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Transfusion And Iron And Blood Derivatives

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https://www.readbyqxmd.com/read/30014351/ferrous-and-ferric-differentially-deteriorate-proliferation-and-differentiation-of-osteoblast-like-umr-106-cells
#1
Kornkamon Lertsuwan, Ketsaraporn Nammultriputtar, Supanan Nanthawuttiphan, Supathra Phoaubon, Jomnarong Lertsuwan, Jirawan Thongbunchoo, Kannikar Wongdee, Narattaphol Charoenphandhu
The association between iron overload and osteoporosis has been found in many diseases, such as hemochromatosis, β-thalassemia and sickle cell anemia with multiple blood transfusion. One of the contributing factors is iron toxicity to osteoblasts. Some studies showed the negative effects of iron on osteoblasts; however, the effects of two biological available iron species, i.e., ferric and ferrous, on osteoblasts are elusive. Since most intracellular ionized iron is ferric, osteoblasts was hypothesized to be more responsive to ferric iron...
July 16, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29666112/increased-erythrophagocytosis-induces-ferroptosis-in-red-pulp-macrophages-in-a-mouse-model-of-transfusion
#2
Lyla A Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P Weisberg, Brent R Stockwell, Eldad A Hod, Steven L Spitalnik
Macrophages play important roles in recycling iron derived from the clearance of red blood cells (RBCs). They are also a critically important component of host defense, protecting against invading pathogens. However, the effects on macrophage biology of acutely ingesting large numbers of RBCs are not completely understood. To investigate this issue, we used a mouse model of RBC transfusion and clearance, which mimics the clinical setting. In this model, transfusions of refrigerator storage-damaged (ie, "old") RBCs led to increased erythrophagocytosis by splenic red pulp macrophages (RPMs)...
June 7, 2018: Blood
https://www.readbyqxmd.com/read/29482624/one-step-genetic-correction-of-hemoglobin-e-beta-thalassemia-patient-derived-ipscs-by-the-crispr-cas9-system
#3
Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Yaowalak U-Pratya, Pakpoom Kheolamai, Nuttha Klincumhom, Surapol Issaragrisil
BACKGROUND: Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoietic stem cell transplantation, which is limited due to lack of HLA-matched donors and the risk of post-transplant complications. Induced pluripotent stem cell (iPSC) technology offers prospects for autologous cell-based therapy which could avoid the immunological problems...
February 26, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29147080/effect-of-the-ginger-derivative-6-shogaol-on-ferritin-levels-in-patients-with-low-to-intermediate-1-risk-myelodysplastic-syndrome-a-small-investigative-study
#4
Terry Golombick, Terrence H Diamond, Arumugam Manoharan, Rajeev Ramakrishna, Vladimir Badmaev
Background: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal stem cell disorders characterized by dysplastic and ineffective hematopoiesis and peripheral cytopenias. Elevated serum ferritin (SF) is often observed in nontransfused, lower risk MDS. It has been reported that ineffective erythropoiesis enhances iron absorption in MDS through downregulation of hepcidin and its prohormones such that SF rises. Aim: To determine the effect of 6-shogaol, a dehydration derivative of ginger, known to have hepatoprotective and chemotherapeutic activity, on 6 early-stage, transfusion-independent patients with MDS, 3 of whom had raised levels of SF...
2017: Clinical Medicine Insights. Blood Disorders
https://www.readbyqxmd.com/read/28611958/management-of-blood-loss-in-hip-arthroplasty-korean-hip-society-current-consensus
#5
REVIEW
Joo-Hyoun Song, Jang Won Park, Young-Kyun Lee, In-Sung Kim, Jae-Hwi Nho, Kyung-Jae Lee, Kwan Kyu Park, Yeesuk Kim, Jai Hyung Park, Seung Beom Han
The volume of hip arthroplasty is stiffly increasing because of excellent clinical outcomes, however it has not been shown to decrease the incidence of transfusions due to bleeding related to this surgery. This is an important consideration since there are concerns about the side effects and social costs of transfusions. First, anemia should be assessed at least 30 days before elective hip arthroplasty, and if the subject is diagnosed as having anemia, an additional examination of the cause of the anemia should be carried and steps taken to address the anemia...
