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https://www.readbyqxmd.com/read/30116955/germany-a-fair-balance-between-scientific-freedom-and-data-subjects-rights
#1
REVIEW
Fruzsina Molnár-Gábor
With the German Bundestag's adoption of the Data Protection Adaptation and Implementation Act EU (DSAnpUG-EU) on 30 June 2017, the adaptation of German law to the General Data Protection Regulation (GDPR) has begun (Gesetz zur Anpassung des Datenschutzrechts an die Verordnung (EU) 2016/679 und zur Umsetzung der Richtlinie (EU) 2016/680 (Datenschutz-Anpassungs- und -Umsetzungsgesetz-DSAnpUG-EU) v. 30. Juni 2017, BGBl. 2017 I p. 2097 et seq.). Despite being directly binding on all EU member states, the GDPR does not render national data protection provision obsolete-they are covered by the GDPR's opening clauses which include regulatory mandates and room for derogation...
August 16, 2018: Human Genetics
https://www.readbyqxmd.com/read/30116820/effect-of-density-on-the-thermal-decomposition-mechanism-of-%C3%AE%C2%B5-cl-20-a-reaxff-reactive-molecular-dynamics-simulation-study
#2
Fuping Wang, Lang Chen, Deshen Geng, Jianying Lu, Junying Wu
The explosive detonation reaction occurs when explosives are compressed by different shock strengths, and the degree of compression affects the chemical reaction of the detonation process. The thermal decomposition mechanism of explosives under different compression densities has thus attracted significant research interest, and a better understanding of this mechanism would be helpful for determining the mechanism of the detonation reaction of explosives. In this study, a ε-CL-20 supercell was constructed, and the thermal decomposition was calculated at different compression densities and temperatures using molecular dynamics simulations based on the ReaxFF-lg reactive force field...
August 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30107514/restrictive-compared-with-liberal-red-cell-transfusion-strategies-in-cardiac-surgery-a-meta-analysis
#3
Nadine Shehata, Nikhil Mistry, Bruno R da Costa, Tiago V Pereira, Richard Whitlock, Gerard F Curley, David A Scott, Gregory M T Hare, Peter Jüni, C David Mazer
Aims: To determine whether a restrictive strategy of red blood cell (RBC) transfusion at lower haemoglobin concentrations is inferior to a liberal strategy of RBC transfusion at higher haemoglobin concentrations in patients undergoing cardiac surgery. Methods and results: We conducted a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials of the effect of restrictive and liberal RBC transfusion strategies on mortality within 30 days of surgery as the primary outcome...
August 10, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30096473/real-time-qcm-d-monitoring-of-endothelial-cells-and-macrophages-adhering-and-spreading-to-sema4d-heparin-surfaces
#4
Yuanyuan Cui, Feng Zhou, Hongli Bai, Lai Wei, Jianying Tan, Zheng Zeng, Qiang Song, Junying Chen, Nan Huang
In vitro evaluation techniques that address cellular interactions under dynamic circumstances are required for the development of advanced biomaterials. In this study, quartz crystal microbalance and dissipation (QCM-D) provided a surface sensitive technique that enabled real-time monitoring of the adhesion and spreading response of endothelial cells (ECs) and macrophages (MAs) to soluble-semaphoring 4D (SEMA4D)/heparin modified substratum. The high heparin and low SEMA4D of substratum promoted ECs adhering and spreading...
August 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30086137/macro-morphological-characterization-and-kinetics-of-mortierella-alpina-colonies-during-batch-cultivation
#5
Xue Fang, Genhai Zhao, Jun Dai, Hui Liu, Peng Wang, Li Wang, Junying Song, Zhiming Zheng
An effective method for research of macro-morphological characterization and its kinetics was developed by studying the macro-morphological characteristics of Mortierella alpina, an oleaginous zygomycete widely used to produce lipids rich in PUFA, in function of culture medium composition and to link morphological features of fungus with the level of lipid production. A number of distinct morphological forms including hollow pellets, fluffy pellets and freely dispersed mycelia were obtained by changing the fermentation factors...
