrado Magnani, Giacomo Muzi, Luigi Rigacci, Maria Giuseppina Cabras, Emanuele Angelucci, Gian Carlo Latte, Attilio Gabbas, Maria Grazia Ennas, Pierluigi Cocco
The aryl hydrocarbon receptor (AhR) is a transcription factor implicated in several pathways known to be relevant in lymphomagenesis. Aim of our study was to explore the link between AhR activation and risk of lymphoma subtypes. We used a Dual-Luciferase Assay(®) and a luminometer to detect the activation of the luciferase gene, in HepG2 cells transfected with a specific reporter systems, by a 50 ml serum aliquot of cases of diffuse large B cell lymphoma (N = 108), follicular lymphoma (N = 85), chronic lymphocytic leukemia (N = 72), multiple myeloma (N = 80), and Hodgkin lymphoma (N = 94) and 357 controls who participated in the multicentre Italian study on gene-environment interactions in lymphoma etiology (ItGxE)...
2017: International Journal of Molecular Epidemiology and Genetics
https://www.readbyqxmd.com/read/29027256/integrated-in-silico-and-in-vivo-approaches-to-investigate-effects-of-bde-99-mediated-by-the-nuclear-receptors-on-developing-zebrafish
#2
Li Zhang, Yaru Jin, Zhihua Han, Hongling Liu, Laihao Shi, Xiaoxue Hua, Jon A Doering, Song Tang, John P Giesy, Hongxia Yu
BDE-99 is one of the most abundant PBDEs, which due to its potential persistence and bioaccumulation occurs in aquatic wildlife. Previous studies in mammals have shown that BDE-99 affected development and disrupted certain endocrine functions through signaling pathways mediated by nuclear receptors (NRs). However, fewer studies have investigated the potential of BDE-99 to interact with NRs in aquatic vertebrates, such as fish. In the present study, interactions between BDE-99 and NRs were investigated by use of in silico and in vivo approaches...
October 12, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29026461/role-of-aryl-hydrocarbon-receptor-in-mesenchymal-stromal-cell-activation-a-minireview
#3
REVIEW
Danilo Candido de Almeida, Laura Sibele Martins Evangelista, Niels Olsen Saraiva Câmara
Mesenchymal stromal cells (MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation. MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response. The aryl-hydrocarbon receptor (AhR) is a sensitive molecule for external signals and it is expressed in MSCs and, upon positive activation, may potentially regulate the MSC-associated immunomodulatory function...
September 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29023933/mir-15a-16-1-suppresses-ahr-dependent-il-22-secretion-in-cd4-t-cells-and-contributes-to-immune-mediated-organ-injury
#4
Zhou Lu, Jiajing Liu, Xiaoming Liu, Enyu Huang, Jiao Yang, Jiawen Qian, Dan Zhang, Ronghua Liu, Yiwei Chu
Interleukin-22 (IL-22), as a link between leukocytic and non-leukocytic cells, has gained increasing attention for its pronounced tissue-protective properties. MicroRNAs (miRNAs), emerging as crucial immune modulators, have been reported to be involved in the production and action of various cytokines. However, the precise control of IL-22 by miRNAs and its subsequent actions remained to be elucidated. In this study, we found a negative correlation between the expression of miR-15a/16-1 and IL-22 in the model of concanavalinA (ConA)-induced immune-mediated liver injury...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29018148/suppression-of-cyp1-members-of-the-ahr-response-by-pathogen-associated-molecular-patterns
#5
Adam G Peres, Robert Zamboni, Irah L King, Joaquín Madrenas
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that triggers a broad response, which includes the regulation of proinflammatory cytokine production by monocytes and macrophages. AHR is negatively regulated by a set of genes that it transcriptionally activates, including the AHR repressor (Ahrr) and the cytochrome P450 1 (Cyp1) family, which are critical for preventing exacerbated AHR activity. An imbalance in these regulatory mechanisms has been shown to cause severe defects in lymphoid cells...
