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Myonecrosis

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https://www.readbyqxmd.com/read/29779119/a-chemosensitizer-drug-disulfiram-prevents-doxorubicin-induced-cardiac-dysfunction-and-oxidative-stress-in-rats
#1
Varsha K Sonawane, Umesh B Mahajan, Sachin D Shinde, Subhajit Chatterjee, Sandip S Chaudhari, Harshada A Bhangale, Shreesh Ojha, Sameer N Goyal, Chanakya N Kundu, Chandragouda R Patil
In the present study, the preventive effects of orally administered disulfiram (DS) against the doxorubicin (DOX)-induced cardiotoxicity were investigated in rats. DS was orally administered for 7 days at doses of 2, 10, and 50 mg/kg/day. DOX (30 mg/kg) was intraperitoneally administered on the 5th day of the initiation of DS treatment. Within 48 h of injection, DOX treatment significantly altered ECG, elevated the ST height, and increased the QT and QRS intervals. It reduced the cardiac levels of injury markers like creatine kinase isoenzyme-MB and lactate dehydrogenase...
May 10, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29759890/distribution-and-absence-of-generalized-lesions-in-mice-following-single-dose-intramuscular-inoculation-of-the-vaccine-candidate-mva-mers-s
#2
Martin C Langenmayer, Anna-Theresa Lülf-Averhoff, Silvia Adam-Neumair, Robert Fux, Gerd Sutter, Asisa Volz
Modified Vaccinia Virus Ankara (MVA) is a highly attenuated and replication-deficient virus serving as vaccine against infectious diseases. Here, we assessed the in vivo distribution of a recombinant MVA candidate vaccine against the Middle Eastern Respiratory Syndrome (MVA-MERS-S) in mice. Intramuscularly inoculated mice were necropsied at different time points and examined by histology, immunohistochemistry and real-time PCR. We detected inflammation and myonecrosis at the parenteral site and hyperplasia of the draining lymph nodes...
May 11, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29742536/biopsy-proven-myonecrosis-in-the-right-forearm-of-a-type-2-diabetic-woman
#3
Jesse A Solomon, Anna O'Connor, Douglas W Lienesch
No abstract text is available yet for this article.
May 4, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29731908/calcific-myonecrosis-mimicking-soft-tissue-sarcoma-a-case-report
#4
Yuichiro Ukon, Takaaki Tanaka, Shigenori Nagata, Hiroki Hagizawa, Yoshinori Imura, Hironari Tamiya, Kazuya Oshima, Norifumi Naka, Yasuaki Aoki, Shigeyuki Kuratsu
Calcific myonecrosis is a rare soft tissue condition. The first case was reported in 1960, however, the precise pathophysiology of calcific myonecrosis remains unclear. The disease was thought to arise from compartment syndrome within a confined space resulting in necrosis and fibrosis, subsequent repeated intralesional hemorrhage, mass enlargement and calcification. Several previous reports have described calcific myonecrosis, which include the formation of calcific myonecrosis after a prolonged period of post trauma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29723952/why-is-skeletal-muscle-regeneration-impaired-after-myonecrosis-induced-by-viperid-snake-venoms
#5
REVIEW
José María Gutiérrez, Teresa Escalante, Rosario Hernández, Stefano Gastaldello, Patricia Saravia-Otten, Alexandra Rucavado
Skeletal muscle regeneration after myonecrosis involves the activation, proliferation and fusion of myogenic cells, and a coordinated inflammatory response encompassing phagocytosis of necrotic cell debris, and the concerted synthesis of cytokines and growth factors. Myonecrosis often occurs in snakebite envenomings. In the case of venoms that cause myotoxicity without affecting the vasculature, such as those of many elapid snakes, regeneration proceeds successfully. In contrast, in envenomings by most viperid snakes, which affect the vasculature and extracellular matrix in addition to muscle fibers, regeneration is largely impaired and, therefore, the muscle mass is reduced and replaced by fibro-adipose tissue...
