keyword
MENU ▼
Read by QxMD icon Read
search

Huiming Cheng

keyword
https://www.readbyqxmd.com/read/30294343/identification-and-functional-analysis-of-two-new-mutant-bnfad2-alleles-that-confer-elevated-oleic-acid-content-in-rapeseed
#1
Weihua Long, Maolong Hu, Jianqin Gao, Song Chen, Jiefu Zhang, Li Cheng, Huiming Pu
Rapeseed ( Brassica napus L.) is a vital oil crop worldwide. High oleic acid content is a desirable quality trait for rapeseed oil, which makes it more beneficial to human health. However, many germplasm resources with high oleic acid content in rapeseed have not been evaluated with regard to their genotypes, making it difficult to select the best strains with this trait for the breeding of high oleic acid rapeseed variety. This work was to explore the gene-regulation mechanism of this trait using a new super-high oleic acid content (∼85%) line N1379T as genetic material...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30243153/synthesis-of-scutellarein-derivatives-with-antiproliferative-activity-and-selectivity-through-the-intrinsic-pathway
#2
Tong Han, Yan Wang, Mingying Wang, Xu Li, Keguang Cheng, Xiang Gao, Zhanlin Li, Jiao Bai, Huiming Hua, Dahong Li
To explore antitumor agents with potent efficacy and low toxicity, scutellarein derivatives with benzoic acid mustard (10a-c, 11a-c and 13a-c) were designed and synthesized. The antiproliferative activities of the target derivatives against A549, MCF-7 and Bel-7402 cancer cell lines were tested. Compound 10a showed the strongest potency with an IC50 value of 1.50 μM against MCF-7 cell line, and displayed low toxicity against human liver L-O2 normal cells (IC50  > 50 μM), showing specificity between normal and malignant cells...
September 18, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30160205/identification-of-flavonolignans-from-silybum-marianum-seeds-as-allosteric-protein-tyrosine-phosphatase-1b-inhibitors
#3
Ningbo Qin, Tatsunori Sasaki, Wei Li, Jian Wang, Xiangyu Zhang, Dahong Li, Zhanlin Li, Maosheng Cheng, Huiming Hua, Kazuo Koike
Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7), dehydrosilychristin A (8), and silydianin (11) were identified as a novel class of natural PTP1B inhibitors (IC50 1.3 7-23.87 µM). Analysis of structure-activity relationship suggested that the absolute configurations at C-7" and C-8" greatly affected the PTP1B inhibitory activity...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/30120587/enhanced-cellular-osteogenic-differentiation-on-zn-containing-bioglass-incorporated-tio-2-nanorod-films
#4
Meng He, Xiaoyi Chen, Kui Cheng, Lingqing Dong, Wenjian Weng, Huiming Wang
Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO2 nanorod film incorporated with Zn-containing bioactive glass (TiO2 /Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO2 /Zn-BG film were significantly upregulated compared to that of the film without TiO2 nanorod nanostructure (Zn-BG) or without Zn (TiO2 /BG)...
August 17, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/30062051/autophagy-activation-contributes-to-lipid-accumulation-in-tubular-epithelial-cells-during-kidney-fibrosis
#5
Qi Yan, Yuan Song, Lu Zhang, Zhaowei Chen, Cheng Yang, Shan Liu, Xiaohan Yuan, Hongyu Gao, Guohua Ding, Huiming Wang
Sustained activation of autophagy and lipid accumulation in tubular epithelial cells (TECs) are both associated with the kidney fibrosis progression. Autophagy has been found involved in the lipid metabolism regulation through a bi-directional mechanism of inducing lipolysis as well as promoting lipid droplet formation. However, whether and how autophagy influences lipid accumulation in kidney fibrosis remain unclear. In the current study, we show that UUO-induced lipid accumulation in tubular cells was significantly reduced when the pharmacological inhibitor 3-MA or CQ was administrated both in vivo and in vitro...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29651725/the-heterogeneous-effects-of-urbanization-and-income-inequality-on-co-2-emissions-in-brics-economies-evidence-from-panel-quantile-regression
#6
Huiming Zhu, Hang Xia, Yawei Guo, Cheng Peng
This paper empirically examines the effects of urbanization and income inequality on CO2 emissions in the BRICS economies (i.e., Brazil, Russia, India, China, and South Africa) during the periods 1994-2013. The method we used is the panel quantile regression, which takes into account the unobserved individual heterogeneity and distributional heterogeneity. Our empirical results indicate that urbanization has a significant and negative impact on carbon emissions, except in the 80th , 90th , and 95th quantiles...
