Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
Miao Ding, Mahyar Heydarpour, Dulce Hiraci Gomez, Hayat Aljaibeji, Wasita Warachit Parksook, Liming Peng, Luminita H Pojoga, Jose R Romero, Gordon H Williams
The authors have withdrawn their manuscript owing to editing error. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
June 15, 2023: bioRxiv
#22
REVIEW
Arshed F Al-Obeidi, Johannes Nowatzky
Behçet's disease (BD) is a multi-system inflammatory disorder with vasculitic features. It does not suit any of the current pathogenesis-driven disease classifications well, a unifying concept of its pathogenesis is not unanimously conceivable at present, and its etiology is obscure. Still, evidence from immunogenetic and other studies supports the notion of a complex-polygenic disease with robust innate effector responses, reconstitution of regulatory T cells upon successful treatment, and first clues to the role of an, as of yet, underexplored adaptive immune system and its antigen recognition receptors...
August 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#23
REVIEW
Irini Evnouchidou, Despoina Koumantou, Mathilde Nugue, Loredana Saveanu
Antigen (Ag)-trimming aminopeptidases belong to the oxytocinase subfamily of M1 metallopeptidases. In humans, this subfamily contains the endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) and the insulin-responsive aminopeptidase (IRAP, synonym oxytocinase), an endosomal enzyme. The ability of these enzymes to trim antigenic precursors and to generate major histocompatibility class-I ligands has been demonstrated extensively for ERAP1, less for ERAP2, which is absent in rodents, and exclusively in the context of cross-presentation for IRAP...
May 20, 2023: Current Opinion in Immunology
#24
JOURNAL ARTICLE
Ioannis Temponeras, Martina Samiotaki, Despoina Koumantou, Martha Nikopaschou, Jonas J W Kuiper, George Panayotou, Efstratios Stratikos
ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues of peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory site that accommodates the C-terminus of at least some peptide substrates, raising questions about its exact influence on antigen presentation and the potential of allosteric inhibition for cancer immunotherapy. We used an inhibitor that targets this regulatory site to study its effect on the immunopeptidome of a human cancer cell line...
May 3, 2023: European Journal of Immunology
#25
JOURNAL ARTICLE
Marta Wagner, Maciej Sobczyński, Monika Jasek, Konrad Pawełczyk, Irena Porębska, Piotr Kuśnierczyk, Andrzej Wiśniewski
BACKGROUND: ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding. As an important component of the antigen processing and presenting machinery - APM, ERAP1 is frequently down-regulated in many cancers. Since ERAP1 expression has not yet been thoroughly investigated in non-small cell lung cancer (NSCLC), we decided to analyze ERAP1 mRNA levels in tissues collected from NSCLC patients...
April 26, 2023: BMC Cancer
#26
JOURNAL ARTICLE
Wenna Gao, Xuemin Jin, Pengyi Zhou, Haiyan Zhu, Kunpeng Xie, Bo Jin, Liping Du
OBJECTIVES: Substantial evidence has highlighted the mediation of endoplasmic reticulum aminopeptidase 1 (ERAP1) in the onset of Behçet's disease (BD), which can be differentially converted by ERAP1 variants. To comprehensively elaborate this issue, we undertook the meta-analysis to estimate the liaison of ERAP1 polymorphisms with BD risk. METHODS: Literatures were retrieved in a standardised fashion and data underwent multi-perspective analyses utilizing STATA Statistical Software...
April 13, 2023: Clinical and Experimental Rheumatology
#27
REVIEW
Fiona Limanaqi, Chiara Vicentini, Irma Saulle, Mario Clerici, Mara Biasin
Type-I diabetes mellitus (T1DM) is generally considered as a chronic, T-cell mediated autoimmune disease. This notwithstanding, both the endogenous characteristics of β-cells, and their response to environmental factors and exogenous inflammatory stimuli are key events in disease progression and exacerbation. As such, T1DM is now recognized as a multifactorial condition, with its onset being influenced by both genetic predisposition and environmental factors, among which, viral infections represent major triggers...
