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https://www.readbyqxmd.com/read/28570329/endocrine-emergencies-with-neurologic-manifestations
#1
Makoto Ishii
PURPOSE OF REVIEW: This article provides an overview of endocrine emergencies with potentially devastating neurologic manifestations that may be fatal if left untreated. Pituitary apoplexy, adrenal crisis, myxedema coma, thyroid storm, acute hypercalcemia and hypocalcemia, hyperglycemic emergencies (diabetic ketoacidosis and hyperglycemic hyperosmolar state), and acute hypoglycemia are discussed, with an emphasis on identifying the signs and symptoms as well as diagnosing and managing these clinical entities...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28540093/myxedema-crisis-presenting-with-seizures-a-rare-life-threatening-presentation-a-case-report-and-review-of-the-literature
#2
Sonali Sihindi Chapa Gunatilake, Uditha Bulugahapitiya
Myxedema crisis is a life-threatening extreme form of hypothyroidism with a high mortality rate if left untreated. Myxedema crisis is commonly seen in older patients, especially in women, and is associated with signs of hypothyroidism, hypothermia, hyponatraemia, hypercarbia, and hypoxemia. Patients might present with different organ specific symptoms. Seizures are a recognized but rare manifestation of myxedema with a very high mortality rate. Prompt diagnosis and appropriate management may improve the prognosis...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28255471/intracerebral-bleeding-and-massive-pericardial-effusion-as-presenting-symptoms-of-myxedema-crisis
#3
M Kirsch, C Rimpau, C H Nickel, P Baier
The endocrinological emergency of a fully blown myxedema crisis can present as a multicolored clinical picture. This can obscure the underlying pathology and easily lead to mistakes in clinical diagnosis, work-up, and treatment. We present a case of an unconscious 39-year-old patient with a medical history of weakness, lethargy, and findings of hyponatremia, intracerebral bleeding, and massive pericardial effusion. Finally, myxedema crisis was diagnosed as underlying cause. Replacement therapy of thyroid hormone and conservative management of the intracerebral bleeding resulted in patient's survival without significant neurological impairment...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28239466/nivolumab-induced-myxedema-crisis
#4
Uqba Khan, Humaira Rizvi, Dahlia Sano, Jane Chiu, Tarik Hadid
BACKGROUND: Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody that is approved by Food and Drug Administration for treatment of metastatic non-small cell lung cancer, metastatic melanoma, relapsed Hodgkin lymphoma and advanced renal cell cancer. We report a rare case of myxedema crisis induced by nivolumab in a patient with metastatic squamous cell carcinoma of lung. CASE PRESENTATION: Fifty three-year old woman with metastatic squamous cell carcinoma currently on treatment with nivolumab presented with diffuse facial and tongue swelling, slurred speech, depressed mentation, fatigue and weakness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/26924647/a-rabbit-model-of-fatal-hypothyroidism-mimicking-myxedema-coma-established-by-microscopic-total-thyroidectomy
#5
Yosuke Ono, Masanori Fujita, Sachiko Ono, Sho Ogata, Shoichi Tachibana, Yuji Tanaka
Myxedema coma (MC) is a life-threatening endocrine crisis caused by severe hypothyroidism. However, validated diagnostic criteria and treatment guidelines for MC have not been established owing to its rarity. Therefore, a valid animal model is required to investigate the pathologic and therapeutic aspects of MC. The aim of the present study was to establish an animal model of MC induced by total thyroidectomy. We utilized 14 male New Zealand White rabbits anesthetized via intramuscular ketamine and xylazine administration...
