keyword
https://read.qxmd.com/read/38492625/exploration-of-gut-microbiome-and-inflammation-a-review-on-key-signalling-pathways
#1
JOURNAL ARTICLE
Manisha Nigam, Kanchan Devi, Henrique D M Coutinho, Abhay Prakash Mishra
The gut microbiome, a crucial component of the human system, is a diverse collection of microbes that belong to the gut of human beings as well as other animals. These microbial communities continue to coexist harmoniously with their host organisms and perform various functions that affect the host's general health. Each person's gut microbiota has a unique makeup. The gut microbiota is well acknowledged to have a part in the local as well as systemic inflammation that underlies a number of inflammatory disorders (e...
March 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38489818/comparison-of-multilevel-low-grade-techniques-versus-three-column-osteotomies-in-adult-spinal-deformity-surgery-does-harmonious-correction-matter
#2
JOURNAL ARTICLE
Peter G Passias, Tyler K Williamson, Jamshaid M Mir, Jordan A Lebovic, Pooja Dave, Peter S Tretiakov, Rachel Joujon-Roche, Bailey Imbo, Oscar Krol, Stephane Owusu-Sarpong, Shaleen Vira, Andrew J Schoenfeld, Alan H Daniels, Bassel G Diebo, Renaud Lafage, Virginie Lafage
OBJECTIVE: Recent debate has arisen between whether to use a three-column osteotomy (3CO) or multilevel low-grade (MLG) techniques to treat severe sagittal malalignment in adult spinal deformity (ASD) surgery. The goal of this study was to compare the outcomes of 3CO and MLG techniques performed in corrective surgeries for ASD. METHODS: ASD patients who had a baseline PI-LL > 30° and 2-year follow-up data were included. Patients underwent either 3CO or MLG (thoracolumbar posterior column osteotomies at ≥ 3 levels or anterior lumbar interbody fusion at ≥ 3 levels with no 3CO)...
March 15, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38486266/harmony-in-nature-understanding-the-cultural-and-ecological-aspects-of-plant-use-in-ladakh
#3
JOURNAL ARTICLE
Kunzes Angmo, Bhupendra S Adhikari, Rainer W Bussmann, Gopal S Rawat
BACKGROUND: Traditional knowledge (TK) in Ladakh encapsulates a repository of experimental wisdom cultivated over millennia. Despite this cultural wealth, dwindling interest among the younger generations in the region's age-old practices underscores the urgency to document TK. The current study investigates the diverse usage of plants in Surru, Wakha and Lower Indus valleys of Western Ladakh exploring the influence of socioeconomic and ecological factors. METHODS: A stratified random sample approach was adopted to select 540 respondents for gathering information of useful plants through interviews and questionnaires...
March 14, 2024: Journal of Ethnobiology and Ethnomedicine
https://read.qxmd.com/read/38483934/highly-bioadaptable-hybrid-conduits-with-spatially-bidirectional-structure-for-precision-nerve-fiber-regeneration-via-gene-therapy
#4
JOURNAL ARTICLE
Renliang Zhao, Xiangtian Deng, Jizhao Dong, Chen Liang, Xiaozhong Yang, Yunfeng Tang, Juan Du, Zilu Ge, Dong Wang, Yifan Shen, Lianghua Jiang, Wei Lin, Tonghe Zhu, Guanglin Wang
Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental nerve defects through autologous nerve transplantation often encounters challenges such as axonal mismatch and suboptimal functional recovery. These issues may stem from the limited regenerative capacity of proximal axons and the subsequent Wallerian degeneration of distal axons. To achieve the integration of sensory and motor functions, a spatially differential plasmid DNA (pDNA) dual-delivery nanohydrogel conduit scaffold is devised...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38482829/the-molecular-theory-of-sweet-taste-revisit-update-and-beyond
#5
REVIEW
Hong Zheng, Xiangqun Xu, Yishan Fang, Rui Sun, Bo Liu
The molecular origin of the sweet taste is still elusive. Herein, the canonical AH-B-X theory of sweet taste is extended by resurveying various sweeteners, which provides deeper insights into an analogous intramolecular connectivity pattern of both glucophores in sweeteners and their interaction counterparts in sweet taste receptor TAS1R2/TAS1R3: electrostatic complementarity and topochemical compatibility. Furthermore, their complementary interaction is elaborately illustrated, accounting for the common molecular feature of eliciting sweetness...
