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JOURNAL ARTICLE
Marco Tagliamento, Alessandra Gennari, Matteo Lambertini, Ramon Salazar, Nadia Harbeck, Lucia Del Mastro, Juan Aguilar-Company, Mark Bower, Rachel Sharkey, Alessia Dalla Pria, Andrea Plaja, Amanda Jackson, Jasmine Handford, Ailsa Sita-Lumsden, Clara Martinez-Vila, Marta Matas, Ana Miguel Rodriguez, Bruno Vincenzi, Giuseppe Tonini, Alexia Bertuzzi, Joan Brunet, Paolo Pedrazzoli, Francesca D'Avanzo, Federica Biello, Alasdair Sinclair, Alvin J X Lee, Sabrina Rossi, Gianpiero Rizzo, Oriol Mirallas, Isabel Pimentel, Maria Iglesias, Ana Sanchez de Torre, Annalisa Guida, Rossana Berardi, Alberto Zambelli, Carlo Tondini, Marco Filetti, Francesca Mazzoni, Uma Mukherjee, Nikolaos Diamantis, Alessandro Parisi, Avinash Aujayeb, Aleix Prat, Michela Libertini, Salvatore Grisanti, Maura Rossi, Federica Zoratto, Daniele Generali, Cristina Saura, Gary H Lyman, Nicole M Kuderer, David J Pinato, Alessio Cortellini
PURPOSE: Although representing the majority of newly diagnosed cancers, patients with breast cancer appear less vulnerable to COVID-19 mortality compared with other malignancies. In the absence of patients on active cancer therapy included in vaccination trials, a contemporary real-world evaluation of outcomes during the various pandemic phases, as well as of the impact of vaccination, is needed to better inform clinical practice. METHODS: We compared COVID-19 morbidity and mortality among patients with breast cancer across prevaccination (February 27, 2020-November 30, 2020), Alpha-Delta (December 1, 2020-December 14, 2021), and Omicron (December 15, 2021-January 31, 2022) phases using OnCovid registry participants (ClinicalTrials...
January 31, 2023: Journal of Clinical Oncology
#22
JOURNAL ARTICLE
Tena Trbojević, Ana Penezić, Ingrid Sitaš, Marko Velimir Grgić, Maja Malenica Ravlić, Iva Mihatov Štefanović
PURPOSE: Orbital cellulitis is a serious condition with potentially severe complications. Treatment requires interdisciplinary care and early introduction of antimicrobial therapy. In our tertiary center, a team of pediatricians, pediatric ophthalmologists, and otorhinolaryngologists successfully participated in the management of pediatric periorbital/orbital cellulitis. This study aimed to demonstrate our interdisciplinary approach and to investigate clinical profile and management of pediatric periorbital/orbital cellulitis...
January 2023: Indian Journal of Ophthalmology
#23
JOURNAL ARTICLE
Husam H Balkhy, Sarah Nisivaco, Hiroto Kitahara, Abdulrahman AbuTaleb, Sandeep Nathan, Ibraheem Hamzat
OBJECTIVE: Advanced hybrid coronary revascularization is the integration of sternal-sparing multivessel coronary artery bypass grafting and percutaneous coronary intervention in patients with multivessel coronary artery disease. We sought to review our advanced hybrid coronary revascularization experience over an 8.5-year period using robotic totally endoscopic coronary artery bypass with bilateral internal thoracic artery grafts and percutaneous coronary intervention. METHODS: From August 2013 to February 2022, 664 patients underwent robotic totally endoscopic coronary artery bypass at our institution...
December 2022: JTCVS techniques
#24
JOURNAL ARTICLE
P Groenewald, R Pacella, F Sitas, O F Awotiwon, N Vellios, C J Van Rensburg, S Manda, R Laubscher, B Nojilana, J D Joubert, D Labadarios, L Ayo-Yusuf, R A Roomaney, E B Turawa, I Neethling, N Abdelatif, V Pillay-van Wyk, D Bradshaw
BACKGROUND: Ongoing quantification of the disease burden attributable to smoking is important to monitor and strengthen tobacco control policies. OBJECTIVES: To estimate the attributable burden due to smoking in South Africa for 2000, 2006 and 2012. METHODS: We estimated attributable burden due to smoking for selected causes of death in South African (SA) adults aged ≥35 years for 2000, 2006 and 2012. We combined smoking prevalence results from 15 national surveys (1998 - 2017) and smoking impact ratios using national mortality rates...