June 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29602176/wang-s-forceps-assisted-percutaneous-insertion-and-fixation-of-peritoneal-dialysis-catheter
#7
Huiming Wang, Yujuan Wang, Jili Zhu, Xinghua Chen, Cheng Chen, Cuizhi Xiang, Houjun Jia, Guohua Ding
Percutaneous insertion of peritoneal dialysis catheters is theoretically most preferred by nephrologists because of the advantages of bedside performing, surgery independence, and minimal injury over other procedures of catheter placement such as open surgical dissection or laparoscopic operation. However, blindly placing catheters in the percutaneous procedure brings the risk of catheter malposition or bowel perforation; this largely retarded it's implementation. We had previously developed a novel technique termed "Wang's forceps-assisted catheter insertion and fixation," which had been successfully applied in the open surgical catheter insertion and displaced catheter reposition in our center...
July 2018: Artificial Organs
https://www.readbyqxmd.com/read/29564888/cell-sheet-derived-ecm-coatings-and-their-effects-on-bmscs-responses
#8
Xiaozhao Wang, Zun Chen, Beibei Zhou, Xiyue Duan, Wenjian Weng, Kui Cheng, Huiming Wang, Jun Lin
Extracellular matrix (ECM) provides a dynamic and complex environment to determine the fate of stem cells. In this work, light harvested cell sheets were treated with paraformaldehyde or ethanol, which eventually become ECM. Such ECM was then immobilized on titanium substrates via polydopamine chemistry. Their effects on bone marrow mesenchymal stromal cells (BMSCs) behaviors were investigated. It was found that paraformaldehyde-treated ECM coating (PT-ECM) showed a well-maintained microstructure, whereas that of ethanol-treated (ET-ECM) was completely changed...
April 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29534051/vdplp-a-patatin-like-phospholipase-in-verticillium-dahliae-is-involved-in-cell-wall-integrity-and-required-for-pathogenicity
#9
Xiliang Qi, Xiaokang Li, Huiming Guo, Ning Guo, Hongmei Cheng
The soil-borne ascomycete fungus Verticillium dahliae causes vascular wilt disease and can seriously diminish the yield and quality of important crops. Functional analysis of growth- and pathogenicity-related genes is essential for revealing the pathogenic molecular mechanism of V. dahliae . Phospholipase is an important virulence factor in fungi that hydrolyzes phospholipids into fatty acid and other lipophilic substances and is involved in hyphal development. Thus far, only a few V. dahliae phospholipases have been identified, and their involvement in V...
March 13, 2018: Genes
https://www.readbyqxmd.com/read/29496346/attenuation-safety-and-efficacy-of-a-qx-like-infectious-bronchitis-virus-serotype-vaccine
#10
Shihong Yan, Jing Zhao, Deqiong Xie, Xiuying Huang, Jinlong Cheng, Ye Guo, Changqing Liu, Zhijun Ma, Huiming Yang, Guozhong Zhang
Avian infectious bronchitis (IB) is a highly contagious disease caused by avian infectious bronchitis virus (IBV), which is a considerable economic threat to the poultry industry. QX-like IBV strains have increasingly emerged in China in recent years. Hence, development of a specific vaccine to guard against their potential threat is important. In this study, we sought to develop an attenuated vaccine strain. First, attenuated QX-like IBV strain SZ130 was created by continuous passage in chicken embryos for 130 generations, and then its safety was tested...
