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https://www.readbyqxmd.com/read/30341420/abin-1-heterozygosity-sensitizes-to-innate-immune-response-in-both-ripk1-dependent-and-ripk1-independent-manner
#1
Zhenyi Su, Slawomir A Dziedzic, Die Hu, Vica Jean Barrett, Nicole Broekema, Wanjin Li, Lihui Qian, Na Jia, Dimitry Ofengeim, Ayaz Najafov, Hong Zhu, David M Knipe, Junying Yuan
ABIN-1 (encoded by the gene Tnip1) is a ubiquitin-binding protein that can interact with ubiquitin-editing enzyme A20 (encoded by the gene TNFAIP3) to restrain the activation of necroptosis and NF-κB activation. Genetic variants in the genes Tnip1 and TNFAIP3 are both strongly associated with susceptibility to autoimmune chronic inflammatory diseases such as psoriasis vulgaris and systemic lupus erythematosus (SLE) in humans. Here we investigated the mechanism by which ABIN-1 regulated innate immune responses...
October 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/30337146/structural-mapping-of-hot-spots-within-human-caspr2-discoidin-domain-for-autoantibody-recognition
#2
Wenjun Liang, Junying Zhang, Margaux Saint-Martin, Fei Xu, Nelly Noraz, Jianmei Liu, Jérôme Honnorat, Heli Liu
Accumulating evidence has showed that anti-CASPR2 autoantibodies occur in a long list of neurological immune disorders including limbic encephalitis (LE). Belonging to the well-known neurexin superfamily, CASPR2 has been suggested to be a central node in the molecular networks controlling neurodevelopment. Distinct from other subfamilies in the neurexin superfamily, the CASPR subfamily features a unique discoidin (Disc) domain. As revealed by our and others' recent studies, CASPR2 Disc domain bears a major epitope for autoantibodies...
October 15, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/30333036/the-ifn-%C3%AE-pd-l1-axis-between-t-cells-and-tumor-microenvironment-hints-for-glioma-anti-pd-1-pd-l1-therapy
#3
Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua Liu, Yiwei Chu
BACKGROUND: PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding to its receptor PD-1, which works in braking inflammatory response and conspiring tumor immune evasion. However, in gliomas, the cause of PD-L1 expression in the tumor microenvironment is not yet clear. Besides, auxiliary biomarkers are urgently needed for screening possible responsive glioma patients for anti-PD-1/PD-L1 therapies. METHODS: The distribution of tumor-infiltrating T cells and PD-L1 expression was analyzed via immunofluorescence in orthotopic murine glioma model...
October 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/30323337/synthetic-lethality-between-her2-and-transaldolase-in-intrinsically-resistant-her2-positive-breast-cancers
#4
Yi Ding, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H Lin, Gehao Liang, Lifeng Yuan, Handan Xiang, Junying Chen, Tao Yin, Peter B Alexander, Qian-Fei Wang, Er-Wei Song, Qi-Jing Li, Kris C Wood, Xiao-Fan Wang
Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle in the clinic, limiting its efficacy. However, the biological basis for intrinsic resistance is poorly understood. Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade. Suppression of TA increases cell susceptibility to HER2 inhibition in two intrinsically resistant breast cancer cell lines with HER2 amplification...
October 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/30323132/the-rat-model-of-placental-ischemia-as-a-model-of-postpartum-posterior-cortical-atrophy
#5
Ashtin B Giambrone, Junie P Warrington
No abstract text is available yet for this article.
December 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30317143/diagnostic-value-of-he4-in-ovarian-cancer-a-meta-analysis
#6
REVIEW
Jinbing Huang, Junying Chen, Qiaoqiao Huang
OBJECTIVE: To analyze and evaluate the overall diagnostic value of Serum Human Epididymis Protein 4 (HE4) in ovarian cancer. METHODS: We searched PubMed, EMBASE, Cochrane Library and Web of Science databases to collect articles in English that evaluated the diagnostic value of HE4 in patients with gynecological or pelvic masses. Two reviewers independently assessed the methodological quality of each study using the QUADAS-2 tool. A chart of literature quality was made using Revman 5...