September 30, 2022: South African Medical Journal
#25
JOURNAL ARTICLE
Alessio Cortellini, Gino M Dettorre, Urania Dafni, Juan Aguilar-Company, Luis Castelo-Branco, Matteo Lambertini, Spyridon Gennatas, Vasileios Angelis, Ailsa Sita-Lumsden, Jacobo Rogado, Paolo Pedrazzoli, David Viñal, Aleix Prat, Maura Rossi, Rossana Berardi, Teresa Alonso-Gordoa, Salvatore Grisanti, Georgia Dimopoulou, Paola Queirolo, Sylvain Pradervand, Alexia Bertuzzi, Mark Bower, Dirk Arnold, Ramon Salazar, Marco Tucci, Kevin J Harrington, Francesca Mazzoni, Uma Mukherjee, Zoi Tsourti, Olivier Michielin, Fanny Pommeret, Joan Brunet, Bruno Vincenzi, Giuseppe Tonini, Andrea Patriarca, Federica Biello, Marco Krengli, Josep Tabernero, George Pentheroudakis, Alessandra Gennari, Solange Peters, Emanuela Romano, David J Pinato
BACKGROUND: As management and prevention strategies against COVID-19 evolve, it is still uncertain whether prior exposure to immune checkpoint inhibitors (ICIs) affects COVID-19 severity in patients with cancer. METHODS: In a joint analysis of ICI recipients from OnCovid (NCT04393974) and European Society for Medical Oncology (ESMO) CoCARE registries, we assessed severity and mortality from SARS-CoV-2 in vaccinated and unvaccinated patients with cancer and explored whether prior immune-related adverse events (irAEs) influenced outcome from COVID-19...
November 2022: Journal for Immunotherapy of Cancer
#26
JOURNAL ARTICLE
Xiaoqin Zhao, Ping Huang, Jie Yuan
OBJECTIVE: This research sets out to investigate the influence of glimepiride (GLIM) plus sitagliptin (SITA) on the treatment outcome, blood glucose (BG), and oxidative stress (OS) in diabetic patients. METHODS: In this retrospective study, 189 patient cases of type 2 diabetes mellitus (T2DM) admitted from July 2017 to July 2021 to the Affiliated Hospital of Nantong University were selected, of whom 99 cases treated with GLIM + SITA were assigned to the research group (RG) and 90 cases receiving GLIM monotherapy were set as the control group (CG)...
2022: American Journal of Translational Research
#27
JOURNAL ARTICLE
Mustafa Sadek, Alaaeldin Mohamed Saad, Patrice Nordmann, Laurent Poirel
An extensively drug-resistant Escherichia coli clinical isolate (N1606) belonging to Sequence Type 361 was recovered from the urine of a patient hospitalized in Switzerland. The strain showed resistance to virtually all β-lactams including the latest generation antibiotics cefiderocol and aztreonam-avibactam. Whole genome sequencing revealed that it possessed two carbapenemase-encoding genes, namely bla NDM-5 and bla KPC-3 , and a series of additional β-lactamase genes, including bla CTX-M-15 and bla SHV-11 encoding extended-spectrum β-lactamases (ESBLs), bla CMY-145 encoding an AmpC-type cephalosporinase, and bla OXA-1 encoding a narrow-spectrum class D ß-lactamase...
October 26, 2022: Antibiotics
#28
JOURNAL ARTICLE
Robert Chapman, Sita Shah
No abstract text is available yet for this article.
July 2022: Future Healthcare Journal
#29
JOURNAL ARTICLE
Sita Shah, Robert Chapman
No abstract text is available yet for this article.
July 2022: Future Healthcare Journal
#30
JOURNAL ARTICLE
Christophe Chiquet, Catherine Vignal, Philippe Gohier, Emmanuel Heron, Gilles Thuret, Marie Bénédicte Rougier, Audrey Lehmann, Laurent Flet, Jean-Louis Quesada, Mathieu Roustit, Dan Milea, Jean-Louis Pepin
BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAAION) is a major cause of blindness in individuals over 50 years of age, with no available effective treatment. The oral dual endothelin receptor antagonist, bosentan, increases retinal optic nerve head blood flow in healthy humans and glaucoma patients. The objective of this trial is to assess the efficacy of bosentan administered at the acute stage in improving outcomes in NAAION patients. METHODS: ENDOTHELION (ENDOTHELin antagonist receptor in Ischemic Optic Neuropathy) is a phase III, interventional, prospective, multicentre, placebo-controlled randomised double-blind clinical trial...
