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Osama Aa Ahmed, Waleed Y Rizq
Introduction: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness...
2018: Drug Design, Development and Therapy
I Sanzari, E J Humphrey, F Dinelli, C M Terracciano, T Prodromakis
We recently demonstrated that patterned Parylene C films could be effectively used as a mask for directly copolymerizing proteins on polyacrylamide hydrogel (PAm). In this work, we have proved the applicability of this technique for studying the effect such platforms render on neonatal rat ventricular myocytes (NRVMs). Firstly, we have characterised topographically and mechanically the scaffolds in liquid at the nano-scale level. We thus establish that such platforms have physical properties that closely mimics the in vivo extracellular environment of cells...
August 10, 2018: Scientific Reports
Kishore K Jena, Saeed M Alhassan, Atul Tiwari, L H Hihara
Understanding the molecular interaction and morphology of organic-inorganic hybrid materials is an important and fundamental assignment to develop novel high-performance materials. In this work, we developed two types of hybrid coating materials by using different silane coupling agents via Michael addition reaction and ring-opening polymerization. The changes in molecular interaction and morphology of the hybrid coatings due to chemical composition and curing temperature were studied by electron microscopy, spectroscopy and solid state 29 Si nuclear magnetic resonance analysis...
August 9, 2018: Scientific Reports
Kandasamy Saravanakumar, Elango Jeevithan, Ramachandran Chelliah, Kandasamy Kathiresan, Wu Wen-Hui, Deog-Hwan Oh, Myeong-Hyeon Wang
Chitosan (CS), a novel biomaterial is widely used as a drug nano-carrier for cancer treatment. Towards this aim, anticancer and antibacterial activities of CS-nanoparticles-linked zinc (Zn-CSNPs) were evaluated. Particle size of CSNPs lowered (113.09 nm) compared to Zn-CSNPs (160.7 nm). Both nanoparticles (CSNPs and Zn-CSNPs) were spherical in shape, polydispersive, homogenous, amorphous and uniform size. Fourier transforms infrared spectrophotometer (FTIR) and energy dispersive X-ray spectroscopy (EDX) analysis confirmed the different molecular arrangement of NPs and presence of Zn in Zn-CSNPs and CS in both NPs, respectively...
August 6, 2018: International Journal of Biological Macromolecules
Mohamad El-Roz, Igor Telegeiev, Natalia E Mordvinova, Oleg Igorevich Lebedev, Nicolas Barrier, Asma Behlil, Moussa Zaarour, Louwanda Lakiss, Valentin Valtchev
Sub-nanometer silver clusters that exhibit discrete electronic structure with molecular-like properties are highly desirable in various technologies. However, the methods for their preparation suffer from limitations related with the reproducibility and particles uniformity, and/or the possibility of the scaling-up. Another critical drawback is that free sub-nanometer silver clusters tend to aggregate into larger particles. In this work, a new approach that successfully overcomes the above limitations is developed...
August 6, 2018: ACS Applied Materials & Interfaces
Thekra I Hamad, Abdalbseet A Fatalla, Amer Subhi Waheed, Zena G M Azzawi, Ying-Guang Cao, Ke Song
The clinical success of dental implants can be improved by achieving optimum implant properties, such as their biomechanical and surface characteristics. Nano-structured coatings can play an important role in improving the implant surface. The purpose of the present study was to determine the most appropriate conditions for electrophoretic deposition (EPD) of nano-zirconia coatings on Ti-6Al-7Nb substrates and to evaluate the structural and biomechanical characteristics of these deposited coatings on the dental implants...
June 2018: Current medical science
Rinky Sha, Nandimalla Vishnu, Sushmee Badhulika
The authors report on a composite based electrocatalyst for methanol oxidation and H2 O2 sensing. The composite consists of Pt nanoparticles (NPs), Pd nanoflakes, and MoS2 . It was synthesized by chemical reduction followed by template-free electro-deposition of Pt NPs. FESEM images of the Pd nanoflakes on the MoS2 reveal nanorod-like morphology of the Pd NPs on the MoS2 support, whilst FESEM images of the Pt-Pd/MoS2 composite show Pt NPs in high density and with the average size of ~15 nm, all homogeneously electrodeposited on the Pd-MoS2 composite...
August 2, 2018: Mikrochimica Acta
Atiyeh Zarifi, Birgit Stiller, Moritz Merklein, Yang Liu, Blair Morrison, Alvaro Casas-Bedoya, Guanghui Ren, Thach G Nguyen, Khu Vu, Duk-Yong Choi, Arnan Mitchell, Steven J Madden, Benjamin J Eggleton
Recent advances in design and fabrication of photonic-phononic waveguides have enabled stimulated Brillouin scattering in silicon-based platforms such as underetched silicon waveguides and hybrid waveguides. Due to the sophisticated design and, more importantly, high sensitivity of the Brillouin resonances to geometrical variations in micro- and nano-scale structures, it is necessary to have access to the localized opto-acoustic response along those waveguides to monitor their uniformity and maximize their interaction strength...
