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Neonatal convulsion

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https://www.readbyqxmd.com/read/30328407/perinatal-outcomes-in-vertically-infected-neonates-during-a-chikungunya-outbreak-on-the-island-of-cura%C3%A3-ao
#1
B J D van Enter, M H W Huibers, L van Rooij, R Steingrover, M Boele van Hensbroek, R R Voigt, J Hol
Recent outbreaks of Chikungunya virus (CHIKV) infection confirm the vulnerability of neonates after vertical transmission. In 2014, CHIKV was reported for the first time in the Americas, including the island of Curaçao. We describe the outcomes of symptomatic neonates with vertically transmitted CHIKV infection during the CHIKV epidemic, who were admitted in the Saint Elisabeth Hospital, Willemstad, Curaçao. There were three symptomatic neonates with serologically confirmed infection. Two neonates developed neurological complications, including convulsions and intracerebral bleeding...
October 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30235725/adducted-thumb-as-an-isolated-morphologic-finding-an-early-sonographic-sign-of-impaired-neurodevelopment-a-strobe-compliant-study
#2
Yun-Shu Ouyang, Yi-Xiu Zhang, Hua Meng, Xi-Ning Wu, Qing-Wei Qi
Fetal adducted thumbs have been described in association with hydrocephalus and other abnormalities, but in cases without other structural malformations the determination of prognosis and recurrence risk is challenging. The aim of our study is to analyze the characteristics, natural history, and postnatal outcome of such cases.A retrospective study was conducted over a period of 4 years in a tertiary referral center. All fetuses diagnosed as adducted thumbs without other structural malformations comprised the study group...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30096466/the-temporal-effect-of-category-ii-fetal-monitoring-on-neonatal-outcomes
#3
Tal Weissbach, Ishai Heusler, Michal Ovadia, Liron David, Yair Daykan, Faye Schreiber, Tal Biron-Shental
OBJECTIVE: To correlate the duration of Category II cardiotocograms (CTG) with adverse neonatal outcomes associated with perinatal asphyxia and determine the duration before fetal compromise. STUDY DESIGN: This retrospective, observational study used electronic medical record data from a cohort of 271 patients, delivered by C-section due to non-reassuring fetal heart rate, at a tertiary medical center, from 2015 through 2017. Duration of Category II CTG, variability, tachycardia and deceleration frequency were analyzed and correlated to immediate postnatal outcomes...
October 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30038819/pilot-study-of-classic-galactosemia-neurodevelopmental-impact-and-other-complications-urge-neonatal-screening-in-egypt
#4
Magd A Kotb, Lobna Mansour, Christine William Shaker Basanti, Wael El Garf, Ghada I Z Ali, Sally T Mostafa El Sorogy, Inas E M Kamel, Naglaa M Kamal
Classic galactosemia is caused by deficiency of galactose-1-phosphate uridylyltransferase (GALT). It causes serious morbidity and mortality if left untreated. Screening for galactosemia is not included in Egyptian neonatal screening program. The study aimed to define clinical presentation and complications of galactosemia at Pediatric Hepatology Clinic, Cairo University, Egypt. Thus, the clinical presentation, course and outcome of 37 children with documented galactosemia was studied. Jaundice was the main presentation (67...