June 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28466891/analogues-of-desferrioxamine-b-designed-to-attenuate-iron-mediated-neurodegeneration-synthesis-characterisation-and-activity-in-the-mptp-mouse-model-of-parkinson-s-disease
#6
Michael P Gotsbacher, Thomas J Telfer, Paul K Witting, Kay L Double, David I Finkelstein, Rachel Codd
Parkinson's disease (PD) is a neurodegenerative disorder characterised by the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the brain and formation of α-synuclein-containing intracellular inclusions. Excess intraneuronal iron in the SNpc increases reactive oxygen species (ROS), which identifies removing iron as a possible therapeutic strategy. Desferrioxamine B (DFOB, 1) is an iron chelator produced by bacteria. Its high Fe(iii) affinity, water solubility and low chronic toxicity is useful in removing iron accumulated in plasma from patients with transfusion-dependent blood disorders...
July 19, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27923273/decision-points-in-the-treatment-of-transfusional-iron-overload-in-patients-with-myelodysplastic-syndromes-why-when-and-how-to-chelate
#7
REVIEW
Farhan Imran, Pradyumna Phatak
Patients with myelodysplastic syndromes (MDS) differ from those with other transfusion-dependent conditions (eg, thalassemia) as they are typically older, have comorbid conditions, and a generally shorter life expectancy. The underlying disease process in MDS and frequent use of red blood cell transfusions lead to iron accumulation and ultimately organ damage. Whether iron-reducing interventions such as chelation therapy can improve outcomes in this population is currently under investigation. Areas covered: We reviewed published English-language articles from PubMed on the topic of iron overload (IO) in MDS, and the use of iron chelation therapies (ICTs) to alleviate iron burden...
January 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/27755646/hydroxyurea-for-reducing-blood-transfusion-in-non-transfusion-dependent-beta-thalassaemias
#8
REVIEW
Wai Cheng Foong, Jacqueline J Ho, C Khai Loh, Vip Viprakasit
BACKGROUND: Non-transfusion dependent beta thalassaemia is a subset of inherited haemoglobin disorders characterised by reduced production of the beta globin chain of the haemoglobin molecule leading to anaemia of varying severity. Although blood transfusion is not a necessity for survival, it is required when episodes of chronic anaemia occur. This chronic anaemia can impair growth and affect quality of life. People with non-transfusion dependent beta thalassaemia suffer from iron overload due to their body's increased capability of absorbing iron from food sources...
October 18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27455830/comparison-of-double-rbc-collection-by-blood-cell-separators
#9
Pimpun Kitpoka, Sarawan Chanthet, Viroje Chongkolwatana, Ampaiwan Chuansumrit, Mongkol Kunakorn
BACKGROUND: The problem of red blood cell (RBC) shortage occurs because of the expanding demand for blood utilization and the dfficulties in donor recruitment and retention. Resources can be maximized by using current technology to collect two units of RBC from the same donor during a single collection session. OBJECTIVE: To evaluate the performance, collection efficiency (CE), production cost, and donor satisfactions of two commercially available blood cell separators (BCS) for double dose red cell (DDRC) collection...
January 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27419608/intraerythrocytic-iron-chelation-a-new-therapy-for-thalassemia
#10
M D Scott
Thalassemic red blood cells (RBC) are characterized by alterations in globin chain stability that result in the release of redox-active iron within the RBC. This iron, via a self-propagating and self-amplifying reaction, destabilizes additional hemoglobin (hence, releasing more iron) and causes significant oxidant damage to other cellular components. To attenuate this iron-mediated damage pharmacologically, an intraerythrocytic iron chelation shuttle system is proposed. The iron shuttle systemconsists of low affinity, RBC permeable, iron-binding agents which enter the cell, bind iron, diffuse out, and hand-off the iron to a high affinity, RBC-impermeable, high molecular weight starch derivative of desferrioxamine (S-DFO)...