2018: PloS One
https://www.readbyqxmd.com/read/30064993/management-of-obstructive-sleep-apnoea-in-a-primary-care-vs-sleep-unit-setting-a-randomised-controlled-trial
#6
Nuria Tarraubella, Manuel Sánchez-de-la-Torre, Nuria Nadal, Jordi De Batlle, Iván Benítez, Anunciación Cortijo, Maria Cruz Urgelés, Virginia Sanchez, Iñigo Lorente, M Mercé Lavega, Araceli Fuentes, Joan Clotet, Laia Llort, Lidia Vilo, M Carmen Juni, Aurelia Juarez, Maribel Gracia, Anabel L Castro-Grattoni, Lydia Pascual, Olga Minguez, Juan F Masa, Ferran Barbé
OBJECTIVE: To assess the effectiveness and cost-effectiveness of primary care (PC) and sleep unit (SU) models for the management of subjects with suspected obstructive sleep apnoea (OSA). METHODS: Multicentre, open-label, two-arm, parallel-group, non-inferiority randomised controlled trial. A total of 302 subjects with suspected OSA and/or resistant hypertension were consecutively enrolled, 149 were treated at 11 PC units and 153 patients at a SU. The primary outcomes were a 6-month change in the Epworth Sleepiness Scale (ESS) score and Health Utilities Index (HUI)...
July 31, 2018: Thorax
https://www.readbyqxmd.com/read/30064917/benefits-of-independent-double-reading-in-digital-mammography-a-theoretical-evaluation-of-all-possible-pairing-methodologies
#7
Patrick C Brennan, Aarthi Ganesan, Miguel P Eckstein, Ernest Usang Ekpo, Kriscia Tapia, Claudia Mello-Thoms, Sarah Lewis, Mordechai Z Juni
RATIONALE AND OBJECTIVES: To establish the efficacy of pairing readers randomly and evaluate the merits of developing optimal pairing methodologies. MATERIALS AND METHODS: Sensitivity, specificity, and proportion correct were computed for three different case sets that were independently read by 16 radiologists. Performance of radiologists as single readers was compared to expected double reading performance. We theoretically evaluated all possible pairing methodologies...
July 29, 2018: Academic Radiology
https://www.readbyqxmd.com/read/30056145/anthocyanins-isolated-from-blueberry-ameliorates-ccl-4-induced-liver-fibrosis-by-modulation-of-oxidative-stress-inflammation-and-stellate-cell-activation-in-mice
#8
Jianchao Sun, Yafeng Wu, Cuizhen Long, Ping He, Junying Gu, Lei Yang, Yaodong Liang, Yuping Wang
To study the mechanism of anthocyanins from blueberry on mice model of hepatic fibrosis. We observed that the levels of serum ALT and AST of 100 mg*kg-1*d-1, 200 mg*kg-1*d-1 anthocyanins group were reduced compared to the CCl4 treated group. Mitochondrial electron chain complex 1 and 2 activities, determined by microplate assays, were reduced in CCl4 treated group and restored by anthocyanin treatment. MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly...
July 27, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30050954/obesity-related-asthma-immune-regulation-and-potential-targeted-therapies
#9
REVIEW
Yuze Yuan, Nan Ran, Lingxin Xiong, Guoqiang Wang, Xuewa Guan, Ziyan Wang, Yingqiao Guo, Zhiqiang Pang, Keyong Fang, Junying Lu, Chao Zhang, Ruipeng Zheng, Jingtong Zheng, Jie Ma, Fang Wang
Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30045297/disease-free-survival-after-robotic-assisted-laparoscopic-total-pelvic-exenteration-for-recurrent-cervical-adenocarcinoma-a-case-report
#10
Qiyu Yang, Junying Tang, Lin Xiao
RATIONALE: Pelvic exenteration is considered a method to treat central recurrent or persistent gynecologic malignancy after the initial therapy. The postoperative survival rate has been greatly increased by the improvement in the surgical technology and the perioperative management. Yet various complications are still impacting the quality of life. New technologies such as robotic surgery system made it possible to approach radical surgical resection by using a minimally invasive method...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30044478/baseline-characteristics-and-patterns-of-care-in-testicular-cancer-patients-first-data-from-the-swiss-austrian-german-testicular-cancer-cohort-study-sag-tccs
#11
Christian Rothermundt, Claudio Thurneysen, Richard Cathomas, Beat Müller, Walter Mingrone, Anita Hirschi-Blickenstorfer, Tobias Wehrhahn, Christian Ruf, Sacha Rothschild, Bettina Seifert, Angelika Terbuch, Thomas Grassmugg, Regina Woelky, Christian Fankhauser, Thomas Kunit, Natalie Fischer Fischer, Roman Inauen, Jörn Kamradt, Katrin Ziegler, Alan Haynes, Peter Jüni, Silke Gillessen
BACKGROUND: The majority of germ cell tumour (GCT) patients can be cured by orchiectomy followed by active surveillance or subsequent systemic and/or local treatments. There are various guidelines for a structured follow-up including radiographic and clinical examinations. OBJECTIVE: The Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS) prospectively evaluates follow-up, indicator of relapse and late toxicities. This is a descriptive analysis; we present baseline characteristics and treatment strategies for the first 299 patients with primary GCT or relapsed GCT after completion of treatment...
