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https://www.readbyqxmd.com/read/28454052/a-multi-biomarker-approach-in-scallop-chlamys-farreri-to-assess-the-impact-of-contaminants-in-qingdao-coastal-area-of-china
#1
Ruiming Guo, Luqing Pan, Rongwang Ji
A multi-biomarker approach was carried out to classify the environmental quality and the adverse effects of contaminants on scallop Chlamys farreri. The scallops were collected from three sampling stations in Qingdao coastal area of China in March, May, August and October of 2015. A suite of environmental factors and biomarkers, including temperature, salinity, pH, the concentrations of polycyclic aromatic hydrocarbons (PAHs), tetrabromobisphenol A (TBBPA) and metals (Cr, Mn, Cu, Zn, Cd, Pb, As) in seawater and soft tissue, mRNA expression of aryl hydrocarbon receptor (AhR) and P-glycoprotein (P-gp), 7-ethoxyresorufin O-deethylase (EROD), glutathione-S-transferase (GST), uridine-diphosphate-glucuronyl-transferase (UGT), sulfotransferase (SULT), metallothionein (MT), Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), lipid peroxidation (LPO) and protein carbonyl (PC) contents and DNA strand breaks, were measured in the gill and digestive gland...
April 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28453693/racial-disparities-in-prostate-cancer-outcome-among-prostate-specific-antigen-screening-eligible-populations-in-the-united-states
#2
B A Mahal, Y-W Chen, V Muralidhar, A R Mahal, T K Choueiri, K E Hoffman, J C Hu, C J Sweeney, J B Yu, F Y Feng, S P Kim, C J Beard, N E Martin, Q-D Trinh, P L Nguyen
Background: In 2012, the United States Preventive Services Task Force (USPSTF) recommended against prostate-specific antigen (PSA) screening, despite evidence that Black men are at a higher risk of prostate cancer-specific mortality (PCSM). We evaluated whether Black men of potentially screening-eligible age (55-69 years) are at a disproportionally high risk of poor outcomes. Patients and methods: The SEER database was used to study 390 259 men diagnosed with prostate cancer in the United States between 2004 and 2011...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453253/athabasca-oil-sands-petcoke-extract-elicits-biochemical-and-transcriptomic-effects-in-avian-hepatocytes
#3
Doug Crump, Kim Williams, Suzanne Chiu, Yifeng Zhang, Jonathan W Martin
Petroleum coke or "petcoke" is a granular carbonaceous material produced during the upgrading of heavy crude oils, including bitumen. Petcoke dust was recently reported as an environmental contaminant in the Athabasca oil sands region, but the ecotoxicological hazards posed by this complex bitumen-derived material - including those to avian species - have not been characterized. In this study, solvent extracts (x) of delayed and fluid petcoke (xDP and xFP) were prepared and dissolved in dimethylsulfoxide. A water accommodated fraction of delayed petcoke (waDP) was also prepared...
April 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#4
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28445828/targeting-the-aryl-hydrocarbon-receptor-nuclear-translocator-complex-with-dmog-and-stemregenin-1-improves-primitive-hematopoietic-stem-cell-expansion
#5
Carlo Stephan Jackson, Chrisna Durandt, Ilse Janse van Rensburg, Vincent Praloran, Philippe Brunet de la Grange, Michael Sean Pepper
Culture conditions used for the expansion of hematopoietic stem and progenitor cells (HSCs and HPCs, collectively HSPCs) should ideally favor the self renewal of long-term HSCs. At 20% O2, the synthesis of HIF-1α is balanced by its hydroxylation and proteasomal degradation. This favors HSPC differentiation, but can be prevented by culturing CD34+ cord blood cells in the presence of dimethyloxaloylglycine (DMOG). This differentiation may also be reduced by culturing the cells in the presence of Stemregenin 1, an antagonist of the aryl hydrocarbon receptor (AhR)...
April 20, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28445794/post-transplant-malignancy-after-pediatric-kidney-transplantation-retrospective-analysis-of-incidence-and-risk-factors-in-884-patients-transplanted-between-1963-and-2015-at-the-university-of-minnesota
#6
Oscar K Serrano, Ananta S Bangdiwala, David M Vock, Srinath Chinnakotla, Ty B Dunn, Erik B Finger, Raja Kandaswamy, Timothy L Pruett, John S Najarian, Arthur J Matas, Blanche M Chavers
BACKGROUND: Post-transplant malignancy (PTM) remains a concern among pediatric kidney transplant (PKT) recipients. STUDY DESIGN: Between 1963 and 2015, 884 pediatric (age: 0-17 years old) recipients received 1055 PKTs at our institution. Cox proportional hazards models were constructed to identify risk factors for PTM after PKT with time-to-first-PTM as a primary outcome. Secondly, the hazard of death or graft loss was calculated in patients who developed PTM. RESULTS: Median patient survival was 33 years (interquartile range [IQR]: 18...