2001: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27067481/the-investigation-of-resveratrol-and-analogs-as-potential-inducers-of-fetal-hemoglobin
#11
Andria Theodorou, Marios Phylactides, Luca Forti, Maria Rita Cramarossa, Pantelis Spyrou, Roberto Gambari, Swee Lay Thein, Marina Kleanthous
Βeta-thalassemia, is a hemoglobinopathy characterized by reduced beta-globin chain synthesis, leading to imbalanced globin chain production, ineffective erythropoiesis and anemia. Increasing gamma-globin gene expression is a promising therapeutic approach as it reduces this imbalance by combining with the excess alpha globin chains and producing fetal hemoglobin (HbF). Furthermore, increased iron absorption and repeated blood transfusions lead to iron overload and tissue damage secondary to reactive oxygen species...
May 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/26999376/unrelated-donor-stem-cell-transplantation-for-transfusion-dependent-thalassemia
#12
REVIEW
Shalini Shenoy, Alexis A Thompson
Thalassemia major is characterized by severe anemia dependent on red cell transfusions from infancy. Conservative management requires a safe source of compatible blood throughout life, strategies to combat iron overload, monitoring and treatment of transfusion-related complications, and management of cardiac and/or hepatic dysfunction from iron accumulation. Complications can result in premature morbidity and mortality. Stem cell transplantation is curative, but outcomes depend on the availability of a histocompatible donor, recipient age, and disease-related complications...
March 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/26821380/glycine-and-folate-ameliorate-models-of-congenital-sideroblastic-anemia
#13
J Pedro Fernández-Murray, Sergey V Prykhozhij, J Noelia Dufay, Shelby L Steele, Daniel Gaston, Gheyath K Nasrallah, Andrew J Coombs, Robert S Liwski, Conrad V Fernandez, Jason N Berman, Christopher R McMaster
Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell precursors. A common subtype of congenital sideroblastic anemia is due to autosomal recessive mutations in the SLC25A38 gene. The current treatment for SLC25A38 congenital sideroblastic anemia is chronic blood transfusion coupled with iron chelation. The function of SLC25A38 is not known. Here we report that the SLC25A38 protein, and its yeast homolog Hem25, are mitochondrial glycine transporters required for the initiation of heme synthesis...
January 2016: PLoS Genetics
https://www.readbyqxmd.com/read/26690864/intakes-of-micronutrients-are-associated-with-early-growth-in-extremely-preterm-infants
#14
Elisabeth S Sjöström, Inger Öhlund, Fredrik Ahlsson, Magnus Domellöf
OBJECTIVES: The aim of the study was to describe micronutrient intakes and explore possible correlations to growth during the first 70 days of life in extremely preterm infants. METHODS: Retrospective population-based study including extremely preterm infants (<27 weeks) born in Sweden during 2004-2007. Detailed nutritional and growth data were derived from hospital records. RESULTS: Included infants (n = 531) had a mean gestational age of 25 weeks and 2 days and a mean birth weight of 765 g...
June 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26205481/platelet-and-not-erythrocyte-microparticles-are-procoagulant-in-transfused-thalassaemia-major-patients
#15
Imane Agouti, Sylvie Cointe, Stéphane Robert, Coralie Judicone, Anderson Loundou, Fathi Driss, Alain Brisson, Dominique Steschenko, Christian Rose, Corinne Pondarré, Emmanuelle Bernit, Catherine Badens, Françoise Dignat-George, Romaric Lacroix, Isabelle Thuret
The level of circulating platelet-, erythrocyte-, leucocyte- and endothelial-derived microparticles detected by high-sensitivity flow cytometry was investigated in 37 β-thalassaemia major patients receiving a regular transfusion regimen. The phospholipid procoagulant potential of the circulating microparticles and the microparticle-dependent tissue factor activity were evaluated. A high level of circulating erythrocyte- and platelet-microparticles was found. In contrast, the number of endothelial microparticles was within the normal range...
