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gastric tumours

Anis Hasnaoui, Raja Jouini, Dhafer Haddad, Haithem Zaafouri, Ahmed Bouhafa, Anis Ben Maamer, Ehsen Ben Brahim
BACKGROUND: Since the advent of immunohistochemistry for the diagnosis of stromal tumours, the incidence of leiomyosarcomas has significantly decreased. Nowadays, gastric leiomyosarcoma is an exceptionally rare tumour. We report the second case in the English literature of gastric leiomyosarcoma revealed with massive bleeding and hemodynamic instability and diagnostic pitfalls that we encountered. CASE PRESENTATION: A 63-year-old woman, with 2 years' history of dizziness and weakness probably related to an anaemic syndrome, presented to the emergency room with hematemesis, melena and hemodynamic instability...
August 17, 2018: BMC Surgery
Dongli Guo, Baogui Zhang, Shiqi Liu, Meng Jin
We assessed the effect of xanthohumol (XN) on gastric cancer (GC) in vitro and in vivo. XN reduced the viability of SGC-7901, SNU216, and SNU668 cells, but not GES-1 non-tumorigenic human gastric epithelial cells. XN induced apoptosis in SGC-7901 cells in a concentration-dependent manner by enhancing the numbers of late and early apoptotic cells. XN also downregulated the anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulated the pro-apoptotic proteins Bax, Bid, PARP, and caspase-3. XN induced phosphorylation of PI3K, Akt, and mTOR in SGC7901 cells...
July 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Riccardo Ricci, Maria Cristina Giustiniani, Marco Gessi, Paola Lanza, Federica Castri, Alberto Biondi, Roberto Persiani, Fabio M Vecchio, Mauro Risio
PDGFRA mutations in the gastrointestinal (GI) tract can cause GI stromal tumour (GIST) and inflammatory fibroid polyp (IFP). Hitherto no cell type has been identified as a physiological counterpart of the latter, while interstitial Cajal cells (ICC) are considered the precursor of the former. However, ICC hyperplasia (ICCH), which strongly supports the ICC role in GIST pathogenesis, has been identified in germline KIT-mutant settings but not in PDGFRA-mutant ones, challenging the precursor role of ICC for PDGFRA-driven GISTs...
August 17, 2018: Journal of Cellular and Molecular Medicine
Mingzhi Cai, Qiuxian Chen, Juntao Shen, Chenbing Lv, Lisheng Cai
Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumorigenesis and development. Although the low expression of miR-125a-5p in gastric cancer has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in gastric cancer was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the GC islands in the miR-125a-5p region were hypermethylated in the tumour tissues. And the hypermethylation was negatively correlated with the miR-125a-5p expression...
August 17, 2018: Journal of Cellular and Molecular Medicine
Aya Cervantes, Ruma G Singh, Sayali A Pendharkar, Sakina H Bharmal, Maxim S Petrov
Background: Maori, indigenous people of New Zealand, have at least two times higher prevalence of obesity and diabetes in comparison with the general population in the country. Gut and pancreatic hormone profile differences as well as pro-inflammatory milieu may contribute to this disparity. The aim was to investigate the differences in gut hormones, pancreatic hormones and pro-inflammatory cytokines between Maori and non-Maori individuals. Methods: This was a cross-sectional study...
August 2018: Gastroenterology Research
S F McGee, W AlGhareeb, C H Ahmad, D Armstrong, S Babak, S Berry, J Biagi, C Booth, D Bossé, P Champion, B Colwell, N Finn, R Goel, S Gray, J Green, M Harb, A Hyde, A Jeyakumar, D Jonker, S Kanagaratnam, P Kavan, A MacMillan, A Muinuddin, N Patil, G Porter, E Powell, R Ramjeesingh, M Raza, S Rorke, M Seal, F Servidio-Italiano, J Siddiqui, J Simms, L Smithson, S Snow, E St-Hilaire, T Stuckless, A Tate, M Tehfe, M Thirlwell, E Tsvetkova, M Valdes, M Vickers, K Virik, S Welch, C Marginean, T Asmis
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2017 was held in St. John's, Newfoundland and Labrador, 28-30 September. Experts in radiation oncology, medical oncology, surgical oncology, and cancer genetics who are involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics in the management of gastric, rectal, and colon cancer, including ■ identification and management of hereditary gastric and colorectal cancer (crc);■ palliative systemic therapy for metastatic gastric cancer;■ optimum duration of preoperative radiation in rectal cancer-that is, short- compared with long-course radiation;■ management options for peritoneal carcinomatosis in crc;■ implications of tumour location for treatment and prognosis in crc; and■ new molecular markers in crc...
August 2018: Current Oncology
Haixiang Chen, Juan Wang, Yi Zhuang, Hao Wu
The genetic alterations in familial intestinal gastric cancer (FIGC) have not been clearly understood. Aiming to explore the molecular basis and the driving mutations underlying the pathogenesis of FIGC, we performed exome sequencing of the blood samples of the members of an extended family with FIGC. The differences in mutation patterns between family members with gastric cancer and controls were analysed and the overlapped variants were screened by comparing previously published data for blood and tumours from gastric cancer patients...