October 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30305199/response-surface-optimization-of-supercritical-carbon-dioxide-extraction-of-tea-polyphenols-from-green-tea-scraps
#7
Weifang Wang, Sai Han, Xianjun Zha, Jiangrui Cheng, Junying Song, Zhen Jiao
Background : The green tea scraps are the waste materials during the process of green tea production, and it is significant to extract valuable tea polyphenols (TP) for reuse. Objective : The objective of this study was to extract valuable TP from green tea scraps, and the extraction conditions were optimized to obtain maximum yield of TP. Methods : The TP were extracted by supercritical carbon dioxide (SC-CO₂) with 65% (v/v) aqueous ethanol solution as cosolvent. The content of TP was determined with the Folin-Ciocalteu method...
October 10, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/30304778/whole-body-12-c-irradiation-transiently-decreases-mouse-hippocampal-dentate-gyrus-proliferation-and-immature-neuron-number-but-does-not-change-new-neuron-survival-rate
#8
Giulia Zanni, Hannah M Deutsch, Phillip D Rivera, Hung-Ying Shih, Junie A LeBlanc, Wellington Z Amaral, Melanie J Lucero, Rachel L Redfield, Matthew J DeSalle, Benjamin P C Chen, Cody W Whoolery, Ryan P Reynolds, Sanghee Yun, Amelia J Eisch
High-charge and -energy (HZE) particles comprise space radiation and they pose a challenge to astronauts on deep space missions. While exposure to most HZE particles decreases neurogenesis in the hippocampus-a brain structure important in memory-prior work suggests that 12 C does not. However, much about 12 C's influence on neurogenesis remains unknown, including the time course of its impact on neurogenesis. To address this knowledge gap, male mice (9⁻11 weeks of age) were exposed to whole-body 12 C irradiation 100 cGy (IRR; 1000 MeV/n; 8 kEV/µm) or Sham treatment...
October 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30299526/paediatric-cerebral-palsy-prevalence-and-high-risk-factors-in-henan-province-central-china
#9
Junying Yuan, Jun Wang, Jieqiong Ma, Dengna Zhu, Zhenhuan Zhang, Jianan Li
OBJECTIVE: To evaluate the prevalence of, and risk factors for, cerebral palsy in Henan province, China. METHODS: The prevalence of cerebral palsy in children aged 0-6 years between September 2011 and September 2012 was investigated using a stratified-clustered-random sampling method. An age-, sex- , and residence-matched control group of typically developing children was recruited. Univariate analysis and multinomial logistic regression analysis were used to identify risk factors associated with cerebral palsy...
October 9, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/30297899/late-stage-tumors-induce-anemia-and-immunosuppressive-extramedullary-erythroid-progenitor-cells
#10
Lintao Zhao, Ran He, Haixia Long, Bo Guo, Qingzhu Jia, Diyuan Qin, Si-Qi Liu, Zhongyu Wang, Tong Xiang, Jue Zhang, Yulong Tan, Jiani Huang, Junying Chen, Fang Wang, Minglu Xiao, Jianbao Gao, Xinxin Yang, Hao Zeng, Xinxin Wang, Chunyan Hu, Peter B Alexander, Alistair L J Symonds, Jia Yu, Yisong Wan, Qi-Jing Li, Lilin Ye, Bo Zhu
Impaired immunity in patients with late-stage cancer is not limited to antitumor responses, as demonstrated by poor vaccination protection and high susceptibility to infection1-3 . This has been largely attributed to chemotherapy-induced impairment of innate immunity, such as neutropenia2 , whereas systemic effects of tumors on hematopoiesis and adoptive immunity remain incompletely understood. Here we observed anemia associated with severe deficiency of CD8+ T cell responses against pathogens in treatment-naive mice bearing large tumors...
