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https://www.readbyqxmd.com/read/29327957/unusual-outbreak-of-fatal-clostridiosis-in-a-group-of-captive-brown-pelicans-pelecanus-occidentalis
#1
Imke Lueders, Carsten Ludwig, Johanna Kasberg, Christoph Georg Baums, Kerstin Klimke, Martin B Dorner, Dana Ströse, Volker Schmidt
Fatal clostridial infections and clostridial toxicoses are common in birds. Most fatalities are associated with toxin production and progress rapidly, often within 24 hours of infection. We describe an unusual and protracted course of disease in 6 captive brown pelicans ( Pelecanus occidentalis), which was believed to result from toxicosis by toxovar A produced by a mixed infection with Clostridium sordellii and Clostridium perfringens. Although the first death in the group occurred 3 days after signs of illness were documented, the remaining birds died over a 38-day period despite aggressive antibiotic and supportive therapy...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29299899/clinical-guidelines-for-the-antibiotic-treatment-for-community-acquired-skin-and-soft-tissue-infection
#2
Yee Gyung Kwak, Seong Ho Choi, Tark Kim, Seong Yeon Park, Soo Hong Seo, Min Bom Kim, Sang Ho Choi
Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. This clinical guideline provides recommendations for the diagnosis and management of SSTI, including impetigo/ecthyma, purulent skin and soft tissue infection, erysipelas and cellulitis, necrotizing fasciitis, pyomyositis, clostridial myonecrosis, and human/animal bite. This guideline targets community-acquired skin and soft tissue infection occurring among adult patients aged 16 years and older...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29278528/treatment-of-severe-skin-and-soft-tissue-infections-a-review
#3
Jason P Burnham, Marin H Kollef
PURPOSE OF REVIEW: To review the salient features of the management of severe skin and soft tissue infections (SSTIs), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis. RECENT FINDINGS: For severe SSTIs, intensive care, source control, and broad-spectrum antimicrobials are required for the initial phase of illness. There is an increasing focus on the utility of rapid diagnostic tests to help in selection and de-escalation of antimicrobials for SSTIs...
December 22, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29234602/neutralization-of-naja-naja-venom-induced-lethality-edema-and-myonecrosis-by-ethanolic-root-extract-of-coix-lacryma-jobi
#4
K S Rajesh, B R Bharath, C V Rao, K I Bhat, K S Chandrashekhar Bhat, Pritesh Bhat
Coix lacryma-jobi, commonly known as job's tear, is a tall grain-bearing tropical plant of the family Poaceae. The ethanolic root extract (ERE) of the plant was investigated for the first time for anti-venom activity against Indian cobra Naja naja venom. In-vitro studies were conducted to determine neutralization of phospholipase A2 (PLA2) activity of the Naja naja venom by the ERE. ERE showed significant inhibition of PLA2 activity, which was further confirmed from effective neutralization of human red blood cells (HRBC) lysis induced by the venom...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29232246/the-role-of-fdg-pet-in-diabetic-myonecrosis-a-rare-and-underrecognized-complication-of-diabetes
#5
Guillaume Chaussé, Gad Abikhzer
A 66-year-old man with poorly controlled type 2 diabetes was admitted for acute bilateral calf pain in the context of coronary artery disease, chronic renal failure, and peripheral neuropathy. Lower-extremity Doppler ultrasound excluded deep vein thrombosis. FDG-PET was performed to exclude a suspected infection because of elevated white blood cells and inflammatory markers but normal creatinine kinase levels. PET scan demonstrated intense bilateral calf muscle and left thigh muscle uptake, which in combination with the patient's history was consistent with diabetic myonecrosis, a rare end-stage complication of diabetes...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29201858/thoracolumbar-paraspinal-myonecrosis-after-aortic-dissection
#6
Sung Min Kim, Ki Chang Lee, Sung Hwa Paeng, Se Yeong Pyo, Yong Tae Jung
Thoracolumbar paraspinal myonecrosis can be developed with various etiologies. It can induce compartment syndrome of spinal muscles and cause elevated pressure on back muscles, resulting in severe back pain. Thoracolumbar paraspinal myonecrosis is a very rare disease. There are only a few studies about paraspinal myonecrosis. Here we report a case of a spontaneous thoracolumbar paraspinal myonecrosis in a patient who had asymptomatic abdominal aortic dissection. Through this case, etiologies, clinical features, radiologic findings, and treatment options for thoracolumbar paraspinal myonecrosis are discussed...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29181643/vibrational-spectroscopy-of-muscular-tissue-intoxicated-by-snake-venom-and-exposed-to-photobiomodulation-therapy
#7
Willians Fernando Vieira, Bruno Kenzo-Kagawa, Maria Helena Mesquita Britto, Helder José Ceragioli, Kumiko Koibuchi Sakane, Vitor Baranauskas, Maria Alice da Cruz-Höfling
The pathogenesis of myonecrosis caused by myotoxins from bothropic venom is associated with local extracellular matrix (ECM) disintegration, hemorrhage, and inflammation. Search for alternative methods associated with serum therapy is mandatory to neutralize the fast development of local damage following snakebites. The experimental use of photobiomodulation therapy (PBMT) in murine models has shown promising results relative to structural and functional recovery from bothropic snakebite-induced myonecrosis...
