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https://www.readbyqxmd.com/read/30509949/corrigendum-spata2-regulates-the-activation-of-ripk1-by-modulating-linear-ubiquitination
#1
Ran Wei, Lily Wen Xu, Jianping Liu, Yanxia Li, Pei Zhang, Bing Shan, Xiaojuan Lu, Lihui Qian, Zheming Wu, Kangyun Dong, Hong Zhu, Lifeng Pan, Junying Yuan, Heling Pan
No abstract text is available yet for this article.
December 1, 2018: Genes & Development
https://www.readbyqxmd.com/read/30508885/clinicopathological-and-prognostic-significance-of-glut1-in-breast-cancer-a-meta-analysis
#2
Yu Deng, Jialing Zou, Ting Deng, Junying Liu
BACKGROUND: Previous studies examining the prognostic value of glucose transporter 1 in breast cancer have yielded inconsistent results. We, therefore, performed a meta-analysis to clarify this issue. METHODS: The research was reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Relevant studies were retrieved from PubMed, Web of Science, EMBASE, and Cochrane library. RESULTS: A total of 7 reports with 1861 patients were finally chosen...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30507333/effects-of-ckmt1-on-radiosensitivity-of-nasopharyngeal-carcinoma-cells
#3
Ruilong Lan, Fei Huang, Guangxian Zhong, Ruiqing Chen, Zeng Wang, Junying Chen, Lengxi Fu, Jinsheng Hong, Lurong Hong
PURPOSE: Radioresistance is an important factor for unsatisfactory prognosis in Nasopharyngeal carcinoma (NPC) patients. Ubiquitous mitochondrial creatine kinase (CKMT1) is always associated with malignancy in a variety of cancers. However, its significance in NPC progression and radiosensitivity remains unclear.The present study focused on investigating the effects of CKMT1 on NPC cell radiosensitivity. MATERIALS AND METHODS: CKMT1 was overexpressed in NPC cell line CNE-1 or knocked out in CNE-2...
December 3, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/30506913/what-do-you-expect-catastrophizing-mediates-associations-between-expectancies-and-pain-facilitatory-processes
#4
Junie S Carriere, Marc Olivier Martel, Samantha M Meints, Marise C Cornelius, Robert R Edwards
BACKGROUND: Pain expectancies are associated with altered pain sensitivity in individuals with chronic pain. However, little is known about the processes by which pain expectancies impact pain processing. This study assessed the association between pain expectancies and temporal summation (TS) of pain, and examined whether pain catastrophizing mediated this association. METHODS: In this cross-sectional study, participants (437 chronic low back pain (CLBP) patients, 115 controls) completed self-report measures of pain intensity, pain expectancies and pain catastrophizing before undergoing psychophysical pain-testing procedures designed to assess mechanical TS of mechanical pain...
December 3, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/30499090/effects-of-long-term-4-nonylphenol-dietary-exposure-on-reproductive-ability-of-japanese-quails-coturnix-japonica
#5
Yan Cheng, Zhengjun Shan, Junying Zhou, Yuanqing Bu, Pengfu Li, Shan Lu
As an endocrine disruptor, 4-nonylphenol (4-NP) is widespread in the environment. Here, we investigated the effect of long-term 4-NP dietary exposure on Japanese quails (Coturnix japonica). A total of 72 quails were evenly divided into 24 cages (12 cages for the reproductive toxicity study and 12 cages for the histopathology study, with one male quail and two female quails in each cage) and fed with various doses of 4-NP in diet. The body weight in quails administered with 4-NP was significantly decreased (P < 0...
November 29, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30496870/long-term-immunogenicity-and-immune-persistence-of-live-attenuated-and-inactivated-hepatitis-a-vaccines-a-report-on-additional-observations-from-a-phase-iv-study
#6
Jia Luo, Xiaodan Wang, Fubao Ma, Guodong Kang, Zhengrong Ding, Chao Ye, Yue Pan, Yujiao Zhao, Shan Hong, Junying Chen, Juemin Xi, Songjiao Wen, Yao Lin, Xiaoman Li, Lijuan Qiu, Xiaolei Yang, Guoliang Li, Jingsi Yang, Qiangming Sun
OBJECTIVES: Our objective was to evaluate and compare long-term immunogenicity and immunological persistence of inactivated (HA-I) and live attenuated (HA-L) hepatitis A vaccines. METHODS: A phase IV clinical trial (NCT02601040) was performed in 9000 participants over 18 months of age. Geometric mean concentrations (GMCs) and seroconversion rates (SRs) were compared at 5 time points during 3 years for 1800 individuals among them. RESULTS: The SRs of HA-L and HA-I were 98...
November 26, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30489272/condel-detecting-copy-number-variation-and-genotyping-deletion-zygosity-from-single-tumor-samples-using-sequence-data
#7
Xiguo Yuan, Jun Bai, Junying Zhang, Liying Yang, Junbo Duan, Yaoyao Li, Meihong Gao
Characterizing copy number variations (CNVs) from sequenced genomes is a both feasible and cost-effective way to search for driver genes in cancer diagnosis. A number of existing algorithms for CNV detection only explored part of the features underlying sequence data and copy number structures, resulting in limited performance. Here, we describe CONDEL, a method for detecting CNVs from single tumor samples using high-throughput sequence data. CONDEL utilizes a novel statistic in combination with a peel-off scheme to assess the statistical significance of genome bins, and adopts a Bayesian approach to infer copy number gains, losses, and deletion zygosity based on statistical mixture models...