May 1, 2018: Toxins
https://www.readbyqxmd.com/read/29684607/effect-of-immunization-of-rohu-labeo-rohita-with-inactivated-germinated-zoospores-in-providing-protection-against-aphanomyces-invadans
#6
Pravata K Pradhan, Neeraj Sood, Manoj K Yadav, Pooja Arya, Dharmendra K Chaudhary, Uday Kumar, Chandra Bhushan Kumar, T R Swaminathan, Gaurav Rathore
Infection with Aphanomyces invadans is one of the most destructive diseases of freshwater fishes. Indian major carps, the dominant cultured species in the Indian sub-continent are highly susceptible to this disease. Till date, there is no effective treatment for control of this disease and immunization can be one of the strategies to reduce disease-related losses. In the present study, inactivated germinated zoospores of A. invadans were evaluated as antigen in conjunction with and without adjuvant Montanide™ ISA 763 A VG, for assessing their efficacy in rendering protection against A...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29658341/calcific-myonecrosis-diagnostic-dilemma
#7
H E Matar, P Stritch, S Connolly, N Emms
Calcific myonecrosis is a rare benign condition affecting mainly the muscles of a single leg compartment. It is thought to follow a history of trauma with a latent period of years. Patients present with a slowly growing mass. Differential diagnosis from a malignant tumour can be made from the history and the distinctive radiographical features of a fusiform lesion with predominantly peripheral calcifications. Magnetic resonance imaging may be necessary to confirm the diagnosis; treatment is largely symptomatic...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29621527/transmammary-transfer-of-toxicity-to-nursing-kids-from-isocoma-pluriflora-rayless-goldenrod-dosed-to-lactating-goats
#8
James A Pfister, Bryan L Stegelmeier, Stephen T Lee, T Zane Davis, Ben T Green
Rayless goldenrod (RG; Isocoma pluriflora) poisons livestock in the southwestern U.S., west Texas, and northern Mexico. The putative toxin(s) have historically been thought to be benzofuran ketones. Goats have been used successfully as a model of RG poisoning. The transmammary transfer of toxicity to offspring from lactating goats has not been studied, thus the objective of this study was to determine if nursing kids would become poisoned via mother's milk when the dams were dosed with RG. Twelve lactating goats (6 controls and 6 treated; all with twin kids) were dosed via oral gavage with alfalfa or rayless goldenrod at 2% of BW per day for 14 days...
April 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29588405/concurrent-host-pathogen-transcriptional-responses-in-a-clostridium-perfringens-murine-myonecrosis-infection
#9
Lee-Yean Low, Paul F Harrison, Jodee Gould, David R Powell, Jocelyn M Choo, Samuel C Forster, Ross Chapman, Linden J Gearing, Jackie K Cheung, Paul Hertzog, Julian I Rood
To obtain an insight into host-pathogen interactions in clostridial myonecrosis, we carried out comparative transcriptome analysis of both the bacterium and the host in a murine Clostridium perfringens infection model, which is the first time that such an investigation has been conducted. Analysis of the host transcriptome from infected muscle tissues indicated that many genes were upregulated compared to the results seen with mock-infected mice. These genes were enriched for host defense pathways, including Toll-like receptor (TLR) and Nod-like receptor (NLR) signaling components...
March 27, 2018: MBio
https://www.readbyqxmd.com/read/29578051/dexpression-patterns-of-regulatory-rnas-including-lncrnas-and-trnas-during-postnatal-growth-of-normal-and-dystrophic-mdx-mouse-muscles-and-their-response-to-taurine-treatment
#10
Lauren C Butchart, Jessica R Terrill, Giulia Rossetti, Robert White, Aleksandra Filipovska, Miranda D Grounds
Post-natal skeletal muscle growth in mice is very rapid and involves complex changes in many cells types over the first 6 weeks of life. The acute onset of dystropathology also occurs around 3 weeks of age in the mdx mouse model of the human disease Duchenne Muscular Dystrophy (DMD). This study investigated (i) alterations in expression patterns of regulatory non-coding RNAs (ncRNAs) in vivo, including miRNAs, lncRNAs and tRNAs, during early growth of skeletal muscles in normal control C57Bl/10Scsn (C57) compared with dystrophic mdx mice from 2-6 weeks of postnatal age, and revealed inherent differences in vivo for levels of 3 ncRNAs between C57 and mdx muscles before the onset of dystropathology...