March 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29449626/molecular-dynamics-study-of-strengthening-mechanism-of-nanolaminated-graphene-cu-composites-under-compression
#11
Shayuan Weng, Huiming Ning, Tao Fu, Ning Hu, Yinbo Zhao, Cheng Huang, Xianghe Peng
Molecular dynamics simulations of nanolaminated graphene/Cu (NGCu) and pure Cu under compression are conducted to investigate the underlying strengthening mechanism of graphene and the effect of lamella thickness. It is found that the stress-strain curves of NGCu undergo 3 regimes i.e. the elastic regime I, plastic strengthening regime II and plastic flow regime III. Incorporating graphene monolayer is proved to simultaneously contribute to the strength and ductility of the composites and the lamella thickness has a great effect on the mechanical properties of NGCu composites...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29234115/the-glutamic-residue-at-position-402-in-the-c-terminus-of-newcastle-disease-virus-nucleoprotein-is-critical-for-the-virus
#12
Xiaohui Yu, Jinlong Cheng, Zirong He, Chuang Li, Yang Song, Jia Xue, Huiming Yang, Rui Zhang, Guozhong Zhang
The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene significantly influenced viral replication. Here, we investigated the roles of certain amino acid residues in the NP C-terminus in viral replication and virulence. Results showed that the glutamic acid residue at position 402 (E402) in the C-terminus of the NP is critical for RNA synthesis in the NDV mini-genome system...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29177887/freb-is-involved-in-the-ferric-metabolism-and-multiple-pathogenicity-related-traits-of-verticillium-dahliae
#13
Latifur Rehman, Xiaofeng Su, Xiaokang Li, Xiliang Qi, Huiming Guo, Hongmei Cheng
Ferric reductases are integral membrane proteins involved in the reduction of environmental ferric iron into the biologically available ferrous iron. In the most overwhelming phytopathogenic fungus, Verticillium dahliae, these ferric reductase are not studied in details. In this study we explored the role of FreB gene (VDAG_06616) in the ferric reduction and virulence of V. dahliae by generating the knockout mutants (ΔFreB) and complementary strains (ΔFreB-C) using protoplast transformation. When cultured on media supplemented with FeSO4 , FeCl3 and no iron, ΔFreB exhibited significantly reduced growth and spore production especially on media with no iron...
June 2018: Current Genetics
https://www.readbyqxmd.com/read/29109393/scalable-whole-exome-sequencing-of-cell-free-dna-reveals-high-concordance-with-metastatic-tumors
#14
Viktor A Adalsteinsson, Gavin Ha, Samuel S Freeman, Atish D Choudhury, Daniel G Stover, Heather A Parsons, Gregory Gydush, Sarah C Reed, Denisse Rotem, Justin Rhoades, Denis Loginov, Dimitri Livitz, Daniel Rosebrock, Ignaty Leshchiner, Jaegil Kim, Chip Stewart, Mara Rosenberg, Joshua M Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, Paz Polak, Max Lloyd, Sairah Mahmud, Karla Helvie, Margaret S Merrill, Rebecca A Santiago, Edward P O'Connor, Seong H Jeong, Rachel Leeson, Rachel M Barry, Joseph F Kramkowski, Zhenwei Zhang, Laura Polacek, Jens G Lohr, Molly Schleicher, Emily Lipscomb, Andrea Saltzman, Nelly M Oliver, Lori Marini, Adrienne G Waks, Lauren C Harshman, Sara M Tolaney, Eliezer M Van Allen, Eric P Winer, Nancy U Lin, Mari Nakabayashi, Mary-Ellen Taplin, Cory M Johannessen, Levi A Garraway, Todd R Golub, Jesse S Boehm, Nikhil Wagle, Gad Getz, J Christopher Love, Matthew Meyerson
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate or breast cancers. In the earliest tested sample for each patient, 34% of patients have ≥10% tumor-derived cfDNA, sufficient for standard coverage whole-exome sequencing...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29089620/investigation-of-thermal-energy-transport-interface-of-hybrid-graphene-carbon-nanotube-polyethylene-nanocomposites
#15
Feng Liu, Xuyang Liu, Ning Hu, Huiming Ning, Satoshi Atobe, Cheng Yan, Fuhao Mo, Shaoyun Fu, Jianyu Zhang, Yu Wang, Xiaojing Mu
It is well known the thermal properties of three-dimensional (3-D) hybrid graphene (GR)-carbon nanotube (CNT) structures are not superior to that of the individual GR and CNT, however, the 3-D hybrid GR-CNT structures can effectively improve the thermal properties of polymer matrix. Therefore, understanding the thermal energy transport in the interface between polymer matrix and 3-D hybrid GR-CNT structure is essential. Here, the enhancement mechanism of interfacial thermal transport of hybrid GR-CNT structure was explored by applying non-equilibrium molecular dynamics (NEMD) simulations...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28984126/light-induced-cell-alignment-and-harvest-for-anisotropic-cell-sheet-technology
#16
Chao Liu, Ying Zhou, Miao Sun, Qi Li, Lingqing Dong, Liang Ma, Kui Cheng, Wenjian Weng, Mengfei Yu, Huiming Wang
Well-organized orientation of cells and anisotropic extracellular matrix (ECM) are crucial in engineering biomimetic tissues, such as muscles, arteries, and nervous system, and so on. This strategy, however, is only beginning to be explored. Here, we demonstrated a light-induced cell alignment and harvest for anisotropic cell sheets (ACS) technology using light-responsive TiO2 nanodots film (TNF) and photo-cross-linkable gelatin methacrylate (GelMA). Cell initial behaviors on TNF might be controlled by micropatterns of light-induced distinct surface hydroxyl features, owing to a sensing mechanism of myosin II-driven retraction of lamellipodia...