November 26, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/30486818/duplex-fluorescence-melting-curve-analysis-as-a-new-tool-for-rapid-detection-and-differentiation-of-genotype-i-ii-and-bartha-k61-vaccine-strains-of-pseudorabies-virus
#8
Zhicheng Liu, Chunhong Zhang, Haiyan Shen, Junying Sun, Jianfeng Zhang
BACKGROUND: Recently, pseudorabies (PR) outbreaks have been reported in a large number of swine herds vaccinated with the Bartha-K61 vaccine in China, the current pseudorabies virus (PRV) belonging to Genotype II is differential genetically from Bartha-K61 vaccine belonging to Genotype I. Furthermore, it has been proved that the Bartha-K61 vaccine cannot provide sufficient protection against the current PRVs in China. Therefore, the accurate and rapid identification of PRVs is essential...
November 28, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/30480814/effects-of-nebulized-n-acetylcystein-on-the-expression-of-hmgb1-and-rage-in-rats-with-hyperoxia-induced-lung-injury
#9
Junying Qiao, Lixia Chen, Xianjie Huang, Feifei Guo
OBJECTIVE: To investigate the role of high mobility group box 1 (HMGB1) and receptor for advanced glycation end product (RAGE) in the lungs of hyperoxia-induced rats and the effect of N--acetlycystein (NAC). METHODS: A model of hyperoxic lung injury was established, rats in the NAC intervention, and control, hyperoxia group were given nebulized NAC aerosol, nebulized same volume of saline once a day for 7 consecutive days, respectively. Wet/dry ( W/ D) ratio of the lungs was determined to evaluate the edema of the lung tissues...
November 27, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30480515/naturally-derived-pha-l-protein-nanoparticle-as-a-radioprotector-through-activation-of-toll-like-receptor-5
#10
Wei Long, Junying Wang, Jiang Yang, Hongying Wu, Jingya Wang, Xiaoyu Mu, Hua He, Qiang Liu, Yuan-Ming Sun, Haichao Wang, Xiao-Dong Zhang
High energy ray in medical diagnosis and therapy can benefit to patients, but can also cause the significant damages to biomolecules such as DNA, as well as free radical generation, inevitably leading to numerous side effects. Small molecular radioprotectors provide an effective route to preserve the healthy tissue and whole body from ionizing radiation, but always have a short circulation time in body. Inorganic nanoparticles show major protection effect but their heavy metal components considerably jeopardize translational promise due to suboptimal biocompatibility...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30474984/genome-mining-for-mycemycin-discovery-and-elucidation-of-related-methylation-and-chlorination-biosynthetic-chemistries
#11
Chunyan Zhang, Zhijie Yang, Xiangjing Qin, Junying Ma, Changli Sun, Hongbo Huang, Qinglian Li, Jianhua Ju
A silent dibenzoxazepinone (DBP) biosynthetic gene cluster ( myc) was mutagenically activated in Streptomyces olivaceus SCSIO T05, enabling the discovery of mycemycin C (4) and three new analogues [mycemycins F-H (1-3)]. Gene disruption, complementation experiments, and enzymatic assays unveiled salicylic acid and 5-Cl-kynurenine as biosynthetic precursors and shed significant functional insights into MycO, MycB, MycR, and MycJ, enzymes responsible for fine-tuning of the DBP scaffold.
November 26, 2018: Organic Letters
https://www.readbyqxmd.com/read/30467385/necroptosis-and-ripk1-mediated-neuroinflammation-in-cns-diseases
#12
REVIEW
Junying Yuan, Palak Amin, Dimitry Ofengeim
Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death. However, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (TNF), can sensitize cells in the CNS to apoptosis and a form of regulated necrotic cell death known as necroptosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL)...
November 22, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/30463023/a-novel-rhein-derivative-activation-of-rac1-nadph-pathway-enhances-sensitivity-of-nasopharyngeal-carcinoma-cells-to-radiotherapy
#13
Zhengying Su, Zhaoquan Li, Chunmiao Wang, Wei Tian, Fu Lan, Dandan Liang, Junying Li, Danrong Li, Huaxin Hou
Radiation resistance and recurrent have become the major factors resulting in poor prognosis in the clinical treatment of patients with nasopharyngeal carcinoma (NPC). New strategies to enhance the efficacy of radiotherapy have been focused on the development of radiosensitizers and searching for directly targets that modulated tumor radiosensitivity. A novel potential radiosensitizer 1,8-Dihydroxy -3-(2'-(4″-methylpiperazin-1″-yl) ethyl-9,10-anthraquinone -3-carboxylate (RP-4) was designed and synthesized based on molecular docking technology, which was expected to regulate the radiosensitivity of tumor cells through targeting Rac1...
