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Coronary imaging

Martina C de Knegt, Morten Haugen, Jesper J Linde, Jørgen Tobias Kühl, Børge G Nordestgaard, Lars V Køber, Jens D Hove, Klaus F Kofoed
PURPOSE: Quantitative computed tomography (QCT) provides important prognostic information of coronary atherosclerosis. We investigated intraobserver and interobserver QCT reproducibility in asymptomatic individuals, patients with acute chest pain without acute coronary syndrome (ACS), and patients with acute chest pain and ACS. METHODS: Fifty patients from each cohort, scanned between 01/02/2010-14/11/2013 and matched according to age and gender, were retrospectively assessed for inclusion...
2018: PloS One
Marjolein A Heuvelmans, Marleen Vonder, Mieneke Rook, Harry J M Groen, Geertruida H De Bock, Xueqian Xie, Maarten J Ijzerman, Rozemarijn Vliegenthart, Matthijs Oudkerk
Lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease are highly prevalent in the general population and expected to cause most deaths by 2050. For these "Big-3," treatment might cure, delay, or stop the progression of disease at a very early stage. Lung nodule growth rate (a biomarker for lung cancer), emphysema/air trapping (a biomarker for chronic obstructive pulmonary disease), and coronary artery calcification (a biomarker for cardiovascular disease) are imaging biomarkers of early stages of the Big-3 that can be acquired with low-dose computed tomography (CT)...
December 13, 2018: Journal of Thoracic Imaging
Tetsuro Uchida, Azumi Hamasaki, Yoshinori Kuroda, Atsushi Yamashita, Mitsuaki Sadahiro
We report the use of intraoperative fluorescence imaging to assist in the surgical management of proximal coronary arteriovenous fistulas in four patients.
December 12, 2018: Journal of Cardiac Surgery
Mia Ståhle, Ville Kytö, Max Kiugel, Heidi Liljenbäck, Olli Metsälä, Meeri Käkelä, Xiang-Guo Li, Vesa Oikonen, Pekka Saukko, Pirjo Nuutila, Juhani Knuuti, Anne Roivainen, Antti Saraste
BACKGROUND: Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate 68 Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats. METHODS AND RESULTS: Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Rats were injected with 68 Ga-NODAGA-exendin-4 and scanned with PET and contrast-enhanced computed tomography (CT) followed by digital autoradiography and histology of left ventricle tissue sections...
December 13, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Claudia Stöllberger, Lenka Gerencerova, Josef Finsterer
Takotsubo syndrome (TTS) is a transient transient left ventricular dysfunction, predominantly affecting elderly women and often preceded by emotional or physical stress. TTS may be the cause as well as the consequence of stroke. We report a 82-years old female with a history of long-standing untreated arterial hypertension who was hospitalized because of a left-sided tongue paralysis and dysarthria. Cerebral magnetic resonance imaging showed ischemic lesions in the territory of the right middle cerebral artery affecting the capsula interna and gyrus praecentralis...
December 2018: ENeurologicalSci
Ernesto Di Cesare, Alessandra Di Sibio, Antonio Gennarelli, Margherita Di Luzio, Ines Casazza, Alessandra Splendiani, Annamaria Di Cesare, Giovanni Luca Gravina, Antonio Barile, Carlo Masciocchi
Purpose: The aim of this study was to compare image quality and mean radiation dose between two groups of patients undergoing coronary computed tomography angiography (CCTA) using a 640-slice CT scanner with two protocols with different noise level thresholds expressed as standard deviation (SD). Materials and Methods: Two-hundred and sixty-eight patients underwent a CCTA with 640 slice CT scanner. In the experimental group (135 patients), an SD 51 protocol was employed; in the control group (133 patients), an SD 33 protocol was used...
2018: Journal of Clinical Imaging Science
Fayçal Ben Bouallçgue, Catherine Nganoa, Jonathan Vigne, Denis Agostini, Alain Manrique
Objective: We evaluated the relative performances of dipyridamole (Dip) and regadenoson (Reg) in a cohort of patients referred for coronary artery disease diagnosis or follow-up using myocardial perfusion imaging. Materials and Methods: We retrospectively included 515 consecutive patients referred for 99m Tc-sestamibi myocardial perfusion single-photon emission computerized tomography (SPECT) on a cadmium-zinc-telluride (CZT) camera after pharmacologic stress. About three quarters ( n = 391, 76%) received Dip...
