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Transfusion Adverse Reactions

Fanjiu Kong, Yingbo Li, Xiaoxin Liu
Influence and clinical value of coagulation test on adverse reactions of blood transfusion in patients with major bleeding of ectopic pregnancy were analyzed. Six hundred and twenty-seven cases of ectopic pregnancy admitted to Zibo First Hospital from July 2014 to March 2017 were retrospectively analyzed. The 369 patients who had adverse reactions after blood transfusion were selected as the experimental group. Another 258 patients without adverse reaction after blood transfusion were selected as the control group...
December 2018: Experimental and Therapeutic Medicine
Fengmin Wang, Xu Zhang
OBJECTIVE: To explore the serological and molecular characteristics of a female with the B(A) phenotype and safety issues related to her blood transfusion. METHODS: The B(A) phenotype of the proband was confirmed by serological testing. Her genotype was determined by using polymerase chain reaction-sequence specific primer (PCR-SSP) and direct sequencing of exons 6 and 7 of the ABO locus. Clinical condition of her blood transfusion was also reviewed. RESULTS: Both A and B antigens were detected on the red blood cells derived from the proband, while anti-A antibody was detected in her serum...
December 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Hisashi Hidaka, Masayuki Kurosaki, Hironori Tanaka, Masatoshi Kudo, Seigo Abiru, Takumi Igura, Toru Ishikawa, Masataka Seike, Takayuki Katsube, Toshimitsu Ochiai, Kazuhiro Kimura, Takahiro Fukuhara, Takeshi Kano, Tsutae Nagata, Katsuaki Tanaka, Mineo Kurokawa, Kazuhide Yamamoto, Yukio Osaki, Namiki Izumi, Michio Imawari
BACKGROUND & AIMS: Platelet transfusion is used to prevent hemorrhagic events in patients with thrombocytopenia undergoing invasive procedures, but there are many disadvantages. We evaluated the efficacy and safety of lusutrombopag in patients with chronic liver disease and thrombocytopenia undergoing invasive procedures. METHODS: We performed a double-blind, parallel-group, phase 3 study of 96 patients with chronic liver disease and thrombocytopenia (platelet counts below 50,000/μL) undergoing invasive procedures from October 2013 to May 2014 at 81 centers in Japan...
November 28, 2018: Clinical Gastroenterology and Hepatology
Zoltan Szittner, Arthur E H Bentlage, Eric van der Donk, Peter C Ligthart, Suzanne Lissenberg-Thunnissen, C Ellen van der Schoot, Gestur Vidarsson
BACKGROUND: Blood-group typing of donors and patients is essential to avoid incompatible transfusions. Transfusion of incompatible RBCs may result in alloimmunization complicating future transfusions or in the presence of antibodies in adverse reactions. With more than 300 blood group antigens identified, it is difficult to provide fully compatible blood. Currently, standard practice is to match for the most immunogenic antigens. While the current agglutination-based RBC-typing methods are reliable for testing a selected number of antigens, they are not easily adaptable for high-throughput multiplex blood typing beyond the current standard...
November 29, 2018: Transfusion
Colin Murphy, Rugvedita Parakh, Ryan Metcalf, Monica B Pagano
BACKGROUND: Chest pain is a common clinical dilemma and is rarely reported as part of suspected adverse events in transfusion recipients. The aim of this study is to describe and characterize the clinical presentation of transfusion-associated chest pain and how it relates to currently defined National Healthcare Safety Network hemovigilance entities. STUDY DESIGN AND METHODS: This is a retrospective chart review at a single large academic institution of patients who reported chest pain during or after a transfusion that resulted in a transfusion reaction investigation during the period January 2004 to December 2016...
November 29, 2018: Transfusion
Marius Roman, Fausto Biancari, Aamer B Ahmed, Seema Agarwal, Leon Hadjinikolaou, Ali Al-Sarraf, Geoff Tsang, Aung Y Oo, M Field, Francesco Santini, Giovanni Mariscalco
BACKGROUND: Prothrombin complex concentrate (PCC) has recently emerged as effective alternative to fresh frozen plasma (FFP) in treating excessive perioperative bleeding. We performed a systematic review and meta-analysis to evaluate the safety and efficacy of PCC administration as first-line treatment for coagulopathy following adult cardiac surgery. METHODS: We searched PubMed/MEDLINE, EMBASE, and the Cochrane Library from inception to the end of March 2018 to identify eligible articles...
November 17, 2018: Annals of Thoracic Surgery
Sejong Chun, Sooin Choi, HongBi Yu, Duck Cho
Cis -AB, a rare ABO variant, is caused by a gene mutation that results in a single glycosyltransferase enzyme with dual A and B glycosyltransferase activities. It is the most frequent ABO subgroup in Korea, and it occurs more frequently in the East Asian region than in the rest of the world. The typical phenotype of cis -AB is A₂B₃, but it can express various phenotypes when paired with an A or B allele, which can lead to misclassification in the ABO grouping and consequently to adverse hemolytic transfusion reactions...