July 2018: Journal of Advanced Research
https://www.readbyqxmd.com/read/30026773/prediction-of-response-to-treatment-in-children-with-epilepsy
#5
Mohammad Ghofrani, Mohammad Mehdi Nasehi, Sasan Saket, Mohsen Mollamohammadi, Mohammad Mahdi Taghdiri, Parvaneh Karimzadeh, Seyed Hassan Tonekaboni, Mohsen Javadzadeh, Narjes Jafari, Azadeh Zavehzad, Masoud Hasanvand Amouzadeh, Mahsa Beshrat, Meysam Babaei
Objective: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs. Material and Methods: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The inclusion criteria were children 2 months to 12 yr of age with epilepsy and patients who experienced fever and seizure attacks at least once were excluded from the study. Patients were followed up for 6 months and the response to their treatment was recorded...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/30017837/early-life-hyperthermic-seizures-upregulate-adenosine-a-2a-receptors-in-the-cortex-and-promote-depressive-like-behavior-in-adult-rats
#6
María Crespo, David Agustín León-Navarro, Mairena Martín
Febrile seizures (FS) represent one of the most frequent convulsive disorders in children which can be classified into simple and prolonged depending on the duration. Although simple FS are generally considered as benign, there is controversy about the outcome of prolonged FS. Here, we have used an animal model of prolonged FS to investigate persistent neurochemical and behavioral alterations in adult rats. Hyperthermic seizures were induced in 12-day-old rats using a warmed air stream from a hair dryer. Neonates exhibited arrest of heat-induced hyperkinesis followed by body flexion and rearing and falling over associated with hindlimb clonus seizures (stage 5 on Racine scale criteria) after hyperthermic induction...
September 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29935542/clinical-evaluation-of-severe-neonatal-hyperbilirubinaemia-in-a-resource-limited-setting-a-4-year-longitudinal-study-in-south-east-nigeria
#7
Chidiebere D I Osuorah, Uchenna Ekwochi, Isaac N Asinobi
BACKGROUND: Neonatal hyperbilirubinaemia is one of the commonest causes of hospital visit in the neonatal period. When severe, it is a leading cause of irreversible neurological and musculoskeletal disability. Prompt recognition and timely interventions are imperative for a drastic reduction in complications associated with severe hyperbilirubinaemia in newborns. METHODS: We report a 4-year descriptive and longitudinal study to determine the causes, clinical presentations and long-term outcomes in newborns admitted for severe neonatal jaundice...
June 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29914278/maternal-fetal-and-neonatal-outcomes-among-different-types-of-hypertensive-disorders-associating-pregnancy-needing-intensive-care-management
#8
Ahmed M Maged, Ameer Elsherief, Hany Hassan, Doaa Salaheldin, Khaled A Omran, Maged Almohamady, Sherif Dahab, Radwa Fahmy, Ahmed AbdelHak, Amira Y Shoab, Rehab Lotfy, Yossra S Lasheen, Hala Nabil, Sahar M Y Elbaradie
OBJECTIVE: To assess the relationship between maternal, fetal, and neonatal outcomes and different forms of hypertensive disorders associating pregnancy in women needed intensive care units (ICUs) admission. METHODS: A prospective case control study was conducted on 1238 women admitted to hypertensive ICU at three university hospitals. They were classified into four groups. Group I included 472 women with severe preeclampsia (PE), Group II included 243 women with eclampsia (E), Group III included 396 women diagnosed with E associated with HELLP syndrome, and Group IV included 127 women diagnosed as HELLP syndrome...
September 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29876916/-neonatal-onset-of-epileptic-syndromes-causations-and-diagnostic-process
#9
M C Fons-Estupina
Neonatal convulsions are the most frequent form of expression of neurological pathology in the neonatal period. They represent a neurological emergency and thus require urgent diagnosis and treatment, as they are associated with a high risk of neonatal mortality or adverse neurological prognosis. Most neonatal convulsions are symptomatic and secondary to an identifiable causation. The causes vary widely. In this review we describe the electroclinical and aetiological aspects, and we also analyse the process of diagnosing the main epileptic syndromes in newborn infants...
June 5, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29858850/a-rare-cause-of-neonatal-hypoglycemia-in-two-siblings-tbx19-gene-mutation
#10
REVIEW
Edip Unal, Ruken Yıldırım, Funda Feryal Taş, Suat Tekin, Askin Sen, Yusuf Kenan Haspolat
Congenital isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) is a rarely seen disease characterized by low serum ACTH and cortisol levels accompanied by normal levels of the other anterior pituitary hormones. In these patients, severe hypoglycemia, convulsions, and prolonged cholestatic jaundice are expected findings in the neonatal period. In this paper, we present two siblings with TBX19 gene mutation. The first case was investigated at the age of 2 months for severe hypoglycemia, recurrent convulsions, and prolonged cholestatic jaundice persisting since the neonatal period...