2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/30042012/interpreting-as-a-mirror-for-language-foundations-comment-on-rethinking-foundations-of-language-from-a-multidisciplinary-perspective-by-t-gong-et-al
#12
Junying Liang, Qianxi Lv, Yiguang Liu
No abstract text is available yet for this article.
June 26, 2018: Physics of Life Reviews
https://www.readbyqxmd.com/read/30033624/reactive-molecular-dynamics-simulations-of-the-thermal-decomposition-mechanism-of-1-3-3-trinitroazetidine
#13
W U Junying, Huang Yanxi, Yang Lijun, Geng Deshen, Wang Fuping, Wang Heqi, Chen Lang
1,3,3-Trinitroazetidine (TNAZ) has a molecular formula of C3 H4 N4 O6 and the characteristics of low melting point, low impact sensitivity and good thermal stability. It is suitable for melt casting and pressed charges, and it has broad prospects for applications in low-sensitivity ammunition. In this study, the thermal decomposition of TNAZ crystals at high temperature was calculated by molecular dynamics simulation with the ReaxFF/lg reactive force field. The change in the potential energy of TNAZ, the formation of small-molecule products and clusters, and the initial reaction path of TNAZ were analysed...
July 22, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/30031936/ida-intensified-hematopoietic-cell-transplantation-improves-relapse-and-survival-of-high-risk-acute-leukemia-patients-with-minimal-residual-disease
#14
Ran Zhang, Xuan Lu, Huafang Wang, Yong You, Zhaodong Zhong, Sibin Zang, Chun Zhang, Wei Shi, Junying Li, Qiuling Wu, Jun Fang, Linghui Xia
The optimal conditioning regimen of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for high-risk patients with minimal residual disease (MRD) remains controversial. We studied the results in 98 high-risk acute leukemia patients being transplanted with idarubicin (IDA)-intensified conditioning regimens between 2012 January and 2017 January. Among these patients, 31 (31.6%) had more than 5% marrow blasts at time of transplantation. 67 patients were in morphologic remission and MRD negative status at time of conditioning was achieved in 39 (39...
July 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30028196/fgf23-impairs-peripheral-microvascular-function-in-renal-failure
#15
Melissa Verkaik, Rio P Juni, Ellen P M van Loon, Erik van Poelgeest, Rick F J Kwekkeboom, Zeineb Gam, William G Richards, Pieter M Ter Wee, Joost G J Hoenderop, Etto C Eringa, Marc G Vervloet
BACKGROUND: Cardiovascular diseases account for approximately 50% of mortality in patients with chronic kidney disease (CKD). Fibroblast growth factor 23 (FGF23) is independently associated with endothelial dysfunction and cardiovascular mortality. We hypothesized that CKD impairs microvascular endothelial function and that this can be attributed to FGF23. METHODS: Mice were subjected to partial nephrectomy (5/6Nx) or sham-surgery. To evaluate the functional role of FGF23, non-CKD mice received FGF23 injections, and CKD mice received FGF23 blocking antibodies following 5/6Nx surgery...