October 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28932943/response-of-magnetic-properties-to-metal-deposition-on-urban-green-in-nanjing-china
#17
Xiang'zi Leng, Cheng Wang, Huiming Li, Xin Qian, Jinhua Wang, Yixuan Sun
Environmental magnetism is a simple and fast method that can be used to assess heavy metal pollution in urban areas from the relationships between magnetic properties and heavy metal concentrations. Leaves of Osmanthus fragrans, one of the most widely distributed evergreen trees in Nanjing, China, were collected from four different district types, i.e., residential, educational, traffic, and industrial. The magnetic properties and heavy metal concentrations were measured both for unwashed (dust-loaded) and washed leaves...
November 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28851943/trace-metals-and-magnetic-particles-in-pm2-5-magnetic-identification-and-its-implications
#18
Jinhua Wang, Shiwei Li, Huiming Li, Xin Qian, Xiaolong Li, Xuemei Liu, Hao Lu, Cheng Wang, Yixuan Sun
Magnetic measurement was combined with geochemical analysis to investigate the trace metal pollution of PM2.5. The study was carried out in Nanjing, China, where the average PM2.5 concentrations in summer and winter in 2013-2014 were 66.37 and 96.92 μg/m(3), respectively. The dominant magnetic mineral in PM2.5 had a low-coercivity pseudo-single domain and consisted of magnetite and hematite. Iron-oxide magnetic particles comprised spherical as well as angular particles. Stable Pb isotopic ratio determinations showed that Pb in summer samples derived from coal emissions while the main sources of winter samples were smelting industry and coal emissions...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798981/the-oligosaccharyl-transferase-subunit-stt3-mediates-fungal-development-and-is-required-for-virulence-in-verticillium-dahliae
#19
Xiaofeng Su, Latifur Rehman, Huiming Guo, Xiaokang Li, Hongmei Cheng
Verticillium dahliae is the most overwhelming plant pathogen, causing Verticillium wilt in a number of economic crops. The molecular mechanism is still unclear and identification of the genes involved in the pathogenicity or virulence of this fungus would benefit to uncover such mechanism. STT3 is a catalytic subunit of the multi-subunit oligosaccharyl transferase (OST) and plays an essential role in glycoprotein modification. Here, we characterized STT3 gene (VDAG_03232.1) of V. dahliae to explore its regulatory role in the development and virulence by deletion and complementation of this gene, as well as its silence in transgenic plants...
February 2018: Current Genetics
https://www.readbyqxmd.com/read/28608346/computational-analysis-of-genome-wide-argonaute-dependent-dna-methylation-in-plants
#20
Kai Tang, Cheng-Guo Duan, Huiming Zhang, Jian-Kang Zhu
Whole-genome bisulfite sequencing (WGBS) has become a powerful tool to dissect genome-wide methylation profiles at single-base resolution. In this chapter we describe in detail the bioinformatics pipeline used for the analysis of ARGONAUTE-dependent DNA methylation in Arabidopsis thaliana. We provide tools and command lines used for mapping bisulfite sequencing reads, for estimating methylation levels at individual cytosine sites, for identifying differentially methylated regions (DMRs), and for calculating methylation levels of DMRs...
2017: Methods in Molecular Biology
keyword
keyword
168354
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"