August 1, 2018: Optics Letters
Yi-Ke Sun, Lei Wang, Masaru Kamano, Saulius Juodkazis
A method to directly explore the effect of electron density on the surface plasmon wave and the corresponding laser-induced structures is demonstrated by controllable doping of silver nitrate (AgNO3 ) into a water-soluble polymer polyvinyl alcohol (PVA). It is shown that periodic nanostructures on PVA appeared only when the electron density was more than 6×1020   cm-3 and became uniform when doping density corresponded to 1.2×1021   cm-3 . Photo-excitation of electrons in the Ag-doped PVA defined by laser fluence determined the conditions of surface plasmon wave and formation of nanostructures on the surface...
August 1, 2018: Optics Letters
Norifumi Kawakami, Hiroki Kondo, Yuki Matsuzawa, Kaoru Hayasaka, Erika Nasu, Kenji Sasahara, Ryoichi Arai, Kenji Miyamoto
Protein-based nanoparticles hold promise for a broad range of applications. Here, we report the production of a uniform anionic hollow protein nanoparticle, designated TIP60, which spontaneously assembles from a designed fusion protein subunit based on the geometric features of polyhedra. We show that TIP60 tolerates mutation and both its interior and exterior surfaces can be chemically modified. Moreover, TIP60 forms larger structures upon the addition of a cationic protein. Therefore, TIP60 can be used as a modifiable nano-building block for further molecular assembly...
July 31, 2018: Angewandte Chemie
Deyu Guo, Chen Ling, Chengzhi Wang, Dan Wang, JingBo Li, Zhengjing Zhao, Zehao Wang, Yongjie Zhao, Jiatao Zhang, Haibo Jin
Preparation of ultrafine highly-dispersed VO2 (M) nanoparticles which are essential materials to fabricate thermochromic flexible films remains a challenge preventing effective use of their promising properties. Here, we report an original hydrothermal approach by controlling oxidizing atmosphere of reaction with hydrogen peroxide to prepare ultrafine VO2 (M) nanoparticles free from annealing. Hydrogen peroxide is separated from precursor solution in reactor which creates a moderate oxygenation environment, enabling the formation of stoichiometric VO2 (M) nanoparticles...
July 31, 2018: ACS Applied Materials & Interfaces
Benoit Couturaud, Panagiotis G Georgiou, Spyridon Varlas, Joseph R Jones, Maria C Arno, Jeffrey C Foster, Rachel K O'Reilly
The preparation of a functional fluorine-containing block copolymer using reversible addition-fragmentation chain-transfer dispersion polymerization in DMSO as a "platform/scaffold" is explored. The nanostructures, comprised of poly(ethyleneglycol)-b-poly(pentafluorophenyl methacrylate) or PEG-b-P(PFMA), are formulated via photo-initiated polymerization-induced self-assembly (PISA) followed by post-polymerization modification using different primary amines. A combination of light scattering and microscopy techniques are used to characterize the resulting morphologies...
July 30, 2018: Macromolecular Rapid Communications
Jiuyu Chen, Qianhong Gao, Xiaomei Zhang, Ying Liu, Peng Wang, Yan Jiao, Yi Yang
Nano mixed-valence silver oxide (Ag2 O-Ag2 O3 ) modified the zeolitic imidazolate framework-8 (ZIF-8) composite (Ag2 O-Ag2 O3 @ZIF-8) was firstly prepared via a simple and efficient method, characterized and applied for iodide ion (I- ) uptake from simulated radioactive wastewater. The results showed that Ag2 O-Ag2 O3 nanoparticles doped and uniformly dispersed on the surface of ZIF-8 matrix. The adsorption capacity of the as-synthesized adsorbents increased with the increasing Ag doped amount, and the maximum adsorption capacity for 20%-Ag2 O-Ag2 O3 @ZIF-8 was 232...
July 21, 2018: Science of the Total Environment
Emil Karshalev, Berta Esteban-Fernández de Ávila, Mara Beltrán-Gastélum, Pavimol Angsantikul, Songsong Tang, Rodolfo Mundaca-Uribe, Fangyu Zhang, Jing Zhao, Liangfang Zhang, Joseph Wang
Tremendous progress has been made during the last decade toward the design of nano/micromotors with high biocompatibility, multi-functionality and efficient propulsion in biological fluids, which collectively have led to the initial investigation of in vivo biomedical applications of these synthetic motors. Despite of these recent advances in micromotor designs and mechanistic research, significant effort is needed to develop appropriate formulations of micromotors to facilitate their in vivo administration and thus to better test their in vivo applicability...