April 12, 2023: Life Sciences
#28
JOURNAL ARTICLE
Hye-Myung Ryu, S M Shamsul Islam, Hasan M Sayeed, Rahar Babita, Je Kyung Seong, Ho Lee, Seonghyang Sohn
Behçet's disease (BD) is a chronic multisystem inflammatory disorder. Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphism has been reported as a risk factor for BD. However, the immunological role of ERAP1 in BD remains unclear. Therefore, the purpose of this study was to investigate the immunological role of ERAP1 in BD using a mouse model. ERAP1 incomplete expressing mice (ERAP1 hetero, +/-) were generated and inoculated with herpes simplex virus 1 to produce a BD mouse model. In these mice, dendritic cell activation markers and other immune response-related markers were analyzed...
May 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#29
REVIEW
Jonas Jw Kuiper, Jörg C Prinz, Efstratios Stratikos, Piotr Kuśnierczyk, Akiko Arakawa, Sebastian Springer, Dillon Mintoff, Ivan Padjen, Russka Shumnalieva, Seçil Vural, Ina Kötter, Marleen G van de Sande, Ayşe Boyvat, Joke H de Boer, George Bertsias, Niek de Vries, Charlotte Lm Krieckaert, Inês Leal, Nataša Vidovič Valentinčič, Ilknur Tugal-Tutkun, Hanane El Khaldi Ahanach, Félicie Costantino, Simon Glatigny, Danijela Mrazovac Zimak, Fabian Lötscher, Floor G Kerstens, Marija Bakula, Elsa Viera Sousa, Peter Böhm, Kees Bosman, Tony J Kenna, Simon J Powis, Maxime Breban, Ahmet Gul, John Bowes, Rik Ju Lories, Johannes Nowatzky, Gerrit Jan Wolbink, Dennis G McGonagle, Franktien Turkstra
The 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis...
July 2023: Annals of the Rheumatic Diseases
#30
Zachary Maben, Richa Arya, Dimitris Georgiadis, Efstratios Stratikos, Lawrence J Stern
No abstract text is available yet for this article.
March 20, 2023: Nature Communications
#31
JOURNAL ARTICLE
Rhea Raghu, Lesia O Kurlak, Eun D Lee, Hiten D Mistry
INTRODUCTION: Endoplasmic reticulum resident protein 44 (ERp44) is a zinc-metalloprotein, regulating Endoplasmic reticulum aminopeptidase 1 (ERAP1) and Angiotensin II (Ang II). We explored placental ERp44 expression and components of the renin-angiotensin-system (RAS) in pre-eclampsia (PE), correlating these to ERAP1 expression and placental zinc concentrations. METHODS: Placental tissue, taken at time of delivery in normotensive women or women with PE (n = 12/group), were analysed for ERp44, AT1R, AT2R and AT4R by qPCR...
February 22, 2023: Placenta
#32
REVIEW
Brian Hur, Veronica Wong, Eun D Lee
The fundamental basis of pregnancy and cancer is to determine the fate of the survival or the death of humanity. However, the development of fetuses and tumors share many similarities and differences, making them two sides of the same coin. This review presents an overview of the similarities and differences between pregnancy and cancer. In addition, we will also discuss the critical roles that Endoplasmic Reticulum Aminopeptidase (ERAP) 1 and 2 may play in the immune system, cell migration, and angiogenesis, all of which are essential for fetal and tumor development...
February 9, 2023: International Journal of Molecular Sciences
#33
JOURNAL ARTICLE
Farhad Babaie, Hamed Mohammadi, Sorayya Salimi, Alireza Ghanavatinegad, Mitra Abbasifard, Mehdi Yousefi, Mehrzad Hajaliloo, Younes Khalili, Sajjad Zamanlou, Roghaiyeh Safari, Maryam Hemmatzadeh, Alireza Rezaiemanesh, Reza Salimi, Behzad Baradaran, Zohreh Babaloo
BACKGROUND: We aimed to assess if Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms might impress Human leukocyte antigen (HLA)-B27-free heavy chains (FHCs) expression on macrophages and eventually NK cell activation in Ankylosing spondylitis (AS). METHODS: Blood samples were obtained from 10 HLAB27+ patients with protective and 10 HLAB27+ patients with non-protective genotype. Monocytes were isolated and polarized toward M1 and M2 macrophages. ERAP1 was inhibited in macrophages, which were then co-cultured with autologous NK cells...
February 16, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#34
REVIEW
Giorgia Paldino, Alessandra Fierabracci
Type 1 diabetes mellitus (T1D) is a multifactorial organ specific autoimmune disease which originates from the destruction of insulin-producing beta cells within the pancreatic islets by autoreactive CD8+ T lymphocytes. The autoimmune responses are raised against autoantigenic peptides presented in the context of the Major Histocompatibility Complex (MHC) class I molecules. Peptides are generated in the cytoplasm of the beta cell by degradation through the proteasome activity and other proteases. Proteolytic intermediate protein fragments are then vehicled into the endoplasmic reticulum (ER) by transporters associated with antigen processing TAP1 and TAP2...