March 14, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38481851/research-on-factors-influencing-chinese-parents-support-for-death-education-a-cross-sectional-survey
#6
JOURNAL ARTICLE
Hejie Chen, Yuan Xiao, Xincheng Huang, Siyuan Fan, Haiwen Wu, Linxiao Li, Yibo Wu
OBJECTIVE: This study aims to explore the factors influencing Chinese parents' attitudes toward death education. Given the current lack of such education in China, this research is particularly significant. Death education is vital for shaping the values of young people and alleviating mental health issues, such as depression and suicidal tendencies. By identifying these influencing factors, this study seeks to provide guidance for policymakers and educators in promoting the development and widespread adoption of death education...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38481849/barriers-and-facilitators-to-feeling-safe-for-inpatients-a-model-based-on-a-qualitative-meta-synthesis
#7
Lupei Yan, Li Liu, Fang Wang, Fanyu Zhao, Xiuying Hu
OBJECTIVES: To review and synthesize qualitative research exploring patients' safe experience and construct a model to present barriers and facilitators to feeling safe for inpatients. DESIGN: A qualitative met-synthesis. METHODS: We conducted a systematic electronic search of articles published in English with no date limitation across five databases (Ovid MEDLINE, EMBASE, Web of Science, CINAIL via EBSCO, and PsyINFO) in May 2023. Qualitative research focused on the safe experiences of inpatients was considered...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38480028/enhancing-skin-lesion-classification-with-advanced-deep-learning-ensemble-models-a-path-towards-accurate-medical-diagnostics
#8
JOURNAL ARTICLE
Kavitha Munuswamy Selvaraj, Sumathy Gnanagurusubbiah, Reena Roy Roby Roy, Jasmine Hephzipah John Peter, Sarala Balu
Skin cancer, including the highly lethal malignant melanoma, poses a significant global health challenge with a rising incidence rate. Early detection plays a pivotal role in improving survival rates. This study aims to develop an advanced deep learning-based approach for accurate skin lesion classification, addressing challenges such as limited data availability, class imbalance, and noise. Modern deep neural network designs, such as ResNeXt101, SeResNeXt101, ResNet152V2, DenseNet201, GoogLeNet, and Xception, which are used in the study and ze optimised using the SGD technique...
March 13, 2024: Current Problems in Cancer
https://read.qxmd.com/read/38478217/a-health-promotion-perspective-on-one-health
#9
JOURNAL ARTICLE
Evelyne de Leeuw, Ilona Kickbusch, Simon R Rüegg
The One Health concept has acquired increasing attention due to the COVID-19 pandemic. We argue for a health promotion perspective that frames One Health in terms of positive health for people, animals, and ecosystems and includes a spiritual-cosmological dimension. This would enhance policy, research, and practice across disciplines and sectors for a more resilient and harmonious planet.
March 13, 2024: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://read.qxmd.com/read/38474390/harmony-of-protein-tags-and-chimeric-molecules-empowers-targeted-protein-ubiquitination-and-beyond
#10
REVIEW
Aggie Lawer, Luke Schulz, Renata Sawyer, Xuyu Liu
Post-translational modifications (PTMs) are crucial mechanisms that underlie the intricacies of biological systems and disease mechanisms. This review focuses on the latest advancements in the design of heterobifunctional small molecules that hijack PTM machineries for target-specific modifications in living systems. A key innovation in this field is the development of proteolysis-targeting chimeras (PROTACs), which promote the ubiquitination of target proteins for proteasomal degradation. The past decade has seen several adaptations of the PROTAC concept to facilitate targeted (de)phosphorylation and acetylation...
