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Near infrared fluorescence

Andrew D Newton, Jarrod D Predina, Shuming Nie, Philip S Low, Sunil Singhal
Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow® ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery...
August 11, 2018: Journal of Surgical Oncology
Yu Liu, Xu-Man Chen, Yong Chen, Qilin Yu, Bo-Han Gu
Organelle-targeted cell imaging still remains a key challenge in supramolecular chemistry in recent years. Herein, we report a two-stage mediated near-infrared (NIR) emissive supramolecular assembly for lysosome-targeted cell imaging. In this system, 4,4'-anthracene-9,10-diylbis(ethene-2,1-diyl))bis(1-ethylpyridin-1-ium) bromide (ENDT) has been synthesized as an organic dye with weak fluorescence emission at 625nm. When ENDT complexes with cucurbit[8]uril (CB[8]), this binary supramolecular complex assembles into nanorods and achieve a near-infrared fluorescence emission (655 nm) and fluorescence enhancement as the first stage...
August 11, 2018: Angewandte Chemie
Daniele Mattevi, L G Luciani, W Mantovani, T Cai, S Chiodini, V Vattovani, M Puglisi, G Malossini
To compare the functional and operative outcomes of robot-assisted partial nephrectomy with selective arterial clamping guided by near infrared fluorescence imaging (NIRF-RAPN) versus a cohort of patients who underwent standard RAPN without selective arterial clamping (S-RAPN). 62 consecutive patients underwent RAPN from January 2016 to May 2017: the last 20 patients underwent NIRF-RAPN. Preoperative and postoperative renal scan at 1 month were performed to evaluate the glomerular filtration rate (GFR) of the operated renal unit and total function...
August 9, 2018: Journal of Robotic Surgery
Eva Achbergerová, Daniela Šmejkalová, Gloria Huerta-Angeles, Karel Souček, Martina Hermannová, Hana Vágnerová, Robert Vícha, Vladimír Velebný
Development of delivery systems which allow real-time visual inspection of tumors is critical for effective therapy. Near-infrared (NIR) fluorophores have a great potential for such an application. To overcome NIR dyes short blood circulation time and increase tumor accumulation, a NIR dye, cypate, was associated with oleyl hyaluronan, which can self-assemble into polymeric aggregates. The cypate association with oleyl hyaluronan was performed either by a covalent linkage, or physical entrapment. The two systems were compared for tumor targeting and contrast enhancement using BALB/c mice bearing 4T1 breast cancer tumors...
October 15, 2018: Carbohydrate Polymers
Huan Tang, Sheng-Tao Yang, Da-Ming Ke, Yi-Fan Yang, Jia-Hui Liu, Xing Chen, Haifang Wang, Yuanfang Liu
Ag2 Se quantum dots (QDs) are novel fluorescent probes in the second near-infrared window with great imaging quality and biocompatibility. Surface modification is an essential step to disperse Ag2 Se QDs into biological fluids, and endow Ag2 Se QDs with diverse surface chemistry. However, the effect of surface chemistry on the biological behaviors and chemical fates of Ag2 Se QDs has not been studied, which hinders the design of suitable Ag2 Se QDs for biomedical applications. Here, the distribution, degradation, excretion and toxicity of 2-aminoethanethiol and mercaptopropionic acid coated Ag2 Se QDs (denoted as QDs-MEA and QDs-MPA, respectively) were systematically investigated in mice for a 28-day observation period after a single intravenous injection...
September 1, 2017: Toxicology Research
Chenxu Yan, Zhiqian Guo, Yajing Liu, Ping Shi, He Tian, Wei-Hong Zhu
The translation of biomarker sensing into programmable diagnostics or therapeutic applications in vivo is greatly challenging, especially for eliminating the 'false positive' signals from OR logic gates. Herein we present a sense-of-logic dual-channel nanoprobe, operating through a sequence-activated AND logic gate by responding ultra-sensitively to pH changes and being subsequently triggered with biothiol for the controllable release of anti-cancer drugs. Specifically, programmable drug release is conducted in a multistage tumor microenvironment (acidic endocytic organelles followed by abnormal glutathione-overexpressing cell cytosol), which is synchronous with dual-channel near-infrared (NIR) fluorescence output...
August 7, 2018: Chemical Science
Luke Henderson, Oara Neumann, Caterina Kaffes, Runmin Zhang, Valeria Marangoni, Murali K Ravoori, Vikas Kundra, James Bankson, Peter Nordlander, Naomi J Halas
Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently we showed that Au@Si@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T1 MRI or fluorescent contrast agents with a photothermal therapeutic response in a compact geometry. Here we show that a near-infrared-resonant NM can provide simultaneous contrast enhancement for both T1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell...
