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https://www.readbyqxmd.com/read/29334723/methacholine-bronchial-provocation-test-in-patients-with-asthma-serial-measurements-and-clinical-significance
#1
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsiveness as an objective outcome. The aim of this study was to assess the relationship between serial MBPT and clinical profiles in patients with asthma. Methods: A total of 323 asthma patients were included in this study...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29334545/bacterial-vaginosis-modifies-the-association-between-hormonal-contraception-and-hiv-acquisition
#2
Lisa Haddad, Kristin M Wall, William Kilembe, Bellington Vwailika, Naw Htee, Ilene Brill, Elwyn Chomba, Amanda Tichacek, Susan Allen
OBJECTIVE: To examine BV as an effect modifier for the association between hormonal contraception (HC) and incident HIV infection DESIGN:: Serodiscordant couples enrolled in an open longitudinal cohort in Lusaka, Zambia from 1994-2012. This analysis was restricted to couples with an HIV-positive man enrolled between1994-2002 when a quarterly genital tract examination and HIV testing was performed. METHODS: Multivariate Cox models evaluated the association between contraceptive method and HIV-acquisition, stratified by time-varying BV status...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334197/increased-non-aids-mortality-among-persons-with-aids-defining-events-after-antiretroviral-therapy-initiation
#3
April C Pettit, Mark J Giganti, Suzanne M Ingle, Margaret T May, Bryan E Shepherd, Michael J Gill, Gerd Fätkenheuer, Sophie Abgrall, Michael S Saag, Julia Del Amo, Amy C Justice, Jose M Miro, Matthias Cavasinni, François Dabis, Antonella D Monforte, Peter Reiss, Jodie Guest, David Moore, Leah Shepherd, Niels Obel, Heidi M Crane, Colette Smith, Ramon Teira, Robert Zangerle, Jonathan Ac Sterne, Timothy R Sterling
INTRODUCTION: HIV-1 infection leads to chronic inflammation and to an increased risk of non-AIDS mortality. Our objective was to determine whether AIDS-defining events (ADEs) were associated with increased overall and cause-specific non-AIDS related mortality after antiretroviral therapy (ART) initiation. METHODS: We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) who initiated ART from 1996 to 2014. Causes of death were assigned using the Coding Causes of Death in HIV (CoDe) protocol...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29334126/methylated-pacs-are-more-potent-than-their-parent-compounds-a-study-on-ahr-mediated-activity-degradability-and-mixture-interactions-in-the-h4iie-luc-assay
#4
Monika M Lam, Rebecca Bülow, Magnus Engwall, John P Giesy, Maria Larsson
In this study, 26 polycyclic aromatic compounds (PACs) including native polycyclic aromatic hydrocarbons (PAHs), hydroxylated PAHs, alkylated and oxygenated PAHs and (alkylated) heterocyclic compounds were investigated for their aryl hydrocarbon receptor (AhR)-mediated potencies in the H4IIE-luc bioassay. Potential degradabilities of PACs were investigated by use of various durations of exposure (24, 48 or 72 h). Furthermore, various mixtures of PACs including PAHs, alkylated and oxygenated PAHs and heterocyclic compounds were tested for their joint AhR-mediated potency...
January 15, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29333639/decreasing-deceased-donor-transplant-rates-among-children-%C3%A2-6-years-under-the-new-kidney-allocation-system
#5
Brittany A Shelton, Deirdre Sawinski, Christopher Ray, Rhiannon D Reed, Paul A MacLennan, Justin Blackburn, Carlton J Young, Stephen Gray, Megan Yanik, Allan Massie, Dorry L Segev, Jayme E Locke
The Kidney Allocation System (KAS) was implemented in December 2014 with unknown impact on the pediatric waitlist. To understand the effect of KAS on pediatric registrants, deceased donor kidney transplant (DDKT) rate was assessed using interrupted time series analysis and time-to-event analysis. Two allocation eras were defined with an intermediary washout period: Era 1 (01/01/2013-09/01/2014), Era 2 (09/01/2014-03/01/2015), and Era 3(03/01/2015-03/01/2017). When using Cox proportional hazards, there was no significant association between allocation era and DDKT likelihood as compared to Era 1 (Era 3: aHR: 1...
