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https://www.readbyqxmd.com/read/30103288/designing-an-ultra-short-antibacterial-peptide-with-potent-activity-against-mupirocin-resistant-mrsa
#1
Giovinna Arfan, Chu Yang Fann Ong, Siew Mei Samantha Ng, Qiu Ying Lau, Fui Mee Ng, Esther Hong Qian Ong, Jeffrey Hill, C S Brian Chia
Staphylococcus aureus is the pathogen responsible for the majority of human skin infections. In particular, the Meticillin-resistant variety, MRSA, has become a global clinical concern. The extensive use of Mupirocin, the first-line topical antibacterial drug of choice, has led to the emergence of Mupirocin-resistant MRSA globally, resulting in the urgent need for a replacement. Antimicrobial peptides are deemed plausible candidates. Herein, we describe a structure-activity relationship approach in the design of an ultra-short peptide with potent anti-MRSA activity with a rapid, bactericidal mode of action...
August 13, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/30103284/bvcold1-a-novel-aquaporin-from-sugar-beet-beta-vulgaris-l-involved-in-boron-homeostasis-and-abiotic-stress
#2
Rosa Porcel, Antonio Bustamante, Roc Ros, Ramón Serrano, José Miguel Mulet
Beta vulgaris (sugar beet) is one of the most important industrial crops. Screening of a cDNA library for sugar beet genes able to confer cold tolerance upon overexpression in yeast identified a novel aquaporin, which we named BvCOLD1. The amino acid sequence of BvCOLD1 indicated that is an acidic protein (pI 5,18) similar to TIP aquaporins. RNA expression analysis indicated that BvCOLD1 is expressed in all sugar beet organs. Confocal microscopy of a GFP tagged version localized BvCOLD1 in the endoplasmic reticulum in yeast and in plant cells...
August 13, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/30103262/fully-automated-and-integrated-multiplex-detection-of-high-consequence-livestock-viral-genomes-on-a-microfluidic-platform
#3
Oliver Lung, Mathew Fisher, Anthony Erickson, Charles Nfon, Aruna Ambagala
Differential diagnosis of diseases that share common clinical signs typically requires the performance of multiple independent diagnostic tests to confirm diagnosis. Diagnostic tests that can detect and discriminate between multiple differential pathogens in a single reaction may expedite, reduce costs and streamline the diagnostic testing workflow. Livestock hemorrhagic diseases like classical swine fever (CSF), African swine fever (ASF), and vesicular diseases such as foot-and-mouth disease (FMD), vesicular stomatitis (VS) and swine vesicular disease (SVD) can have an enormous impact on the livestock industry and economy of countries that were previously free of the diseases...
August 13, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/30103259/isolation-and-characterization-of-a-highly-pathogenic-strain-of-porcine-enteric-alphacoronavirus-causing-watery-diarrhea-and-high-mortality-in-newborn-piglets
#4
Zhichao Xu, Yun Zhang, Lang Gong, Licheng Huang, Ying Lin, Jianru Qin, Yunping Du, Qingfeng Zhou, Chunyi Xue, Yongchang Cao
Porcine enteric alphacoronavirus (PEAV) was first discovered in China in February 2017, and the origin and virulence of this novel porcine coronavirus were not fully characterized. Here, we isolated a strain of PEAV, named GDS04 that is identified by immunofluorescence and typical crown-shaped particles observed with electron microscopy. Genomic analysis reveals that PEAV GDS04 shares a close relationship with SADS-CoV and SeACoV. Furthermore, newborn piglets orally challenged with PEAV GDS04 developed typical clinical symptoms as watery diarrhea in neonatal piglets...
August 13, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/30103258/novel-nr5a1-mutations-found-in-chinese-patients-with-46-xy-disorders-of-sex-development
#5
Bingqing Yu, Zhaoxiang Liu, Yinjie Gao, Jiangfeng Mao, Xi Wang, Ming Hao, Wanlu Ma, Qibin Huang, Rui Zhang, Min Nie, Xueyan Wu
OBJECTIVE: To analyze nuclear receptor subfamily 5 group A member 1 (NR5A1) gene mutations in a cohort of Chinese patients with 46,XY Disorders of Sex Development (DSD). METHODS: Sixty 46,XY DSD patients were recruited at Peking Union Medical College Hospital. Targeted next-generation and Sanger sequencing were performed to investigate pathogenic gene variants and validate NR5A1 gene variants, respectively. In silico tools and in vitro function studies were used to analyze the pathogenicity of rare variants...