November 2015: British Journal of Haematology
https://www.readbyqxmd.com/read/26190429/the-role-of-magnetic-resonance-imaging-in-the-evaluation-of-transfusional-iron-overload-in-myelodysplastic-syndromes
#16
Emmanouil Petrou, Sophie Mavrogeni, Vasiliki Karali, Genovefa Kolovou, Marie-Christine Kyrtsonis, Petros P Sfikakis, Panayiotis Panayiotidis
Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective erythropoiesis. Anemia is a common finding in myelodysplastic syndrome patients, and blood transfusions are the only therapeutic option in approximately 40% of cases. The most serious side effect of regular blood transfusion is iron overload. Currently, cardiovascular magnetic resonance using T2 is routinely used to identify patients with myocardial iron overload and to guide chelation therapy, tailored to prevent iron toxicity in the heart...
July 2015: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/26175134/transfused-older-stored-red-blood-cells-improve-the-clinical-course-and-outcome-in-a-canine-lethal-hemorrhage-and-reperfusion-model
#17
Steven B Solomon, Irene Cortés-Puch, Junfeng Sun, Kenneth E Remy, Dong Wang, Jing Feng, Sameena S Khan, Derek Sinchar, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson
BACKGROUND: In canine models, transfused older stored red blood cells (RBCs) hemolyze in vivo resulting in significantly increased intravascular cell-free hemoglobin (CFH) and non-transferrin-bound iron (NTBI). During canine bacterial pneumonia with septic shock, but not in controls, older stored RBCs were associated with significantly increased lung injury and mortality. It is unknown if in shock without infection transfusion of older RBCs will result in similar adverse effects. STUDY DESIGN AND METHODS: Two-year-old purpose-bred beagles (n = 12) were transfused similar quantities of either older (42-day) or fresher (7-day) stored universal donor canine RBCs 2...
November 2015: Transfusion
https://www.readbyqxmd.com/read/25855341/ongoing-risk-of-thrombosis-with-factor-xi-concentrate-5%C3%A2-years-experience-in-two-centres
#18
P Batty, A Honke, L Bowles, D P Hart, K J Pasi, J Uprichard, S K Austin
INTRODUCTION: Factor XI (FXI) deficiency is the commonest of the rare bleeding disorders, affecting 2079 individuals in the United Kingdom. Treatment options for bleeding or surgery include antifibrinolytics, fresh frozen plasma or plasma-derived (pd) FXI concentrates. There were a number of reports of thrombosis following treatment with FXI concentrates prior to changes in their manufacturing processes made in the mid-1990's. AIMS: The aim of the study was to determine the occurrence of adverse events (haemorrhagic and thrombotic) following usage of pd-FXI concentrates at two large UK haemophilia centres...
July 2015: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/25714295/effect-of-inversion-recovery-fat-suppression-on-hepatic-r2-quantitation-in-transfusional-siderosis
#19
Antonella Meloni, J Michael Tyszka, Alessia Pepe, John C Wood
OBJECTIVE. The purpose of this study is to evaluate whether the application of spectral pre-saturation inversion recovery (SPIR) fat suppression in standard multiecho gradient-echo sequences has a significant effect on hepatic R2* quantitation in patients with iron overload syndromes. MATERIALS AND METHODS. Eighty patients were scanned with a multiecho gradient-echo sequence without and with the application of SPIR. Six different postprocessing approaches were used to extract R2* values for maximum generality...
March 2015: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/25156334/successful-treatment-of-severe-immune-hemolytic-anemia-after-allogeneic-stem-cell-transplantation-with-bortezomib-report-of-a-case-and-review-of-literature
#20
REVIEW
Sakura Hosoba, David L Jaye, Cynthia Cohen, John D Roback, Edmund K Waller
BACKGROUND: Immune hemolytic anemia is a well-known complication after allogeneic hematopoietic stem cell transplantation (HSCT). Posttransplant hemolytic anemia results in increased red blood cell transfusions and medical sequelae including iron overload. CASE REPORT: We present a case report of immune hemolytic anemia that occurred after allogeneic HSCT from an ABO major-mismatched, HLA-matched unrelated donor. The patient had high anti-donor A type antibodies that were unresponsive to treatment with steroids and rituximab, resulting in persistent transfusion dependence...
February 2015: Transfusion
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