August 1, 2018: Oncology Reports
Xin Yu, Heyi Zheng, Gary Tse, Lin Zhang, William Ka Kei Wu
Deregulation of long noncoding RNAs (lncRNAs) has been implicated in tumourigenesis. Cancer Susceptibility Candidate 2 (CASC2) is a lncRNA downregulated in multiple cancer types, including endometrial, lung, gastric and colorectal cancers. CASC2 functions as a tumour-suppressive lncRNA though multiple mechanisms, such as sequestration of oncogenic microRNAs and repression of Wnt/β-catenin signalling. Pertinent to clinical practice, the use of CASC2 as a prognostic marker has been demonstrated in sporadic studies...
August 9, 2018: Cell Proliferation
Ljubomir Ognjenovic, Gjorgji Trajkovski, Stojan Gjoshev, Aleksandar Shumkovski, Darko Dzambaz, Dragan Hadzi-Manchev, Goce Volcevski, Igor Fildishevski, Dafina Nikolova, Gordana Petrushevska, Vesna Janevska, Vlado Janevski
BACKGROUND: HER2 protein expression in gastric carcinoma, in correlation with existing, acknowledged prognostic factors which include the parameters that determine the TNM stage of the disease, could become the basis for ongoing research in the field of molecular targeted and personalised therapy. AIM: To determine the expression of the HER2 protein in gastric carcinoma and to correlate the expression of a HER2 protein with clinicopathological characteristics of the disease...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Bernardo Marques, Raquel G Martins, Guilherme Tralhão, Joana Couto, Sandra Saraiva, Henrique Ferrão, João Ribeiro, Jacinta Santos, Teresa Martins, Ana Teresa Cadime, Fernando Rodrigues
Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetiology. We present a clinical case of a female patient of 66 years and a well-differentiated (grade 2), type 3 GNEN with late liver metastasis (LM). The patient underwent surgical excision of a gastric lesion at 50 years of age, without any type of follow-up. Sixteen years later, she was found to have a neuroendocrine tumour (NET) metastatic to the liver. The histological review of the gastric lesion previously removed confirmed that it was a NET measuring 8 mm, pT1NxMx (Ki67 = 4%)...
2018: Endocrinology, Diabetes & Metabolism Case Reports
Changming Wang, Jiapeng Xu, Hongbing Fu, Yu Zhang, Xin Zhang, Dejun Yang, Zhenxin Zhu, Ziran Wei, Zunqi Hu, Ronglin Yan, Qingping Cai
The tripartite motif (TRIM) family comprises more than 70 members involved in the regulation of many cellular pathways. TRIM32 acts as an E3 ubiquitin ligase and has been reported to participate in many human cancers. Here, we aimed to investigate the role of TRIM32 in gastric cancer (GC) and the clinical implications. High expression of TRIM32 was observed in GC tissues and cell lines, and was significantly associated with poor prognosis. Knockdown TRIM32 expression remarkably suppressed the proliferation, migration, and invasion of GC cells in vitro and tumour growth in vivo, whereas overexpression of TRIM32 yielded the opposite results...
August 5, 2018: Journal of Cellular and Molecular Medicine
W R C Knight, J Zylstra, W Wulaningsih, M Van Hemelrijck, D Landau, N Maisey, A Gaya, C R Baker, J A Gossage, J Largergren, A R Davies
Background: Previous analyses of the oesophageal circumferential resection margin (CRM) have focused on the prognostic validity of two different definitions of a positive CRM, that of the College of American Pathologists (tumour at margin) and that of the Royal College of Pathologists (tumour within 1 mm). This study aimed to analyse the validity of these definitions and explore the risk of recurrence and survival with incremental tumour distances from the CRM. Methods: This cohort study included patients who underwent resection for adenocarcinoma of the oesophagus between 2000 and 2014...
August 2018: BJS open
Ji Eun Lee, Seo-Youn Choi, Hae Kyung Lee, Boem Ha Yi, Min Hee Lee, Sunyoung Lee, So Jung Lee, Jisun Lee, Woo Kyoung Jeong
INTRODUCTION: The aim of this study was to describe the clinical and computed tomography (CT) features of gastric inflammatory myofibroblastic tumour (IMT) in adult patients and provide a review of the literature. METHODS: Five adult patients with surgically resected and pathologically confirmed gastric IMT were included in the study from four tertiary referral centres. Clinical history was assessed for determination of patient demographics and symptoms at presentation...
August 3, 2018: Journal of Medical Imaging and Radiation Oncology
Dimitrios Pantelis, Philipp Lingohr, Robert Hueneburg, Isabel Spier, Tim Vilz, Jan F Lau, Jacob Nattermann, Stefan Aretz, Christian P Strassburg, Jörg C Kalff
INTRODUCTION: Prophylactic total gastrectomy is the treatment of choice in patients with germline mutation in the CDH1 gene and therefore high risk for hereditary diffuse gastric cancer (HDGC). Minimally invasive techniques have been established in recent years for treatment of gastric cancer. METHODS: We report findings with 12 patients with proven CDH1 mutation who underwent multidisciplinary treatment between 2013 and 3/2018 in our centre for hereditary tumour diseases, followed by prophylactic total gastrectomy in our department...