March 2019: Annals of Laboratory Medicine
Chris Edens, Kathryn A Haass, Melissa Cumming, Anthony Osinski, Lynne O'Hearn, Kelly Passanisi, Lynn Eaton, Paul Visintainer, Alexandra Savinkina, Matthew J Kuehnert, Sridhar V Basavaraju, Chester Andrzejewski
INTRODUCTION: The National Healthcare Safety Network (NHSN) Hemovigilance Module (HM) collects data on the frequency, severity, and imputability of transfusion-associated adverse events. These events contribute to significant morbidity and mortality among transfusion patients. We report results from the first systematic assessment of eight attributes of the HM. MATERIALS AND METHODS: Standard methods were used to assess the HM. Evaluation data included training materials, system modification history, and facility survey information...
November 14, 2018: Transfusion
Rahul Naithani, Tulika Seth, Nikhil Tandon, Jagdish Chandra, V P Choudhry, H Pati, Renu Saxena
To determine the efficacy of zoledronic acid (ZA) in thalassemia major associated low bone mineral density. Prospective, open label, single arm trial. Bone mineral density (BMD) at lumbar, hip and forearm region were performed at baseline and after 1 year of therapy. Initial, 9 patients received a first dose of 4 mg. Due to severe adverse effects, further doses for these patients and all new recruited patients were 1 mg once every 3 months for 4 doses. All patients were receiving 500 mg of calcium carbonate twice daily and 0...
October 2018: Indian Journal of Hematology & Blood Transfusion
Magali Pellerey, Anne Laure Couderc, Vanessa Pauly, Stephane Gayet, Pierre Leveque, Barbara Mizzi, Nirvina Gobin, Pierre Caunes, Christine Clapasson, Jacques Chiaroni, Aurelie Daumas, Patrick Villani
Anemia is the most common hematological pathology in geriatrics. Its prevalence increases with age. It is considered as a fragility factor because leading to loss of autonomy and other complications. Transfusion is a common practice in geriatrics. In 2014, the French national health authority guidelines recommended hemoglobin concentration rates for transfusion on the elderly over 80 years-old. The objective of this study is to compare transfusion practices in geriatric short-stay units, before and after these guidelines were edited...
October 23, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Giovanna Sirianni, Giulia Perri, Jeannie Callum, Sandra Gardner, Anna Berall, Debbie Selby
BACKGROUND: There remains limited data in the literature on the frequency, clinical utility and effectiveness of transfusions in palliative care, with no randomized controlled trials or clinical practice guidelines on this topic. There are no routinely accepted practices in place for the appropriate transfusion of blood products in this setting. AIM: The aim of this study was to retrospectively review all transfusions in the palliative care units of 2, tertiary care hospitals in Canada...
October 18, 2018: American Journal of Hospice & Palliative Care
Caroline Sut, Hind Hamzeh-Cognasse, Charles-Antoine Arthaud, Marie-Ange Eyraud, Kamel Chettab, Charles Dumontet, Sandrine Laradi, Thierry Burnouf, Olivier Garraud, Fabrice Cognasse
BACKGROUND: Platelet transfusions are safe but can nevertheless cause serious adverse reactions (SARs). This study investigated the effects of platelet biological response modifiers (BRMs) that accumulate during storage and are commonly associated with transfusion adverse reactions. STUDY DESIGN AND METHODS: Endothelial cells (ECs), that is, EA.hy926, were exposed in vitro to supernatants of platelet components (PCs) that had been either implicated or not in SARs...
October 16, 2018: Transfusion
Kevin J Land, Mary Townsend, Mindy Goldman, Barbee I Whitaker, Gabriela E Perez, Jo C Wiersum-Osselton
BACKGROUND: In December 2014, a multinational collaboration of hemovigilance experts from the International Society of Blood Transfusion (ISBT), the International Hemovigilance Network, and AABB published harmonized definitions of complications related to blood donation titled "Standard for Surveillance of Complications Related to Blood Donation." Both mandatory and optional terms were included. The definitions are endorsed by the Alliance of Blood Operators and the European Blood Alliance...
November 2018: Transfusion
Shunsuke Kojima, Ryu Yanagisawa, Miyuki Tanaka, Yozo Nakazawa, Shigetaka Shimodaira
BACKGROUND: Two different platelet additive solutions (PASs), M-sol and BRS-A, used in succession, have been reported as novel PASs in Japan. However, there are not enough clinical data comparing platelet concentrates (PCs) suspended in these PASs. STUDY DESIGN AND METHODS: A retrospective cohort study of consecutive cases was performed between 2013 and 2018. For the first 30 months, children with primary hematologic and/or malignant diseases were transfused resuspended PCs in M-sol (RPC-M) as plasma-replaced PCs...
