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Near infrared fluorescence

Jacqueline van den Bos, Lottie van Kooten, Sanne M E Engelen, Tim Lubbers, Laurents P S Stassen, Nicole D Bouvy
BACKGROUND: This study assessed the feasibility of near-infrared fluorescence imaging with indocyanine green (ICG) to identify the parathyroid glands (PGs) intraoperatively and to assess their perfusion after thyroid resection. METHODS: Patients undergoing elective thyroidectomy were enrolled in this prospective study. An intravenous bolus of 7.5 mg ICG was administered twice: the first bolus to identify the PGs before resection of the thyroid and the second to assess vascularization of the PGs after resection...
December 11, 2018: Head & Neck
Fernanda Ramos-Gomes, Wiebke Möbius, Luigi Bonacina, Frauke Alves, Marietta Andrea Markus
Recently, second harmonic generation (SHG) nanomaterials have been generated that are efficiently employed in the classical (NIR) and extended (NIR-II) near infrared windows using a multiphoton microscope. The aim was to test bismuth ferrite harmonic nanoparticles (BFO-HNPs) for their ability to monitor pulmonary macrophages in mice. BFO-loaded MH-S macrophages are given intratracheally to healthy mice or BFO-HNPs are intranasally instilled in mice with allergic airway inflammation and lung sections of up to 100 μM are prepared...
December 10, 2018: Small
Margaret Chern, Joshua C Kays, Shashi Bhuckory, Allison Dennis
Fluorescent sensors benefit from high signal-to-noise and multiple measurement modalities, allowing for a multitude of applications and flexibility of design. Semiconductor nanocrystal quantum dots (QDs) are excellent fluorophores for sensors because of their extraordinary optical properties. They have high thermal and photochemical stability compared to organic dyes or fluorescent proteins and are extremely bright due to their large molar cross-sections. In contrast to organic dyes, QD emission profiles are symmetric, with relatively low full width half maxima...
December 7, 2018: Methods and Applications in Fluorescence
Jing Ning, Tao Liu, Peipei Dong, Wei Wang, Guangbo Ge, Bo Wang, Zhenlong Yu, Lei Shi, Xiangge Tian, Xiaokui Huo, Lei Feng, Chao Wang, Chengpeng Sun, Jing-Nan Cui, Tony D James, Xiaochi Ma
Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in a diverse array of physiological and pathological processes in humans. Its biological role in tumorigenesis and cancer diagnosis remains poorly understood, owing to the lack of molecular tools suitable for real-time monitoring CYP2J2 in complex biological systems. Using molecular design principles we were able to modify the distance between the catalytic unit and metabolic recognition moiety, allowing us to develop a CYP2J2 selective fluorescent probe using a near-infrared fluorophore (E)-2-(2-(6-hydroxy-2, 3-dihydro-1H-xanthen-4-yl)vinyl)-3,3- dimethyl-1-propyl-3H-indol-1-ium iodide (HXPI)...
December 10, 2018: Journal of the American Chemical Society
Michael A Lee, Freddy T Nguyen, Kathleen Scott, Nathan Y L Chan, Naveed Ali Bakh, Kelvin K Jones, Crystal Pham, Pablo Garcia-Salinas, Daniel Garcia-Parraga, Andreas Fahlman, Vicente Marco, Volodymyr B Koman, Ronald J Oliver, Lloyd W Hopkins, Consuelo Rubio, Rory P Wilson, Mark G Meekan, Carlos M Duarte, Michael S Strano
In recent decades, biologists have sought to tag animals with various sensors to study aspects of their behavior otherwise inaccessible from controlled laboratory experiments. Despite this, chemical information, both environmental and physiological, remains challenging to collect despite its tremendous potential to elucidate a wide range of animal behaviors. In this work, we explore the design, feasibility, and data collection constraints of implantable, near-infrared fluorescent nanosensors based on DNA-wrapped single-wall carbon nanotubes (SWNT) embedded within a biocompatible poly(ethylene glycol) diacrylate (PEGDA) hydrogel...
December 11, 2018: ACS Sensors
Yuehui Zhao, Keyan Wei, Fanpeng Kong, Xiaonan Gao, Kehua Xu, Bo Tang
NADH and NADPH are ubiquitous coenzymes in all living cells and play vital roles in numerous redox reactions in cellular energy metabolism. To accurately detect the distribution and dynamic changes of NAD(P)H under physi-ological condition is essential for understanding its biological functions and pathological roles. In this work, we developed a near-infrared (NIR) emission fluorescent small-molecule probe (DCI-MQ) composed of a dicyanoisophorone chromophore conjugated with a quinolinium moiety for in vivo NAD(P)H detection...