August 1, 2018: Zentralblatt Für Chirurgie
Etienne St-Louis, Stephen Donald Gowing, Pedram Mossallanejad, Mara Laura Leimanis, Carmen Mueller, Lorenzo Edwin Ferri
BACKGROUND: There is controversy about the safety and outcomes of completion total gastrectomy (CTG) for gastric adenocarcinoma. We compared a cohort of patients who underwent CTG for gastric remnant cancer (GRC) after partial gastrectomy for benign disease with patients who underwent primary total gastrectomy (PTG) for sporadic gastric cancer. METHODS: We retrospectively reviewed a single-institution, prospectively maintained clinical database of patients who had undergone gastrectomy from 2005 to 2016 for demographic, surgical, clinical and tumour pathology data, as well as postoperative, pathologic and oncologic outcomes including complications, length of stay, disease-free survival and overall survival...
August 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Tanis D Godwin, S Thomas Kelly, Tom P Brew, Nicola M Bougen-Zhukov, Andrew B Single, Augustine Chen, Cassie E Stylianou, Lawrence D Harris, Sophie K Currie, Bryony J Telford, Henry G Beetham, Gary B Evans, Michael A Black, Parry J Guilford
BACKGROUND: The E-cadherin gene (CDH1) is frequently mutated in diffuse gastric cancer and lobular breast cancer, and germline mutations predispose to the cancer syndrome Hereditary Diffuse Gastric Cancer. We are taking a synthetic lethal approach to identify druggable vulnerabilities in CDH1-mutant cancers. METHODS: Density distributions of cell viability data from a genome-wide RNAi screen of isogenic MCF10A and MCF10A-CDH1-/- cells were used to identify protein classes affected by CDH1 mutation...
July 31, 2018: Gastric Cancer
Niko Kemi, Maarit Eskuri, Anni Herva, Joni Leppänen, Heikki Huhta, Olli Helminen, Juha Saarnio, Tuomo J Karttunen, Joonas H Kauppila
BACKGROUND: Tumour microenvironment, including tumour-stroma ratio (TSR), might help identifying high-risk cancer patients. However, the significance of TSR in gastric cancer is unclear, especially in the intestinal and diffuse subtypes. The aim of this study was to investigate the tumour-stroma ratio in gastric adenocarcinoma, and its intestinal and diffuse histological subtypes, in relation to prognosis. METHODS: Five hundred and eighty-three gastric adenocarcinoma patients who underwent surgery in Oulu University hospital during years 1983-2016 were included in this retrospective cohort study...
July 30, 2018: British Journal of Cancer
J Zheng, S-H Xie, G Santoni, J Lagergren
BACKGROUND: Gastric adenocarcinoma is a common cause of cancer death globally. It remains unclear whether coexisting diabetes mellitus influences survival in patients with this tumour. A cohort study was conducted to determine whether coexisting diabetes increases mortality in gastric adenocarcinoma. METHODS: This nationwide population-based cohort study included all patients diagnosed with gastric adenocarcinoma in Sweden between 1990 and 2014. Cox proportional hazards regression and competing risks regression were used to assess the influence of coexisting diabetes on disease-specific mortality in gastric adenocarcinoma with adjustment for sex, age, calendar year and co-morbidity (Charlson Co-morbidity Index score excluding diabetes)...
July 27, 2018: British Journal of Surgery
A R Davies, D Myoteri, J Zylstra, C R Baker, W Wulaningsih, M Van Hemelrijck, N Maisey, W H Allum, E Smyth, J A Gossage, J Lagergren, D Cunningham, M Green
BACKGROUND: The aim was to define the pathological response in lymph nodes following neoadjuvant chemotherapy for oesophageal adenocarcinoma and to quantify any associated survival benefit. METHODS: Lymph nodes retrieved at oesophagectomy were examined retrospectively by two pathologists for evidence of a response to chemotherapy. Patients were classified as lymph node-negative (either negative nodes with no evidence of previous tumour involvement or negative with evidence of complete regression) or positive (allocated a lymph node regression score based on the proportion of fibrosis to residual tumour)...
July 26, 2018: British Journal of Surgery
M Kasi, Samin Rashid, S A J Wallace, Vijayendran Sujendran, Bill Griffiths, Andrew Butler, Paul Gibbs, Loveena Sreedharan, A M Zaitoun, S Venkatachalapathy, M W James, G P Aithal
Delayed gastrointestinal metastasis is a rare complication of hepatocellular carcinoma (HCC). We present the case of a patient who presented with melaena and microcytic anaemia 6 years after receiving an orthotopic liver transplant for hepatitis B-induced HCC. Oesophagogastroduodenoscopy revealed a fungating gastric mass at the lesser curve and histology from biopsies confirmed metastatic recurrence of HCC in the stomach. The route of metastasis is likely due to iatrogenic seeding of tumour cells during pre-transplant endoscopic ultrasound (EUS) and fine needle aspiration (FNA) biopsy...
July 2018: Oxford Medical Case Reports
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