April 23, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28445259/the-role-of-stat3-and-ahr-in-the-differentiation-of-cd4-t-cells-into-th17-and-treg-cells
#7
Xingxing Liu, Hui Hu, Heng Fan, Dongmei Zuo, Zhexing Shou, Yi Liao, Zhen Nan, Qing Tang
BACKGROUND: This study aimed to investigate the role of aryl hydrocarbon receptor (AhR) and STAT3 gene during the differentiation of cluster of differentiation (CD)4 T cells into T helper (Th)17 and T regulatory (Treg) cells. METHODS: First, CD4 T cells were isolated from the spleen of BALB/c mice. Then, stable CD4 T cells expressing STAT3 shRNA were constructed. CD4 T cells were assigned to one of the following treatments: Th17 group: antibodies against CD3 and CD28, 2...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28443594/diastolic-electrocardiographic-parameters-predict-implantable-device-detected-asymptomatic-atrial-fibrillation
#8
Ahmet İlker Tekkeşin, Yalçın Velibey, Ceyhan Türkkan, Ahmet Taha Alper, Yasin Çakıllı, Tolga Sinan Güvenç, Ozan Tanık, Adnan Kaya, Özlem Yıldırımtürk, Nazmiye Özbilgin, Özge Güzelburç, Ahmet Öz, Regayip Zehir, Kadir Gürkan
BACKGROUND: Atrial fibrillation (AF) is the most common clinically significant arrhythmia. It is now established that atrial high rate episodes (AHRE) correlate highly with AF. AIMS: Present study aimed to investigate the relation between diastolic electrocardiographic parameters and subclinical AF detected by cardiac implantable electronic devices. STUDY DESIGN: This study was cross-sectional study that included a total of 203 patients who had a DDDR pacemaker due to sinus node dysfunction...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28442821/patients-with-diabetes-and-chronic-liver-disease-are-at-increased-risk-for-overall-mortality-a-population-study-from-the-united-states
#9
Maria Stepanova, Stephen Clement, Robert Wong, Sammy Saab, Aijaz Ahmed, Zobair M Younossi
IN BRIEF Chronic liver disease (CLD) and type 2 diabetes have both been linked to increased morbidity and mortality. In this study, the impact of CLD and diabetes on all-cause mortality was quantified at the population level using U.S. population data. Both type 2 diabetes and CLD were found to be independently associated with increased mortality (age-adjusted hazard ratio [aHR] 1.98 and 1.37 for diabetes and CLD, respectively), and having both diabetes and CLD substantially increased the risk of mortality (aHR 2...
April 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/28440659/alleviation-of-multiple-asthmatic-pathologic-features-with-orally-available-and-subtype-selective-gabaa-receptor-modulators
#10
Gloria S Forkuo, Amanda N Nieman, Nina Y Yuan, Revathi Kodali, Olivia B Yu, Nicolas M Zahn, Rajwana Jahan, Guanguan Li, Michael Rajesh Stephen, Margaret L Guthrie, Michael M Poe, Benjamin D Hartzler, Ted William Harris, Gene T Yocum, Charles W Emala, Douglas A Steeber, Douglas C Stafford, James M Cook, Leggy A Arnold
We describe pharmacokinetic and pharmacodynamic properties of two novel oral drug candidates for asthma. Phenolic α4β3γ2 GABAAR selective compound 1 and acidic α5β3γ2 selective GABAAR positive allosteric modulator compound 2 relaxed airway smooth muscle ex vivo and attenuated airway hyperresponsiveness (AHR) in a murine model of asthma. Importantly, compound 2 relaxed acetylcholine contracted human tracheal airway smooth muscle strips. Oral treatment of compound 1 and 2 decreased eosinophils in bronchoalveolar lavage fluid in ovalbumin sensitized and challenged mice, thus exhibiting anti-inflammatory properties...