August 13, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/30103257/microbiological-decontamination-of-water-improving-the-solar-disinfection-technique-sodis-with-the-use-of-non-toxic-vital-dye-methylene-blue
#6
Janine S Cardoso-Rurr, Juliana Patrão de Paiva, Ivan G Paulino-Lima, Tatiana A M de Alencar, Claudia A S Lage, Alvaro C Leitão
Rational use of water is a major challenge for governments and global organizations, with easy and inexpensive interventions being sought by communities that are not supplied with drinking water. In this context, solar disinfection (SODIS) has shown great efficiency for water disinfection. To speed up the process and improve inactivation, we studied the effects of methylene blue (MB) as a photodynamic agent because of its ability to absorb visible light (red wavelength) and generate singlet oxygen as a reactive species, thereby inactivating bacteria and viruses present in water...
August 13, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/30103196/intranasal-immunization-of-cocktail-fusion-protein-containing-tir-along-with-%C3%AE-g-active-fragment-of-zot-as-mucosal-adjuvant-confers-enhanced-immunogenicity-and-reduces-e-coli-o157-h7-shedding-in-mice
#7
Aravind Shekar, Shylaja Ramlal, Joseph Kingston Jeyabalaji, Murali Harishchandra Sripathy
Ruminants are the major reservoirs of Escherichia coli O157:H7 and its fecal shedding mainly act as a source of entry of this pathogen into the human food chain. In humans, E. coli O157:H7 infection causes diarrhea, hemorrhagic colitis and hemolytic uremic syndrome. Intimate adherence of E. coli O157:H7 is mediated by Translocated intimin receptor (Tir) to which intimin binds in the host cell. Since E. coli O157:H7 colonizes intestinal epithelium, the mucosal vaccine has a potential to prevent its colonization...
August 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30103157/arch-shaped-multiple-target-sensing-for-rapid-diagnosis-and-identification-of-emerging-infectious-pathogens
#8
Bonhan Koo, Ki Ho Hong, Choong Eun Jin, Ji Yeun Kim, Sung-Han Kim, Yong Shin
Rapid identification of emerging infectious pathogens is crucial for preventing public health threats. Various pathogen detection techniques have been introduced; however, most techniques are time-consuming and lack multiple-target detection specificity. Although multiple-target detection techniques can distinguish emerging infectious pathogens from related pathogens, direct amplification methods have not been widely examined. Here, we present a novel arch-shaped multiple-target sensor capable of rapid pathogen identification using direct amplification in clinical samples...
August 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30103148/overexpression-of-rcc3-improves-root-system-architecture-and-enhances-salt-tolerance-in-rice
#9
Xingxing Li, Rongrong Chen, Yanli Chu, Junyang Huang, Liang Jin, Guixue Wang, Junli Huang
Root system architecture represents an underexplored target for improving global crop yields. In this study, we investigated the biological role of the rice root-specific gene RCc3 in improving root growth and responses to abiotic stress by overexpressing RCc3 in rice plants. RCc3 was induced by osmotic and heat stress. RCc3 overexpression produced pleiotropic phenotypes of improved root system architecture, including increased growth of primary root, adventitious roots and lateral roots at the seedling stage...
August 8, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/30103083/a-novel-mutation-of-dystrophin-in-a-becker-muscular-dystrophy-family-with-severe-cardiac-involvement-from-genetics-to-clinicopathology
#10
Liang Chen, Jie Ren, Xiao Chen, Kai Chen, Man Rao, Ningning Zhang, Wenhua Yu, Jiangping Song
BACKGROUND: Dystrophin gene defects are the pathogenic molecular basis of Becker muscular dystrophy (BMD), characterised by skeletal myopathy and cardiomyopathy. Because of the broad phenotype spectrum, it was difficult to use the traditional diagnostic method to achieve an early accurate diagnosis of BMD-associated cardiomyopathy. METHODS: We applied an in-house gene panel testing and a gene-filtering strategy to investigate the genetic defect in a four-generation family with 73 members...