July 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30016453/lrif1-interacts-with-hp1%C3%AE-to-coordinate-accurate-chromosome-segregation-during-mitosis
#16
Saima Akram, Fengrui Yang, Junying Li, Gregory Adams, Yingying Liu, Xiaoxuan Zhuang, Lingluo Chu, Xu Liu, Nerimah Emmett, Winston Thompson, McKay Mullen, Saravana Muthusamy, Wenwen Wang, Fei Mo, Xing Liu
Heterochromatin protein 1α (HP1α) regulates chromatin specification and plasticity during cell fate decision. Different structural determinants account for HP1α localization and function during cell division cycle. Our earlier study showed that centromeric localization of HP1α depends on the epigenetic mark H3K9me3 in interphase, while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors. Here, we identified a PXVXL-containing protein, ligand-dependent nuclear receptor-interacting factor 1 (LRIF1), which recruits HP1α to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis...
July 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/30014843/toxoplasmosis-in-transplant-recipients-europe-2010-2014
#17
Florence Robert-Gangneux, Valeria Meroni, Damien Dupont, Françoise Botterel, José M Aguado Garcia, Marie-Pierre Brenier-Pinchart, Isabelle Accoceberry, Hamdi Akan, Isabella Abbate, Katia Boggian, Fabrizio Bruschi, Jordi Carratalà, Miruna David, Lubos Drgona, Olgica Djurković-Djaković, Maria Carmen Farinas, Francesca Genco, Effrossyni Gkrania-Klotsas, Andreas H Groll, Edward Guy, Cédric Hirzel, Nina Khanna, Özgür Kurt, Lia Monica Junie, Tiziana Lazzarotto, Oscar Len, Nicolas J Mueller, Patricia Munoz, Zoi Dorothea Pana, Emmanuel Roilides, Tijana Stajner, Christian van Delden, Isabelle Villena, Hervé Pelloux, Oriol Manuel
Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%...
August 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/30014806/synthesis-and-anticancer-activity-of-9-o-pyrazole-alkyl-substituted-berberine-derivatives
#18
Daipeng Xiao, Fen He, Dongming Peng, Junying Peng, Min Zou, Yanfei Liu, Zhenbao Liu
BACKGROUND: Berberine (BBR), an isoquinoline plant alkaloid isolated from plants such as Coptis chinensis and Hydrastis canadensis, own multiple pharmacological activities. OBJECTIVE: In this study, seven BBR derivatives were synthesized and their anticancer activity against HeLa cervical and A549 human lung cancer cell lines were evaluated in vitro. METHODS: The anti-cancer activity was measured by MTT assay, and apoptosis was demonstrated by the annexin V-FITC/PI staining assay...
July 17, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30012058/scaling-relationship-of-in-vivo-muscle-contraction-strength-of-rabbits-exposed-to-high-frequency-nanosecond-pulse-bursts
#19
Yan Mi, Jin Xu, Xuefeng Tang, Changhao Bian, Hongliang Liu, Qiyu Yang, Junying Tang
We studied the influence of various parameters of high-frequency nanosecond pulse bursts on the strength of rabbit muscle contractions. Ten unipolar high-frequency pulse bursts with various field intensities E (1 kV/cm, 4 kV/cm, and 8 kV/cm), intraburst frequencies f (10 kHz, 100 kHz, and 1 MHz), and intraburst pulse numbers N (1, 10, and 100) were applied using a pair of plate electrodes to the surface skin of the rabbits' biceps femoris, and the acceleration signal of muscle contraction near the electrode was measured using a 3-axis acceleration sensor...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/30008394/anti-aging-properties-of-curcuma-heyneana-valeton-zipj-a-scientific-approach-to-its-use-in-javanese-tradition
#20
Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Maat, Katsuyoshi Matsunami
ETHNOPHARMACOLOGICAL RELEVANCE: Temu giring, the rhizome of Curcuma heyneana Valeton & Zipj (C. heyneana), is native to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and body freshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer and antiinflammatory. AIM OF THE STUDY: The purpose of this study was to determine the antiaging activity of C. heyneana to prove its traditional use...
October 28, 2018: Journal of Ethnopharmacology
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