April 25, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28440019/cervical-cancer-risk-and-impact-of-pap-based-screening-in-hiv-positive-women-on-antiretroviral-therapy-in-johannesburg-south-africa
#11
Eliane Rohner, Mazvita Sengayi, Bridgette Goeieman, Pamela Michelow, Cindy Firnhaber, Mhairi Maskew, Julia Bohlius
Data on invasive cervical cancer (ICC) incidence in HIV-positive women and the effect of cervical cancer screening in sub-Saharan Africa are scarce. We estimated i) ICC incidence rates in women (≥18 years) who initiated antiretroviral therapy (ART) at the Themba Lethu Clinic (TLC) in Johannesburg, South Africa, between 2004-2011; and ii) the effect of a Pap-based screening program. We included 10,640 women; median age at ART initiation: 35 years (interquartile range [IQR] 30-42), median CD4 count at ART initiation: 113 cells/µl (IQR 46-184)...
April 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28439954/survival-and-recurrent-venous-thromboembolism-in-patients-with-first-proximal-or-isolated-distal-deep-vein-thrombosis-and-no-pulmonary-embolism
#12
S Barco, M Corti, A Trinchero, C Picchi, C Ambaglio, S V Konstantinides, F Dentali, M Barone
BACKGROUND: A few studies focused on the risk of recurrence after first acute isolated distal deep vein thrombosis (IDDVT) compared to proximal DVT (PDVT), while the incremental risk of death has never been explored beyond the first three years after acute event. METHODS: Our single-center cohort study included patients with first symptomatic acute PDVT or IDDVT. Patients were excluded if they had concomitant pulmonary embolism (PE) or prior venous thromboembolism...
April 25, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28439933/effect-of-anti-ige-in-occupational-asthma-caused-by-exposure-to-low-molecular-weight-agents
#13
M Ollé-Monge, M J Cruz, S Gomez-Ollés, I Ojanguren, J Vanoirbeek, X Muñoz
BACKGROUND: The role of immunoglobulin (Ig)-E in occupational asthma (OA) due to low molecular weight (LMW) agents is not well established compared to classical atopic asthma. In the present study we evaluate whether anti-IgE monoclonal antibody (mAb) has an effect in a mouse model of OA, using persulfate salts. METHODS: On days 1 and 8, BALB/C mice were dermally sensitized with 5% ammonium persulfate (AP) or dimethyl sulfoxide (DMSO). On days 15, 18 and 21 animals were injected intraperitoneally with anti-IgE mAb or PBS 6 hours before challenge with AP or saline...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28438295/risk-factors-for-oropharynx-cancer-in-a-cohort-of-hiv-infected-veterans
#14
Erin Y Chew, Christine M Hartman, Peter A Richardson, Jose P Zevallos, Andrew G Sikora, Jennifer R Kramer, Elizabeth Y Chiao
OBJECTIVE: To evaluate HIV-related and other clinical risk factors associated with oropharynx cancer (OPSCC) in HIV-infected U.S. Veterans. METHODS: Retrospective cohort study utilizing Veterans Affairs HIV Clinical Case Registry (CCR) data from 1985 to 2010. Outcome was incident OPSCC as indicated by 1 inpatient or 2 outpatient ICD-9 codes. Cox proportional hazard models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to OPSCC diagnosis...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28434239/pcb-126-effects-on-aryl-hydrocarbon-receptor-ubiquitin-and-p53-expression-levels-in-a-fish-product-sparus-aurata-l
#15
Calò Margherita, Bitto Alessandra, Lo Cascio Patrizia, Giarratana Filippo, Altavilla Domenica, Gervasi Teresa, Campone Luca, Cicero Nicola, Licata Patrizia
The aim of the present study is to determine if Ahr ligands as PCB-126, a dioxin-like, might contribute to inhibition of the tumour suppressor p53 by promoting its degradation through proteasome-ubiquitin system (UPS). The findings show, in the presence of PCB-126, a significant increase in p53 immunoreactivity in fish compared to the control. Subsequently, there is a decrease in p53 immunoreactivity at 24 h which is maintained even at 72 h. There is also a slight decrease in ubiquitin immunoreactivity to 12 h compared to the control and a marked decrease to 24 and 72 h...
