Read by QxMD icon Read

Traumatic Brain Injury And Long Term Potentiation

Guilherme Gozzoli Podolsky-Gondim, Luciano Lopes Furlanetti, Dinark Conceição Viana, Matheus Fernando Manzolli Ballestero, Ricardo Santos de Oliveira
INTRODUCTION: Head injury is a significant economic, social, and medical problem in developing countries and remains one of the leading causes of pediatric morbidity and mortality. The association of traumatic brain injury and coagulopathy in children is linked with an increase in mortality and poor functional outcomes. However, its impact on long-term outcome has not been discussed in the literature so far. OBJECTIVES: The aim of this paper was to investigate the effect of coagulopathy diagnosed by routine laboratory tests on neurological outcome following traumatic brain injury in children...
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Andriy O Glushakov, Olena Y Glushakova, Tetyana Y Korol, Sandra A Acosta, Cesar V Borlongan, Alex B Valadka, Ronald L Hayes, Alexander V Glushakov
Traumatic brain injury (TBI) is associated with long-term disabilities and devastating chronic neurological complications including problems with cognition, motor function, sensory processing, as well as behavioral deficits and mental health problems such as anxiety, depression, personality change and social unsuitability. Clinical data suggest that disruption of the thalamo-cortical system including anatomical and metabolic changes in the thalamus following TBI might be responsible for some chronic neurological deficits following brain trauma...
October 13, 2018: International Journal of Molecular Sciences
Hsiao-Yue Wee, Chung-Han Ho, Ching-Hung Chang, Chung-Ching Chio, Jhi-Joung Wang, Che-Chuan Wang, Jinn-Rung Kuo
BACKGROUND: Traumatic brain injury (TBI) has been reported as a risk factor for brain tumor, but whether TBI affects systemic cancer remains to be determined. We aimed to investigate the incidence and factors associated with cancer development in TBI patients. MATERIALS AND METHODS: A propensity score (age, gender, and comorbidity)-matched longitudinal cohort study of 34,556 pre-existing TBI patients and 69,112 patients without TBI between January 2000 and December 2015 was presented using Taiwan's National Health Insurance Research Database...
October 9, 2018: World Neurosurgery
Lonnie G Petersen, Justin S Lawley, Alexander Lilja-Cyron, Johan Cg Petersen, Erin J Howden, Satyam Sarma, William K Cornwell, Rong Zhang, Louis A Whitworth, Michael A Williams, Marianne Juhler, Benjamin D Levine
KEY POINTS: During long-term missions, some astronauts experience structural and functional changes of the eyes and brain which resemble signs/symptoms experienced by patients with intracranial hypertension. Weightlessness prevents the normal cerebral volume and pressure "unloading" associated with upright postures on Earth, which may be part of the cerebral and ocular pathophysiology. By placing the lower body in a negative pressure device (LBNP) that pulls fluid away from cranial compartments, we simulated effects of gravity and significantly lowered pressure within the brain parenchyma and ventricle compartments...
October 4, 2018: Journal of Physiology
Quan Du, Jian-Feng Weng, Li-Feng Luo, Meng Cen, Wen-Hua Yu, Yong-Ke Zheng, Wei Hu, Jian-Wei Pan, Xiao-Qiao Dong
BACKGROUND: ST2, a receptor of interleukin-33, is involved in inflammation. We discerned the relationship between serum soluble ST2 (sST2) concentrations, inflammation, severity and prognosis following traumatic brain injury (TBI). METHODS: We measured serum sST2, interleukin-6, tumor necrosis factor-alpha, C-reactive protein, myelin basic protein, glial fibrillary astrocyte protein, S100B, neuron-specific enolase, phosphorylated axonal neurofilament subunit H, Tau and ubiquitin carboxyl-terminal hydrolase L1 concentrations in 106 healthy controls and 106 severe TBI patients...
September 25, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Ashley L Russell, Robert J Handa, T John Wu
Traumatic brain injury (TBI) affects 1.7 million people in the United States every year, resulting in increased risk of death and disabilities. A significant portion of TBIs experienced by military personnel are induced by explosive blast devices. Active duty military personnel are especially vulnerable to mild blast-induced (mb)TBI and the associated long-term effects, such as anxiety disorders. Additionally, females are at an increased risk of being diagnosed with anxiety-related disorders. The mechanism by which mbTBI results in anxiety disorders in males and females is unknown...