October 29, 2022: Trials
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REVIEW
Zahra Zhu, Elizabeth Bolt, Kyra Newmaster, Wendy Osei-Bonsu, Stacey Cohen, Vishnu Anand Cuddapah, Siddharth Gupta, Sita Paudel, Debopam Samanta, Louis T Dang, Paul R Carney, Sunil Naik
BACKGROUND: Pathogenic variants in SCN1B, the gene encoding voltage-gated sodium channel b1/b1B subunits are associated with a spectrum of epileptic disorders. This study describes a child with early myoclonic encephalopathy and a compound heterozygous variant in the SCN1B gene (p.Arg85Cys and c.3G>C/p.Met1), along with the child's clinical response to anti-seizure medications (ASMs) and the ketogenic diet. We reviewed the current clinical literature pertinent to SCN1B-related epilepsy...
October 1, 2022: Children
#32
JOURNAL ARTICLE
Sita J Saunders, Jody L Grisamore, Tess Wong, Rafael Torrejon Torres, Rhodri Saunders, Brett Einerson
BACKGROUND: Leveraging the safety profile of the synthetic hygroscopic cervical dilator (SHCD), one potential way to reduce the burden-of-care provision in the labor-and-delivery unit without compromising safety is to introduce a low-acuity care room (ripening room) for patients undergoing cervical ripening as a part of labor induction at term. METHODS: Implementing a ripening room using SHCDs was compared to scenarios using prostaglandins including a dinoprostone insert (PGE2 insert) or gel (PGE2 gel) and misoprostol given orally (oral PGE1) or vaginally (vaginal PGE1)...
October 24, 2022: Journal of Medical Economics
#33
JOURNAL ARTICLE
Sita T Clark, Hilary R Barker, Luke R Bradshaw, Jyoti Kathuria, Charlotte Oyston
AIMS: Cervical cancer is the fourth most common malignancy in females worldwide. Large loop excision of the transformation zone (LLETZ) procedures remain the preferred surgical technique to remove squamous cervical intraepithelial neoplasia (CIN) lesions globally. This study aimed to assess whether the depth of LLETZ procedures at Counties Manukau District Health Board (CMDHB) met established standards of care. METHODS: Hospital records were reviewed for all LLETZ procedures performed at CMDHB between 1 June 2020 to 3 May 2021, and these were compared to Public Health England's (PHE) 2020 Colposcopy Guidelines...
September 2, 2022: New Zealand Medical Journal
#34
JOURNAL ARTICLE
Radha Devi Dhakal, Shobhana Nepal, Namuna Thapa, Sushma Sapkota, Sita Kc, Prativa Adhikari
BACKGROUND: The utilization of institutional delivery services is pivotal to improve maternal health and reducing maternal mortality amid childbirth. But COVID-19 pandemic is posturing considerable challenges to maintain essential maternal and newborn health services. So study aims to assess the factors associated with the utilization of institutional delivery during the COVID -19 pandemic. METHODS: Data was collected from the 116 mothers of Kalika Municipality, Chitwan...
June 2, 2022: Journal of Nepal Health Research Council
#35
JOURNAL ARTICLE
Rikke Munk Killingmo, Alessandro Chiarotto, Danielle A van der Windt, Kjersti Storheim, Sita M A Bierma-Zeinstra, Milada C Småstuen, Zinajda Zolic-Karlsson, Ørjan N Vigdal, Bart W Koes, Margreth Grotle
BACKGROUND: Back pain is an extensive burden to our healthcare system, yet few studies have explored modifiable prognostic factors associated with high costs related to healthcare utilization, especially among older back pain patients. The aims of this study were to identify modifiable prognostic factors for high costs related to healthcare utilization among older people seeking primary care with a new episode of back pain; and to replicate the identified associations in a similar cohort, in a different country...