July 26, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30103077/advancement-of-near-infrared-nir-laser-interceded-surface-enactment-of-proline-functionalized-graphene-oxide-with-silver-nanoparticles-for-proficient-antibacterial-antifungal-and-wound-recuperating-therapy-in-nursing-care-in-hospitals
#11
Xin Wu, Hui Li, Ning Xiao
Medication obstruction of microscopic organisms has turned into a worldwide medical issue, as it makes the ordinary anti-toxins less effective. It is desperately expected to investigate novel antibacterial materials and create viable treatment techniques to defeat the medication obstruction of anti-infection agents. Herein, we effectively fabricated silver nanoparticles improved proline/graphene oxide nano-flakes (GO-Pro/n-Ag) as novel anti-pathogenic substance through simplistic technique. The property of the silver nanoparticles activated discharge gave amazing antibacterial and antifungal movement against the pathogenic microorganism...
July 18, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30103073/potential-of-mesenchymal-stromal-cells-for-improving-islet-transplantation-outcomes
#12
REVIEW
Chloe L Rackham, Peter M Jones
Allogeneic islet transplantation as a therapy for Type 1 Diabetes (T1D) is restricted by the limited availability of donor islets, loss of functional islets during pre-transplantation culture in vitro and further extensive loss during the immediate post-transplantation period when islet function and survival is compromised by the hypoxic, inflammatory host environment. In the longer term pathogenic T cell responses drive autoimmunity and chronic allograft rejection. Experimental studies have demonstrated that mesenchymal stromal cells (MSCs) have significant potential to improve the outcomes of clinical islet transplantation...
August 10, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/30103048/occurrence-and-fate-of-endotoxin-activity-at-drinking-water-purification-plants-and-healthcare-facilities-in-japan
#13
Dai Simazaki, Masaaki Hirose, Hisashi Hashimoto, Shunji Yamanaka, Mitsuki Takamura, Junya Watanabe, Michihiro Akiba
Occurrence of residual endotoxin activity (ET) in dialysis water and also tap water as its source is a matter of great concern to medical professionals conducting dialysis therapy at healthcare facilities (HCFs). The present study was performed to determine the occurrence and fate of the ET at selected Japanese drinking water purification plants and HCFs between 2014 and 2016. Chemical coagulation and sedimentation, rapid sand filtration, and membrane filtration were highly effective to decrease both ET dissolved in water (free-ET) and ET bound to cells/particles (bound-ET)...
August 6, 2018: Water Research
https://www.readbyqxmd.com/read/30103044/recommendations-and-barriers-to-vaccination-in-systemic-lupus-erythematosus
#14
REVIEW
Megha Garg, Naaima Mufti, Tara Palmore, Sarfaraz Hasni
Patients with Systemic Lupus Erythematosus (SLE) pose a unique dilemma pertaining to immunization against common pathogens. SLE patients are usually not immunized with vaccines based on the fear of either precipitating infection in this immunosuppressed patient population (with live vaccines) or aggravating autoimmunity and hence lupus flares (with any vaccines). However, elevated vulnerability to infection makes patients with SLE precisely the population that needs protection from vaccine-preventable diseases...
August 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30103036/further-delineation-of-tbck-infantile-hypotonia-with-psychomotor-retardation-and-characteristic-facies-type-3
#15
Eugenio Zapata-Aldana, David Dongkyung Kim, Salma Remtulla, Chitra Prasad, Cam-Tu Nguyen, Craig Campbell
Deleterious homozygous or compound heterozygous mutations in the TBCK (TBC1-domain-containing kinase) gene (implicated in the MTOR pathway) produce profound hypotonia, global developmental delay, facial dysmorphic features, and brain abnormalities. The disorder has been named "infantile hypotonia with psychomotor retardation and characteristic facies-3" (IHPRF3). Here we present two sisters with a novel mutation in TBCK (NM_001163435.2: c.753dup; p.(Lys252*)) who have this ultrarare disorder. We have reviewed the literature on the 33 previously reported cases to provide a characterization of this emerging phenotype...