June 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/26155541/a-rare-case-of-myxedema-coma-with-neuroleptic-malignant-syndrome-nms
#6
Siddharth Dixit, Manoj Kumar Dutta, Mayank Namdeo
Myxedema coma or hypothyroid crisis is an endocrine emergency and needs ICU management. Neuroleptic malignant syndrome (NMS) is another medical emergency which needs high degree of clinical suspicion else mortality can be high. There is a paradox in co existence of myxedema coma and NMS. While one is hypometabolic state another is hypermetabolic state and both can be precipitated by antipsychotics use. Hypothermia and flaccidity commonly expected in myxedema coma may mask fever and rigidity of classical NMS contributing to diagnostic problem and treatment delay...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/24910829/lithium-toxicity-and-myxedema-crisis-in-an-elderly-patient
#7
Shahnaz Ahmad Mir, Arshad Iqbal Wani, Shariq Rashid Masoodi, Mir Iftikhar Bashir, Nadeem Ahmad
UNLABELLED: While thyroid dysfunction is a frequent complication of lithium treatment, myxedema crisis is a rare occurrence with a handful of cases described. Here, we describe a patient receiving lithium for about a decade for bipolar disorder, who presented with myxedema crisis and lithium toxicity. In this patient, myxedema crisis was likely precipitated by lithium toxicity and community acquired pneumonia. The effects of lithium on thyroid are briefly reviewed. OBJECTIVE: To describe an elderly male who was diagnosed with myxedema crisis and lithium toxicity...
December 2013: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23491778/endokrine-krisen
#8
Bürgi, Perrig
Pituitary apoplexy, diabetes insipidus, thyroid storm, myxedema coma, parathyrotoxic crisis, hypocalcemia tetany, pheochromocytoma and Addison crisis, diabetic ketoacidosis, diabetic hyperosmolar nonketotic coma, hypoglycemia and carcinoid crisis are the most important endocrine crises. Some of them are common, others very rare. All physicians nevertheless need to have at least a basic knowledge of all of them, since symptoms and signs of endocrine crises overlap with those of other severe disease states, and the failure to recognise endocrine crises as such and to begin rapidly the specific therapy can have fatal consequences...
June 1, 2005: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/22443982/thyroid-emergencies
#9
REVIEW
Joanna Klubo-Gwiezdzinska, Leonard Wartofsky
This review presents current knowledge about the thyroid emergencies known as myxedema coma and thyrotoxic storm. Understanding the pathogenesis of these conditions, appropriate recognition of the clinical signs and symptoms, and their prompt and accurate diagnosis and treatment are crucial in optimizing survival.
March 2012: Medical Clinics of North America
https://www.readbyqxmd.com/read/22308583/-endocrine-emergencies-what-should-be-done-immediately-so-the-patient-survives-the-crisis
#10
Angelika Bischoff
No abstract text is available yet for this article.
December 8, 2011: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/21941682/myxedema-coma-a-new-look-into-an-old-crisis
#11
Vivek Mathew, Raiz Ahmad Misgar, Sujoy Ghosh, Pradip Mukhopadhyay, Pradip Roychowdhury, Kaushik Pandit, Satinath Mukhopadhyay, Subhankar Chowdhury
Myxedema crisis is a severe life threatening form of decompensated hypothyroidism which is associated with a high mortality rate. Infections and discontinuation of thyroid supplements are the major precipitating factors while hypothermia may not play a major role in tropical countries. Low intracellular T3 leads to cardiogenic shock, respiratory depression, hypothermia and coma. Patients are identified on the basis of a low index of suspicion with a careful history and examination focused on features of hypothyroidism and precipitating factors...
2011: Journal of Thyroid Research
https://www.readbyqxmd.com/read/21879658/modern-concepts-of-preoperative-preparation-of-patients-with-thyroid-gland-disease
#12
REVIEW
Vera Sabljak, Nevena Kalezić, Branislava Ivanović, Vladan Zivaljević, Aleksandar Diklić, Ivan Paunović
Preoperative evaluation of patients with thyroid land disease, in any kind of surgery, should include the possibility of difficult intubation caused by thyromegaly, the hormonal status (its disbalance), as well as the screening, and therapy of consequences of thyroid imbalance on specific organ systems, especially cardiovascular. It is necessary to select the adequate anesthetics and other pharmacological agents, according to current hormonal status. It is also necessary to select the adequate medications and other therapeutic measures for prevention and treatment of possible complications in perioperative period, some of which are life-threatening (thyroid storm and mixedema coma)...