October 10, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29017096/enhancing-mir-132-expression-by-aryl-hydrocarbon-receptor-attenuates-tumorigenesis-associated-with-chronic-colitis
#6
Abdullah M Alzahrani, Hamza Hanieh, Hairul-Islam Mohamed Ibrahim, Omar Mohafez, Tamer Shehata, Mohammad Bani Ismail, Manal Alfwuaires
BACKGROUND: Chronic inflammation in ulcerative colitis (UC) patients is the major risk factor for colitis-associated colon cancer (CAC). Recent evidences have shown that microRNAs (miRNAs) are implicated in CAC pathogenesis. However, the interaction of miRNAs with the transcription factors that alleviate CAC has not been reported. METHODS: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3'-diindolylmethane (DIM) were used to activate aryl hydrocarbon receptor (Ahr) in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CAC in mice...
October 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28992707/-overgrowth-in-children-and-in-adults-novel-clinical-view-novel-genes-novel-phenotypes
#7
Jan Lebl, Lukáš Plachý, Květa Bláhová, Lenka Elblová, Filip Fencl, Stanislava Koloušková, Štěpánka Průhová
Novel genetic findings allow to more reliably elucidate the aetiology and pathogenesis of overgrowth syndromes in children and in adults. The relatively prevalent overgrowth syndromes in foetuses and neonates include Beckwith-Wiedemann (BWS) and Sotos syndromes; in addition, several rare conditions may occur e.g. Simpson-Golabi-Behmel and Weaver syndromes. These syndromes are not connected with overproduction of growth hormone. Their carriers are at risk of hypoglycaemia (in BWS), of congenital malformations and of childhood tumours...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28992067/the-uremic-toxin-indoxyl-sulfate-interferes-with-iron-metabolism-by-regulating-hepcidin-in-chronic-kidney-disease
#8
Hirofumi Hamano, Yasumasa Ikeda, Hiroaki Watanabe, Yuya Horinouchi, Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya, Toshiaki Tamaki
Background: Hepcidin secreted by hepatocytes is a key regulator of iron metabolism throughout the body. Hepcidin concentrations are increased in chronic kidney disease (CKD), contributing to abnormalities in iron metabolism. Levels of indoxyl sulfate (IS), a uremic toxin, are also elevated in CKD. However, the effect of IS accumulation on iron metabolism remains unclear. Methods: We used HepG2 cells to determine the mechanism by which IS regulates hepcidin concentrations...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28986273/ite-suppresses-angiogenic-responses-in-human-artery-and-vein-endothelial-cells-differential-roles-of-ahr
#9
Yan Li, Kai Wang, Qing-Yun Zou, Yi-Zhou Jiang, Chi Zhou, Jing Zheng
Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor is involved in regulation of many essential biological processes including vascular development and angiogenesis. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is an AhR ligand, which regulates immune responses and cancer cell growth. However, the roles of the ITE/AhR pathway in mediating placental angiogenesis remains elusive. Here, we determined if ITE affected placental angiogenic responses via AhR in human umbilical vein (HUVECs) and artery endothelial (HUAECs) cells in vitro...
October 3, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28985473/red-clover-aryl-hydrocarbon-receptor-ahr-and-estrogen-receptor-er-agonists-enhance-genotoxic-estrogen-metabolism
#10
Tareisha L Dunlap, Caitlin E Howell, Nita Mukand, Shao-Nong Chen, Guido F Pauli, Birgit Maria Dietz, Judy L Bolton
Many women consider botanical dietary supplements (BDSs) as safe alternatives to hormone therapy for menopausal symptoms. However, the effect of BDSs on breast cancer risk is largely unknown. In the estrogen chemical carcinogenesis pathway, P450 1B1 metabolizes estrogens to 4-hydroxylated catechols, which are oxidized to genotoxic quinones that initiate and promote breast cancer. In contrast, P450 1A1 catalyzed 2-hydroxylation represents a detoxification pathway. The current study evaluated the effects of red clover, a popular BDS used for women's health, and its isoflavones, biochanin A (BA), formononetin (FN), genistein (GN), and daidzein (DZ), on estrogen metabolism...