February 28, 2024: Cells
https://read.qxmd.com/read/38470889/from-theory-to-practice-an-integrated-ttf-utaut-study-on-electric-vehicle-adoption-behavior
#11
JOURNAL ARTICLE
Ayed Alwadain, Suliman Mohamed Fati, Kashif Ali, Rao Faizan Ali
In Industry 4.0, the adoption of new technology has played a major role in the transportation sector, especially in the electric vehicles (EVs) domain. Nevertheless, consumer attitudes towards EVs have been difficult to gauge but researchers have tried to solve this puzzle. The prior literature indicates that individual attitudes and technology factors are vital to understanding users' adoption of EVs. Thus, the main aim is to meticulously investigate the unexplored realm of EV adoption within nations traditionally reliant on oil, exemplified by Saudia Arabia...
2024: PloS One
https://read.qxmd.com/read/38467711/low-energy-consumption-layout-of-exhibition-buildings-in-yangtze-river-delta-region
#12
JOURNAL ARTICLE
Wei Zhu, Xinyu Han, Xiaoyu Ying, Yang Tan, Liying Shen, Fanyu Huangfu
The issue of high energy consumption in exhibition buildings has long been a focal point in the field of architectural design. However, current energy consumption assessments for exhibition buildings mainly focus on post-construction evaluations, lacking corresponding guidance during the initial design phase. To address this issue, this study selected 48 well-known exhibition buildings both domestically and internationally as research subjects. Utilizing scatter plot curve fitting, it was discovered that there exists a nonlinear quadratic relationship between the building area of the first floor and the courtyard area...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38466720/hybrid-immunity-and-sars-cov-2-antibodies-results-of-the-heroes-recover-prospective-cohort-study
#13
JOURNAL ARTICLE
James K Romine, Huashi Li, Melissa M Coughlin, Jefferson M Jones, Amadea Britton, Harmony L Tyner, Sammantha B Fuller, Robin Bloodworth, Laura J Edwards, Jini N Etoule, Tyler C Morrill, Gabriella Newes-Adeyi, Lauren E W Olsho, Manjusha Gaglani, Ashley Fowlkes, James Hollister, Edward J Bedrick, Jennifer L Uhrlaub, Shawn Beitel, Ryan S Sprissler, Zoe Lyski, Cynthia J Porter, Patrick Rivers, Karen Lutrick, Alberto J Caban-Martinez, Sarang K Yoon, Andrew L Phillips, Allison L Naleway, Jefferey L Burgess, Katherine D Ellingson
BACKGROUND: There are limited data on whether hybrid immunity differs by count and order of immunity-conferring events (SARS-CoV-2 infection or COVID-19 vaccination). From a cohort of health care personnel, first responders, and other frontline workers in six US states, we examined heterogeneity of the effect of hybrid immunity on SARS-CoV-2 antibody levels. METHODS: Exposures included event-count (sum of infections and vaccine doses) and event-order, categorized into seven permutations of vaccination and/or infection...
March 11, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38466530/peer-stress-spills-over-to-family-stress-in-the-context-of-emotion-regulation-difficulties-a-daily-diary-study-with-chinese-adolescents
#14
JOURNAL ARTICLE
Hui Wang, Yutong Zhang, Molly Elizabeth Hale, Sihan Liu, Jianjie Xu, Chenxi Zhu, Cynthia Suveg, Zhuo Rachel Han
Conflict in peer and family relationships becomes more common in the adolescent period when compared to previous developmental periods. These typical developmental challenges can be exacerbated in the context of poor emotion regulation skills. Using daily diary data, the current study examined the stress spillover effects of peer and family stress on one another, as well as the moderating role of emotion regulation challenges (i.e., emotional inhibition, dysregulation). A sample of 310 Chinese adolescents (Mage  = 13...
March 11, 2024: Journal of Youth and Adolescence
https://read.qxmd.com/read/38460822/use-of-nasal-retainers-in-the-primary-management-of-cleft-lip-current-practices-in-france
#15
JOURNAL ARTICLE
Vinciane Poulet, Zoé Cavallier, Frédéric Vaysse, Frédéric Lauwers, Alice Prevost
BACKGROUND: The primary surgical management of cleft lip (CL) or cleft lip and palate (CLP) aims to achieve harmonious lip and nasal symmetry while ensuring satisfactory ventilation. Postoperative nasal retainers are commonly used, though both duration of use and conformer type used vary widely. This study aimed to establish an inventory of current practices for primary cheilorhinoplasty and nasal retainer use in France. METHODS: A survey was sent to surgeons within and outside the French National Clefts and Facial Malformations (MAFACE) network...