January 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29331644/ozone-exposure-induces-respiratory-barrier-biphasic-injury-and-inflammation-controlled-by-interleukin-33
#6
Chloé Michaudel, Claire Mackowiak, Isabelle Maillet, Louis Fauconnier, Cezmi Akdis, Milena Sokolowska, Anita Dreher, Hern-Tze Tina Tan, Valérie F Quesniaux, Bernhard Ryffel, Dieudonnée Togbe
BACKGROUND: IL-33 plays critical role in the regulation of tissue homeostasis, injury and repair. Whether IL-33 regulates neutrophil recruitment and function independently of airways hyperresponsiveness (AHR) in ozone induced lung injury and inflammation is unclear. OBJECTIVE: To examine the role of IL-33/ST2 axis in lung inflammation upon acute ozone exposure in mice. METHODS: ST2 and IL-33 deficient mice, IL-33-citrine reporter and C57BL/6 (WT) mice underwent a single ozone exposure (1 ppm for 1h) in all studies...
January 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29330220/regulation-of-drug-metabolism-by-the-interplay-of-inflammatory-signaling-steatosis-and-xeno-sensing-receptors-in-heparg-cells
#7
Norman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M Zanger, Linda Bohmert, Alfonso Lampen, Albert Braeuning
Non-alcoholic fatty liver disease (NAFLD), characterized by triglyceride deposition in hepatocytes due to imbalanced lipid homeostasis, is of increasing concern in Western countries, with progression to non-alcoholic steatohepatitis (NASH), liver fibrosis, and cirrhosis. Previous studies suggest a complex, mutual influence of hepatic fat accumulation, NASH-related inflammatory mediators, and drug-sensing receptors regulating xenobiotic metabolism. Here, we investigated the suitability of human HepaRG hepatocarcinoma cells as a model for NAFLD and NASH...
January 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29330063/risk-of-ischemic-kidney-injury-in-patients-with-nonarteritic-anterior-ischemic-optic-neuropathy-a-nationwide-population-based-study
#8
Ju-Yeun Lee, Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To investigate the risk of acute tubular necrosis (ATN) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN: Population-based cohort study METHODS: This is a nationwide, population-based, retrospective study using data from the Korean national health claims database from 2011 through 2015. Patients with NAION and randomly selected control subjects from the entire Korean population were enrolled. A log rank analysis was used to evaluate a risk of ATN in the group of patients with NAION (study group) compared to an age-, sex-, and comorbidities-matched control group...
January 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29329975/risk-of-suicide-and-non-fatal-self-harm-after-bariatric-surgery-results-from-two-matched-cohort-studies
#9
Martin Neovius, Gustaf Bruze, Peter Jacobson, Kajsa Sjöholm, Kari Johansson, Fredrik Granath, Johan Sundström, Ingmar Näslund, Claude Marcus, Johan Ottosson, Markku Peltonen, Lena M S Carlsson
BACKGROUND: Bariatric surgery reduces mortality, but might have adverse effects on mental health. We assessed the risk of suicide and self-harm after bariatric surgery compared with non-surgical obesity treatment. METHODS: Suicide and non-fatal self-harm events retrieved from nationwide Swedish registers were examined in two cohorts. The non-randomised, prospective Swedish Obese Subjects (SOS) study compared bariatric surgery (n=2010; 1369 vertical-banded gastroplasty, 376 gastric banding, and 265 gastric bypass) with usual care (n=2037; recruitment 1987-2001)...
January 9, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29329322/methylene-tetrahydrofolate-reductase-contributes-to-allergic-airway-disease
#10
Kenneth R Eyring, Brent S Pedersen, Kenneth N Maclean, Sally P Stabler, Ivana V Yang, David A Schwartz
RATIONALE: Environmental exposures strongly influence the development and progression of asthma. We have previously demonstrated that mice exposed to a diet enriched with methyl donors during vulnerable periods of fetal development can enhance the heritable risk of allergic airway disease through epigenetic changes. There is conflicting evidence on the role of folate (one of the primary methyl donors) in modifying allergic airway disease. OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms...