October 6, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28982082/modification-and-quantification-of-in-vivo-erod-live-imaging-with-zebrafish-danio-rerio-embryos-to-detect-both-induction-and-inhibition-of-cyp1a
#11
Britta Kais, Richard Ottermanns, Franziska Scheller, Thomas Braunbeck
The visualization of specific activation of the aryl hydrocarbon receptor (AhR) directly in the zebrafish embryo (Danio rerio) via live-imaging is a reliable tool to investigate the presence of dioxin-like substances in environmental samples. The co-existence of inducers and inhibitors of cytochrome P450-dependent monooxygenases (CYP1A) is typical of complex environmental mixtures and requires modifications of the in vivo EROD assay: For this end, zebrafish embryos were used to evaluate the EROD-modifying potentials of common single-compound exposures as well as binary mixtures with the PAH-type Ah-receptor agonist β-naphthoflavone...
October 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28978690/aryl-hydrocarbon-receptor-activation-suppresses-ebf1-and-pax5-and-impairs-human-b-lymphopoiesis
#12
Jinpeng Li, Sudin Bhattacharya, Jiajun Zhou, Ashwini S Phadnis-Moghe, Robert B Crawford, Norbert E Kaminski
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates biological responses to endogenous and environmental chemical cues. Increasing evidence shows that the AHR plays physiological roles in regulating development, homeostasis, and function of a variety of cell lineages in the immune system. However, the role of AHR in human B cell development has not been investigated. Toward this end, an in vitro feeder-free human B cell developmental model system was employed using human cord blood CD34(+) hematopoietic stem/progenitor cells...
October 4, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28973690/early-life-exposure-to-low-levels-of-ahr-agonist-pcb126-3-3-4-4-5-pentachlorobiphenyl-reprograms-gene-expression-in-adult-brain
#13
Neelakanteswar Aluru, Sibel I Karchner, Lilah Glazer
Early life exposure to environmental chemicals can have long-term consequences that are not always apparent until later in life. We recently demonstrated that developmental exposure of zebrafish to low, non-embryotoxic levels of 3,3',4,4',5-pentachlorobiphenyl (PCB126) did not affect larval behavior, but caused changes in adult behavior. The objective of this study was to investigate the underlying molecular basis for adult behavioral phenotypes resulting from early life exposure to PCB126. We exposed zebrafish embryos to PCB126 during early development and measured transcriptional profiles in whole embryos, larvae and adult male brains using RNA-sequencing...
September 9, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973660/high-susceptibility-of-lrig1-sebaceous-stem-cells-to-tcdd-in-mice
#14
F Fontao, L Barnes, G Kaya, J H Saurat, O Sorg
We have previously shown that CYP1A1 was highly induced for a long period of time in a patient who had been poisoned by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a compound known to activate the aryl hydrocarbon receptor (AhR). During that period of time no sebaceous glands could be observed in the skin of this patient. In the present study, starting from observations in the patient exposed to TCDD, we analysed the seboatrophy induced by dioxins in mice. We observed a very different pattern of AhR and CYP1A1 immunostaining in skin biopsies of the patient...
August 30, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973413/aryl-hydrocarbon-receptor-ablation-in-cardiomyocytes-protects-male-mice-from-heart-dysfunction-induced-by-nkx2-5-haploinsufficiency
#15
Qin Wang, Yunxia Fan, Hisaka Kurita, Min Jiang, Sheryl Koch, Marepalli B Rao, Jack Rubinstein, Alvaro Puga
Epidemiological studies in humans and research in vertebrates indicates that developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a ubiquitous and biopersistent environmental toxicant, is associated with incidence of early congenital heart disease in the embryo and later in the adult. TCDD-mediated toxicity depends on the aryl hydrocarbon receptor (AHR) but the role of the TCDD-activated AHR in cardiac function is not well defined. To characterize the mechanisms responsible for AHR-mediated disruption of heart function, we generated several mouse strains with cardiomyocyte-specific Ahr gene knockout...
