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Near infrared fluorescence

S Favril, E Stock, S Hernot, M Hesta, I Polis, K Vanderperren, H de Rooster
Sentinel lymph node (SLN) mapping is a valuable and crucial diagnostic procedure in staging malignancies. We compared two non-invasive techniques, near-infrared (NIR) fluorescence imaging and contrast-enhanced ultrasound (CEUS), to identify the SLNs in 3 superficial anatomical regions in an animal model. Six healthy laboratory dogs were included in a proof-of-concept trial. A NIR fluorescent dye (Indocyanine Green) and microbubbles (Sonovue) were consecutively injected subdermally in the inguinal, axillary, and popliteal region to map the SLNs...
October 11, 2018: Veterinary and Comparative Oncology
Wei Sheng, Setare Tahmasebi Nick, Elizabeth M Santos, Xinliang Ding, Jun Zhang, Chrysoula Vasileiou, James Geiger, Babak Borhan
FR-1V, a fluorene-based aldehydic chromophore, binds its target protein as an imine to yield a highly bathochromic pigment, CF-2, a prototypic protein-dye tagging system whose NIR emission can be spatiotemporally switched ON by rapid UV-light activation. This is achieved through photoisomerization of the imine and its subsequent protonation. We demonstrate a no-wash protocol for live cell imaging of subcellular compartments in a variety of mammalian cell lines with minimal fluorescence background.
October 11, 2018: Angewandte Chemie
Hainan Yang, Zaijia Liu, Xufeng Li, Zhenfeng Zhang, Deji Chen, Hui Lian
Herein, a tumor-targeted multifunctional theranostic agent was synthetized using a facile method, combining four clinically approved materials: artesunate (Arte), human serum albumin (HSA), folic acid (FA), and indocyanine green (ICG). The obtained nanocomposites (FA-IHA NPs) showed an excellent photo- and physiological stability. The ICG in the FA-IHA NPs was used not only for near infrared (NIR) fluorescence imaging, but also for photothermal and photodynamic (PTT-PDT) therapy under a single NIR irradiation...
October 11, 2018: Nanoscale Research Letters
Ting-Ting Zhang, Cong-Hui Xu, Wei Zhao, Yu Gu, Xiang-Ling Li, Jing-Juan Xu, Hong-Yuan Chen
Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO2 ) and gold nanoshell coated silicon nanoparticles for synergistic chemo-photothermal therapy of hypoxia solid tumors. In highly reducing tumor tissues, the outer MnO2 nanosheet with the loaded drug would be dissociated by intracellular glutathione (GSH), resulting in on-demand drug release, as well as generating Mn2+ ions which provided high contrast magnetic resonance imaging (MRI), and fluorescence imaging (FI) in vitro and in vivo ...
September 7, 2018: Chemical Science
Penghui Cheng, Jianjian Zhang, Jiaguo Huang, Qingqing Miao, Chenjie Xu, Kanyi Pu
Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of diseases. Although an abnormally high RONS level has been identified in keloids - a benign dermal tumour developed after lesion, the ability of employing RONS probes for keloid detection has not yet been exploited. Herein, we report two near-infrared (NIR) fluorescent probes ( CyTF and CyBA ) that can specifically distinguish keloid fibroblasts from normal dermal fibroblasts...
August 14, 2018: Chemical Science
Qiaoli Ma, Miriam Ries, Yann Decker, Andreas Müller, Chantal Riner, Arno Bücker, Klaus Fassbender, Michael Detmar, Steven T Proulx
The relationships between cerebrospinal fluid (CSF) and brain interstitial fluid are still being elucidated. It has been proposed that CSF within the subarachnoid space will enter paravascular spaces along arteries to flush through the parenchyma of the brain. However, CSF also directly exits the subarachnoid space through the cribriform plate and other perineural routes to reach the lymphatic system. In this study, we aimed to elucidate the functional relationship between CSF efflux through lymphatics and the potential influx into the brain by assessment of the distribution of CSF-infused tracers in awake and anesthetized mice...
October 10, 2018: Acta Neuropathologica
Suk Ho Hong, Yan Li, Joo Beom Eom, Yongdoo Choi
Background: Atherosclerosis is a major global health concern. Targeting macrophages is hypothesized as an alternative treatment for atherosclerosis. Methods: We synthesized alginate-based cisplatin-loaded nanogels (TANgel) as a pH-responsive drug-releasing theranostic nanoplatform for macrophage cells. Carboxylic acid groups of alginic acid were modified with iminodiacetic acid (IDA) to enhance chelation of platinum ions. The near infrared (NIR) fluorophore ATTO655 was conjugated to the modified alginic acid...