November 28, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29107082/purification-and-characterization-of-an-anti-hemorrhagic-protein-from-naja-naja-indian-cobra-venom
#8
K N Suvilesh, M Yariswamy, M N Savitha, Vikram Joshi, A N Nanjaraj Urs, Amog P Urs, M Choudhury, D Velmurugan, B S Vishwanath
Snake venom Kunitz-type proteins are well known to inhibit serine proteases but a few studies have also shown matrix metalloproteases (MMPs) inhibition. In view of the fact that MMPs and snake venom metalloproteases (SVMPs) have similar catalytic site, inhibition of SVMP activity by Kunitz-type proteins remains to be studied. Recent proteomic studies of Naja naja (N. naja) venom revealed the abundance of Kunitz-type proteins. In this regard, present study aimed at purification of a protease inhibitor from N...
October 26, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29076298/a-challenging-case-of-calcific-myonecrosis-of-tibialis-anterior-and-hallucis-longus-muscles-with-a-chronic-discharging-wound
#9
Alethea My Tan, Charles Yuen Yung Loh, Metin Nizamoglu, Makarand Tare
The occurrence of calcific myonecrosis of the anterior compartment of the leg is rare. Common risk factors include a history of trauma, although little is known about the exact pathophysiology, latency period or triggering factors resulting in disease progression. Macroscopically, it begins with a single muscle being replaced by a fusiform calcified mass, which progresses peripherally. We present a rare case of a 7-year history of chronic discharging sinus overlying the site with protruding calcified muscle and discuss the senior author's wound management strategy and surgical considerations...
October 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28947747/a-whole-blood-molecular-signature-for-acute-myocardial-infarction
#10
Evan D Muse, Eric R Kramer, Haiying Wang, Paddy Barrett, Fereshteh Parviz, Mark A Novotny, Roger S Lasken, Timothy A Jatkoe, Glenn Oliveira, Hongfan Peng, Jerry Lu, Mark C Connelly, Kurt Schilling, Chandra Rao, Ali Torkamani, Eric J Topol
Chest pain is a leading reason patients seek medical evaluation. While assays to detect myocyte death are used to diagnose a heart attack (acute myocardial infarction, AMI), there is no biomarker to indicate an impending cardiac event. Transcriptional patterns present in circulating endothelial cells (CEC) may provide a window into the plaque rupture process and identify a proximal biomarker for AMI. Thus, we aimed to identify a transcriptomic signature of AMI present in whole blood, but derived from CECs. Candidate genes indicative of AMI were nominated from microarray of enriched CEC samples, and then verified for detectability and predictive potential via qPCR in whole blood...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912893/the-role-of-nitric-oxide-during-sonoreperfusion-of-microvascular-obstruction
#11
Francois T H Yu, Xucai Chen, Adam C Straub, John J Pacella
Rationale: Microembolization during PCI for acute myocardial infarction can cause microvascular obstruction (MVO). MVO severely limits the success of reperfusion therapies, is associated with additional myonecrosis, and is linked to worse prognosis, including death. We have shown, both in in vitro and in vivo models, that ultrasound (US) and microbubble (MB) therapy (termed "sonoreperfusion" or "SRP") is a theranostic approach that relieves MVO and restores perfusion, but the underlying mechanisms remain to be established...
