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Neuromodulation Rehabilitation

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https://www.readbyqxmd.com/read/30113757/bladder-emptying-method-is-the-primary-determinant-of-urinary-tract-infections-in-patients-with-spinal-cord-injury-results-from-a-prospective-rehabilitation-cohort-study
#1
Collene E Anderson, Jonviea D Chamberlain, Xavier Jordan, Thomas M Kessler, Eugenia Luca, Sandra Möhr, Jürgen Pannek, Martin Schubert, Martin Wg Brinkhof
OBJECTIVE: To understand the occurrence of and risk factors for urinary tract infections (UTIs) in patients with spinal cord injury (SCI) undergoing specialized SCI rehabilitation in Switzerland. PATIENTS AND METHODS: This study used data collected from 369 patients, who participated in a nationwide rehabilitation cohort for SCI in Switzerland between 2013 and 2017. Information on UTIs as well as their potential determinants, including demographics, lesion characteristics, and time-updated data on functional independence and bladder management was used...
August 16, 2018: BJU International
https://www.readbyqxmd.com/read/30049887/transneuronal-down-regulation-of-the-premotor-cholinergic-system-after-corticospinal-tract-loss
#2
Yu-Qiu Jiang, Adrish Sarkar, Alzahraa Amer, John H Martin
Injury to the supraspinal motor systems, especially the corticospinal tract, leads to movement impairments. In addition to direct disruption of descending motor pathways, spinal motor circuits that are distant to and not directly damaged by the lesion undergo remodeling that contributes significantly to the impairments. Knowing which spinal circuits are remodeled and the underlying mechanisms are critical for understanding the functional changes in the motor pathway and for developing repair strategies. Here we target spinal premotor cholinergic interneuron that directly modulate motoneuron excitability via their cholinergic C-bouton terminals...
July 26, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/30018913/urology-as-rehabilitation-medicine-a-literature-review
#3
REVIEW
Tae Beom Kim, Chang Hee Kim, Kwang Taek Kim, Sang Jin Yoon, Kyung Jin Chung
As a urologist, we usually encounter with two representative functional behaviors, namely, voiding and sexual function. These are not only important but also complex and synchronized so if these functions are impaired, patients need active functional rehabilitation to recover. These functional impairments should be recognized and corrected early because they could not only cause direct damage to the affected functions but also have harmful consecutive consequences such as kidney damage due to voiding abnormality and self-esteem damage due to decreased sexual function...
June 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/30014759/cortical-neuromodulation-of-remote-regions-after-experimental-tbi-normalizes-forelimb-function-but-is-temporally-dependent
#4
Derek Ray Verley, Daneil Torolira, Brittany A Hessell, Richard L Sutton, Neil G Harris
Traumatic brain injury results in well-known, significant alterations in structural and functional connectivity. While this is especially likely to occur in areas of pathology, deficits in function to, and from remotely connected brain areas, or diaschisis, also occur as a consequence to local deficits. As a result, consideration of the network wiring of the brain may be required to design the most efficacious rehabilitation therapy to target specific functional networks to improve outcome. In this work, we model remote connections after controlled cortical impact injury in the rat through the effect of callosal deafferentation to the opposite, contralesional cortex...
July 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30009212/systematic-review-of-rehabilitation-in-focal-dystonias-classification-and-recommendations
#5
REVIEW
Cecília N Prudente, Lena Zetterberg, Annika Bring, Lynley Bradnam, Teresa J Kimberley
Background: Rehabilitation interventions are rarely utilized as an alternative or adjunct therapy for focal dystonias. Reasons for limited utilization are unknown, but lack of conclusive evidence of effectiveness is likely a crucial factor. Methods and Findings: The purpose of this systematic review was to determine the level of evidence for rehabilitation interventions in focal dystonias. Rehabilitation interventions were classified based upon the underlying theoretical basis of different approaches, and the strength of evidence for each category was evaluated to identify gaps in the field...
May 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29988534/spinal-control-of-locomotion-individual-neurons-their-circuits-and-functions
#6
REVIEW
Marie-Pascale Côté, Lynda M Murray, Maria Knikou
Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century. Despite significant progress in our understanding of these networks and their role in generating and modulating movement, it has remained a challenge to elucidate the properties of the locomotor rhythm across species. Neurophysiological experimental evidence indicates similarities in the function of interneurons mediating afferent information regarding muscle stretch and loading, being affected by motor axon collaterals and those mediating presynaptic inhibition in animals and humans when their function is assessed at rest...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29909301/intrinsic-functional-neurocircuitry-associated-with-treatment-response-to-transdiagnostic-cbt-in-bipolar-disorder-with-anxiety
#7
Kristen K Ellard, Aishwarya G Gosai, Emily E Bernstein, Navneet Kaur, Lousia G Sylvia, Joan A Camprodon, Darin D Dougherty, Andrew A Nierenberg, Thilo Deckersbach
BACKGROUND: Anxiety in bipolar disorder (BD) exacerbates emotion dysregulation and reduces treatment response. We recently conducted a pilot trial of transdiagnostic CBT to target anxiety and emotion dysregulation in BD adjunctive to pharmacotherapy. Reductions in depression and anxiety symptoms were significantly predicted by baseline levels of neuroticism and perceived affective control, as well as changes over time in emotion regulation skills. The present study investigates mechanism of treatment response by examining the relationship between baseline emotion regulation-related neural circuitry and trial outcomes...