June 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29769490/comparison-of-outcome-of-eclamptic-patient-following-vaginal-delivery-versus-caeserian-delivery-by-spinal-anaesthesia
#11
M A Hossain, R K Karmoker, M S Rahman, H O Rashid, S H Khan, M A Rahman
Eclampsia is a common problem in pregnancy in Bangladesh. It is a severe form of preeclampsia which affects 5 to 7% of pregnancies is a significant cause of maternal & neonatal morbidity & mortality. Pre-eclampsia when complicated with generalized tonic-clonic convulsions and/or coma is called eclampsia. The term eclampsia is derived from a Greek word, meaning "like a flash of lightening". It may occur quite abruptly, without any warning manifestations. Eclampsia is a major cause of maternal mortality & morbidity as well as foetal loss worldwide, particularly in the third world...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29624207/large-differences-in-neonatal-drug-use-between-nicus-are-common-practice-time-for-consensus
#12
Robert B Flint, Floor van Beek, Peter Andriessen, Luc J Zimmermann, Kian D Liem, Irwin K M Reiss, Ronald de Groot, Dick Tibboel, David M Burger, Sinno H P Simons
AIMS: Evidence for drug use in newborns is sparse, which may cause large differences in drug prescriptions. We aimed to investigate the differences between neonatal intensive care units (NICUs) in the Netherlands in currently prescribed drugs. METHODS: This multicentre study included neonates admitted during 12 months to four different NICUs. Drugs were classified in accordance with the Anatomical Therapeutic Chemical (ATC) classification system and assessed for on/off-label status in relation to neonatal age...
June 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29568539/low-level-of-knowledge-about-neonatal-danger-signs-and-its-associated-factors-among-postnatal-mothers-attending-at-woldia-general-hospital-ethiopia
#13
Mekdes Mengesha Jemberia, Elsa Tesfa Berhe, Hawi Bersisa Mirkena, Destaw Molla Gishen, Abera Endale Tegegne, Melese Abate Reta
Background: Neonatal mortality has persisted high in Ethiopia in spite of many efforts being applied to decrease this adverse trend. Early detection of neonatal illness is an important step towards improving newborn survival. Toward this end, there is a need for the mothers to be able to identify signs in neonates that signify severe illnesses. The aim of this study was to assess knowledge about neonatal danger signs and its associated factors among postnatal mothers attending at Woldia general hospital, Ethiopian...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29429466/-recurrent-convulsion-and-pulmonary-infection-complicated-by-psychomotor-retardation-in-an-infant
#14
Juan Xiong, Jing Peng, Hao-Lin Duan, Chen Chen, Xiao-Le Wang, Shi-Meng Chen, Fei Yin
A 4-month-old girl developed convulsion in the neonatal period, which was focal motor seizures in the initial stage and later became spasm and tonic spasm. And the girl also had psychomotor retardation and recurrent pulmonary infection. Electroencephalography showed hypsarrhythmia, normal results were obtained from cranial magnetic resonance imaging, cerebrospinal fluid examination, and urine organic acid analysis, as well as the spectral analyses of blood ammonia, blood lactic acid, blood amino acids, and acylcarnitines...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29422393/a-de-novo-gabra2-missense-mutation-in-severe-early-onset-epileptic-encephalopathy-with-a-choreiform-movement-disorder
#15
Naama Orenstein, Hadassa Goldberg-Stern, Rachel Straussberg, Lily Bazak, Monika Weisz Hubshman, Nesia Kropach, Oded Gilad, Oded Scheuerman, Yahav Dory, Dror Kraus, Shay Tzur, Nurit Magal, Yael Kilim, Vered Shkalim Zemer, Lina Basel-Salmon
BACKGROUND: Early-onset epileptic encephalopathy (EOEE) is a severe convulsive disorder with a poor developmental prognosis. Although it has been associated with mutations in a number of genes, the fact that there is a large proportion of patients who remain undiagnosed suggests that there are many more still-unknown genetic causes of EOEE. Achieving a genetic diagnosis is important for understanding the biological basis of the disease, with its implications for treatment and family planning...