October 6, 2018: Transfusion
Kazuma Ikeda, Kenneth E Nollet, Hans Vrielink, Hitoshi Ohto
Hematopoietic stem cell transplantation requires a wide-range of expertise and procedural competence, in which nurses play important roles throughout, including stem cell mobilization and collection by apheresis. Little is published about post-licensure nursing education in apheresis, which suggests that it proceeds at the discretion of individual institutions, supplemented with practical training by equipment manufacturers. Information can be obtained on a small number of apheresis training courses for nurses in Australia, Canada, Indonesia, Italy, The Netherlands, Sweden and Turkey, and on nurse certification systems in Turkey and the United States...
September 11, 2018: Transfusion and Apheresis Science
Luigi Fiocca, Alberto F Cereda, Chiara Bernelli, Paolo A Canova, Federica Serino, Tullio Niglio, Giuseppe Musumeci, Giulio Guagliumi, Angelina Vassileva, Michele Senni, Orazio Valsecchi
BACKGROUND: Iatrogenic hemorrhagic pericardial tamponade (IHPT) represents a life-threating condition requiring emergency pericardiocentesis. In this clinical context, reinfusion of pericardial blood can stabilize the patient and sustain hemodynamic conditions. AIMS AND METHODS: We reviewed all cases of IHPT occurred at our hospital over a 10 years span. In all patient autologous blood reinfusion through a femoral vein was performed. RESULTS: In our clinical experience of 30 consecutive patients with hemorrhagic cardiac tamponade, this technique was successful to limit blood transfusions, to prevent further clinical worsening and bridge patients with intractable bleeding, to cardiac surgery...
September 23, 2018: Catheterization and Cardiovascular Interventions
Dora García, Ana Aguilera, Francisco Antolín, José-Luis Arroyo, Miguel Lozano, Pedro Sanroma, Iñigo Romón
BACKGROUND: Hospital at Home (HH) provides specialized care at the patients' homes. Keeping patients in familial surroundings can result in better outcomes reducing readmission to hospital, mortality, and costs of care. Home transfusion (HT) can be a key element in HH management but is scarcely deployed due to concerns about safety and cost. We have reviewed our HT practice to assess its feasibility and safety. STUDY DESIGN AND METHODS: We prospectively reviewed data collected from 1985 to 2015, focusing specially on feasibility and procedural safety, looking for adverse events of transfusion...
October 2018: Transfusion
Yanfen Liu, Xinfeng Chen, Dao Wang, Hong Li, Jianmin Huang, Zhen Zhang, Yingjin Qiao, Hongling Zhang, Ying Zeng, Chao Tang, Shuangning Yang, Xiaochun Wan, Youhai H Chen, Yi Zhang
Cytokine release syndrome (CRS) remains to be a major adverse effect of chimeric antigen receptor T (CAR-T) cell therapy in B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. It was urgent to explore novel strategy for managing severe CRS. We conducted a clinical trial to assess the safety and efficacy of CD19-targeting CAR-T-cells in the treatment of relapsed and chemotherapy-refractory B-ALL and lymphoma. A 10-year-old boy with B-ALL who never achieved minimal residual disease (MRD) negative status after 5 courses of chemotherapy was enrolled into our study and received a total of 3...
November 2018: Journal of Immunotherapy
C Aubron, P Aries, C Le Niger, R L Sparrow, Y Ozier
OBJECTIVES: Transfusion-related adverse events (TRAE) can contribute to patient morbidity and mortality. In this brief narrative review, the strategies that clinicians can apply at the bedside to avoid TRAE are discussed. METHODS: Strategies to avoid the following five types of TRAE were reviewed: transfusion-associated circulatory overload (TACO), transfusion-related acute lung injury (TRALI), transfusion-associated hypothermia (TAH), transfusion-related allergic reactions (TRAR) and acute haemolytic transfusion reactions (AHTR)...
August 25, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Theodore E Warkentin, Pierre-Aurèle Morin, Nancy M Heddle
BACKGROUND: Transfusion-associated anaphylaxis has been associated with anti-immunoglobulin A (anti-IgA) of IgG class in patients with IgA deficiency. In recent years, however, the frequency and clinical impact of this syndrome has been questioned. We present a case of recurrent red blood cell (RBC) transfusion-associated anaphylactoid reactions (rigors, hypertension, transient monocytopenia, and neutropenia) associated with anti-IgA. CASE REPORT: An 88-year-old woman developed anemia after a traumatic right humerus fracture...
October 2018: Transfusion
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