December 11, 2018: Analytical Chemistry
Xunzhou Yu, Danfeng He, Ximu Zhang, Hongmei Zhang, Jinlin Song, DeZhi Shi, Yahan Fan, Gaoxing Luo, Jun Deng
Since generating toxic reactive oxygen (ROS) is largely dependent on oxygen, bacteria infected wounds hypoxia significantly inhibits photodynamic therapy's (PDT) antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria is developed based on the light-activated alkyl free radical generation (that is oxygen-independent). According to the polydopamine coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was synthesized...
December 7, 2018: ACS Applied Materials & Interfaces
Yi Liu, Zhengjie Wang, Xiang Li, Xiaowei Ma, Shuailiang Wang, Fei Kang, Weidong Yang, Wenhui Ma, Jing Wang
The complete excision of glioblastomas with maximal retention of surrounding normal tissues can significantly improve patient prognosis. Near-infrared fluorescence (NIRF) optical imaging of the tumor vasculature offers a non-invasive method for detection of early-stage glioblastoma and efficient monitoring of therapeutic responses. The aim of this study was to develop a novel NIRF imaging probe as a visualization tool for image-guided surgical resection of orthotopic glioblastoma. In this study, Cy5.5-RKL, Cy5...
December 5, 2018: Molecular Pharmaceutics
Lei Zhang, Xiao Yu Tian, Cecilia K W Chan, Qianqian Bai, Chak Kwong Cheng, Francis M Chen, Maggie S H Cheung, Bohan Yin, Hongrong Yang, Wing-Yin Yung, Zhong Chen, Fei Ding, Ken Cham-Fai Leung, Chuan Zhang, Yu Huang, James Y W Lau, Chung Hang Jonathan Choi
Many nanoparticle-based carriers to atherosclerotic plaques contain peptides, lipoproteins, and sugars, yet the application of DNA-based nanostructures for targeting plaques remains infrequent. In this work, we demonstrate that DNA-coated superparamagnetic iron oxide nanoparticles (DNA-SPIONs), prepared by attaching DNA oligonucleotides to poly(ethylene glycol)-coated SPIONs (PEG-SPIONs), effectively accumulate in the macrophages of atherosclerotic plaques following an intravenous injection into apolipoprotein E knockout (ApoE-/- ) mice...
December 5, 2018: ACS Applied Materials & Interfaces
Hailong Guo, Guang Chen, Min Gao, Rui Wang, Yuxia Liu, Fabiao Yu
Hydrogen peroxide (H2O2) is emerging as a new second messenger, which plays vital roles in intracellular signaling, thereby triggering physiological variations in terms of proliferation, differentiation, and migration. As known, cell mitosis has closely association to the intracellular level of H2O2, which contribute to the significant effects on the brain development, especially during the critical period of immaturity. To further investigate the biological roles of endogenous H2O2 in cells mitosis, we develop a near-infrared ratiometric fluorescent probe BCy-PFS for specifically imaging of endogenous H2O2 in cells and in vivo...
December 5, 2018: Analytical Chemistry
Xiaoli Li, Guoliang An, Yan Wang, Di Liang, Zhonghui Zhu, Lin Tian
BACKGROUND: Silicosis is a common occupational disease, characterized by silicotic nodules and diffuse pulmonary fibrosis. We demonstrated an anti-fibrotic effect of bone marrow mesenchymal stem cells (BMSCs) in silica-induced lung fibrosis. In the present study, we sought to clarify the homing ability of BMSCs and the specific mechanisms for their effects. METHODS AND RESULTS: The biodistribution of BMSCs was identified by near-infrared fluorescence (NIRF) imaging in vivo and in vitro...
December 4, 2018: Stem Cell Research & Therapy
Ziming Zheng, Hongjuan Li, Shiguo Sun, Yongqian Xu
Abnormal level of proteins is proved to be associated with diseases. Thus, protein sensing is helpful for clinical diagnosis and therapy. However, there is a great variety of protein species and relatively low concentration of each protein in complicated biological systems including other non-protein biomolecules. Therefore, it remains challenging to develop an effective method for detecting protein with high selectivity and sensitivity. Herein, a new self-assembly method based on a robust dye SQSS of which two squaraine molecules were conjugated through disulfide bond was developed for highly selective and sensitive detection of serum albumin (SA) in aqueous solution and live cells...
December 4, 2018: ACS Applied Materials & Interfaces
Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Rie Takashima, Masaki Morishita, Toshiyasu Sakane, Akira Yamamoto
l-cysteine (Cys)- and l-serine (Ser)-modified, third-generation polyamidoamine (PAMAM) dendrimer with multiple reduced thiols (Ser-PAMAM-Cys) was synthesized as a kidney-targeting reactive oxygen species (ROS) scavenger to help prevent renal ischemia/reperfusion injury. Ser-PAMAM-Cys effectively scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and ROS (hydrogen peroxide and hydroxyl radical) in phosphate-buffered saline (PBS). In addition, ~64% of 111 In-labeled Ser-PAMAM-Cys accumulated in mouse kidney 3 h after intravenous administration...