May 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29397615/-clinical-features-and-gene-mutation-analysis-of-patients-with-niemann-pick-disease-type-c
#16
S C Ren, Z X Tian, Y X Deng, Y J Wang, X J Wu, Y Z Zhang, B Q Gao
Objective: To analyze the clinical manifestations, therapeutic efficacy, prognosis and characteristics of NPC1 mutation in Chinese patients with Niemann-Pick disease type C(NPC). Methods: Ten unrelated Chinese NPC patients were diagnosed by NPC1 mutation analysis from July 2013 to February 2017 in Beijing Tian Tan Hospital of Capital Medical University. Clinical data of 10 cases were analyzed retrospectively which included clinical manifestations, laboratory results and NPC1 gene mutation features, and a series of follow-up were carried out about therapeutic efficacy and prognosis...
January 23, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29386157/vitex-negundo-induces-an-anticonvulsant-effect-by-inhibiting-voltage-gated-sodium-channels-in-murine-neuro-2a-cell-line
#17
Faisal Khan, Zafar Saeed Saify, Khawar Saeed Jamali, Saima Naz, Sohail Hassan, Sonia Siddiqui
Vitex negundo (Vn) extract is famous for the treatment of neurological diseases such as migraine and epilepsy. These neurological diseases have been associated with abnormally increased influx of sodium ions into the neurons. Drugs that inhibit voltage gated sodium channels can be used as potent anti-epileptics. Till now, the effects of Vn on sodium channels have not been investigated. Therefore, we have investigated the effects of methalonic fraction of Vn extract in Murine Neuro 2A cell line. Cells were cultured in a defined medium with or without the Vn extract (100 μg/ml)...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29360435/cerebellar-oxidative-stress-and-fine-motor-impairment-in-adolescent-rats-exposed-to-hyperthermia-induced-seizures-is-prevented-by-maternal-caffeine-intake-during-gestation-and-lactation
#18
María Crespo, David Agustín León-Navarro, Mairena Martín
Febrile seizures (FS) is one of the most common convulsive disorders in infants and young children that only occurs during the first years of life in humans, when the cerebellum is still developing. Several works have shown that maternal caffeine consumption during gestation and lactation can exert protective effects on developing brain under pathological conditions. Here, we have used an animal model of FS to know whether maternal caffeine consumption during gestation and lactation exhibited protective effects on rat cerebellum...
March 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29352657/electroencephalographic-monitoring-for-seizure-identification-and-prognosis-in-term-neonates
#19
REVIEW
Shavonne L Massey, Frances E Jensen, Nicholas S Abend
Seizures represent a manifestation of neurological disease in the neonatal period. Historically, neonatal seizures were identified by direct clinical observation. However, since most seizures are electroencephalographic (EEG)-only (subclinical, non-convulsive) and clinical manifestations may be subtle, many clinicians place increasing importance on EEG data including conventional EEG or amplitude-integrated EEG to identify seizures in neonates. Beyond seizure identification, the EEG is a robust source of information about brain function that can be useful for neurobehavioral prognostication in some neonates...
June 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29335781/peripartum-events-associated-with-severe-neurologic-morbidity-and-mortality-among-acidemic-neonates
#20
Sivan Zuarez-Easton, Sally Hosary, Noah Zafran, Gali Garmi, Clari Felszer, Raed Salim
PURPOSE: To identify peripartum events that may predict the development of short-term neurologic morbidity and mortality among acidemic neonates. METHODS: Retrospective case-control study conducted at a single-teaching hospital on data from January 2010 to December 2015. The study cohort group included all acidemic neonates (cord artery pH ≤ 7.1) born at ≥ 34 weeks. Primary outcome was a composite including any of the following: neonatal encephalopathy, convulsions, intra-ventricular hemorrhage, or neonatal death...
April 2018: Archives of Gynecology and Obstetrics
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