September 22, 2018: Neuroscience
Patricia E G Bestelmeyer, Nick J Davis, Oren Poliva, Robert D Rafal
Auditory agnosia is an inability to make sense of sound that cannot be explained by deficits in low-level hearing. In view of recent promising results in the area of neurorehabilitation of language disorders after stroke, we examined the effect of transcranial direct current stimulation (tDCS) in a young woman with general auditory agnosia caused by traumatic injury to the left inferior colliculus. Specifically, we studied activations to sound embedded in a block design using functional magnetic resonance imaging before and after application of anodal tDCS to the right auditory cortex...
September 2018: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
Xiao-Hong Wang, Qiang Liu, Ze-Tao Shao
Traumatic brain injury (TBI) is a major cause of death and disability, also resulting in long-term serious neurological impairment in survivors. However, the pathogenesis of TBI has not been fully understood. Jun dimerization protein 2 (JDP2) is a member of the AP-1 family of transcription factors, containing a basic region-leucine zipper motif. JDP2 plays essential roles in various cellular processes, including differentiation, apoptosis, senescence and aging. In the study, we attempted to explore the effects of JDP2 on TBI progression both in vivo and in vitro...
October 12, 2018: Biochemical and Biophysical Research Communications
Jenny E Ozga, Jessica M Povroznik, Elizabeth B Engler-Chiurazzi, Cole Vonder Haar
Executive function is an umbrella term that includes cognitive processes such as decision-making, impulse control, attention, behavioral flexibility, and working memory. Each of these processes depends largely upon monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in the frontal cortex, striatum, and hippocampus, among other brain areas. Traumatic brain injury (TBI) induces disruptions in monoaminergic signaling along several steps in the neurotransmission process - synthesis, distribution, and breakdown - and in turn, produces long-lasting deficits in several executive function domains...
October 2018: Behavioural Pharmacology
Bao-Liang Zhang, Yue-Shan Fan, Ji-Wei Wang, Zi-Wei Zhou, Yin-Gang Wu, Meng-Chen Yang, Dong-Dong Sun, Jian-Ning Zhang
Traumatic brain injury can cause loss of neuronal tissue, remote symptomatic epilepsy, and cognitive deficits. However, the mechanisms underlying the effects of traumatic brain injury are not yet clear. Hippocampal excitability is strongly correlated with cognitive dysfunction and remote symptomatic epilepsy. In this study, we examined the relationship between traumatic brain injury-induced neuronal loss and subsequent hippocampal regional excitability. We used hydraulic percussion to generate a rat model of traumatic brain injury...
October 2018: Neural Regeneration Research
Colleen N Bodnar, Josh M Morganti, Adam D Bachstetter
A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury (TBI). Depression is one of these long-term complications that influences many aspects of life. Depression can limit the ability to return to work, and even worsen cognitive function and contribute to dementia. The mechanistic cause for the increased depression risk associated with a TBI remains to be defined. As TBI results in chronic neuroinflammation, and priming of glia to a secondary challenge, the inflammatory theory of depression provides a promising framework for investigating the cause of depression following a TBI...
October 2018: Neural Regeneration Research
Xintong Ge, Jinwen Yu, Shan Huang, Zhenyu Yin, Zhaoli Han, Fanglian Chen, Zengguang Wang, Jianning Zhang, Ping Lei
BACKGROUND: Athletes, military personnel and mobility-declined elderly people are prone to repetitive mild traumatic brain injury (rmTBI). The injury does not cause acute pathological changes, but leads to chronic neurodegeneration, long-term cognitive dysfunction and even chronic traumatic encephalopathy (CTE). Many existing rmTBI animal models reported uncontrollable adverse effects and long experiment period. Therefore, an improved model needs to be designed. NEW METHOD: Our rmTBI mouse model is a modification of the closed head injury method using electronic controlled cortical impact system...
August 1, 2018: Journal of Neuroscience Methods
Hugh H Chan, Connor A Wathen, Nicole D Mathews, Olivia Hogue, James P Modic, Ronak Kundalia, Cara Wyant, Hyun-Joo Park, Imad M Najm, Bruce D Trapp, Andre G Machado, Kenneth B Baker
BACKGROUND: Many traumatic brain injury (TBI) survivors live with persistent disability from chronic motor deficits despite contemporary rehabilitation services, underscoring the need for novel treatment. OBJECTIVE/HYPOTHESIS: We have previously shown that deep brain stimulation (DBS) of the lateral cerebellar nucleus (LCN) can enhance post-stroke motor recovery and increase the expression of markers of long-term potentiation in perilesional cerebral cortex. We hypothesize that a similar beneficial effect will be for motor deficits induced by unilateral fluid percussion injury (FPI) in rodents through long-term potentiation- and anti-inflammatory based mechanisms...