2017: Theranostics
https://www.readbyqxmd.com/read/28906474/non-clinical-studies-for-evaluation-of-8-c-rhamnosyl-apigenin-purified-from-peperomia-obtusifolia-against-acute-edema
#12
Cinthia I Tamayose, Paulete Romoff, Daniela O Toyama, Henrique H Gaeta, Caroline R C Costa, Mariana N Belchor, Bruna D Ortolan, Leosvaldo S M Velozo, Maria A C Kaplan, Marcelo J P Ferreira, Marcos H Toyama
Compound 8-C-rhamnosyl apigenin (8CR) induced a moderate reduction in the enzymatic activity of secretory phospholipase A2 (sPLA2) from Crotalus durissus terrificus and cytosolic phospholipase A2 (cPLA2), but the compound also significantly inhibited the enzymatic activity of the enzyme cyclooxygenase. In vitro assays showed that the compound induced a slight change in the secondary structure of sPLA2 from Crotalus durissus terrificus snake venom. In vivo assays were divided into two steps. In the first step, the 8CR compound was administered by intraperitoneal injections 30 min prior to administration of sPLA2...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28899512/nepeta-deflersiana-attenuates-isoproterenol-induced-myocardial-injuries-in-rats-possible-involvement-of-oxidative-stress-apoptosis-inflammation-through-nuclear-factor-nf-%C3%AE%C2%BAb-downregulation
#13
Areej Mohammad Al-Taweel, Mohammad Raish, Shagufta Perveen, Ghada Ahmed Fawzy, Ajaz Ahmad, Mushtaq Ahmad Ansari, Shahid Mudassar, Majid Ahmad Ganaie
BACKGROUND: Nepeta deflersiana (Lamiaceae) is a perennial herb used in the Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. PURPOSE: This study explores the phytochemistry of the plant and the cardioprotective effect of N. deflersiana ethanolic extract (NDEE) against isoproterenol (ISP)-induced myocardial injury in rats. DESIGN/METHODS: Cardiac function, serum cardiac enzymes, myocardial antioxidants, inflammatory, and apoptotic biomarkers, and histopathological parameters were studied in ISP-injured Wistar rat heart tissues...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28865532/magnetic-resonance-imaging-of-musculoskeletal-emergencies
#14
Parthiv Mehta, Micheal Morrow, Joshua Russell, Nikhil Madhuripan, Michael Habeeb
Musculoskeletal trauma and infections are commonly encountered in the emergency department. Magnetic resonance imaging (MRI) is rarely employed in true emergencies and most musculoskeletal studies can be deferred to the outpatient setting. This article seeks to address the urgent conditions in which MRI can play a role in diagnosis, management, and treatment. This article outlines MRI's role in the evaluation of posterolateral corner injuries and other soft-tissue pathologies such as rhabdomyolysis, diabetic myonecrosis, septic arthritis, cellulitis, necrotizing fasciitis, and compartment syndrome...
August 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28746861/investigation-of-the-inhibitory-potential-of-phospholipase-a2-inhibitor-gamma-from-sinonatrix-annularis-to-snake-envenomation
#15
Shengwei Xiong, Yunyun Luo, Lipeng Zhong, Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang
SaPLIγ is a novel gamma phospholipase A2 inhibitor (PLI) recently isolated from Sinonatrix annularis, a Chinese endemic non-venomous snake. To explore the neutralization effects of saPLIγ in snakebite envenomation, a dose equivalent to LD50 of Deinagkistrodon acutus, Agkistrodon halys and Naja atra venom with/without saPLIγ was inoculated into the gastrocnemius muscle of female Kunming mice. The ability of saPLIγ to inhibit myonecrosis and systemic toxicity were evaluated through investigations of muscle histopathology, and determination of the serum levels of creatine kinase (CK), lactate dehydrogenase isoenzyme1 (LDH1) and aspartate transferase (AST)...