March 7, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38459662/the-severity-assessment-of-parkinson-s-disease-based-on-plasma-inflammatory-factors-and-third-ventricle-width-by-transcranial-sonography
#16
JOURNAL ARTICLE
Yue Lu, Wenwen Dong, Xingya Xue, Jian Sun, Jiuqi Yan, Xiang Wei, Lei Chang, Liang Zhao, Bei Luo, Chang Qiu, Wenbin Zhang
BACKGROUND: Predicting Parkinson's disease (PD) can provide patients with targeted therapies. However, disease severity can be roughly evaluated in clinical practice based on the patient's symptoms and signs. OBJECTIVE: The current study attempted to explore the factors linked with PD severity and construct a predictive model. METHOD: The PD patients and healthy controls were recruited from our study center while recording their basic demographic information...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38456473/patient-screening-for-self-expanding-percutaneous-pulmonary-valves-using-virtual-reality
#17
JOURNAL ARTICLE
Jenny E Zablah, Jeannie Than, Lorna P Browne, Salvador Rodriguez, Gareth J Morgan
BACKGROUND: In recent years, self-expanding technology to treat pulmonary regurgitation in the native right ventricular outflow tract became Food and Drug Administration approved in the United States and is now routinely used. The current practice for selection of patients who are candidates for these devices includes screening for "anatomic fit," performed by each of the manufacturing companies. Our study aims to validate the use of virtual reality (VR) as a tool for local physician-led screening of patients...
March 8, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38455508/revolutionizing-patient-care-the-harmonious-blend-of-artificial-intelligence-and-surgical-tradition
#18
JOURNAL ARTICLE
Michael Stark, Ospan Mynbaev, Antonio Malvasi, Andrea Tinelli
Surgery has undergone remarkable evolution over the past decades, propelled by unprecedented technological advancement. Despite these changes, the role of surgeons and their irreplaceable qualities remains pivotal. This article delves into the intersection of surgery and artificial intelligence (AI), underscoring the enduring significance of human expertise and values. The potential of AI to learn and improve over time holds great promise for enhancing various facets of surgery, including diagnostics, personalized treatment, preoperative planning, real-time support in the operating room, and comprehensive postoperative analytics of the outcome...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38454670/an-ensemble-acute-lymphoblastic-leukemia-model-for-acute-lymphoblastic-leukemia-image-classification
#19
JOURNAL ARTICLE
Mei-Ling Huang, Zong-Bin Huang
The timely diagnosis of acute lymphoblastic leukemia (ALL) is of paramount importance for enhancing the treatment efficacy and the survival rates of patients. In this study, we seek to introduce an ensemble-ALL model for the image classification of ALL, with the goal of enhancing early diagnostic capabilities and streamlining the diagnostic and treatment processes for medical practitioners. In this study, a publicly available dataset is partitioned into training, validation, and test sets. A diverse set of convolutional neural networks, including InceptionV3, EfficientNetB4, ResNet50, CONV_POOL-CNN, ALL-CNN, Network in Network, and AlexNet, are employed for training...
January 5, 2024: Mathematical Biosciences and Engineering: MBE
https://read.qxmd.com/read/38451164/a-healable-quasi-solid-polymer-electrolyte-with-balanced-toughness-and-ionic-conductivity
#20
JOURNAL ARTICLE
Li Ding, Yu Tan, Guiliang Li, Kaiqiang Zhang, Xu Wang
Solid polymer electrolytes (SPEs) have garnered extensive attention as potential alternatives to traditional liquid electrolytes, primarily due to their prowess in curbing lithium dendrite formation and preventing electrolyte leaks. The quest for SPEs that are both mechanically robust and exhibit superior ionic conductivity has been vigorous. However, achieving a harmonious balance between these two attributes remains a significant challenge. In this study, we introduce a novel quasi-solid electrolyte, ingeniously crafted from a poly(urethane-urea) network, enriched with lithium salts and plasticizers...
March 7, 2024: Chemistry: a European Journal
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