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Chronical kidney disease

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https://www.readbyqxmd.com/read/29933406/anemia-modifies-the-prognostic-value-of-glycated-hemoglobin-in-patients-with-diabetic-chronic-kidney-disease
#1
I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Jia-Jung Lee, Yi-Wen Chiu, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
A common complication of chronic kidney disease (CKD), anemia can influence glycated hemoglobin (HbA1c) levels. In diabetic patients, anemia occurs earlier and with higher severity over the course of CKD stages. To elucidate the effect of hemoglobin (Hb) on the predictive value of HbA1c, we enrolled 1558 diabetic patients with stages 3-4 CKD, categorized according to baseline Hb and HbA1c quartiles. Linear regression revealed that higher HbA1c correlated significantly with higher Hb in the Hb < 10 g/dL group (β = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29932968/time-trends-in-the-prevalence-of-cancer-and-non-cancer-diseases-among-older-u-s-adults-medicare-based-analysis
#2
Igor Akushevich, Julia Kravchenko, Arseniy P Yashkin, Anatoliy I Yashin
Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medical expenditures. We evaluated 15-year time trends (from 1998 to 2013) in the prevalence of 48 acute and chronic non-cancer diseases and cancers in older U.S. adults aged 65+ and estimated the annual percentage changes of these prevalence trends using SEER-Medicare and HRS-Medicare data...
June 19, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29932881/rab7-empowers-renal-tubular-epithelial-cells-with-autophagy-mediated-protection-against-albumin-induced-injury
#3
Lei Liu, Yiping Li, Zhi Wang, Fengan Ding, Zhengyuan Cheng, Qing Xu, Yingying Cai, Manoj Hang Limbu, Yiqiong Yang, Bicheng Liu, Pingsheng Chen
Most patients with chronic kidney disease (CKD) present with proteinuria and extracellular matrix (ECM) deposition in the interstitium. Matrix metalloproteinase-2 (MMP-2) is important for maintaining ECM metabolism and it affects the formation and development of CKD. Autophagy has been reported to be protective against renal tubular injury, but the role of autophagy related to ECM metabolism is unclear. Rab7 is a shared molecule of endocytosis and autophagy. The aim of this study is to explore the role of autophagy in regulating MMP-2 activity and to determine whether Rab7 functions in regulating MMP-2 activity and injury in albumin-overloaded TECs...
June 19, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29932345/nitric-oxide-decreases-acute-kidney-injury-and-stage-3-chronic-kidney-disease-after-cardiac-surgery
#4
Chong Lei, Lorenzo Berra, Emanuele Rezoagli, Binglan Yu, Hailong Dong, Shiqiang Yu, Lihong Hou, Min Chen, Wensheng Chen, Hongbing Wang, Qijun Zheng, Jie Shen, Zhenxiao Jin, Tao Chen, Rong Zhao, Emily Christie, Venkata S Sabbisetti, Francesco Nordio, Joseph V Bonventre, Lize Xiong, Warren M Zapol
RATIONALE: No medical intervention has been identified that decreases acute kidney injury and improves renal outcome at 1-year after cardiac surgery. OBJECTIVE: To determine whether administration of nitric oxide reduces the incidence of post-operative acute kidney injury and improves long-term kidney outcomes after multiple cardiac valve replacement requiring prolonged cardiopulmonary bypass. METHODS: 244 Patients undergoing elective, multiple valve replacement surgery mostly due to rheumatic fever were randomized to receive either nitric oxide (treatment) or nitrogen (control)...
June 22, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29932281/diagnosis-based-cohort-augmentation-using-laboratory-results-data-the-case-of-chronic-kidney-disease
#5
David H Smith, Susan Shetterly, James Flory, Kevin Haynes, Christine Y Lu, Joshua J Gagne, Lisa Herrinton, Carsie Nyirenda, Elisabetta Patorno, Azadeh Shoaibi, Marsha A Raebel
PURPOSE: In this report, we use data from FDA's Sentinel System to focus on how augmenting a diagnosis-based chronic kidney disease cohort with patients identified through laboratory results impacts cohort characteristics and outcomes. METHODS: We used data from 2 Data Partners. Patients were eligible if they were health plan members on January 1, 2012. We classified chronic kidney disease patients into mutually exclusive categories according to the hierarchy of (1) ICD-9-CM diagnosis (DXGroup), or (2) two estimated glomerular filtration rates <60 mL/min/1...
June 22, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29931746/neurological-and-psychological-changes-in-hemodialysis-patients-before-and-after-the-treatment
#6
Silvia Lai, Alessio Molfino, Oriano Mecarelli, Patrizia Pulitano, Santo Morabito, Valentina Pistolesi, Roberto Romanello, Alessia Zarabla, Alessandro Galani, Nicla Frassetti, Paola Aceto, Carlo Lai
Neurological, psychological, and cognitive disorders in chronic kidney disease may contribute to poor quality of life in these patients. The aim of this study was to assess the electroencephalographic, psychological, and cognitive changes before and after hemodialysis (HD) compared with healthy controls (HC). Sixteen HD patients and 15 HC were enrolled. Electroencephalogram (EEG), Minnesota multiphasic personality inventory (MMPI-2) Satisfaction profile (SAT-P), and Neuropsychological test Global z-scores (NPZ5) were performed before (T0) and after (T1) HD treatment and in HC...