July 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28739197/type-1-and-2-myocardial-infarction-and-myocardial-injury-clinical-transition-to-high-sensitivity-cardiac-troponin-i
#16
Yader Sandoval, Stephen W Smith, Anne Sexter, Sarah E Thordsen, Charles A Bruen, Michelle D Carlson, Kenneth W Dodd, Brian E Driver, Yan Hu, Katherine Jacoby, Benjamin K Johnson, Sara A Love, Johanna C Moore, Karen Schulz, Nathaniel L Scott, Fred S Apple
BACKGROUND: Studies addressing patients with type 2 myocardial infarction and myocardial injury, including the impact of using high-sensitivity (hs) cardiac troponin (cTn) assays on their incidence are needed. METHODS: Ours is a prospective, observational US cohort study. Consecutive emergency department patients with serial cTnI measurements were studied. Outcomes included 180-day mortality and major adverse cardiac events, including 2-year follow-up for those with myonecrosis...
July 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28730321/age-and-dressing-type-as-independent-predictors-of-post-operative-infection-in-patients-with-acute-compartment-syndrome-of-the-lower-leg
#17
Mark E Hake, Jordan Etscheidt, Vivek P Chadayammuri, Jacob M Kirsch, Cyril Mauffrey
PURPOSE: The purpose of this study was to determine independent factors, including timing of fasciotomy, that confer an increased risk of post-operative surgical site infection (SSI) in patients presenting with acute compartment syndrome (ACS) of the lower extremity. METHODS: A retrospective analysis was performed on a consecutive cohort of 53 adult patients requiring fasciotomy for lower-extremity fractures complicated by ACS presenting to a single Level I trauma center over a seven-year study period...
December 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28728682/-statin-and-risk-of-falls-in-the-elderly-a-sytematic-review-of-the-literature
#18
Luis Carlos Venegas Sanabria, Stephany Barbosa Balaquera, Ana María Suarez Acosta, Ángel Alberto García Peña, Carlos Alberto Cano Gutiérrez
BACKGROUND: With the high incidence of cardiovascular events in the elderly population the effectiveness of statins in reducing mortality from coronary events has been demonstrated. However, there have been adverse effects, such as myalgia, myopathy, myonecrosis, not to mention the falls as a result of muscle damage with statin use. OBJECTIVE: The purpose of this study is to conduct a systematic review to assess the literature on the association between statin use and the risk of falls...
July 17, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28720440/first-report-of-two-complete-clostridium-chauvoei-genome-sequences-and-detailed-in-silico-genome-analysis
#19
Prasad Thomas, Torsten Semmler, Inga Eichhorn, Antina Lübke-Becker, Christiane Werckenthin, Mostafa Y Abdel-Glil, Lothar H Wieler, Heinrich Neubauer, Christian Seyboldt
Clostridium (C.) chauvoei is a Gram-positive, spore forming, anaerobic bacterium. It causes black leg in ruminants, a typically fatal histotoxic myonecrosis. High quality circular genome sequences were generated for the C. chauvoei type strain DSM 7528(T) (ATCC 10092(T)) and a field strain 12S0467 isolated in Germany. The origin of replication (oriC) was comparable to that of Bacillus subtilis in structure with two regions containing DnaA boxes. Similar prophages were identified in the genomes of both C. chauvoei strains which also harbored hemolysin and bacterial spore formation genes...
July 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28720432/adhesion-and-invasion-of-clostridium-perfringens-type-a-into-epithelial-cells
#20
Luis A Llanco, Viviane Nakano, Claudia T P de Moraes, Roxane M F Piazza, Mario J Avila-Campos
Clostridium perfringens is the causative agent for necrotic enteritis. It secretes the major virulence factors, and α- and NetB-toxins that are responsible for intestinal lesions. The TpeL toxin affects cell morphology by producing myonecrosis, but its role in the pathogenesis of necrotic enteritis is unclear. In this study, the presence of netB and tpeL genes in C. perfringens type A strains isolated from chickens with necrotic enteritis, their cytotoxic effects and role in adhesion and invasion of epithelial cells were evaluated...
October 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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