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gastric tumours

Aleena Jain, Manjusha Karegar, Amita Joshi, Amey Rojekar
Granular cell tumours are uncommon, usually benign soft tissue tumours. They are thought to be neural, arising from Schwann cells and can occur at various sites. Their occurrence in gastrointestinal tract is rare, the commonest site being oesophagus followed by large intestine. Gastric localization is unusual. A young female presented with abdominal discomfort since 3 months. Endoscopy showed a nodule in the body of stomach. Biopsy revealed features of granular cell tumour on microscopy, which was confirmed by immunohistochemical positivity for S100 and CD68...
December 2018: Indian Journal of Surgical Oncology
Tingyi Sun, Dandan Li, Shilong Hu, Li Huang, Haimei Sun, Shu Yang, Bo Wu, Fengqing Ji, Deshan Zhou
Aging is a significant risk factor for gastrointestinal dysmotility, but aging-associated differences between different organs and the exact time to start degenerating have remained obscure. Here we evaluated alterations of interstitial cells of Cajal, enteric neurons and connexin43 expression in the stomach, jejunum and colon in 2-, 12-, 16-, 20- and 24-month-old mice, as well as in aged human colon. Interstitial cells of Cajal, cholinergic and nitrergic neurons within the whole digestive tract were reduced over time, but their loss first appeared in stomach, then in intestine, helping to understand that gastric function was first impaired during aging...
December 11, 2018: Aging
S Watson, C de la Fouchardière, S Kim, R Cohen, J B Bachet, C Tournigand, J M Ferraz, M Lefevre, D Colin, M Svrcek, A Meurisse, C Louvet
BACKGROUND: 5-Fluorouracil (5-FU) and platinum-based perioperative chemotherapy is standard of care for resectable gastric adenocarcinoma (RGA). Nanoparticle albumin-bound (Nab-) paclitaxel is active in advanced disease but has never been evaluated in the perioperative setting. The objective was to evaluate the efficacy of Nab-paclitaxel in combination with FOLFOX for RGA patients. METHODS: We performed a non-randomised, open-label, phase II study. RGA patients were assigned to receive neoadjuvant Nab-paclitaxel (150 mg/m2 ) and FOLFOX q2w for six cycles...
December 7, 2018: European Journal of Cancer
Alexander N C Boucher, Oliver Ng, John H Saunders, Austin G Acheson, Simon L Parsons
Background: Anaemia reduces the efficacy of chemotherapy in gastric cancer. However, it has not been studied in oesophageal cancer. We investigated whether anaemia impacts on survival and the efficacy of chemotherapy, in adenocarcinoma of the oesophagus for those undergoing neoadjuvant chemotherapy and then surgical resection. Methods: This prospective study included 268 patients who received neoadjuvant chemotherapy for oesophageal adenocarcinoma. Patient clinical data as well as Mandard's tumor regression grading (TRG), haemoglobin pre-chemotherapy and during the chemotherapy were compiled...
October 2018: Journal of Gastrointestinal Oncology
Deepak Balasubramanian, Narayana Subramaniam, Priyank Rathod, Samskruthi Murthy, Mohit Sharma, Jimmy Mathew, Krishnakumar Thankappan, Subramania Iyer
Background: Pharyngeal reconstruction is a challenging aspect of reconstruction after resections for head-and-neck cancer. The goals of reconstruction are to restore the continuity of the pharyngeal passage to enable oral alimentation and rehabilitation of speech wherever possible. This study was performed to determine the outcomes following pharyngeal reconstruction in total laryngectomy (TL) using different reconstructive options and to determine the predictors of pharyngocutaneous fistula (PCF) and swallowing dysfunction...
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Sávia Raquel Costa Normando, Pamela de Oliveira Delgado, Ana Katherine Soares Barbosa Rodrigues, Waldec Jorge David Filho, Fernando Luiz Affonso Fonseca, Felipe José Silva Melo Cruz, Auro Del Giglio
Background: Advanced gastric cancers are usually associated with incurable conditions for which systemic treatments are indicated. Recent studies suggest that circulating cell-free plasma DNA of tumour origin (tDNA) is a promising non-invasive biomarker that can be used to predict the prognosis and monitor the efficacy of systemic treatments in patients with certain types of cancer. We conducted a pilot study to analyse the potential role of tDNA as a biomarker in patients with advanced gastric cancer...
2018: BMC Clinical Pathology
Egesta Lopci, Juha Kauppi, Marialuisa Lugaresi, Benedetta Mattioli, Niccolò Daddi, Francesca Fortunato, Jari Rasanen, Sandro Mattioli
OBJECTIVES: In Siewert type I/II oesophageal adenocarcinoma, the sensitivity and specificity of computed tomography (CT), positron emission tomography (PET)-CT and endoscopic ultrasound (EUS) for assessment of the N descriptor in defined groups of lymph nodes were investigated. METHODS: CT, PET/CT, EUS images and the pathological data of 101 oesophageal adenocarcinomas submitted to primary resection were compared. The lymph nodes were identified as (a) right paratracheal/subcarinal/pulmonary ligament; (b) paraoesophageal; (c) paracardial; (d) left gastric artery, lesser curvature; (e) coeliac trunk, hepatic/splenic artery...