December 1, 2018: Pharmaceutics
Marina V Novoselova, Daniil N Bratashov, Mustafa Sarimollaoglu, Dmitry A Nedosekin, Walter Harringston, J Alex Watts, Mikyung Han, Boris N Khlebtsov, Ekaterina I Galanzha, Dmitry A Gorin, Vladimir P Zharov
Progress in understanding the cell biology and progression of disease depends on advanced imaging and labeling techniques. Here, we address this demand by exploring novel multilayered nanocomposites (MNCs) with plasmonic nanoparticles and adsorbing dyes in thin nonabsorbing shells as supercontrast multimodal photoacoustic (PA) and fluorescent agents in the near-infrared range. The proof of concept was performed with gold nanorods (GNRs) and indocyanine green (ICG) dispersed in a matrix of biodegradable polymers...
December 3, 2018: Journal of Biophotonics
Babs G Sibinga Mulder, Henricus Jm Handgraaf, Danielle J Vugts, Claudia Sewing, Albert D Windhorst, Marieke Stammes, Lioe-Fee de Geus-Oei, Mark W Bordo, J Sven D Mieog, Cornelis Jh van de Velde, John V Frangioni, Alexander L Vahrmeijer
cRGD peptides target integrins associated with angiogenesis (e.g., αv β3 ) and cancer, and have been used as binding ligands for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) optical imaging. This study introduces the hybrid tracer cRGD-ZW800-1-Forte-[89 Zr]Zr-DFO, which is based on a novel zwitterionic fluorophore structure that reduces non-specific background uptake during molecular imaging of tumors. An in vitro binding assay was used to validate tracer performance. 10 nmol ZW800F-cRGD-Zr-DFO was injected in mice (n=7) bearing orthotopic human colorectal tumors (HT29-luc2) for tumor detection with NIRF imaging...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Jacopo Desiderio, Stefano Trastulli, Alessandro Gemini, Domenico Di Nardo, Giorgio Palazzini, Amilcare Parisi, Vito D'Andrea
In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations during radical gastrectomy, thus starting a new research frontier in this field called " navigation surgery". Among the different reported solutions, the introduction of the indocyanine green (ICG) has drawn attention for its characteristics, a fluorescence dye that can be detected in the near infrared spectral band (NIR). A fluorescence imaging technology has been integrated in the latest version of the Da Vinci robotic system and surgeons have extensively reported their experiences in colorectal and hepato-biliary surgery for tumors, vascular and lymphatic structures visualization...
October 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Longguang Tang, Xiaoli Sun, Nian Liu, Zijian Zhou, Fei Yu, Xianzhong Zhang, Xiaolian Sun, Xiaoyuan Chen
To meet the criteria of effective theranostics, biocompatible nanomedicine endowing intrinsic therapeutic and imaging properties have gained extraordinary momentum. In this study, an ultra-stable near-infrared (NIR) dye croconaine (CR780) was engineered with arginine-glycine-aspartic acid (RGD) peptide and polyethylene glycol (PEG), which was then self-assembled into uniform nanoparticles (NPs). These RGD-CR780-PEG5K assemblies were radiolabeled with 125 I through a facile standard Iodo-Gen method. The resulting [125 I]RGD-CR780-PEG5K NPs showed effective accumulation in αv β3 integrin expressing glioblastoma, as evidenced by single photon emission computed tomography (SPECT)/CT and NIR fluorescence imaging...
April 27, 2018: ACS applied nano materials
Junichi Kaneko, Takashi Kokudo, Yoshinori Inagaki, Kiyoshi Hasegawa
Indocyanine green (ICG) is not new in the field of liver surgery. Early studies performed in the 1980s and 1990s revealed the value of the ICG clearance test in predicting post-hepatectomy morbidity and mortality. ICG clearance and retention tests are crucial for determining precise liver function before liver surgery and offer several benefits for safe surgery. Whereas ICG is well-known and has long history in medicine, recent progress in infrared light technology over the last decade has highlighted another feature of ICG...
2018: Translational Gastroenterology and Hepatology
Vadim G Pischik, Aleksandr Kovalenko
Background: According to recent studies, thoracoscopic segmentectomy is an acceptable alternative to lobectomy for treating different lung diseases. This approach appears to have equivalent rates of postoperative morbidity with potentially similar long-term results even in selected lung cancer patients. At the same time, surgical success is highly dependent on intraoperative interpretation of segmental anatomy. We aimed to analyze our lung segmentectomy experience and identify the role of indocyanine green (ICG)-fluorescence for intersegmental plane detection...
November 2018: Journal of Thoracic Disease
Bingbing Ding, Yuling Xiao, Hui Zhou, Xiao Zhang, Chunrong Qu, Fuchun Xu, Zixin Deng, Zhen Cheng, Xuechuan Hong
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes with both absorption and emission in NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in NIR-IIa (1300-1400 nm) sub-window under 1064 nm excitation with that in NIR-II window under 808 nm excitation...
December 2, 2018: Journal of Medicinal Chemistry
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