June 22, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29931711/evaluation-of-nutrition-imbalance-in-chinese-chronic-kidney-disease-children
#7
Ke Wang, Yeping Jiang, Yuting Lai Master, Ying Shen
BACKGROUND: Nutrition imbalance is common in chronic kidney disease (CKD) children. This study was to evaluate nutrition status of CKD children at different stages using bioimpedance analysis (BIA) compared with anthropometric measurements. METHODS: Fifty-five CKD children at III, IV, V stages and 19 age and sex-matched healthy controls were recruited. Fat, protein and mineral compositions monitored by BIA were analyzed together with anthropometric measurements including height, weight and body mass index (BMI)...
June 22, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29931675/correlations-between-plasma-strontium-concentration-components-of-calcium-and-phosphate-metabolism-and-renal-function-in-type-2-diabetes-mellitus
#8
Y S Van den Berkhof, C M Gant, R Maatman, A De Graaf, G J Navis, S J L Bakker, G D Laverman
BACKGROUND: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas Strontium (Sr2+ ) has many similarities with calcium, little is known about Sr2+ in this respect. We studied the association of plasma Sr2+ concentration and parameters associated with an altered calcium and phosphate metabolism in diabetic kidney disease. MATERIALS AND METHODS: Plasma Sr2+ concentration was measured in 450 patients included in the DIAbetes and LifEstyle Cohort Twente-1...
June 21, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29931555/uric-acid-and-progression-of-chronic-kidney-disease
#9
Donald J Weaver
The association between serum uric acid levels and human disease has garnered intense interest over the last decade including chronic kidney disease. Animal studies have provided evidence for a potential mechanistic role of uric acid in promoting progression of chronic kidney disease. Epidemiologic studies have also suggested an association between elevated serum uric acid levels and worsening renal function in the general population as well as in patients with chronic kidney disease. However, there is currently insufficient evidence to recommend the use of uric acid-lowering therapy to delay progression of chronic kidney disease in this patient population...
June 21, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29931336/potential-benefits-and-harms-of-nadph-oxidase-type-4-in-the-kidneys-and-cardiovascular-system
#10
Renuga D Rajaram, Romain Dissard, Vincent Jaquet, Sophie de Seigneux
The main function of NADPH oxidases is to catalyse the formation of reactive oxygen species (ROS). NADPH oxidase 4 (NOX4) is expressed at high levels in kidney tubular cells, and at lower levels in endothelial cells, cardiomyocytes and other cell types under physiological conditions. NOX4 is constitutively active producing hydrogen peroxide (H2O2) as the prevalent ROS detected, whereas other NOX isoforms present in the renal and cardiovascular systems (i.e. NOX1, NOX2 and NOX5) generate superoxide radical anions as main products...
June 21, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29930419/-impact-of-anemia-and-chronic-kidney-disease-on-the-risk-of-cardiovascular-disease-and-all-cause-mortality-among-diabetic-patients
#11
C Yang, J W Wang, Y Z Yang, K H Bai, B X Gao, M H Zhao, L X Zhang, S L Wu, F Wang
OBJECTIVE: To explore the association between anemia and cardiovascular disease and all-cause mortality among diabetic patients, and whether the association is modified by the presence of chronic kidney disease (CKD). METHODS: Physical examination data of 8 563 patients with diabetes who met the inclusion and exclusion criteria between 2010 and 2011 were collected, based on the prospective cohort data of Kailuan study. The deadline of the follow-up was December 31, 2015, and the endpoints comprised all-cause mortality and cardiovascular disease...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29930407/-incidence-and-risk-factors-of-chronic-kidney-disease-in-community-based-patients-with-diabetes
#12
H B Lin, Y Chen, P Shen, X Y Li, Y Q Si, D D Zhang, X Tang, P Gao
OBJECTIVE: To estimate the incidence rate and effects of risk factors on chronic kidney disease (CKD) in Chinese patients with diabetes, based on Electronic Health Records (EHRs) from the Chinese Electronic health Records Research in Yinzhou (CHERRY) Study. METHODS: Using the CHERRY cohort study with the individual-level information on chronic disease management; and health administrative, clinical and laboratory databases, patients with diabetes without kidney disease at baseline were enrolled and followed up from January 2009 through December 2016...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29929599/end-stage-renal-disease-chronic-itch-and-its-management
#13
REVIEW
Radomir Reszke, Jacek C Szepietowski
End-stage renal disease chronic itch is a frequent symptom that bothers patients with advanced stages of chronic kidney disease. The pathogenesis of the chronic itch symptom is complex and not yet fully understood and includes many metabolic, immunologic, and neurogenic factors. A significant burden of the disease results in decreased quality of life with sleep impairment, depressive symptoms, and increased mortality of affected individuals. No treatment of choice is available; topical therapy (emollients), phototherapy (UV-B), and systemic therapy (antiepileptics, opioid agonists, and antagonists) provide significant relief in varying percentages of patients...