March 22, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29560007/-clostridium-perfringens-septicemia-and-a-bleeding-ulcer-of-a-jejunal-interposition-a-case-report-and-short-review-of-the-literature
#11
W Wild, F Bormann, H Sweiti, N Tamimi, D Pichulek, M Divo, P Dörr, M Schwarzbach
Introduction: We report a case of Clostridium perfringens septicemia in a patient presenting with a bleeding ulcer of a jejunal interposition. Case Presentation: An 81-year-old female patient was acutely admitted to our hospital due to hematemesis and melena. She had a history of metastatic gastrointestinal stromal tumor, for which she was receiving second line treatment with sunitinib. She had also undergone a Merendino procedure 4 years prior to presentation. The patient underwent emergency gastroscopy, which revealed a bleeding ulcer in the jejunal interposition...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29534840/atraumatic-clostridial-myonecrosis-in-an-immunocompromised-host
#12
Kristine M Thompson, Brian T Kruse, Mary Ann S Hedges
BACKGROUND: Necrotizing fasciitis is usually associated with a surgical or traumatic wound. Clostridial myonecrosis is an uncommon but deadly infection that can develop in the absence of a wound and is often associated with occult gastrointestinal cancer or immunocompromise, or both. CASE REPORT: We report a case of catastrophic atraumatic Clostridium septicum infection in an immunocompromised host. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Emergency physicians most commonly associate necrotizing fasciitis with superinfection of an open wound...
March 10, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29527509/diabetic-muscle-infarction-in-end-stage-renal-disease-a-scoping-review-on-epidemiology-diagnosis-and-treatment
#13
REVIEW
Tuck Yean Yong, Kareeann Sok Fun Khow
Diabetic muscle infarction (DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease (ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (PubMed/MEDLINE, CINAHL, SCOPUS and EMBASE) searches were conducted for ("diabetic muscle infarction" or "diabetic myonecrosis") and ("chronic kidney disease" or "renal impairment" or "dialysis" or "renal replacement therapy" or "kidney transplant") from January 1980 to June 2017...
March 6, 2018: World Journal of Nephrology
https://www.readbyqxmd.com/read/29505564/purification-and-characterization-of-the-first-%C3%AE-phospholipase-inhibitor-%C3%AE-pli-from-bothrops-jararaca-snake-serum
#14
Caroline Serino-Silva, Karen Morais-Zani, Marcos Hikari Toyama, Daniela de Oliveira Toyama, Henrique Hessel Gaeta, Caroline Fabri Bittencourt Rodrigues, Wéslei da Silva Aguiar, Alexandre Keiji Tashima, Kathleen Fernandes Grego, Anita Mitico Tanaka-Azevedo
Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids resulting in fatty acids and lysophospholipids and deconstructing the cell membrane. This protein is commonly found in snake venoms, causing tissue inflammation in the affected area. Evidence indicates that snakes have natural resistance to their own venom due to protective properties in plasma, that inhibit the action of proteins present in their venom. Given that, this study aimed to purify and characterize a γPLI from Bothrops jararaca serum, named γBjPLI...
2018: PloS One
https://www.readbyqxmd.com/read/29487658/compartment-syndrome-of-the-hand-a-case-report-and-review-of-literature
#15
Varun Mehta, Varun Chowdhary, Cheryl Lin, Marlena Jbara, Shirley Hanna
Elevation of pressure within tightly bound myofascial compartments has detrimental consequences if not treated promptly, leading to a loss of circulation, ischemia, myonecrosis, nerve damage, and limb loss. They are commonly seen in the distal upper and lower extremities; however, compartment syndrome of the hand is rarely encountered and prompt recognition can prevent permanent damage and tissue loss. This case study presents a complicated case of compartment syndrome of the hand and discusses the interrelationship between compartment syndrome and rhabdomyolysis...