October 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29862163/recent-trends-in-the-use-of-electrical-neuromodulation-in-parkinson-s-disease
#8
REVIEW
John-Stuart Brittain, Hayriye Cagnan
Purpose of Review: This review aims to survey recent trends in electrical forms of neuromodulation, with a specific application to Parkinson's disease (PD). Emerging trends are identified, highlighting synergies in state-of-the-art neuromodulation strategies, with directions for future improvements in stimulation efficacy suggested. Recent Findings: Deep brain stimulation remains the most common and effective form of electrical stimulation for the treatment of PD...
2018: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/29764702/a-novel-neuromodulation-technique-for-the-rehabilitation-of-balance-and-gait-a-case-study
#9
L Eduardo Cofré Lizama, Andisheh Bastani, Maya G Panisset, Katharine Drummond, Fary Khan, Mary P Galea
Cranial-nerve non-invasive neuromodulation (CN-NINM) through the tongue has been proposed as an adjuvant intervention to improve efficacy of rehabilitation. However, CN-NINM effects have only been explored in multiple sclerosis and stroke populations. In this report we used CN-NINM during a 2-week (2 × 1.5 h sessions daily) physiotherapy program for the rehabilitation of a 57 y/o woman presenting with balance and gait impairments after a surgical resection of a fourth ventricular ependymoma. Clinical and instrumented balance and gait assessments showed improved performance in all tests and without adverse effects This study shows the beneficial effects and feasibility of combined physiotherapy and CN-NINM in this patient...
August 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29721010/targeted-neuromodulation-of-abnormal-interhemispheric-connectivity-to-promote-neural-plasticity-and-recovery-of-arm-function-after-stroke-a-randomized-crossover-clinical-trial-study-protocol
#10
Michael R Borich, Steven L Wolf, Andrew Q Tan, Jacqueline A Palmer
Background: Despite intensive rehabilitation efforts, most stroke survivors have persistent functional disability of the paretic arm and hand. These motor impairments may be due in part to maladaptive changes in structural and functional connections between brain regions. The following early stage clinical trial study protocol describes a noninvasive brain stimulation approach to target transcallosally mediated interhemispheric connections between the ipsi- and contralesional motor cortices (iM1 and cM1) using corticocortical paired associative stimulation (ihPAS)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29686644/technological-approaches-for-neurorehabilitation-from-robotic-devices-to-brain-stimulation-and-beyond
#11
Marianna Semprini, Matteo Laffranchi, Vittorio Sanguineti, Laura Avanzino, Roberto De Icco, Lorenzo De Michieli, Michela Chiappalone
Neurological diseases causing motor/cognitive impairments are among the most common causes of adult-onset disability. More than one billion of people are affected worldwide, and this number is expected to increase in upcoming years, because of the rapidly aging population. The frequent lack of complete recovery makes it desirable to develop novel neurorehabilitative treatments, suited to the patients, and better targeting the specific disability. To date, rehabilitation therapy can be aided by the technological support of robotic-based therapy, non-invasive brain stimulation, and neural interfaces...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29643759/changes-in-h-reflex-recruitment-after-trans-spinal-direct-current-stimulation-with-multiple-electrode-configurations
#12
Alexander Kuck, Dick F Stegeman, Herman van der Kooij, Edwin H F van Asseldonk
Trans-spinal direct current stimulation (tsDCS) is an electro-modulatory tool with possible application in the rehabilitation of spinal cord injury. TsDCS generates a small electric field, aiming to induce lasting, functional neuromodulation in the targeted neuronal networks. Earlier studies have shown significant modulatory effects after application of lumbar tsDCS. However, for clinical application, a better understanding of application specific factors is required. Our goal was to investigate the effect of different electrode configurations using lumbar spinal tsDCS on spinal excitability...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29556411/the-combined-effect-of-cranial-nerve-non-invasive-neuromodulation-with-high-intensity-physiotherapy-on-gait-and-balance-in-a-patient-with-cerebellar-degeneration-a-case-report
#13
Andisheh Bastani, L Eduardo Cofré Lizama, Maryam Zoghi, Grant Blashki, Stephen Davis, Andrew H Kaye, Fary Khan, Mary P Galea
Background: Cranial-nerve non-invasive neuromodulation (CN-NINM) using the portable neuromodulation stimulator (PoNS™) device has been proposed as a novel adjuvant intervention to improve efficacy of gait and balance. This device modulates input and output signals during motor tasks which prompts neuroplastic changes. In this study, we investigated the efficacy of physiotherapy using the PoNS™ in a case with cerebellar degeneration. Case presentation: The PoNS™ was used during a high-intensity physiotherapy programme delivered over 2 weeks (2 × 1...