June 18, 2022: BMC Health Services Research
#36
JOURNAL ARTICLE
Shirish Silwal, Dinesh Prasad Koirala, K M Didarul Islam, Sanjeev Kharel, Sita Thapa, Subita Neupane
Background: Splenectomy is a palliative management technique in children with β-thalassemia. Portal thrombosis is the most dreaded complication after splenectomy that requires fast diagnosis, effective therapy, and good follow-up to prevent protal hypertension. Thus, there is the importance of constant evaluation of portal venous system through Color Doppler Ultrasound. This cohort study aimed to observe the changes in the portal venous system in post-splenectomised β-thalassemic children...
May 2022: Annals of Medicine and Surgery
#37
JOURNAL ARTICLE
Ajay Prabhakar Sankhe, Nanasaheb Somnath Memane, Vijaykumar P Gawali, Sonal Nanasaheb Memane, Ganesh Ramakrishnan, Tapanendu Kundu, Mayur Nimba Bagul, Ashotosh Kumar, Vikram Bansal, Rashmi Tiwari
INTRODUCTION: Limited treatment options exist for COVID-19 infections; thus, attempts from complementary and alternative systems (CAM) of medicine are being explored as possible therapeutic options. Ayurcov is a formulation made of ingredients mentioned in Ayurveda. These constituents have proven antiviral, detoxifying, immune-modulating, and bio-enhancing properties. The present study was carried out to evaluate the therapeutic effect and safety of Ayurcov in patients with various severity states of COVID-19 infections...
March 24, 2022: Complementary Therapies in Medicine
#38
JOURNAL ARTICLE
Floris H de Vos, Duncan E Meuffels, Marleen de Mul, Marjan Askari, Erwin Ista, Suzanne Polinder, Erwin Waarsing, Sita M Bierma-Zeinstra, Max Reijman
BACKGROUND: Anterior cruciate ligament (ACL) rupture is a very common knee injury in the sport active population. There is much debate on which treatment (operative or non-operative) is best for the individual patient. In order to give a more personalized recommendation we aim to evaluate the effectiveness and cost-effectiveness of a treatment algorithm for patients with a complete primary ACL rupture. METHODS: The ROTATE-trial is a multicenter, open-labeled cluster randomized controlled trial with superiority design...
February 5, 2022: BMC Musculoskeletal Disorders
#39
JOURNAL ARTICLE
Daniele Roberto Giacobbe, Michele Mirabella, Matteo Rinaldi, Angela Raffaella Losito, Francesca Raffaelli, Filippo Del Puente, Carolina Saffioti, Malgorzata Mikulska, Maddalena Giannella, Pierluigi Viale, Mario Tumbarello, Matteo Bassetti, On Behalf Of Sita Giovani Young Investigators Group Of The Società Italiana Terapia Antinfettiva And The Coli-Cross Study Group
Colistin is a last-resort agent for the treatment of infections due to Gram-negative bacteria with difficult-to-treat resistance. The primary objective of this post hoc analysis of a cross-sectional study conducted in 22 Italian hospitals was to assess factors associated with inadequate intravenous colistin dosage. Overall, 187 patients receiving intravenous colistin were included in the analyses. Inadequate colistin dosages were administered in 27% of cases (50/187). In multivariable analysis, AKI (dummy variable with KDIGO stage 0 as a reference, odds ratio (OR) 3...
December 19, 2021: Antibiotics
#40
JOURNAL ARTICLE
Mwiza Gideon Singini, Freddy Sitas, Debbie Bradshaw, Wenlong Carl Chen, Melitah Motlhale, Abram Bunya Kamiza, Chantal Babb de Villiers, Cathryn M Lewis, Christopher G Mathew, Tim Waterboer, Robert Newton, Mazvita Muchengeti, Elvira Singh
BACKGROUND: Aside from human papillomavirus (HPV), the role of other risk factors in cervical cancer such as age, education, parity, sexual partners, smoking and human immunodeficiency virus (HIV) have been described but never ranked in order of priority. We evaluated the contribution of several known lifestyle co-risk factors for cervical cancer among black South African women. METHODS: We used participant data from the Johannesburg Cancer Study, a case-control study of women recruited mainly at Charlotte Maxeke Johannesburg Academic Hospital between 1995 and 2016...
2021: PloS One
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