October 2018: Nature Medicine
https://www.readbyqxmd.com/read/30296378/dual-ion-mode-maldi-ms-detection-of-small-molecules-with-the-o-p-n-doped-carbon-graphene-matrix
#11
Huifang Zhao, Yanqiu Li, Jie Wang, Miao Cheng, Zheng Zhao, Huinian Zhang, Congwei Wang, Junying Wang, Yan Qiao, Junzhong Wang
It is challenging to realize a dual-ion mode of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detecting small molecules. Herein, graphene coated by porous amorphous carbon with P-O surface group and codoped by phosphorus and nitrogen (O-P,N-C/G) was synthesized from an aerogel formed by phytic acid, polyaniline, and electrochemically exfoliated graphene. The carbon material synthesized has the feature of large surface area (583 m2 /g), good electrical conductivity, strong UV absorption, heteroatom doping, and surface functional groups suitable for laser- induced desorption/ionization...
October 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30291678/gender-and-age-differences-in-outcomes-of-patients-with-acute-coronary-syndromes-referred-for-coronary-angiography
#12
Barbara E Stähli, Manfred B Wischnewsky, Philipp Jakob, Roland Klingenberg, Slayman Obeid, Dik Heg, Lorenz Räber, Stephan Windecker, François Mach, Baris Gencer, David Nanchen, Peter Jüni, Ulf Landmesser, Christian M Matter, Thomas F Lüscher, Willibald Maier
OBJECTIVES: The number of elderly patients undergoing coronary revascularization is steadily increasing, and data on the impact of gender on outcomes are scarce. This study sought to assess gender-related differences in outcomes in elderly patients with acute coronary syndromes (ACS). METHODS: We investigated outcomes in elderly ACS patients referred for coronary angiography and prospectively enrolled in the Swiss ACS Cohort between December 2009 and October 2012...
October 5, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30273491/tailoring-the-tribocorrosion-and-antifouling-performance-of-cr-cu-glc-coatings-for-marine-application
#13
Xudong Sui, Rongnian Xu, Jian Liu, Shuaituo Zhang, Yang Wu, Jun Yang, Junying Hao
Doped graphite-like coating (GLC) has aroused great interests as one of the promising protective material in marine application. However, there is a lack of systematic research on the tribocorrosion and antifouling performance of doped GLC coatings in harsh marine environments. Herein, a multi-functional (Cr, Cu)-GLC coating with combined antifouling and tribocorrosion properties was prepared via a magnetron sputtering method. The experimental results indicate that the resultant coatings changed from a dense structure to a loose columnar structure with the increment of Cr and Cu doping amount...
October 1, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30266232/development-of-water-compatible-molecularly-imprinted-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-the-detection-of-six-sulfonamides-in-animal-derived-foods
#14
Xiaolei Zhao, Junying Wang, Junping Wang, Shuo Wang
A water-compatible molecularly imprinted polymer (MIP) was prepared by combining reversible addition-fragmentation chain transfer (RAFT) with reflux precipitation polymerization (RPP) for solid-phase extraction (SPE) coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to detect six sulfonamides (SAs) in animal-derived foods and water samples. The SEM images indicated the spherical structure of MIP materials. In water medium, MIPs still performed good specific adsorption for SAs...
August 22, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30259626/aberrant-methylation-induced-dysfunction-of-p16-is-associated-with-osteoblast-activation-caused-by-fluoride
#15
Shouli Wu, Weimin Yan, Bing Qiu, Yongfang Liao, Junying Gu, Shaofeng Wei, Aihua Zhang, Xueli Pan
Chronic exposure to fluoride continues to be a public health problem worldwide, affecting thousands of people. Fluoride can cause abnormal proliferation and activation of osteoblast and osteoclast, leading to skeletal fluorosis that can cause pain and harm to joints and bones and even lead to permanent disability. Nevertheless, there is no recognized mechanism to explain the bone lesions of fluorosis. In this work, we performed a population study and in vitro experiments to investigate the pathogenic mechanism of skeletal fluorosis in relation to methylation of the promoter of p16...