2018: Journal of Clinical Imaging Science
Laura E Mantella, Kayla Colledanchise, Milena Bullen, Marie-France Hétu, Andrew G Day, Catherine S McLellan, Amer M Johri
BACKGROUND: Coronary Artery Disease (CAD) is the leading cause of death worldwide. Ultrasound-detected carotid plaque has been previously shown to predict significant CAD. Despite this evidence, carotid plaque assessment has not been implemented in cardiac risk screening, likely due to the cost associated with a formal carotid ultrasound examination. This study sought to determine whether a handheld vascular ultrasound device could be used as an accurate point-of-care imaging tool for the assessment of carotid artery plaque...
December 5, 2018: International Journal of Cardiology
Mihaela Ratiu, Monica Chitu, Imre Benedek, Theodora Benedek, Istvan Kovacs, Nora Rat, Ciprian Rezus
INTRODUCTION: Coronary computed tomography angiography (CCTA) has emerged as a valuable noninvasive imaging tool for assessing atheromatous plaque morphology and composition, and several CCTA features have been validated as reliable indicators of the plaque-associated risk. However, the role of lesion geometry as a CCTA feature of plaque vulnerability has not been investigated so far. MATERIAL AND METHODS: Here we present the study protocol of the GEOMETRY trial, a prospective, single center, cohort study in which we aim to investigate the relationship between plaque geometry (as expressed by cross-sectional and longitudinal plaque eccentricity) and the risk for major adverse cardiac events (MACE) during 2 years of follow-up, in order to validate plaque eccentricity as a new CCTA marker of coronary plaque vulnerability...
December 2018: Medicine (Baltimore)
Michel Villatoro-Villar, Michael S Bold, Kenneth J Warrington, Cynthia S Crowson, Gaurav Goyal, Mithun Shah, Ronald S Go, Matthew J Koster
Erdheim-Chester disease (ECD) is a rare histiocytosis of the "L" (Langerhans) group with multisystem involvement that can affect the large and medium-sized arteries mimicking vasculitis. Aortic involvement is common but the frequency and outcome of aortic branch vessel abnormalities are less well described.Patients with ECD were retrospectively identified. Images containing information of arterial involvement within 6 months of diagnosis were considered baseline and compared to last follow-up studies...
December 2018: Medicine (Baltimore)
Joseph A Ladapo, John M Pfeifer, James M Pitcavage, Brent A Williams, Alana A Choy-Shan
BACKGROUND: Cardiovascular care sex differences are controversial. We examined sex differences in management and clinical outcomes among patients undergoing noninvasive testing for ischemic heart disease (IHD). METHODS: In a rural integrated healthcare system, we identified adults age 40-79 without diagnosed IHD who underwent initial evaluation with a cardiac stress test with imaging or coronary computed tomographic angiography (CTA), 2013-2014. We assessed sex differences in statin/aspirin therapy, revascularization, and adverse cardiovascular events...
December 13, 2018: Journal of Women's Health
Daryl Sudasena, Dinu Valentin Balanescu, Teodora Donisan, Saamir Hassan, Nicolas Palaskas, Peter Kim, Kaveh Karimzad, Juan Lopez-Mattei, Salman Arain, K Lance Gould, Cezar Iliescu
The use of vascular endothelial growth factor inhibitors such as sorafenib is limited by a risk of severe cardiovascular toxicity. A 28-year-old man with acute myeloid leukemia treated with prednisone, tacrolimus, and sorafenib following stem cell transplantation presented with severe bilateral lower extremity claudication. The patient was discharged against medical advice prior to finalizing a cardiovascular evaluation, but returned 1 week later with signs suggestive of septic shock. Laboratory tests revealed troponin I of 12...
December 12, 2018: Cardiovascular Toxicology
Elizabeth Chandy, Alexander Ivanov, Devindra S Dabiesingh, Alexandra Grossman, Prasanthi Sunkesula, Lakshmi Velagapudi, Virna L Sales, Edward J Colombo, Igor Klem, Terrence J Sacchi, John F Heitner
BACKGROUND/OBJECTIVES: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta. METHODS: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up...
2018: PloS One
Davide Ippolito, Luca Riva, Cammillo R Talei Franzesi, Cecilia Cangiotti, Andrea De Vito, Filiberto Di Gennaro, Gabriele D'andrea, Andrea Crespi, Sandro Sironi
PURPOSE: To evaluate the image quality and radiation dose exposure of low-dose coronary CTA (cCTA) study, reconstructed with the new model-based iterative reconstruction algorithm (IMR), compared with standard hybrid-iterative reconstruction (iDose4 ) cCTA in patients with suspected coronary artery disease. MATERIALS AND METHODS: Ninety-eight patients with an indication for coronary CT study were prospectively enrolled. Fifty-two patients (study group) underwent 256-MDCT low-dose cCTA (80 kV; automated-mAs; 60 mL of CM, 350 mgL/mL) with prospective ECG-triggering acquisition and IMR...