November 27, 2018: Interactive Cardiovascular and Thoracic Surgery
Ziling Fang, Min Zhong, Yi Wang, Xiang Yuan, Hui Guo, Yangyang Yao, Miao Feng, Jun Chen, Jianping Xiong, Xiaojun Xiang
Accumulating evidence has highlighted the critical role of cullin 4B (CUL4B) in driving tumourigenesis in several malignancies, including gastric cancer (GC); however, the mechanisms underlying CUL4B upregulation remain unclear. The dysregulation of microRNAs (miRNAs or miRs) is known to be involved in tumourigenesis. In this study, we report that the expression of miR‑381 and miR‑489 is downregulated and is negatively correlated with that of CUL4B in GC tissues and cell lines. Further analysis verified that miR‑381 and miR‑489 directly targeted CUL4B...
November 26, 2018: International Journal of Oncology
Zdravko Štor, Jurij Hanžel
INTRODUCTION: The diagnosis and management of upper gastrointestinal tract submucosal tumours can be challenging due to the difficulties with adequate pre-operative characterization and tissue sampling. PRESENTATION OF THE CASE: A 61-year-old female patient underwent esophagogastroduodenoscopy because of epigastric pain and episodic vomiting. A submucosal tumour was found along the greater curvature in the antrum. On endoscopic ultrasound, the mass was suspected to be a gastrointestinal stromal tumour...
November 16, 2018: International Journal of Surgery Case Reports
Yijing Cao, Yichen Luo, Juan Zou, Jun Ouyang, Zhihong Cai, Xi Zeng, Hui Ling, Tiebing Zeng
Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a vital intracellular homeostatic process through which defective proteins and organelles are degraded and recycled under starvation, hypoxia or other specific cellular stress conditions. For both normal cells and tumour cells, autophagy not only sustains cell survival but can also promote cell death. Autophagy-related signalling pathways include mTOR-dependent pathways, such as the AMPK/mTOR and PI3K/Akt/mTOR pathways, and non-mTOR dependent pathways, such as the P53 pathway...
November 22, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Bochao Zhao, Jiale Zhang, Di Mei, Xinyu Huang, Shihui Zou, Rui Luo, Huimian Xu, Baojun Huang
AIMS: The prognostic significance of infiltration growth pattern (INF) in patients with gastric cancer (GC) remains controversial. In the present study, we evaluated the impact of INF pattern on the prognosis of patients with advanced GC. METHODS: A total of 1455 patients with advanced GC who underwent curative gastrectomy in our institution were retrospectively analysed. All patients were histopathologically classified as INFa/b and INFc pattern according to the Japanese Classification of Gastric Cancer...
November 22, 2018: Journal of Clinical Pathology
Nianshuang Li, Yan Feng, Yi Hu, Cong He, Chuan Xie, Yaobin Ouyang, Stephen C Artim, Deqiang Huang, Yin Zhu, Zhijun Luo, Zhongming Ge, Nonghua Lu
BACKGROUND: Helicobacter pylori (H. pylori) delivers oncoprotein CagA into gastric epithelial cells via the T4SS and drives activation of multiple oncogenic signalling pathways. YAP, a core effector of the Hippo tumour suppressor pathway, is frequently overexpressed in human cancers, suggesting its potential tumor-promoting role. Although CagA is a casual factor in H. pylori induced gastric carcinogenesis, the link between CagA and YAP pathway has not been identified. In this work, we investigated the regulation of oncogenic YAP pathway by H...
November 22, 2018: Journal of Experimental & Clinical Cancer Research: CR
A L Mahar, A El-Sedfy, M Dixon, M Siddiqui, M Elmi, A Ritter, J Vasilevska-Ristovska, Y Jeong, L Helyer, C Law, B Zagorski, N G Coburn
Background: Gastrectomy with negative resection margins and adequate lymph node dissection is the cornerstone of curative treatment for gastric cancer (gc). However, gastrectomy is a complex and invasive operation with significant morbidity and mortality. Little is known about surgical practice patterns or short- and long-term outcomes in early-stage gc in Canada. Methods: We undertook a population-based retrospective cohort study of patients with gc diagnosed between 1 April 2005 and 31 March 2008...
October 2018: Current Oncology
Ljubomir Ognjenovic, Aleksandar Shumkovski, Stojan Gjoshev, Goce Volchevski, Gjorgji Trajkovski, Zoran Karadzov, Darko Dzambaz, Dragan Hadzi-Manchev, Todor Hadzi-Manchev, Gordana Petrushevska, Vesna Janevska, Vlado Janevski, Nikola Brzanov
BACKGROUND: The understanding of the etiopathogenesis of gastric carcinoma (GC) can be a base for development of new therapeutic methods to reduce mortality and to increase survival in patients with GC. The percentage of Epstein - Barr virus (EBV) positive gastric carcinomas is uncertain, and the etiologic importance of EBV in the pathogenesis of GC has still not been elucidated. AIM: This study aimed to determine the percentage of EBV associated GC as well as to determine their clinicopathological characteristics...