August 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973376/the-integrity-and-organization-of-the-human-aipl1-functional-domains-is-critical-for-its-role-as-a-hsp90-dependent-co-chaperone-for-rod-pde6
#16
Almudena Sacristan-Reviriego, James Bellingham, Chrisostomos Prodromou, Neruban Kumaran, James Bainbridge, Michel Michaelides, Jacqueline van der Spuy
Biallelic mutations in the photoreceptor-expressed aryl hydrocarbon receptor interacting protein-like 1 (AIPL1) are associated with autosomal recessive Leber congenital amaurosis (LCA), the most severe form of inherited retinopathy in early childhood. AIPL1 functions as a photoreceptor-specific co-chaperone that interacts with the molecular chaperone HSP90 to facilitate the stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoenzyme. In this study, we characterised the functional deficits of AIPL1 variations, some of which induce aberrant pre-mRNA AIPL1 splicing leading to the production of alternative AIPL1 isoforms...
August 26, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28973351/ah-receptor-activation-potentiates-neutrophil-chemoattractant-c-x-c-motif-ligand-5-expression-in-keratinocytes-and-skin
#17
Kayla J Smith, Jacob A Boyer, Gulsum E Muku, Iain A Murray, Krishne Gowda, Dhimant Desai, Shantu G Amin, Adam B Glick, Gary H Perdew
Chemokines are components of the skin microenvironment, which enable immune cell chemotaxis. Traditionally, transcription factors involved in inflammatory signaling (e.g. NFκB) are important mediators of chemokine expression. To what extent xenobiotics and their associated receptors control chemokine expression is poorly understood. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor known to mediate physiological responses in the skin through the regulation of genes involved in xenobiotic metabolism, epidermal differentiation, and immunity...
August 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972393/aryl-hydrocarbon-receptor-suppresses-the-prostate-cancer-lncap-cell-growth-and-invasion-by-promoting-dna-damage-response-under-oxidative-stress
#18
Jing-Song Yu, Peng-Fei Leng, Yi-Fu Li, Yong-Quan Wang, Yan Wang, Rui-Hua An, Ji-Ping Qi
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts with multiple signaling pathways during prostate development. In the present study, LNCaP cells were knocked down of AhR by siRNA, or treated with the AhR agonist 3-methylcholanthrene (3MC). The effects of AhR on LNCaP cells and the associated mechanisms were studied both under normal condition and under hydrogen peroxide (H2O2)-induced oxidative stress. MTT, transwell chamber assays and flow cytometry were employed to investigate cell proliferation, invasion, and apoptosis, respectively, whereas the DNA damage response (DDR) signaling (phosphorylation of ataxia-telangiectasia mutated [ATM], check-point kinase 2 [Chk2], histone H2AX, p53, and cleaved poly-ADP-ribose polymerase [PARP]) was detected by western blotting...
October 3, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28971163/the-aryl-hydrocarbon-receptor-repressor-more-than-a-simple-feedback-inhibitor-of-ahr-signaling-clues-for-its-role-in-inflammation-and-cancer
#19
Christoph F A Vogel, Thomas Haarmann-Stemmann
The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs). Like AhR, AhRR belongs to the basic Helix-Loop-Helix/Per-ARNT-Sim (bHLH/PAS) protein family but lacks functional ligand-binding and transactivation domains. Transient transfection experiments with ARNT and AhRR mutants examining the inhibitory mechanism of AhRR suggested a more complex mechanism than the simple mechanism of negative feedback through sequestration of ARNT to regulate AhR signaling...
February 2017: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/28965292/co-culture-of-jeg-3-bewo-and-syncbewo-cell-lines-with-adrenal-h295r-cell-line-an-alternative-model-for-examining-endocrine-and-metabolic-properties-of-the-fetoplacental-unit
#20
Eliza Drwal, Agnieszka Rak, Ewa Gregoraszczuk
Monocultures of different placental cells are used for many physiological and toxicological studies; however, they are not a true reflection of the interaction between placenta and fetus. To develop the most appropriate model to study endocrine and metabolic properties of fetoplacental unit we used three co-culture models of placental cells nonfusogenic JEG-3, unsyncytialised BeWo (BeWo) and syncytialised BeWo (syncBeWo) cultured with adrenal (H295R) cells. As an end point of endocrine properties we investigated steroids receptors expression and steroid secretion, while as metabolic properties AhR, CYP1A1and COMT expression...
September 30, 2017: Cytotechnology
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