July 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29929485/practice-patterns-in-transitioning-patients-from-chronic-kidney-disease-to-dialysis-a-survey-of-united-states-nephrologists
#14
Mary C Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos, Moro Salifu
BACKGROUND: There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patients to dialysis. METHODS: We designed an electronic survey with 39 questions and sent it to a database of practicing nephrologists at the National Kidney Foundation. Factors that were important for transitioning a patient to hemodialysis were evaluated, including medication changes on dialysis initiation, dry weight and dialysis prescription...
June 22, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29929484/contemporary-rates-and-predictors-of-fast-progression-of-chronic-kidney-disease-in-adults-with-and-without-diabetes-mellitus
#15
Alan S Go, Jingrong Yang, Thida C Tan, Claudia S Cabrera, Bergur V Stefansson, Peter J Greasley, Juan D Ordonez
BACKGROUND: Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether factors associated with fast progression vary by diabetes status is also not well understood. We examined a large community-based cohort of adults with CKD to identify predictors of fast progression during the first 2 years of follow-up in the presence or absence of diabetes mellitus...
June 22, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29929186/increased-fatty-acid-oxidation-in-differentiated-proximal-tubular-cells-surviving-a-reversible-episode-of-acute-kidney-injury
#16
Aurélien Bataille, Pierre Galichon, Nadjim Chelghoum, Badreddine Mohand Oumoussa, Marie-Julia Ziliotis, Iman Sadia, Sophie Vandermeersch, Noémie Simon-Tillaux, David Legouis, Raphaël Cohen, Yi-Chun Xu-Dubois, Morgane Commereuc, Eric Rondeau, Stéphane Le Crom, Alexandre Hertig
BACKGROUND/AIMS: Fatty acid oxidation (FAO), the main source of energy produced by tubular epithelial cells in the kidney, was found to be defective in tubulo-interstitial samples dissected out in kidney biopsies from patients with chronic kidney disease (CKD). Experimental data indicated that this decrease was a strong determinant of renal fibrogenesis, hence a focus for therapeutic interventions. Nevertheless, whether persistently differentiated renal tubules, surviving in a pro-fibrotic environment, also suffer from a decrease in FAO, is currently unknown...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29928990/asymmetric-dimethylarginine-adma-as-an-important-risk-factor-for-the-increased-cardiovascular-diseases-and-heart-failure-in-chronic-kidney-disease
#17
REVIEW
Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen
Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. Increased plasma ADMA and/or L-NMMA are strong and independent risk factor for chronic kidney disease, and various cardiovascular diseases such as hypertension, coronary artery disease, atherosclerosis, diabetes, and heart failure...
June 18, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29928760/mild-electrical-stimulation-with-heat-shock-reduces-the-inflammatory-symptoms-in-imiquimod-induced-psoriasis-mouse-model
#18
Yu Tsurekawa, Misaki Morita, Mary Ann Suico, Masataka Moriuchi, Yoshio Nakano, Mariam Piruzyan, Masafumi Takada, Sanako Fukami, Tsuyoshi Shuto, Hirofumi Kai
Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biological responses by modulating intracellular signaling pathways. Our previous studies showed that the optimized combination treatment of mild electrical stimulation (MES, 0.1-millisecond; ms, 55-pulses per second; pps) and heat shock (HS, 42°C) modulates inflammatory symptoms of metabolic disorders and chronic kidney disease in mice models and clinical trials...
June 21, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29928644/the-case-chronic-kidney-disease-unmasked-by-single-subject-research
#19
Benjamin Gollasch, Oskar Wischnewski, Birgit Rudolph, Yoland-Marie Anistan, Friedrich C Luft, Maik Gollasch
We present a 42-year-old man with a BMI of 32, who was referred because of proteinuria and decreased renal function. We were impressed by his markedly muscular physique. A renal biopsy was performed, which showed focal segmental glomerular sclerosis (FSGS). Is this patient merely an obese person with FSGS or is something else going on here? We performed extensive clinical and laboratory examinations, genetic testing, and anthropometric data monitoring over time. We transferred our methodology for routine FSGS mutation screening (Sanger sequencing) to the Ion Torrent PGM platform with a new custom-targeted NGS gene panel (Ion Ampliseq FSGS panel) and tested the performance of the system in two cohorts of patients with FSGS...
May 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29927463/expenses-of-the-brazilian-public-healthcare-system-with-chronic-kidney-disease
#20
Paulo Roberto Alcalde, Gianna Mastroianni Kirsztajn
INTRODUCTION: The prevalence of chronic kidney disease (CKD) is increasing worldwide, with costs that can be impeditive. OBJECTIVE: To establish the expenses of the Brazilian Public Healthcare System (SUS), with hospitalizations due to CKD and related diseases; evaluating expenses with renal replacement therapy (RRT). METHODS: We have assessed the values paid by the SUS in the triennium 2013-2015, for estimating annual expenses with CKD treatment and hospitalization, associated diseases, and exams...
June 4, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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