October 25, 2018: Open Access Macedonian Journal of Medical Sciences
Tarek Aboushousha, Noha Helal, Olfat Hammam, Manar Ibrahim, Samar Khaled, Amr Mostafa, Amgad Anas
BACKGROUND: Globally, gastric cancer (GC) it is the fourth most common cancer and the third cause of cancer-related deaths. Overexpression of MDM2 and B-RAF appeared to be increased in malignancy and associated with poor prognosis in several human tumours, but their role in gastric cancer remains controversial. AIM: We had investigated the immunohistochemical expression of MDM2 and B-RAF in 136 gastric lesions with/without H. pylori association. MATERIAL AND METHODS: Studied specimens include chronic gastritis (32), intestinal type GC (70), diffuse GC (22) and gastrointestinal stromal tumours (GIST) (12)...
October 25, 2018: Open Access Macedonian Journal of Medical Sciences
Karol Rawicz-Pruszyński, Johanna Wilhelmina van Sandick, Jerzy Mielko, Bogumiła Ciseł, Wojciech P Polkowski
Gastric cancer (GC) remains one of the most common causes of cancer death worldwide with expected 5-year survival rates around 25% in Western countries. In order to improve treatment strategy, a most effective staging process should be completed. A novel TNM staging for GC has been proposed recently, along with a separate staging system for GC patients who underwent preoperative therapy (ypStage). Availability of high-quality imaging and access to diagnostic laparoscopy with lavage cytology should be applied while planning the multimodal therapy...
December 2018: Surgical Oncology
Massimiliano Salati, Nicola Valeri, Andrea Spallanzani, Chiara Braconi, Stefano Cascinu
Gastric cancer (GC) remains responsible for a high burden worldwide being the third leading cause of cancer-related mortality. Most of patients present at an advanced stage at diagnosis and are thus candidates to standard chemotherapy resulting in median survival of less than 1 year. Oligometastatic gastric cancer is an increasingly recognized clinical entity characterized by limited metastatic spread that has been showing to benefit from aggressive multimodality strategies encompassing chemotherapy and surgery...
November 10, 2018: European Journal of Surgical Oncology
Jun Lu, Jian-Xian Lin, Peng-Yang Zhang, Yu-Qin Sun, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Long-Long Cao, Yao Lin, Chang-Ming Huang, Chao-Hui Zheng
Several previous studies have demonstrated that cyclin‑dependent kinase (CDK)‑5 expression serves an important role in promoting the development of malignant tumours. We have previously reported that CDK5 suppresses gastric tumourigenesis. The aim of the present study was to investigate the mechanistic basis of CDK5. The results of immunoprecipitation and western blot analysis demonstrated that CDK5 could interact with serine/threonine‑protein phosphatase 2A (PP2A). The use of an inhibitor of PP2A in CDK5‑overexpressing gastric cancer (GC) cell lines antagonized CDK5‑mediated suppression in GC cells...
November 9, 2018: Oncology Reports
Saori Mishima, Akihito Kawazoe, Hiroshi Matsumoto, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Toshihiko Doi, Atsushi Ohtsu, Takayuki Yoshino, Elizabeth M Nonte, Sudhakar Chintharlapalli, Aejaz Nasir, Takeshi Kuwata, Kohei Shitara
Background: Ramucirumab (RAM), a monoclonal antibody for vascular endothelial growth factor 2 (VEGFR2), has been effective for advanced gastric adenocarcinoma (AC). However, little is known about the efficacy of RAM-containing chemotherapy (RAM-CTx) in gastric neuroendocrine carcinoma (G-NEC). Methods: We retrospectively analysed and compared the clinical outcomes of patients (pts) with G-NEC receiving RAM-CTx, G-NEC receiving CTx without RAM and AC receiving RAM-CTx in our hospital...
2018: ESMO Open
Aoife J McCarthy, Jose-Mario Capo-Chichi, Tara Spence, Sylvie Grenier, Tracy Stockley, Suzanne Kamel-Reid, Stefano Serra, Peter Sabatini, Runjan Chetty
Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status; being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear tumour staining (MMR protein deficient). Four colonic adenocarcinomas and a gastric adenocarcinoma with associated dysplasia that displayed heterogenous IHC staining patterns in at least 1 of the 4 MMR proteins were characterised by next generation sequencing (NGS). In order to examine a potential molecular mechanism for these staining patterns, the respective areas were macrodissected, analysed for microsatellite instability (MSI), and investigated by NGS and multiplex ligation-dependent probe amplification (MLPA) analysis of MLH1, MSH2, MSH6 and PMS2 genes, including MLH1 methylation analysis...
November 1, 2018: Journal of Pathology. Clinical Research
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