February 3, 2023: Autoimmunity Reviews
#35
JOURNAL ARTICLE
Nigil Haroon, Robert D Inman
No abstract text is available yet for this article.
March 2023: Nature Reviews. Rheumatology
#36
JOURNAL ARTICLE
Alina I Marusina, Antonio Ji-Xu, Stephanie T Le, Atrin Toussi, Lam C Tsoi, Qinyuan Li, Guillaume Luxardi, Jordan Nava, Lauren Downing, Annie R Leal, Nikolay Y Kuzminykh, Olga Kruglinskaya, Marie-Charlotte Brüggen, Iannis E Adamopoulos, Alexander A Merleev, Johann E Gudjonsson, Emanual Maverakis
ERAP1, ERAP2 and LNPEP are aminopeptidases implicated in autoimmune pathophysiology. Here, we demonstrate that ERAP2 is upregulated and ERAP1 is downregulated in patients with psoriasis who are homozygous for autoimmune-linked variants of ERAP. We also demonstrate that aminopeptidase expression is not uniform in the skin. Specifically, the intracellular antigen-processing aminopeptidases ERAP1 and ERAP2 were strongly expressed in basal and early spinous layer keratinocytes, while granular layer keratinocytes expressed predominantly LNPEP, an aminopeptidase specialized in the processing of extracellular antigens for MHC class I cross-presentation...
January 27, 2023: Journal of Investigative Dermatology
#37
JOURNAL ARTICLE
R Naveen, Shivika Guleria, Namita Mohindra, Amita Aggarwal
OBJECTIVES: Long-term functional outcomes in enthesitis-related arthritis (ERA) is limited from developing countries. We assessed the clinical and genetic factors that predicted the long-term functional outcome in ERA. METHODS: Patients with ERA having ≥5 years of disease and > 16 years of age were included in this cross-sectional study. Data on clinical features within 6 months of disease onset was collected from hospital records...
January 25, 2023: Rheumatology
#38
JOURNAL ARTICLE
Karin Schmidt, Matthias Leisegang, Peter-Michael Kloetzel
The therapy of cancer by adoptive T cell transfer (ACT) requires T cell receptors (TCRs) with optimal affinity for HLA class I-bound peptides (pHLA-I). But not every patient responds to ACT. Therefore, it is critical to understand the individual factors influencing the recognition of HLA class I-bound peptides (pHLA-I) by TCRs. Focusing on three immunotherapy-targeted human HLA-A* 02:01-presented T cell epitopes we investigated the contribution of the ER-resident aminopeptidases ERAP1 and ERAP2 to TCR recognition of cancer cells...
January 4, 2023: Molecular Immunology
#39
JOURNAL ARTICLE
Salma Abo El Nazar, Amany A Ghazy, Ibrahim Amer, Salwa Tawfik, Marwa Nassar, Eman M Osman
Different genetic and environmental factors are implicated in type I diabetes (T1DM) pathogenesis. About 50% of the genetic susceptibility for T1DM is related to human leukocyte antigen (HLA) genes. Other non-HLA genes have variable roles in the destruction of pancreatic β cells. A highly variable gene called endoplasmic reticulum associated with antigen processing gene 1(ERAP1) shares in activating autoreactive CD8+ T lymphocytes, peptide trimming, and subsequent pancreatic β cells destruction...
January 2023: Egyptian Journal of Immunology
#40
JOURNAL ARTICLE
W J Venema, S Hiddingh, G M C Janssen, J Ossewaarde, N Dam van Loon, J H de Boer, P A van Veelen, J J W Kuiper
BACKGROUND: HLA-A29-positive birdshot chorioretinitis (BCR) is an inflammatory eye disorder that is generally assumed to be caused by an autoimmune response to HLA-A29-presented peptides from retinal arrestin (SAG), yet the epitopes recognized by CD8+ T cells from patients remain to be identified. OBJECTIVES: The identification of natural ligands of SAG presented by HLA-A29. To quantify CD8+ T cells reactive to antigenic SAG peptides presented by HLA-A29 in patients and controls...
December 26, 2022: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