2011: Acta Chirurgica Iugoslavica
https://www.readbyqxmd.com/read/21819006/thyroid-emergencies
#13
Siddharth N Shah
No abstract text is available yet for this article.
January 2011: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/19930169/iatrogenic-sulfonamide-induced-hypothyroid-crisis-in-a-labrador-retriever
#14
K Brenner, K Harkin, T Schermerhorn
This case report describes a sulfonamide-induced hypothyroid crisis in a 4-year-old Labrador Retriever bitch. Empirical therapy with high-dose trimethoprim-sulfamethoxazole for 10 days produced signs of weakness, ataxia and mental depression and the clinicopathological results supported hypothyroid-induced central nervous system depression. Short-term levothyroxine sodium therapy led to complete resolution of all clinical signs and follow-up thyroid hormone assays ruled out underlying thyroid pathology. This case report is the first to highlight this potentially life-threatening manifestation of sulfonamide-induced hypothyroidism...
December 2009: Australian Veterinary Journal
https://www.readbyqxmd.com/read/17344150/-some-neurologic-and-psychiatric-complications-in-endocrine-disorders-the-thyroid-gland
#15
REVIEW
Zsuzsa Aszalós
Thyroid hormones are of primary importance for the perinatal development of the central nervous system, and for normal function of the adult brain. These hormones primarily regulate the transcription of specific target genes. They increase the cortical serotonergic neurotransmission, and play an important role in regulating central noradrenergic and GABA function. Thyroid deficiency during the perinatal period results in mental retardation. Hypothyroidism of the adults causes most frequently dementia and depression...
February 18, 2007: Orvosi Hetilap
https://www.readbyqxmd.com/read/17308209/diabetic-and-endocrine-emergencies
#16
REVIEW
T Kearney, C Dang
Endocrine emergencies constitute only a small percentage of the emergency workload of general doctors, comprising about 1.5% of all hospital admission in England in 2004-5. Most of these are diabetes related with the remaining conditions totalling a few hundred cases at most. Hence any individual doctor might not have sufficient exposure to be confident in their management. This review discusses the management of diabetic ketoacidosis, hyperosmolar hyperglycaemic state, hypoglycaemia, hypercalcaemia, thyroid storm, myxoedema coma, acute adrenal insufficiency, phaeochromocytoma hypertensive crisis and pituitary apoplexy in the adult population...
February 2007: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/17209300/-diagnosis-and-management-of-endocrine-crises-in-adulthood
#17
REVIEW
János Vadász
Diagnosis and management of endocrine crises in adulthood. The homeostasis of the body is regulated by concerted action of the endocrine, nervous and immune systems. An imbalance in this equilibrium, as a consequence of disease or endocrine failure, may lead to crisis, characterized by sudden onset and severe symptoms. The classical endocrine emergencies are rare but life-threatening conditions. Prompt and aggressive treatment significantly reduces mortality. Immediate therapy might be necessitated in cases of suspected endocrine emergencies, even prior to laboratory confirmation...
November 5, 2006: Orvosi Hetilap
https://www.readbyqxmd.com/read/15999934/-endocrine-crises
#18
REVIEW
U Bürgi, M Perrig
Pituitary apoplexy, diabetes insipidus, thyroid storm, myxedema coma, parathyrotoxic crisis, hypocalcemia tetany, pheochromocytoma and Addison crisis, diabetic ketoacidosis, diabetic hyperosmolar nonketotic coma, hypoglycemia and carcinoid crisis are the most important endocrine crises. Some of them are common, others very rare. All physicians nevertheless need to have at least a basic knowledge of all of them, since symptoms and signs of endocrine crises overlap with those of other severe disease states, and the failure to recognise endocrine crises as such and to begin rapidly the specific therapy can have fatal consequences...
June 2005: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/14231515/sheehan-s-syndrome-with-myxedema-crisis
#19
A M PAULL
No abstract text is available yet for this article.
November 1964: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/14162895/myxedema-crisis-of-pituitary-or-thyroid-origin
#20
M PERLMUTTER, H COHN
No abstract text is available yet for this article.
June 1964: American Journal of Medicine
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