September 2018: Quantitative Imaging in Medicine and Surgery
Mo Zhang, Naoko Kobayashi, Kirstin A Zettlitz, Evelyn A Kono, Joyce M Yamashiro, Wen-Ting K Tsai, Ziyue Karen Jiang, Chau P Tran, Chun Wang, Johnny Guan, Anna M Wu, Robert E Reiter
PURPOSE: The inability to intraoperatively distinguish the primary tumor, as well as lymphatic spread, increases the probability of positive surgical margins, tumor recurrence, and surgical toxicity. The goal of this study was to develop a tumor-specific optical probe for real-time fluorescence-guided surgery. EXPERIMENTAL DESIGN: A humanized antibody fragment against PSCA (A11 minibody, A11 Mb) was conjugated with a near-infrared fluorophore, IRDye800CW. The integrity and binding of the probe to PSCA were confirmed by gel electrophoresis, size exclusion chromatography, and flow cytometry, respectively...
October 9, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Ryosuke Yale Shimizu, Takeshi Yanai, Yuki Kurashige, Daisuke Yokogawa
For theoretically studying molecules with fluorescence in the near-infrared region, high-accuracy determination of state energy level is required for meaningful analyses since the spectra of interest are of very narrow energy range. In particular, these molecules are in many cases handled in solution; therefore, consideration of the solvation effect is essential upon calculation together with the electronic structure of the excited state. Earlier studies showed that they cannot be described with conventional methods such as PCM-TD-DFT, yielding results far from experimental data...
October 9, 2018: Journal of Chemical Theory and Computation
Antony J Wightman, Robyn H Guymer
Reticular pseudodrusen (RPD), also known as subretinal drusenoid deposits, represent a morphological change to the retina distinct from other subtypes of drusen by being located above the level of the retinal pigment epithelium. Although they can infrequently appear in individuals with no other apparent pathology, their highest rates of occurrence are in association with age-related macular degeneration (AMD), for which they hold clinical significance by being highly correlated with end-stage disease sub-types, choroidal neovascularisation and geographic atrophy...
October 8, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Haijuan Liu, Feng Liu, Fenglin Wang, Ru-Qin Yu, Jian-Hui Jiang
γ-Glutamyl transpeptidase (GGT) plays an essential role in regulating cellular glutathione and cysteine homeostasis, and its abnormal elevation is associated with different diseases including cancers. Here a novel mitochondrial-targeting near-infrared fluorescent probe was designed for GGT by conjugating glutamate acid to a newly synthesized amine hemicyanine fluorophore. The fluorescent probe was initially non-emissive due to the formation of an amide bond which destroyed the electronic-donating ability of the amine moiety and disrupted the push-pull structure...
October 9, 2018: Analyst
Tanitra Tantitamit, Chyi-Long Lee
OBJECTIVE: This report outlines our first experience of SLN mapping in NOTES technique which is the combination of the least invasive surgical approach and the least invasive way of assessing lymph node status. DESIGN: Descriptive study (Canadian Task Force Classification III) SETTING: Tertiary referral and educational center. PATIENTS: A total of 4 patients with endometrial cancer clinical stage1. INTERVENTIONS: NOTES with SLN mapping using indocyanine green (ICG)-based near-infrared fluorescence imaging technique...
October 5, 2018: Journal of Minimally Invasive Gynecology
Hironobu Wada, Jinzi Zheng, Alexander Gregor, Kentaro Hirohashi, Hsin-Pei Hu, Priya Patel, Hideki Ujiie, Tatsuya Kato, Takashi Anayama, David A Jaffray, Kazuhiro Yasufuku
OBJECTIVE: A novel liposomal nanoparticle, CF800, that co-encapsulates indocyanine green for near-infrared (NIR) imaging and iohexol for CT imaging has shown preferential tumor accumulation after intravenous injection via the enhanced permeability and retention (EPR) effect. We hypothesized that CF800-enhanced NIR imaging would facilitate intraoperative localization of small lung nodules. METHODS: A rabbit VX2 lung tumor model was implemented. CF800 was injected intravenously followed by sequential CT acquisitions to track the biodistribution of CF800...
October 5, 2018: Annals of Thoracic Surgery
Sakkarapalayam M Mahalingam, Sumith A Kularatne, Carrie H Myers, Pravin Gagare, Mohammad Norshi, Xin Liu, Sunil Singhal, Philip S Low
Because the most reliable therapy for cancer involves quantitative resection of all diseased tissue, considerable effort has been devoted to improving a surgeon's ability to locate and remove all malignant lesions. With the aid of improved optical imaging equipment, we and others have focused on developing tumor-targeted fluorescent dyes to selectively illuminate cancer nodules during surgery. We describe here the design, synthesis, optical properties, in vitro and in vivo tumor specificity/affinity, pharmacokinetics, preclinical toxicology and some clinical application of a folate receptor (FR)-targeted NIR dye (OTL38) that concentrates specifically in cancer tissues and clears rapidly from healthy tissues...