2018: PloS One
https://www.readbyqxmd.com/read/29327362/p-wave-and-interatrial-block-new-predictor-for-atrial-high-rate-episodes-in-patients-with-cardiac-implantable-electronic-devices
#11
José M Rubio Campal, Juan Benezet-Mazuecos, José Antonio Iglesias Bravo, Pepa Sánchez Borque, Ángel Miracle Blanco, Juan José de la Vieja Alarcón, Jaime Martínez Mariscal, Adrian M Baranchuk, Jerónimo Farré Muncharaz
BACKGROUND: The presence of interatrial block (IAB) is associated with the development of atrial fibrillation (AF). The aim of this study was to determine whether P-wave duration and presence of IAB before the implantation of a cardiac implantable electronic device (CIED) are associated with the presence of atrial high rate episodes (AHRE), during long-term follow-up. METHODS: 380 patients (57% men; 75±10 years) were included. IAB was defined according to the International Consensus Criteria...
January 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29325309/-association-of-crohn-s-disease-with-aryl-hydrocarbon-receptor-gene-polymorphisms-and-haplotypes
#12
C Q Wu, S G Cao, X P Xia, C L Xu, S L Xia, X Q Lin, J Jin, R Ding, Y Jiang
Objective: To explore the relationship of Crohn's disease (CD) susceptibility to aryl hydrocarbon receptor (AhR) polymorphisms and haplotypes in Han population in Wenzhou city, China. Methods: A total of 310 CD patients and 573 age- and sex-matched healthy controls were enrolled in our study. Three single nucleotide polymorphisms (SNPs) of AhR(rs10249788,rs2158041,rs2066853) were determined by the improved multiple ligase detection reaction technique. Unconditional logistic regression analyses was applied to analyze the allelic and genotypic differences of each SNP between CD patients and controls, as well as their influence on the clinicopathologic characteristics in CD patients...
January 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29325067/cardiac-rehabilitation-in-patients-with-acute-coronary-syndrome-with-primary-percutaneous-coronary-intervention-is-associated-with-improved-10-year-survival
#13
Madoka Sunamura, Nienke Ter Hoeve, Rita Jg van den Berg-Emons, Eric Boersma, Ron T van Domburg, Marcel L Geleijnse
Aims: We aimed to assess the effects of a multidisciplinary cardiac rehabilitation program (CR) on survival after treatment with primary percutaneous coronary intervention (pPCI) for acute coronary syndrome (ACS). Methods and results: Using propensity matching analysis, a total of 1,159 patients undergoing CR were 1:1 matched with ACS patients who did not undergo CR and survived at least 60 days. Kaplan-Meier analyses and multivariate Cox regression analysis were applied to study differences in survival...
January 9, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29324985/urine-tb-lipoarabinomannan-lam-predicts-mortality-in-hospitalized-hiv-infected-children
#14
Sylvia M LaCourse, Lisa M Cranmer, Irene N Njuguna, John Gatimu, Joshua Stern, Elizabeth Maleche-Obimbo, Judd L Walson, Dalton Wamalwa, Grace John-Stewart, Patricia Pavlinac
Despite diagnostic performance limitations, urine lipoarabinomannan (LAM) predicts death in HIV-infected adults with TB. Pediatric data are limited. Among 137 hospitalized HIV-infected children, mortality was 4.9-fold higher among LAM-positives (127 vs. 31/100 py, aHR 4.92 [95%CI 1.79-13.49]; p=0.002). LAM identifies HIV-infected children at risk for death potentially missed by respiratory sampling.