August 8, 2018: ACS Nano
Yuhua Yao, Qian Sun, Zhaoyang Chen, Rui Huang, Weibing Zhang, Junhong Qian
A near infrared fluorescent probe YSP for sulfite was synthesized, in which a julolidine fused with a pyran-2-one was employed as the fluorophore and the vinyl activated by an indole salt as the receptor. The introduction of julolidine and indole salt strengthens the electron push-pull effect of the probe and allows it to absorb (597 nm) and emit (681 nm) in red wavelength region. The addition of sulfite to the C˭C bond led to prominent blue-shifts in both absorption (171 nm) and emission (165 nm) spectra, which made it possible for colorimetric and ratiometric fluorescent detection of sulfite...
November 1, 2018: Talanta
Xiao Zheng, Fan Zhang, Yawei Zhao, Jing Zhang, Jianati Dawulieti, Yue Pan, Lianzhi Cui, Madi Sun, Dan Shao, Mingqiang Li, Kan He, Ming Zhang, Jing Li, Li Chen
Despite the vital role miRNA-27a plays in driving the development and progress of liver cancer, miRNA-based inhibition therapy is hampered due to its undesired degradation and off-target effects. Herein, a multifunctional nanoparticle for noninvasive tracking of targeted delivery of anti-miR-27a oligonucleotides against liver cancer was constructed. Methods: Dual-fluorescent conjugates (QD-HA-PEI) were first fabricated through crosslinking hyaluronic acid (HA), polyethyleneimine (PEI) and near-infrared (NIR) fluorescent quantum dots (QDs) via a facile one-pot approach...
2018: Theranostics
Hannah R Shanks, Mingning Zhu, Amir H Milani, James Turton, Sarah Haigh, Nigel W Hodson, Daman Adlam, Judith Hoyland, Tony Freemont, Brian R Saunders
Polymer dots (PDs) are promising fluorescent probes for biomaterials applications. Here, novel cytocompatible composite PD particles have been synthesised with a core-shell-shell morphology. The particles show near-infrared emission, improved fluorescent brightness and enhanced colloidal stability compared to pure PDs. The particles also show non-radiative resonance energy transfer (NRET) with a model dye.
August 6, 2018: Chemical Communications: Chem Comm
M Al-Taher, J van den Bos, R M Schols, B Kubat, N D Bouvy, L P S Stassen
Background: Iatrogenic ureteric injury remains a risk in laparoscopic pelvic procedures. Near-infrared fluorescence (NIRF) imaging is a promising new technique for enhanced intraoperative visualization of anatomical structures that could improve the safety of laparoscopic surgery. A new dye, IRDye® 800-BK, has been developed for intraoperative visualization of the ureters using NIRF. The present study was a first evaluation of the performance of IRDye® 800-BK for ureteric imaging during NIRF laparoscopy...
August 2018: BJS open
Jeffery Chakedis, Lawrence A Shirley, Alicia M Terando, Roman Skoracki, John E Phay
BACKGROUND: Injury to the thoracic duct (TD) is the most common complication after a left lateral neck dissection, and it carries a high degree of morbidity. Currently, no routine diagnostic imaging is used to assist with TD identification intraoperatively. This report describes the first clinical experience with lymphangiography using indocyanine green (ICG) during lateral neck dissections. METHODS: In six patients undergoing left lateral neck dissection (levels 2-4) for either thyroid cancer or melanoma, 2...
August 3, 2018: Annals of Surgical Oncology
Xiaobing Wang, Fei Yan, Xiufang Liu, Pan Wang, Shuai Shao, Yue Sun, Zonghai Sheng, Quanhong Liu, Jonathan F Lovell, Hairong Zheng
Small molecules that interfere with nucleic acid are widely used in chemotherapy, however, improved delivery approaches are required to improve anti-tumor outcomes. Here, we present the development of an ultrasound-activatable porphyrin-phospholipid-liposome (pp-lipo) that responds to low intensity focused ultrasound (LIFU) for sonodynamic therapy (SDT). The pp-lipo is constructed by incorporating a small proportion of porphyrin (pyropheophorbide) conjugated lipid into a liposome formulation. This enables sonosensitization-induced lipid oxidation and efficient disruption of liposomes to release loaded doxorubicin (Dox)...