July 25, 2018: Brain Stimulation
Daniel M Costello, Andrew H Kaye, Terence J O'Brien, Sandy R Shultz
Sport-related concussion is a common form of mild traumatic brain injury that is now recognised as a serious health issue. Growing evidence suggests concussion may result in long-term and severe neurological disabilities. Recent research into the diagnosis and management of concussion may provide new approaches to concussion management that limit the potential long-term adverse effects of concussion. This paper summarises the problem of sport-related concussion and reviews key factors (sex, age, genetics) that may modify concussion outcomes...
July 25, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Rajesh K Aneja, Alicia M Alcamo, Jessica Cummings, Vincent Vagni, Keri Feldman, Qingde Wang, C Edward Dixon, Timothy R Billiar, Patrick M Kochanek
High mobility group box 1 (HMGB1) is a prototypical danger-associated molecular pattern molecule that is considered a late mediator of neuro-inflammation after traumatic brain injury (TBI). Prior studies have suggested that targeting HMGB1 may lead to neuroprotective effects, but none of these studies have reported cognitive outcomes. We hypothesized that loss of HMGB1 before and after TBI would markedly attenuate post-traumatic brain edema, blood-brain barrier (BBB) permeability, improve functional deficits and long-term neuropathology versus control mice...
September 5, 2018: Journal of Neurotrauma
Nicholas B Angstman, Hans-Georg Frank, Christoph Schmitz
Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, we show that cavitation is a key injurious factor in the damaging shock wave component. Short and long lifespan C. elegans mutants demonstrated the interaction of genetic and environmental longevity-determining factors...
July 12, 2018: Scientific Reports
Niketa A Patel, Lauren Daly Moss, Jea-Young Lee, Naoki Tajiri, Sandra Acosta, Charles Hudson, Sajan Parag, Denise R Cooper, Cesario V Borlongan, Paula C Bickford
BACKGROUND: Neuroinflammation is a common therapeutic target for traumatic brain injury (TBI) due to its contribution to delayed secondary cell death and has the potential to occur for years after the initial insult. Exosomes from adipose-derived stem cells (hASCs) containing the long noncoding RNA MALAT1 are a novel, cell-free regenerative approach to long-term recovery after traumatic brain injury (TBI) that have the potential to modulate inflammation at the genomic level. The long noncoding RNA MALAT1 has been shown to be an important component of the secretome of hASCs...
July 12, 2018: Journal of Neuroinflammation
Bamini Gopinath, Gerald Liew, Ashley Craig, Ilaria Pozzato, Susanne Meares, George Burlutsky, Ian D Cameron, Paul Mitchell
The adverse long-term consequences following traumatic brain injury are poorly understood, particularly on the cerebral microvasculature. Retinal vessels are a surrogate marker of cerebral vascular changes. We therefore aimed to examine the cross-sectional association between serious head injury or being knocked unconscious, and/or concussion and retinal microvascular signs, specifically, mean retinal arteriolar and venular calibre, in older adults after accounting for potential confounders. This cohort study involved 2,624 adults with mean age of 66...
2018: PloS One
Daniel Agustin Godoy, Jose Orquera, Alejandro A Rabinstein
Paroxysmal sympathetic hyperactivity represents an uncommon and potentially life-threatening complication of severe brain injuries, which are most commonly traumatic. This syndrome is a clinical diagnosis based on the recurrent occurrence of tachycardia, hypertension, diaphoresis, tachypnea, and occasionally high fever and dystonic postures. The episodes may be induced by stimulation or may occur spontaneously. Underdiagnosis is common, and delayed recognition may increase morbidity and long-term disability...
April 2018: Revista Brasileira de Terapia Intensiva
Vedrana Đurić, Bojan Batinić, Jelena Petrović, Dušanka Stanić, Zorica Bulat, Vesna Pešić
Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 μg/animal), mimicking the stress- and depression-like conditions...
February 1, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"