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29324662/aryl-hydrocarbon-receptor-antagonists-mitigate-the-effects-of-dioxin-on-critical-cellular-functions-in-differentiating-human-osteoblast-like-cells
#15
Chawon Yun, Karina M Katchko, Michael S Schallmo, Soyeon Jeong, Jonghwa Yun, Charlotte H Chen, Joseph A Weiner, Christian Park, Andrew George, Samuel I Stupp, Wellington K Hsu, Erin L Hsu
The inhibition of bone healing in humans is a well-established effect associated with cigarette smoking, but the underlying mechanisms are still unclear. Recent work using animal cell lines have implicated the aryl hydrocarbon receptor (AhR) as a mediator of the anti-osteogenic effects of cigarette smoke, but the complexity of cigarette smoke mixtures makes understanding the mechanisms of action a major challenge. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity AhR ligand that is frequently used to investigate biological processes impacted by AhR activation...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29322661/utility-of-three-novel-insulin-resistance-related-lipid-indexes-for-predicting-type-2-diabetes-mellitus-among-people-with-normal-fasting-glucose-in-rural-china
#16
Bingyuan Wang, Ming Zhang, Yu Liu, Xizhuo Sun, Lu Zhang, Chongjian Wang, Li Linlin, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu
BACKGROUND: Inexpensive and easily measurable indexes are needed to predict type 2 diabetes mellitus (T2DM) early in rural areas of China. We aimed to compare triglyceride glucose (TyG), visceral adiposity (VAI), and lipid accumulation product (LAP) along with traditional individual measures and their ratios for predicting T2DM. METHODS: Data for 11,113 people with baseline normal fasting glucose in a rural Chinese cohort were followed for a median of 6.0 years...
January 11, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29322167/use-of-high-risk-coronary-atherosclerotic-plaque-detection-for-risk-stratification-of-patients-with-stable-chest-pain-a-secondary-analysis-of-the-promise-randomized-clinical-trial
#17
Maros Ferencik, Thomas Mayrhofer, Daniel O Bittner, Hamed Emami, Stefan B Puchner, Michael T Lu, Nandini M Meyersohn, Alexander V Ivanov, Elizabeth C Adami, Manesh R Patel, Daniel B Mark, James E Udelson, Kerry L Lee, Pamela S Douglas, Udo Hoffmann
Importance: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide practice-changing optimizations in coronary artery disease care. Objective: To determine whether high-risk plaque detected by coronary CTA was associated with incident MACE independently of significant stenosis (SS) and cardiovascular risk factors...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29321568/characterization-of-the-cry1ah-resistance-in-asian-corn-borer-and-its-cross-resistance-to-other-bacillus-thuringiensis-toxins
#18
Muhammad Zeeshan Shabbir, Yudong Quan, Zhenying Wang, Alejandra Bravo, Mario Soberón, Kanglai He
Transgenic crops producing insecticidal proteins are effective to manage lepidopteran pests. Development of insect-resistance is the major threat to Bacillus thuringiensis (Bt) crops such as Cry1Ah-Maize. Laboratory selection with Bt-Cry1Ah toxin incorporated in artificial diet, during 48 generations of Asian corn borer (ACB) Ostrinia furnacalis produced 200-fold resistance. This resistant colony ACB-AhR readily consumed and survived on Cry1Ah-expressing Bt-maize. Cross-resistance analysis showed high cross-resistance to Cry1F (464-fold), moderate cross-resistance to Cry1Ab (28...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321166/fetal-and-early-life-antibiotics-exposure-and-very-early-onset-inflammatory-bowel-disease-a-population-based-study
#19
Anne K Örtqvist, Cecilia Lundholm, Jonas Halfvarson, Jonas F Ludvigsson, Catarina Almqvist
OBJECTIVE: Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD. DESIGN: In this cohort study of 827 239 children born in Sweden between 2006 and 2013, we examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models...
January 10, 2018: Gut
https://www.readbyqxmd.com/read/29320557/high-ahr-expression-in-breast-tumors-correlates-with-expression-of-genes-from-several-signaling-pathways-namely-inflammation-and-endogenous-tryptophan-metabolism
#20
Sophie Vacher, Patrice Castagnet, Walid Chemlali, François Lallemand, Didier Meseure, Marc Pocard, Ivan Bieche, Martine Perrot-Applanat
Increasing epidemiological and animal experimental data provide substantial support for the role of aryl hydrocarbon receptor (AhR) in mammary tumorigenesis. The effects of AhR have been clearly demonstrated in rodent models of breast carcinogenesis and in several established human breast cancer cell lines following exposure to AhR ligands or AhR overexpression. However, relatively little is known about the role of AhR in human breast cancers. AhR has always been considered to be a regulator of toxic and carcinogenic responses to environmental contaminants such as TCDD (dioxin) and benzo[a]pyrene (BaP)...
2018: PloS One
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