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gastric tumours

Liping Liu, Yongxun Zhao, Guangrui Fan, Tiankui Shuai, Bin Li, Yumin Li
Helicobacter pylori (H. pylori) infection is the most important factor in the development of gastric cancer. Heparanase (HPA) is involved in tissue remodelling and cell migration, which leads to inflammation and tumour metastasis. The current study aimed was to explore whether a H. pylori infection leads to an increase in the level of HPA in gastric cancer and to investigate the specific mechanism underlying this association. Reverse transcription‑polymerase chain reaction and western blotting were used to detect HPA mRNA and protein expression, respectively, in MKN‑45 cells infected by H...
October 15, 2018: Molecular Medicine Reports
Haijin Huang, Jie Tang, Lei Zhang, Yanzhi Bu, Xiaoyu Zhang
Chemotherapy is an important treatment option for gastric cancer (GC); however, chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR). In our previous studies, microRNA (miR)‑874 was demonstrated to serve an important role in tumour growth, apoptosis and angiogenesis. In the present study, the precise roles and underlying mechanisms of miR‑874 in MDR were investigated in GC. The overexpression of miR‑874 reversed cancer cell drug resistance in vitro. According to reporter gene and western blot assays, Autophagy‑related 16‑like 1 (ATG16 L1) was identified as a direct target of miR‑874...
October 11, 2018: International Journal of Oncology
Jingsheng Yuan, Lulu Tan, Zhijie Yin, Kaixiong Tao, Guobing Wang, Wenjia Shi, Jinbo Gao
Gastric cancer is currently the fourth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Studies have identified that certain biomarkers contribute to the prognosis, diagnosis and treatment of gastric cancer. However, the biomarkers of gastric cancer are rarely used clinically. Therefore, it is imperative to define novel molecular networks and key genes to guide the further study and clinical treatment of gastric cancer. In the present study, raw RNA sequencing data and clinicopathological information on patients with gastric cancer were downloaded from The Cancer Genome Atlas, and a weighted gene co‑expression network analysis was conducted...
October 15, 2018: Oncology Reports
Yui Hattori, Kazuhiro Sentani, Shunsuke Shinmei, Htoo Zarni Oo, Takuya Hattori, Takeharu Imai, Yohei Sekino, Naoya Sakamoto, Naohide Oue, Hiroaki Niitsu, Takao Hinoi, Hideki Ohdan, Wataru Yasui
AIMS: Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. Genes expressed only in cancer tissue may be useful biomarkers for cancer diagnosis and therapeutics. The aim of the present study was to analyse the regulators of calcineurin 2 (RCAN2) in a large number of GCs and to investigate how these expression patterns correlate with clinicopathologic parameters and various markers. METHODS AND RESULTS: An immunohistochemical analysis of RCAN2 in 207 GC tissue samples showed that 110 (53%) GC cases were positive for RCAN2...
October 11, 2018: Histopathology
Janet R Vos, Lisette Giepmans, Claas Röhl, Nicoline Geverink, Nicoline Hoogerbrugge
Approximately 27-36 million patients in Europe have one of the ~ 5.000-8.000 known rare diseases. These patients often do not receive the care they need or they have a substantial delay from diagnosis to treatment. In March 2017, twenty-four European Reference Networks (ERNs) were launched with the aim to improve the care for these patients through cross border healthcare, in a way that the medical knowledge and expertise travels across the borders, rather than the patients. It is expected that through the ERNs, European patients with a rare disease get access to expert care more often and more quickly, and that research and guideline development will be accelerated resulting in improved diagnostics and therapies...
October 9, 2018: Familial Cancer
Richard Azevedo, Tobias Teles, Ana Caldeira, Eduardo Pereira, António Banhudo
No abstract text is available yet for this article.
October 5, 2018: Gastroenterología y Hepatología
Katy L Simonsen, Paula M Fracasso, Steven H Bernstein, Megan Wind-Rotolo, Manish Gupta, Adriana Comprelli, Timothy P Reilly, Jim Cassidy
BACKGROUND: The unprecedented success of immuno-oncology (I-O) agents targeting the cytotoxic T lymphocyte-associated antigen 4 and programmed death-1/programmed death-ligand 1 pathways has stimulated the rapid development of other I-O agents against novel immune targets. Bristol-Myers Squibb has designed a novel phase II platform trial, the Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) Program, to efficiently identify promising combinations for patients with specific malignancies...