July 31, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Zheng Zheng, Tianfu Zhang, Haixiang Liu, Yuncong Chen, Ryan T K Kwok, Chao Ma, Pengfei Zhang, Herman H-Y Sung, Ian D Williams, Jacky W Y Lam, Kam Sing Wong, Ben Zhong Tang
Far red/near-infrared (NIR) fluorescent materials possessing the characteristics of strong two-photon absorption and aggregation-induced emission (AIE) as well as specific targeting capability are much sought after for bioimaging and therapeutic applications for their deeper penetration depth and higher resolution. Herein, a series of dipolar far red/NIR AIE luminogens with strong push-pull effect are designed and synthesized. The obtained fluorophores display bright far red/NIR solid-state fluorescence with high quantum yield of up to 30%, large Stokes shifts of up to 244 nm and large two-photon absorption cross-section of up to 887 GM...
August 3, 2018: ACS Nano
Yasuharu Oguchi, Tetsuju Sekiryu, Mika Takasumi, Yuko Hashimoto, Minoru Furuta
PURPOSE: To determine histopathologic characteristics of near-infrared autofluorescence (NIR-AF) and short-wave autofluorescence (SW-AF) in ocular tissue. STUDY DESIGN: Retrospective study. METHODS: Unstained specimens from four enucleated eyes with uveal melanoma were prepared for evaluation by fluorescence microscopy. The filter settings for SW-AF were 450-490 nm for excitation, 500-550 nm for emission and for NIR-AF 672.5-747.5 nm and 765-855 nm respectively...
August 2, 2018: Japanese Journal of Ophthalmology
JinHong Jiang, YaLi Peng, XueYa Liang, Shu Li, Xin Chang, LongFei Li, Min Chang
Cortistatin-14 (CST-14), a recently discovered cyclic neuropeptide, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. However, the role of CST-14 in the control of depression processes is not still clarified. Here, we tested the behavioral effects of CST-14 in the in a variety of classical rodent models of depression [forced swimming test (FST), tail suspension test (TST) and novelty-suppressed feeding test]...
2018: Frontiers in Pharmacology
Congping Chen, Zhuoyi Liang, Biao Zhou, Xuesong Li, Caleb Lui, Nancy Y Ip, Jianan Qu
Abnormal deposition of brain amyloid is a major hallmark of Alzheimer's disease (AD). The toxic extracellular amyloid plaques originating from the aberrant aggregation of beta-amyloid (Aβ) protein are considered to be the major cause of clinical deficits such as memory loss and cognitive impairment. Two-photon excited fluorescence (TPEF) microscopy provides high spatial resolution, minimal invasiveness and long-term monitoring capability. TPEF imaging of amyloid plaques in AD transgenic mice models has greatly facilitated the studies of AD pathological mechanism...
August 1, 2018: ACS Chemical Neuroscience
Jade E Jones, Susheel Bhanu Busi, Jonathan B Mitchem, James M Amos-Landgraf, Michael R Lewis
The goal of these studies was to use a tumor-targeting, near-infrared (NIR) fluorescent peptide to evaluate early detection and to guide surgical removal of polyps in a genetically engineered rat model of spontaneous colorectal cancer. This peptide, LS301, was conjugated to Cy7.5 and applied topically to the colon of adenoma-bearing Pirc rats. Ten minutes after administration, rats underwent targeted NIR laser colonoscopy. Rats were also evaluated by white light colonoscopy and narrow-band imaging, for comparison to the NIR technique...
January 2018: Molecular Imaging
Sheryl Roberts, Chrysafis Andreou, Crystal Choi, Patrick Donabedian, Madhumitha Jayaraman, Edwin C Pratt, Jun Tang, Carlos Pérez-Medina, M Jason de la Cruz, Willem J M Mulder, Jan Grimm, Moritz Kircher, Thomas Reiner
Optoacoustic imaging offers the promise of high spatial resolution and, at the same time, penetration depths well beyond the conventional optical imaging technologies, advantages that would be favorable for a variety of clinical applications. However, similar to optical fluorescence imaging, exogenous contrast agents, known as sonophores, need to be developed for molecularly targeted optoacoustic imaging. Despite numerous optoacoustic contrast agents that have been reported, there is a need for more rational design of sonophores...
July 7, 2018: Chemical Science
Xuan Mei, Jialing Ma, Xue Bai, Xin Zhang, Shaomin Zhang, Ruizheng Liang, Min Wei, David G Evans, Xue Duan
Recently, ultrathin two-dimensional (2D) nanomaterials have attracted considerable research interest in biomedical applications, owing to their intriguing quantum size and surface effects. In this work, a one-step "bottom-up" method is developed to prepare rare-earth (Gd3+ and Yb3+ ) co-doped layered double hydroxide (LDH) monolayer nanosheets, with a precisely controlled composition and uniform morphology. Due to the successful introduction of Gd3+ and Yb3+ into the LDH host layer, the Gd&Yb-LDH monolayer nanosheets exhibit excellent magnetic resonance (MR)/X-ray computed tomography (CT) dual-mode imaging functionality...
July 7, 2018: Chemical Science
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