April 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28433937/perturbation-effect-of-reduced-graphene-oxide-quantum-dots-rgoqds-on-aryl-hydrocarbon-receptor-ahr-pathway-in-zebrafish
#16
Jing-Hui Zhang, Tai Sun, Aping Niu, Yu-Mei Tang, Shun Deng, Wei Luo, Qun Xu, Dapeng Wei, De-Sheng Pei
Graphene quantum dots (GQDs) has been widely used in enormous fields, however, the inherent molecular mechanism of GQDs for potential risks in biological system is still elusive to date. In this study, the outstanding reduced graphene quantum dots (rGOQDs) with the QY as high as 24.62% were successfully synthesized by the improved Hummers method and DMF hydrothermal treatment approach. The rGOQDs were N-doped photoluminescent nanomaterials with functional groups on the surface. The fluorescent bio-imaging was performed by exposing zebrafish in different concentrations of the as-prepared rGOQDs, and the distribution of rGOQDs was successfully observed...
April 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28433708/toxicological-characterisation-of-two-novel-selective-aryl-hydrocarbon-receptor-modulators-in-sprague-dawley-rats
#17
Selma Mahiout, Jere Lindén, Javier Esteban, Ismael Sánchez-Pérez, Satu Sankari, Lars Pettersson, Helen Håkansson, Raimo Pohjanvirta
The aryl hydrocarbon receptor (AHR) mediates the toxicity of dioxins, but also plays important physiological roles. Selective AHR modulators, which elicit some effects imparted by this receptor without causing the marked toxicity of dioxins, are presently under intense scrutiny. Two novel such compounds are IMA-08401 (N-acetyl-N-phenyl-4-acetoxy-5-chloro-1,2-dihydro-1-methyl-2-oxo-quinoline-3-carboxamide) and IMA-07101 (N-acetyl-N-(4-trifluoromethylphenyl)-4-acetoxy-1,2-dihydro-5-methoxy-1-methyl-2-oxo-quinoline-3-carboxamide)...
April 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28433444/risk-of-ocular-hypertension-in-adults-with-noninfectious-uveitis
#18
Ebenezer Daniel, Maxwell Pistilli, Srishti Kothari, Naira Khachatryan, R Oktay Kaçmaz, Sapna S Gangaputra, H Nida Sen, Eric B Suhler, Jennifer E Thorne, C Stephen Foster, Douglas A Jabs, Robert B Nussenblatt, James T Rosenbaum, Grace A Levy-Clarke, Nirali P Bhatt, John H Kempen
PURPOSE: To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN: Retrospective, multicenter, cohort study. PARTICIPANTS: Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics. METHODS: Demographic, ocular, and treatment data were extracted from medical records of uveitis cases. MAIN OUTCOME MEASURES: Prevalent and incident OHT with intraocular pressures (IOPs) of ≥21 mmHg, ≥30 mmHg, and increase of ≥10 mmHg from documented IOP recordings (or use of treatment for OHT)...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28431065/cha2ds2-vasc-score-and-blood-biomarkers-to-identify-patients-with-atrial-high-rate-episodes-and-paroxysmal-atrial-fibrillation
#19
Paulina Wakula, Benjamin Neumann, Jens Kienemund, Eva Thon-Gutschi, Tatjana Stojakovic, Martin Manninger, Daniel Scherr, Hubert Scharnagl, Martin Kapl, Burkert Pieske, Frank R Heinzel
Aims: Paroxysmal atrial fibrillation (PAF) is often asymptomatic but nonetheless harmful. We evaluated the performance of disease-related blood biomarkers and CHA2DS2-VASc score to discriminate for PAF in patients with continuous rhythm monitoring. Methods and Results: Clinical data and blood samples were obtained from patients with dual-chamber pacemakers selected according to the absence (no_AHRE) or presence of Atrial High-Rate Episodes (AHRE) >6 min in recent device history (case-control approach)...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28428138/pregnane-x-receptor-regulates-the-ahr-cyp1a1-pathway-and-protects-liver-cells-from-benzo-%C3%AE-pyrene-induced-dna-damage
#20
Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian
Pregnane X receptor (PXR) plays an important role in protecting cells from mutagenic DNA damages induced by endogenous and exogenous toxicants. This protective function is often attributed to the PXR-regulated metabolic detoxification. Here we report a novel potential mechanism that PXR reduces benzo-[α]-pyrene(BaP)-induced DNA damage through inhibiting the transcriptional activity of aryl hydrocarbon receptor (AhR) which plays a pivotal role in the bioactivation of BaP. We have utilized three well-characterized cell lines, i...
April 17, 2017: Toxicology Letters
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