December 11, 2018: La Radiologia Medica
David M Thomas, Patrick D McLaughlin, James P Nugent, Sarah A Barrett, John R Mayo, Ana-Maria Bilawich, Graham C Wong, Savvas Nicolaou
PURPOSE: This retrospective study reports the frequency and severity of coronary artery motion on dual-source high-pitch (DSHP), conventional pitch single-source (SS), and dual-source dual-energy (DE) CT pulmonary angiography (CTPA) studies. METHODS: Two hundred eighty-eight consecutive patients underwent CTPA scans for suspected pulmonary embolism between September 1, 2013 and January 31, 2014. One hundred ninety-four at DSHP scans, 57 SS scans, and 37 DE scans were analyzed...
December 12, 2018: Emergency Radiology
Minyoung Oh, Cheol Whan Lee, Jung-Min Ahn, Duk-Woo Park, Su-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Dae Hyuk Moon, Seong-Wook Park, Seung-Jung Park
BACKGROUND: The renin-angiotensin system plays an important role in promoting atherosclerotic plaque inflammation, which may be inhibited by angiotension-II receptor blockers. HYPOTHESIS: We investigated the effects of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation using 18 F-fluorodeoxyglucose (18 FDG) positron emission tomography (PET) imaging. METHODS: Fifty patients with acute coronary syndrome and at least one lesion with 18 FDG uptake in the carotid artery (target to background ratio (TBR) ≥ 1...
December 9, 2018: Clinical Cardiology
Kensuke Matsushita, Kiyoshi Hibi, Kozo Okada, Kentaro Sakamaki, Eiichi Akiyama, Yuichiro Kimura, Yasushi Matsuzawa, Nobuhiko Maejima, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Peter J Fitzgerald, Yasuhiro Honda, Kouichi Tamura, Kazuo Kimura
Anatomical measurements obtained by intracoronary imaging devices are reported to correlate significantly with fractional flow reserve (FFR). Instantaneous wave-free ratio (iFR) is a nonhyperemic index of stenosis severity with discordant reports regarding its accuracy in relation to FFR. There is no information on the correlation of iFR with measurements derived from intracoronary imaging devices. The purpose of this study was to assess the relationship among iFR, intravascular ultrasound (IVUS), and optical frequency domain imaging (OFDI) parameters...
December 7, 2018: Heart and Vessels
Yimin Zhang, Su Zhang, Jelmer Westra, Daixin Ding, Qiuyang Zhao, Junqing Yang, Zhongwei Sun, Jiayue Huang, Jun Pu, Bo Xu, Shengxian Tu
To assess a novel approach for automatic flow velocity computation in deriving quantitative flow ratio (QFR) from coronary angiography. QFR is a novel approach for assessment of functional significance of coronary artery stenosis without using pressure wire and induced hyperemia. Patient-specific coronary flow is estimated semi-automatically by frame count method, which is subjective and inconvenient in the workflow of QFR analysis. The vascular structures were automatically delineated from coronary angiogram...
December 8, 2018: International Journal of Cardiovascular Imaging
Jeff M Smit, Gerhard Koning, Alexander R van Rosendael, Mohammed El Mahdiui, Bart J Mertens, Martin J Schalij, J Wouter Jukema, Victoria Delgado, Johan H C Reiber, Jeroen J Bax, Arthur J Scholte
Aims: Quantitative flow ratio (QFR) is a recently developed technique to calculate fractional flow reserve (FFR) based on 3D quantitative coronary angiography and computational fluid dynamics, obviating the need for a pressure-wire and hyperaemia induction. QFR might be used to guide patient selection for FFR and subsequent percutaneous coronary intervention (PCI) referral in hospitals not capable to perform FFR and PCI. We aimed to investigate the feasibility to use QFR to appropriately select patients for FFR referral...
December 11, 2018: European Heart Journal Cardiovascular Imaging
Yan Li, Zhongping Chen
The rupture of atherosclerotic plaques is the leading cause of death in developed countries. Early identification of vulnerable plaque is the essential step in preventing acute coronary events. Intravascular photoacoustic (IVPA) technology is able to visualize chemical composition of atherosclerotic plaque with high specificity and sensitivity. Integrated with intravascular ultrasound (IVUS) imaging, this multimodal intravascular IVPA/IVUS imaging technology is able to provide both structural and chemical compositions of arterial walls for detecting and characterizing atherosclerotic plaques...
May 2018: Biomedical Engineering Letters
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