October 3, 2018: European Journal of Cancer
Anbang He, Shiming He, Xuesong Li, Liqun Zhou
Long noncoding RNAs (lncRNAs) are a class of noncoding, endogenous, single-stranded RNAs longer than 200 nucleotides in length that are transcribed by RNA polymerase II. Mounting evidence has indicated that lncRNAs play key roles in several physiological and pathological processes by modifying gene expression at the transcriptional, posttranscriptional, epigenetic, and translation levels. Many reports have demonstrated that lncRNAs function as potential oncogene or tumour suppressors and thus play vital regulatory roles in tumourigenesis and tumour progression...
October 5, 2018: Cell Proliferation
Olof Sjöström, Gustav Silander, Ingvar Syk, Roger Henriksson, Beatrice Melin, Barbro N Hellquist
BACKGROUND: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities in colorectal cancer between Northern and Southern Sweden. METHODS: Cancer-specific data from the National Cancer Quality Registers for colorectal, gastric and oesophageal cancer and brain tumours were linked to several nationwide registers hereby creating a new database - RISK North...
October 3, 2018: Acta Oncologica
Francesco Giganti, Lei Tang, Hideo Baba
The current standard of care for gastric cancer imaging includes heterogeneity in image acquisition techniques and qualitative image interpretation. In addition to qualitative assessment, several imaging techniques, including diffusion-weighted magnetic resonance imaging (DW-MRI), contrast-enhanced multidetector computed tomography (CE-MDCT), dynamic-contrast enhanced MRI and 18F-fluorodeoxyglucose positron emission tomography, can allow quantitative analysis. However, so far there is no consensus regarding the application of functional imaging in the management of gastric cancer...
October 2, 2018: European Radiology
De-Shen Wang, Ze-Xian Liu, Yun-Xin Lu, Hua Bao, Xue Wu, Zhao-Lei Zeng, Zekun Liu, Qi Zhao, Cai-Yun He, Jia-Huan Lu, Zhi-Qiang Wang, Miao-Zhen Qiu, Feng Wang, Feng-Hua Wang, Yu-Hong Li, Xiao-Nan Wang, Dan Xie, Wei-Hua Jia, Yang W Shao, Rui-Hua Xu
OBJECTIVE: To monitor trastuzumab resistance and determine the underlying mechanisms for the limited response rate and rapid emergence of resistance of HER2+ metastatic gastric cancer (mGC). DESIGN: Targeted sequencing of 416 clinically relevant genes was performed in 78 paired plasma and tissue biopsy samples to determine plasma-tissue concordance. Then, we performed longitudinal analyses of 97 serial plasma samples collected from 24 patients who were HER2+  to track the resistance during trastuzumab treatment and validated the identified candidate resistance genes...
September 29, 2018: Gut
Masaki Suzuki, Takehiko Yokobori, Navchaa Gombodorj, Masakazu Yashiro, Andrei Turtoi, Tadashi Handa, Kyoichi Ogata, Tetsunari Oyama, Ken Shirabe, Hiroyuki Kuwano
BACKGROUND AND OBJECTIVES: Transforming growth factor β-induced (TGFBI) protein is a secreted extracellular matrix protein with conflicting roles in cancer, acting as a tumour suppressor and a promoter, which appears to be tissue specific. The role of TGFBI in gastric cancer (GC) remains unclear, which we aimed to investigate using the clinical samples as well as an in vitro coculture model of GC. METHODS: The clinical significance of TGFBI was assessed in 208 GC samples using immunohistochemistry...
September 9, 2018: Journal of Surgical Oncology
Xi Luo, Gui-Hua Wang, Zhao-Lian Bian, Xi-Wen Li, Bing-Ying Zhu, Chun-Jing Jin, Shao-Qing Ju
Early evidence indicates that the long non-coding RNA CCAL plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of CCAL in gastric tumourigenesis and progression remain largely unknown. We observed that CCAL was upregulated in gastric cancer tissues and was associated with the tumour-node-metastasis stage. Functional experiments showed that CCAL promoted gastric cancer cell proliferation and metastasis in vitro and in vivo. Luciferase reporter assay indicated that CCAL directly bind to miR-149...
September 24, 2018: Cell Death & Disease
Daniel N Velasco Hernández, Santiago B De Battista, Héctor R Horiuchi, Maria M Zicavo
INTRODUCTION: Although carcinoid tumours are a rare gastrointestinal neoplasm with an incidence rate of 1-2.5 cases per 100 000 inhabitants, they are the most common neuroendocrine tumour of the stomach. PRESENTATION OF CASE: A 70-year-old-man consulted for epigastric pain and dyspepsia symptoms. His past medical and surgical history included obesity (BMI: 53.9 kg/m2 ), hypertension, hyperlipidemia, diabetes mellitus type 2, cardiac failure and a surgical treatment with laparoscopic gastric banding...