September 26, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/30253275/construction-and-evaluation-of-ha-epitope-tag-introduction-onto-the-vp1-structural-protein-of-a-novel-hy12-enterovirus
#16
Dan Liu, Changming Liu, Junying Hu, Liping Hang, Xin Li, Yanwu Wei, Hongzhen Zhu, Qun Zhang, Xinping Wang
In this study, we investigated the feasibility of using enterovirus HY12 as a vector to express an exogenous hemagglutinin (HA)-epitope tag onto the HY12-encoded VP1 protein via a reverse genetic system. Characteristics of recombinant (r) HY12-VP1-HA marker virus were determined by immunoperoxidase monolayer assay, western blot, electron microscopy, and serum-neutralisation assay. Sequence analysis demonstrated that the marker virus stably maintained the HA-epitope-tag in MDBK cells, with no changes in viral morphological features observed relative to those of the parental rHY12 virus...
September 22, 2018: Virology
https://www.readbyqxmd.com/read/30230922/signature-oriented-investigation-of-the-efficacy-of-multicomponent-drugs-against-heart-failure
#17
Junying Wei, Feifei Guo, Minyu Zhang, Minghua Xian, Tingting Wang, Jinhuan Gao, Hongwei Wu, Lei Song, Yi Zhang, Defeng Li, Hongjun Yang, Luqi Huang
Increasing attention has been paid to the application of precision medicine in heart failure (HF), and biomarker-based personalized medical care has shown great progress in HF management. Additionally, multicomponent drugs represented by traditional Chinese medicine (TCM) are demonstrating safety and efficacy in the management of HF. However, the potential mechanism is unclear, and the ambiguous clinical locations of TCM remain a hindrance to its extensive application. To meet this requirement, a precise investigation on the efficacy of multicomponent drugs against HF using the signature biomarkers-oriented approach was developed and applied to a conventional drug for cardiac disease, YiXinShu (YXS)...
September 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30221056/s100a4-promotes-colon-inflammation-and-colitis-associated-colon-tumorigenesis
#18
Jinhua Zhang, Shasha Hou, Jianchun Gu, Tian Tian, Qi Yuan, Junying Jia, Zhihai Qin, Zhinan Chen
S100A4 plays important roles in tumor development and metastasis, but its role in regulating inflammation and colitis-associated tumorigenesis has not been well characterized. Here, we report that S100A4 expression was increased in azoxymethane (AOM) and dextran sulfate sodium (DSS) induced colorectal cancer (CRC) in mice. After AOM/DSS treatment, both S100A4-TK mice with the selective depletion of S100A4-expressing cells and S100A4-deficient (S100A4-/- ) mice developed fewer and smaller tumors than wild-type (WT) control littermates...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/30221043/-%C3%AE-catenin-peptide-vaccines-repress-hepatocellular-carcinoma-growth-via-cd8-t-cell-activation
#19
Fei Huang, Junying Chen, Ruilong Lan, Zeng Wang, Ruiqing Chen, Jingan Lin, Lurong Zhang, Lengxi Fu
As classical therapy method of advanced hepatocellular carcinoma (HCC) is not effective enough, HCC immunotherapy is a hot spot for research in recent years. Although in recent years, immune checkpoint inhibitors are focused in cancer therapy, vaccines and adoptive cell therapy (ACT), as traditional immunotherapy methods for HCC are still promising. We found that δ-Catenin might be a new tumor-associated antigen for HCC, for it could be upregulated as a stress associated protein under hypoxia and irradiation treatment...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/30210533/deep-convolutional-neural-network-used-in-single-sample-per-person-face-recognition
#20
Junying Zeng, Xiaoxiao Zhao, Junying Gan, Chaoyun Mai, Yikui Zhai, Fan Wang
Face recognition (FR) with single sample per person (SSPP) is a challenge in computer vision. Since there is only one sample to be trained, it makes facial variation such as pose, illumination, and disguise difficult to be predicted. To overcome this problem, this paper proposes a scheme combined traditional and deep learning (TDL) method to process the task. First, it proposes an expanding sample method based on traditional approach. Compared with other expanding sample methods, the method can be used easily and conveniently...
2018: Computational Intelligence and Neuroscience
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