2018: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29556028/cortico-reticulo-spinal-circuit-reorganization-enables-functional-recovery-after-severe-spinal-cord-contusion
#14
Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A Anderson, Polina Shkorbatova, Laura Batti, Stephane Pagès, Julie Kreider, Bernard L Schneider, Quentin Barraud, Gregoire Courtine
Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished all motor cortex projections below injury. However, the motor cortex immediately regained adaptive control over the paralyzed legs during electrochemical neuromodulation of lumbar circuits. Glutamatergic reticulospinal neurons with residual projections below the injury relayed the cortical command downstream...
April 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29533186/closed-loop-neuromodulation-restores-network-connectivity-and-motor-control-after-spinal-cord-injury
#15
Patrick D Ganzer, Michael J Darrow, Eric C Meyers, Bleyda R Solorzano, Andrea D Ruiz, Nicole M Robertson, Katherine S Adcock, Justin T James, Han S Jeong, April M Becker, Mark P Goldberg, David T Pruitt, Seth A Hays, Michael P Kilgard, Robert L Rennaker
Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model...
March 13, 2018: ELife
https://www.readbyqxmd.com/read/29485334/spinal-cord-injury-pharmacotherapy-current-research-development-and-competitive-commercial-landscape-as-of-2015
#16
Jason R Guercio, Jason E Kralic, Eric J Marrotte, Michael L James
CONTEXT: Current treatment of spinal cord injury (SCI) focuses on cord stabilization to prevent further injury, rehabilitation, management of non-motor symptoms, and prevention of complications. Currently, no approved treatments are available, and limited treatment options exist for symptoms and complications associated with chronic SCI. This review describes the pharmacotherapy landscape in SCI from both commercial and research and development (R&D) standpoints through March 2015...
February 27, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29436519/low-intensity-focused-ultrasound-alters-the-latency-and-spatial-patterns-of-sensory-evoked-cortical-responses-in-vivo
#17
Jonathan A N Fisher, Iryna Gumenchuk
OBJECTIVE: The use of transcranial, low intensity focused ultrasound (FUS) is an emerging neuromodulation technology that shows promise for both therapeutic and research applications. Among many, one of the most exciting applications is the use of FUS to rehabilitate or augment human sensory capabilities. While there is compelling empirical evidence demonstrating this capability, basic questions regarding the spatiotemporal extent of the modulatory effects remain. Our objective was to assess the basic, yet often overlooked hypothesis that FUS in fact alters sensory-evoked neural activity within the region of the cerebral cortex at the beam's focus...
June 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29432505/the-use-of-eeg-biofeedback-neurofeedback-in-psychiatric-rehabilitation
#18
REVIEW
Renata Markiewcz
The aim of the systematic review was to evaluate the use of EEG Biofeedback/Neurofeedback in patients treated for mental disorders. The review covered publications analyzing influences and effects of therapy in patients receiving psychiatric treatment based on EEG Biofeedback/Neurofeedback. Selection of publications was made by searching PubMed and Scopus databases. 328 records concerning applications of the presented method were identified in total, including 84 records for patients diagnosed with mental disorders...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29289680/the-potential-effects-of-transcranial-direct-current-stimulation-tdcs-on-language-functioning-combining-neuromodulation-and-behavioral-intervention-in-aphasia
#19
REVIEW
Paola Marangolo
Aphasia is a highly disabling language disorder usually caused by a left stroke brain damage. Even if traditional language therapies have been proved to induce an adequate clinical recovery, a large percentage of patients are left with chronic deficits at 6 months post-stroke. Therefore, new strategies to common speech therapies are urgently needed in order to maximize the recovery from aphasia. The recent application of transcranial direct current stimulation (tDCS) to language rehabilitation has already provided promising results...
December 28, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29077132/-brain-stimulation-the-most-direct-form-of-neurostimulation
#20
T A de Graaf, C Baeken, P Sienaert, A Aleman, A T Sack
BACKGROUND: Brain stimulation is the most direct form of neuromodulation. Direct brain stimulation is an older procedure that has taken various forms, but 'non-invasive brain stimulation' is a more recent development. AIM: To provide an overview of the current arsenal of non-invasive brain stimulation techniques. METHOD: We discuss the underlying principles, the pros and cons, and the applicability of non-invasive brain stimulation in experimental research and treatment of neuropsychiatric disorders...
2017: Tijdschrift Voor Psychiatrie
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