November 18, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/30458179/hypoxia-induced-%C3%AE-catenin-to-enhance-mice-hepatocellular-carcinoma-progression-via-wnt-signaling
#14
Fei Huang, Junying Chen, Ruilong Lan, Zeng Wang, Ruiqing Chen, Jingan Lin, Lengxi Fu
Hypoxia frequently occurs in solid tumors, hepatocellular carcinoma included. Hypoxia-inducible factors (HIFs) upregulated in hypoxia can induce various downstream target genes to resist hypoxia stress, resulting in tumor growth, angiogenesis and metastasis in vivo. Therefore, hypoxia associated genes are usually cancer progression associated genes and can be potential therapy targets for cancer therapy. In our present work, we find that the hypoxia-inducible transcriptional factor, HIF1α, can directly upregulate the expression of the gene Ctnnd2, which codes the protein δ-Catenin...
November 17, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30454657/antimicrobial-plant-growth-promoting-and-genomic-properties-of-the-peanut-endophyte-bacillus-velezensis-ldo2
#15
Liang Chen, Hao Shi, Junying Heng, Dianxuan Wang, Ke Bian
Peanut suffer from a number of fungal and bacterial pathogens, while plant endophytes were considered excellent candidates as biocontrol agents. In this study, the peanut endophytic bacterium LDO2 was evaluated for the potential of peanut pathogens inhibition and growth-promotion, and the genetic mechanisms were explored by genome mining. Strain LDO2 significantly inhibited the growth of peanut pathogenic fungi and pathogenic bacteria, and specifically, it showed pronounced inhibition on mycelia growth of Aspergillus flavus mycelia and caused mycelial deformity...
January 2019: Microbiological Research
https://www.readbyqxmd.com/read/30452907/comparison-of-different-chemically-modified-inhibitors-of-mir-199b-in-vivo
#16
Burcu Duygu, Rio Juni, Lara Ottaviani, Nicole Bitsch, Jan B M Wit, Leon J de Windt, Paula A da Costa Martins
MicroRNAs (miRNAs) have recently received great attention for their regulatory roles in diverse cellular processes and for their contribution to several human pathologies. Modulation of miRNAs in vivo provides beneficial therapeutic strategies for the treatment of many diseases as evidenced by various preclinical studies. However, specific issues regarding the in vivo use of miRNA inhibitors (antimiRs) such as organ-specific delivery, optimal dosing and formulation of the best chemistry to obtain efficient miRNA inhibition remain to be addressed...
November 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/30424891/pump-pipes-and-filter-do-sglt2-inhibitors-cover-it-all
#17
Subodh Verma, Peter Jüni, C David Mazer
No abstract text is available yet for this article.
November 9, 2018: Lancet
https://www.readbyqxmd.com/read/30424024/ethanolic-extract-of-folium-sennae-mediates-the-glucose-uptake-of-l6-cells-by-glut4-and-ca-2
#18
Ping Zhao, Qian Ming, Junying Qiu, Di Tian, Jia Liu, Jinhua Shen, Qing-Hua Liu, Xinzhou Yang
In today's world, diabetes mellitus (DM) is on the rise, especially type 2 diabetes mellitus (T2DM), which is characterized by insulin resistance. T2DM has high morbidity, and therapies with natural products have attracted much attention in the recent past. In this paper, we aimed to study the hypoglycemic effect and the mechanism of an ethanolic extract of Folium Sennae (FSE) on L6 cells. The glucose uptake of L6 cells was investigated using a glucose assay kit. We studied glucose transporter 4 (GLUT4) expression and AMP-activated protein kinase (AMPK), protein kinase B (PKB/Akt), and protein kinase C (PKC) phosphorylation levels using western blot analysis...
November 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30423146/development-of-a-gexp-based-multiplex-rt-pcr-assay-for-detection-of-long-noncoding-rna-in-hepatocellular-carcinoma
#19
Xiaofeng Mu, Wen Chen, Junying Shi, Xinmin Li, Ye Wang
Objective: To develop a multiplex quantitative polymerase chain reaction (qPCR) assay based on the GenomeLab™ GeXP Genetic Analysis System (GeXP) for detection of long noncoding RNA in hepatocellular carcinoma (HCC). Methods: From PubMed database articles published between 2011 and 2016, we selected 8 kinds of long noncoding RNAs (lncRNAs) related to HCC. Further, we examined 23 pairs of HCC and adjacent noncancerous tissues, using the optimized GeXP multiplex reverse transcription polymerase chain reaction (RT-PCR) assay...
November 13, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/30411736/defect-engineering-on-electrocatalysts-for-gas-evolving-reactions
#20
Junying He, Yuqin Zou, Shuangyin Wang
The hydrogen evolution reaction (HER) and oxygen redox reaction, including the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are the core processes used for water splitting and in metal-air batteries. Thus, the design of electro-catalysts for use in the oxygen redox reaction and HER have received a lot attention around the world. Many strategies have been developed to improve these catalysts, including increasing the surface area, creating unique facet structures, enhancing the conductivities and so on...
November 9, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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