July 30, 2018: ACS Nano
Wu Li, Francois-Marie Allioux, Judy Lee, Muthupandian Ashokkumar, Ludovic F Dumée
Metal nano-porous architectures are a novel class of nanomaterials which has been applied in the fields of catalysis, sensing and gas storage because of their high surface-to-volume ratio, high mechanical strength and long-range ordered architectures. A commonly-used synthetic strategies to achieve architectures with high precision and diverse porosity design is the seed-and-growth method. In this work, using a dual-frequency sequential sonication approach, we have demonstrated a sonochemical-assisted one-pot seeding with a successive shell growth synthetic strategy for mesoporous metal deposition via a gold (Au) nanoparticle and poly(styrene) beads system...
July 17, 2018: Ultrasonics Sonochemistry
Wei-En Chen, Chengke Chen, Chien-Jui Yeh, Xiaojun Hu, Keh-Chyang Leou, I-Nan Lin, Chii-Ruey Lin
The present work reports the plasma post treatment (PPT) process that instigates the evolution of granular structure of nanocrystalline diamond (NCD), consequently conducing the enhancement of the electron field emission (EFE) properties. The NCD films contain uniform and nano-sized diamond grains (~20 nm) with negligible thickness for grain boundaries that is distinctly different from the microstructure of ultra nano crystalline (UNCD) films with uniformly sized ultra-nano-diamond grains (~5 nm) having relatively thick grain boundaries (~0...
July 27, 2018: ACS Applied Materials & Interfaces
Mahsa Jalali, Tamer AbdelFatah, Sahar Sadat Mahshid, Mahmoud Labib, Ayyappasamy Sudalaiyadum Perumal, Sara Mahshid
Efficient capture and rapid detection of pathogenic bacteria from body fluids lead to early diagnostics of bacterial infections and significantly enhance the survival rate. We propose a universal nano/microfluidic device integrated with a 3D nanostructured detection platform for sensitive and quantifiable detection of pathogenic bacteria. Surface characterization of the nanostructured detection platform confirms a uniform distribution of hierarchical 3D nano-/microisland (NMI) structures with spatial orientation and nanorough protrusions...
July 26, 2018: Small
Xin Zhang, Qi Zhang, Dan Yue, Jun Zhang, Jintong Wang, Bin Li, Yu Yang, Yuanjing Cui, Guodong Qian
Metal-organic framework (MOF)-polymer mixed-matrix membranes (MMMs) have shown great potential and superior performance in gas separations. However, their sensing application has not been fully established yet. Herein, a rare example of using flexible MOF-based MMMs as a fluorescent turn-on sensor for the detection of hydrogen sulfide (H2 S) is reported. These MOF-based MMMs are readily prepared by mixing a highly stable aluminum-based nano-MOF (Al-MIL-53-NO2 ) into poly(vinylidene fluoride) with high loadings up to 70%...
July 26, 2018: Small
Ying-Lan Yu, Ya-Nan Li, Yong Zhang, Ru-Ning Sun, Jia-Sheng Tu, Yan Shen
The therapeutic application of deoxypodophyllotoxin (DPT) is limited due to its poor water solubility and stability. In the present study, the micelles assembled by the amphiphilic block copolymers (mPEG-PDLLA) were constructed to improve the solubility and safety of DPT for their in vitro and in vivo application. The central composite design was utilized to develop the optimal formulation composed of 1221.41 mg mPEG-PDLLA, the weight ratio of 1 : 4 (mPEG-PDLLA : DPT), 30 mL hydration volume and the hydration temperature at 40 °C...
June 2018: Chinese Journal of Natural Medicines
Sumbul Mirza, Iram Zia, Reshma Jolly, Shadab Kazmi, Mohd Owais, Mohammad Shakir
In this work, we have explored the polysaccharide nature of bael fruit gum (BFG) motivated from the current findings about the substantial role of the polysaccharides in bone tissue engineering. The nanocomposite scaffold (CSH-BFG) was prepared by blending BFG, nano-hydroxyapatite (n-HA) and chitosan (CS) by co-precipitation approach and compared with n-HA and CS binary system (CSH). The analysis of different properties was carried out by SEM, TEM, FTIR, XRD and mechanical testing. The CSH-BFG scaffolds revealed a rough morphology and uniform distribution of particles along with strong chemical interactions among different components compared to the CSH scaffold...
July 21, 2018: International Journal of Biological Macromolecules
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