February 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29475177/impact-of-pre-procedural-dual-antiplatelet-therapy-on-periprocedural-myocardial-infarction-in-patients-undergoing-percutaneous-coronary-interventions-with-adjunctive-tirofiban
#16
Monica Verdoia, Patrizia Pergolini, Lucia Barbieri, Roberta Rolla, Matteo Nardin, Federica Negro, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Recent trials have failed to demonstrate any clinical benefit from pre-treatment with dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary interventions, (PCI), even in the setting of acute coronary syndrome. However, suboptimal platelet inhibition during (PCI) has been shown to enhance the risk of acute ischemic complications, such as stent thrombosis and periprocedural myocardial infarction (PMI), thus raising the attention on the potential advantages of adjunctive glycoprotein IIbIIIa inhibitors to obviate to the delayed onset of action of oral antiplatelet drugs...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29461290/volume-resuscitation-in-patients-with-high-voltage-electrical-injuries
#17
Derek M Culnan, Kelley Farner, Genevieve H Bitz, Karel D Capek, Yiji Tu, Carlos Jimenez, William C Lineaweaver
Volume resuscitation of patients with high-voltage electrical injuries (>1000 V) is a more complex challenge than standard burn resuscitation. High voltages penetrate deep tissues. These deep injuries are not accounted for in resuscitation formulae dependent on percentage of cutaneous burn. Myonecrosis occurring from direct electrical injury and secondary compartment syndromes can result in rhabdomyolysis, compromising renal function and urine output. Urine output is the primary end point, with a goal of 1 mL/kg/h for adult patients with high-voltage electrical injuries...
March 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29451848/mr-imaging-of-atraumatic-muscle-disorders
#18
Edward Smitaman, Dyan V Flores, Catalina Mejía Gómez, Mini N Pathria
Atraumatic disorders of skeletal muscles include congenital variants; inherited myopathies; acquired inflammatory, infectious, or ischemic disorders; neoplastic diseases; and conditions leading to muscle atrophy. These have overlapping appearances at magnetic resonance (MR) imaging and are challenging for the radiologist to differentiate. The authors organize muscle disorders into four MR imaging patterns: (a) abnormal anatomy with normal signal intensity, (b) edema/inflammation, (c) mass, and (d) atrophy, highlighting each of their key clinical and imaging findings...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29399847/effects-of-myogenic-precursor-cells-c2c12-transplantation-and-low-level-laser-therapy-on-muscle-repair
#19
Lucas Andreo, Raquel A Mesquita-Ferrari, Beatriz G Ribeiro, Adriana Benitte, Tatiane de Fátima Nogueira, Cristiane M França, Daniela de Fátima Teixeira da Silva, Sandra K Bussadori, Kristianne P S Fernandes, Fernanda I Corrêa, João C F Corrêa
OBJECTIVE: The aim of the present study was to evaluate the effects of myoblast inoculation in combination with photobiomodulation therapy (PBMT) on skeletal muscle tissue following injury. MATERIALS AND METHODS: Sixty-five Wistar rats were divided into five groups: Control-animals not submitted to any procedure; Injury-cryoinjury of the tibialis anterior muscle; HBSS-animals submitted to cryoinjury and intramuscular Hank's Balanced Salt Solution; Injury + Cells-animals submitted to cryoinjury, followed by myogenic precursor cells (C2C12) transplantation; Injury + Cells + LLLT-animals submitted to cryoinjury, followed by myogenic precursor cells (C2C12) transplantation and PBMT (780 nm, 40 mW, 3...
February 5, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29369060/tendon-transfers-to-restore-ankle-dorsiflexion-after-anterior-compartment-myonecrosis-a-case-report
#20
Wesley Zhang Yang, Joseph S Park, Seth Robert Yarboro
CASE: A 47-year-old Caucasian woman spontaneously developed an isolated anterior compartment pressure of >100 mm Hg in the left leg. Despite fasciotomies, the musculature was nonviable and required debridement. Following Achilles tendon lengthening, a posterior tibial tendon (PTT) to anterior tibial tendon (ATT) transfer was supplemented with a flexor digitorum longus tendon transfer to the remaining PTT in order to prevent a flatfoot deformity while restoring active dorsiflexion. CONCLUSION: Preservation of the tendinous portion of the ATT during debridement allowed for transfer of the PTT to the ATT using a modified Pulvertaft transfer...
January 24, 2018: JBJS Case Connector
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