October 8, 2018: Journal of Medicinal Chemistry
Yu Gao, Huijuan Zhang, Yingying Zhang, Tingting Lv, Lu Zhang, Ziying Li, Xiaodong Xie, Fengqiao Li, Haijun Chen, Lee Jia
The outcome of molecular targeted therapies is restricted by the ambiguous molecular subtypes of non-small cell lung cancer (NSCLC) which are difficult to be defined with druggable mutations, and the inevitable emergence of drug-resistance. Here we used the Cu-catalyzed click chemistry to synthesize a chitosan-based self-assembled nanotheranostics (CE7Ns) composing of a near-infrared (NIR) fluorescent photosensitizer Cy7 and molecular targeted drug erlotinib. The well-characterized CE7Ns can release erlotinib and Cy7 fast under acidic condition in the presence of lysozyme, distinguish three molecular subtypes of NSCLC and specifically bind to the erlotinib-sensitive EGFR-mutated PC-9 cells...
October 8, 2018: Molecular Pharmaceutics
Sorel Kurbegovic, Karina Juhl, Hao Chen, Chunrong Qu, Bingbing Ding, Julie Maja Leth, Krzysztof Tadeusz Drzewiecki, Andreas Kjær, Zhen Cheng
Optical imaging strategies for improving delineation of glioblastoma (GBM) is highly desired for guiding surgeons to distinguish cancerous tissue from healthy and precious brain tissue. Fluorescence imaging (FLI) in the second near-infrared window (NIR-II) outperforms traditional NIR-I imaging with better tissue penetration, higher spatial and temporal resolution, and less auto fluorescence and scattering. Because of high expression in GBM and many other tumors, urokinase Plasminogen Activator Receptor (uPAR) is an attractive and well proven target for FLI...
October 8, 2018: Bioconjugate Chemistry
Yongquan Wu, Aiping Shi, Yuanyan Li, Hong Zeng, Xiaoyong Chen, Jie Wu, Xiaolin Fan
Peroxynitrite (ONOO-) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO- in physiological conditions is imperative for elucidating its functions. However, studies on high signal-to-noise-ratio (SNR) fluorescence imaging of ONOO- in vivo for its detection are currently lacking. Thus, a novel NIR xanthene fluorescence probe (NOF2) for the endogenous detection of ONOO- is designed and synthesized...
October 8, 2018: Analyst
Rong Yan, Jie Chen, Jianhao Wang, Jiaming Rao, Xuancheng Du, Yongming Liu, Leshuai Zhang, Lin Qiu, Bo Liu, Yuan-Di Zhao, Pengju Jiang, Chunying Chen, Yong-Qiang Li
Accurate tumor margin demarcation in situ remains a paramount challenge. Herein, a NanoFlare (also known as spherical-nucleic-acid technology) based strategy is reported for in situ tumor margin delineation by transforming and amplifying the pathophysiological redox signals of tumor microenvironment. The NanoFlare designed (named AuNS-ASON) is based on gold nanostar (AuNS) coated with a dense shell of disulfide bridge-inserted and cyanine dyes-labeled antisense oligonucleotides (ASON) targeting survivin mRNA...
October 7, 2018: Small
Zihnil Adha Islamy Mazrad, Pham Thi My Phuong, Cheong A Choi, Insik In, Kang Dae Lee, Sung Young Park
In the present study, pH/redox responsive cationic polymer dot (CD) was successfully prepared for a near-infrared (NIR)-mediated simultaneously controllable photothermal temperature guided imaging off/on system to monitor therapeutic delivery. The carbonized disulfide crosslinked branched-polyethyleneimine (bPEI) with a folic acid (FA) conjugation as the targeting moiety and a partially ionic complex between anionic indocyanine green (ICG) and bPEI-based CD (ICG-CD). This was responsive to mild reductive (GSH) and acidic tumor conditions, which enabled the simultaneous biodegradation of those hydrophobic and complex sites...
October 4, 2018: ChemMedChem
Rajendra Prasad, Deepak S Chauhan, Amit S Yadav, Janhavi Devrukhkar, Barkha Singh, Mahadeo Gorain, Mayur Temgire, Jayesh Bellare, Gopal C Kundu, Rohit Srivastava
Specific targeting and phototriggered therapy in mouse model have recently emerged as the starting point of cancer theragnosis. Herein, we report a bioresponsive and degradable nanohybrid, a liposomal nanohybrid decorated with red emissive carbon dots, for localized tumor imaging and light-mediated tumor growth inhibition. Unsaturated carbon dots (C-dots) anchored to liposomes convert near-infrared (NIR) light into heat and also produce reactive oxygen species (ROS), demonstrating the capability of phototriggered cancer cell death and tumor regression...
October 5, 2018: Nanoscale
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