September 4, 2018: International Journal of Surgery Case Reports
Fenghua Guo, Wenting Hong, Mingjie Yang, Dongke Xu, Qianming Bai, Xiaobo Li, Zongyou Chen
Gastric cancer (GC) is one of the most common cancers and is the second-leading cause of cancer-associated morbidity worldwide. Oxysterols are oxidized derivatives of cholesterol that may be important in many biological processes, but the levels and roles of oxysterols in gastric tumours remain to be elucidated. The levels of cholesterol, oxysterols and sulfated oxysterols in human gastric tumour tissues, adjacent normal mucosal tissues, cancerous gastric juice and gastric juice obtained from healthy subjects were detected by LC-MS...
October 12, 2018: Biochemical and Biophysical Research Communications
Desmond Kwan Kit Chan, Fion Siu Yin Chan, Daniel King Hung Tong, Ian Yu Hong Wong, Claudia Lai Yin Wong, Tsz Ting Law, Simon Ying Kit Law
Background: Esophagectomy remains the mainstay treatment for esophageal cancer. Minimally invasive techniques have gained popularity in recent years. Whether minimally invasive methods result in equivalent or superior outcome to open esophagectomy or not is still controversial. The aim of the current study is to compare outcomes of minimally invasive and open esophagectomy from a single institution, using propensity score matching to lessen biases. Methods: From 1994-2016, 724 patients with squamous cell cancer of the esophagus who underwent esophagectomy were studied...
September 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Yu Ting Felicia Wee, Syed Muhammad Fahmy Alkaff, Jeffrey Chun Tatt Lim, Josh Jie Hua Loh, Maryam Hazly Hilmy, Clara Ong, Wen Long Nei, Amit Jain, Alvin Lim, Angela Takano, Rafay Azhar, Wei Keat Wan, Evan Newell, Joe Yeong, Tony Kiat Hon Lim
BACKGROUND/AIM: Epstein-Barr virus (EBV) is an oncovirus that is commonly associated with the development of lymphomas and epithelial carcinomas. In the era of immunotherapy, histological evaluation of EBV-related cancers is currently a multi-sample, multi-technique process requiring separate time-consuming detection of EBV-encoded small RNAs by in situ hybridisation (ISH), and parallel labelling of sections for cancer-associated protein markers. METHODS: Using EBV-associated tumours as proof-of-concept for feasibility, here we developed an approach that allows simultaneous detection of EBV RNAs and multiple protein markers such as PD-L1, EBV-LMP, CD8, CD4, CD20, CD30 and CD15on a single tissue section based on our recently reported automated staining protocol...
September 11, 2018: Annals of Diagnostic Pathology
Josep Tabernero, Paulo M Hoff, Lin Shen, Atsushi Ohtsu, Manish A Shah, Karen Cheng, Chunyan Song, Haiyan Wu, Jennifer Eng-Wong, Katherine Kim, Yoon-Koo Kang
BACKGROUND: Adding pertuzumab to trastuzumab and chemotherapy improves survival in HER2-positive early breast cancer and metastatic breast cancer. We assessed the efficacy and safety of pertuzumab versus placebo in combination with trastuzumab and chemotherapy in first-line HER2-positive metastatic gastric or gastro-oesophageal junction cancer. METHODS: JACOB was a double-blind, placebo-controlled, randomised, multicentre, phase 3 trial in patients aged 18 years or older with HER2-positive metastatic gastric or gastro-oesophageal junction cancer...
October 2018: Lancet Oncology
Alexander Stein, Moehler Markus, Trojan Jörg, Eray Goekkurt, Arndt Vogel
The use of immune checkpoint inhibitors constitutes an emerging therapeutic field for the therapy of gastrointestinal (GI) malignancies following the recent FDA approvals of PD-1 inhibitors for esophago-gastric adenocarcinoma, hepatocellular carcinoma and for microsatellite-instable tumors, which are mainly colorectal cancers. This paper reviews the clinical evidence end of 2017 and discusses the clinical development programs of atezolizumab, avelumab, durvalumab, nivolumab and pembrolizumab in GI-tract cancers...
October 2018: Critical Reviews in Oncology/hematology
Bogdan Filip, Catalin Toma, Mihaela Buna-Arvinte, Dragos Viorel Scripcariu, Viorel Scripcariu
Background: Surgery remains one of the most important part of the multimodal treatment of patients diagnosed with gastric cancer. Due to the fact that the consequences in terms of postoperative morbidity can delay the onset of postoperative chemotherapy or even can make the patient unfitted for adjuvant treatment, a thorough clinical evaluation of patient prior to surgery is mandatory. Methods: We performed a retrospective study, which included all the patients diagnosed with gastric cancer in which radical surgery was performed during a 5-year period in a single center...
July 2018: Chirurgia
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