August 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/30103014/draft-genome-sequence-of-a-ndm-5-ctx-m-15-and-oxa-1-co-producing-escherichia-coli-st167-clinical-strain-isolated-from-urine-sample
#16
Long Sun, Juan Xu, Fang He
OBJECTIVES: Escherichia coli is the leading cause of urinary tract infections worldwide. Carbapenemase producing clinical isolates leave few therapeutic options. Here we report the draft genome sequence of a NDM-5, CTX-M-15, and OXA-1 co-producing E. coli ST167: a multidrug-resistant strain isolated from urine sample of a male hospitalized patient diagnosed with intracranial injury from a traffic accident. METHODS: The genome of E. coli ECWJ1 was sequenced using the Illumina HiSeq™ 4000 platform...
August 10, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/30103001/fraxinellone-has-anticancer-activity-in-vivo-by-inhibiting-programmed-cell-death-ligand-1-expression-by-reducing-hypoxia-inducible-factor-1%C3%AE-and-stat3
#17
Yue Xing, Chunliu Mi, Zhe Wang, Zhi Hong Zhang, Ming Yue Li, Hong Xiang Zuo, Jing Ying Wang, Xuejun Jin, Juan Ma
Dictamnus dasycarpus is a traditional Chinese medicine that has been commonly used in the treatment of cancer. Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. However, whether fraxinellone exerts anticancer effects and the mechanisms by which it may inhibit tumor growth remain unknown. Here, we found that fraxinellone, in a dose-dependented manner, inhibited the expression of programmed cell death ligand-1 (PD-L1), which plays a pivotal role in tumorigenesis...
August 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30102993/bioassay-guided-isolation-and-uhplc-dad-esi-ms-ms-quantification-of-potential-anti-inflammatory-phenolic-compounds-from-flowers-of-inula-montana-l
#18
Elnur Garayev, Carole Di Giorgio, Gaëtan Herbette, Fathi Mabrouki, Philippe Chiffolleau, David Roux, Huguette Sallanon, Evelyne Ollivier, Riad Elias, Béatrice Baghdikian
ETHNOPHARMACOLOGICAL RELEVANCE: Flowers of Inula montana L. (Asteraceae), commonly known as "Arnica de Provence", are used in the traditional medicine of Provence in France with the same indication as Arnica montana, for the relief of bruises, as an anti-inflammatory agent. AIMS OF THE STUDY: The aim of our study is to evaluate its anti-inflammatory properties and to justify its traditional uses. Its potential valorization is evaluated in order to propose Inula montana as an alternative to Arnica montana...
August 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30102990/using-bioreactors-to-study-the-effects-of-drugs-on-the-human-microbiota
#19
REVIEW
Mabel Guzman-Rodriguez, Julie A K McDonald, Richard Hyde, Emma Allen-Vercoe, Erika C Claud, Prameet M Sheth, Elaine O Petrof
The study of complex microbial communities has become a major research focus as mounting evidence suggests the pivotal role microbial communities play in host health and disease. Microbial communities of the gastrointestinal tract, known as the gut microbiota, have been implicated in aiding the host with vitamin biosynthesis, regulation of host energy metabolism, immune system development, and resistance to pathogen invasion. Conversely, disruptions of the gut microbiota have been linked to host morbidity, including the development of inflammatory diseases, metabolic disorders, increased cardiovascular risk, and increased risk of infectious diseases...
August 10, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/30102976/the-genetic-relationship-between-r-microplus-and-r-decoloratus-ticks-in-south-africa-and-their-population-structure
#20
Samantha Baron, Nicolaas A van der Merwe, Christine Maritz-Olivier
Rhipicephalus microplus and R. decoloratus are one-host ticks that preferentially feed on cattle. They are capable of transmitting various tick-borne pathogens which may be detrimental to the agricultural and livestock industry in South Africa. Previous studies have shown that R. microplus forms five lineages in the R. microplus complex, segregating into different geographical areas based on mitochondrial markers. This study examined the phylogenetic relationship within and between R. microplus and R. decoloratus using the nuclear internal transcribed spacer 2 (ITS2) and mitochondrial cytochrome oxidase subunit I (COI) genes...
August 10, 2018: Molecular Phylogenetics and Evolution
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