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https://www.readbyqxmd.com/read/29666150/epigenetics-and-epitranscriptomics-in-temporal-patterning-of-cortical-neural-progenitor-competence
#1
REVIEW
Ki-Jun Yoon, Caroline Vissers, Guo-Li Ming, Hongjun Song
During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give rise to different subtypes of neurons and glia via a highly orchestrated process. To accomplish the ordered generation of distinct progenies, NPCs go through multistep transitions of their developmental competence. The molecular mechanisms driving precise temporal coordination of these transitions remains enigmatic. Epigenetic regulation, including changes in chromatin structures, DNA methylation, and histone modifications, has been extensively investigated in the context of cortical neurogenesis...
April 17, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29663183/three-visions-of-doctoring-a-gadamerian-dialogue
#2
Benjamin Chin-Yee, Atara Messinger, L Trevor Young
Medicine in the twenty-first century faces an 'identity crisis,' as it grapples with the emergence of various 'ways of knowing,' from evidence-based and translational medicine, to narrative-based and personalized medicine. While each of these approaches has uniquely contributed to the advancement of patient care, this pluralism is not without tension. Evidence-based medicine is not necessary individualized; personalized medicine may be individualized but is not necessarily person-centered. As novel technologies and big data continue to proliferate today, the focus of medical practice is shifting away from the dialogic encounter between doctor and patient, threatening the loss of humanism that many view as integral to medicine's identity...
April 16, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29662181/author-correction-niche-harmony-search-algorithm-for-detecting-complex-disease-associated-high-order-snp-combinations
#3
Shouheng Tuo, Junying Zhang, Xiguo Yuan, Zongzhen He, Yajun Liu, Zhaowen Liu
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660340/alteration-of-global-protein-sumoylation-in-neurons-and-astrocytes-in-response-to-alzheimer-s-disease-associated-insults
#4
Takuma Maruyama, Harmony Wada, Yoichiro Abe, Takako Niikura
SUMOylation, a post-translational modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has been implicated in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD), and in neuron- and astrocyte-specific physiological functions. Global SUMOylation is increased in the AD mouse brain in the pre-plaque-forming stage but returns to wild-type levels in the plaque-bearing stage. To clarify the reason for the transient change in SUMOylation, we analyzed the alteration of global SUMOylation induced by AD-associated cytotoxic stimuli in neurons and astrocytes individually...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29656801/-the-law-of-march-5-2007-and-the-care-of-persons-placed-under-guardianship
#5
Matthieu Modot, Clotilde Rougé-Maillart
The care of persons placed under guardianship has changed considerably since the law of March 5, 2007, as greater autonomy is granted to them. By advocating greater autonomy of protected adults, the French Civil Code is in opposition with the French Public Health Code since the latter states that the systematic consent of the guardian is required in addition to that of the protected adult for so-called general care. In cases of serious injury to bodily integrity, the guardianship judge's opinion must be sought by the guardian...
April 12, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29656617/-neurospine-harmonious-launch-of-a-new-intellectual-odyssey
#6
Yoon Ha
No abstract text is available yet for this article.
March 2018: Neurospine
https://www.readbyqxmd.com/read/29652571/hemolasertherapy-a-novel-procedure-for-gingival-papilla-regeneration-case-report
#7
Fatima Zanin, Maria Stella Moreira, Ana Clara Fagundes Pedroni, Mateus Windlin, Ana Paula Brugnera, Aldo Brugnera Júnior, Marcia Martins Marques
BACKGROUND: Interdental papilla is of major importance to patients' orofacial aesthetics, especially regarding anterior teeth as part of the smile's harmony. Loss of gingival tissue, which constitutes interdental papilla, forms what in odontology is called black spaces. This loss, besides affecting the smile's aesthetics, also provokes phonetic and functional damage. OBJECTIVE: The objective of the authors is to present the result of three clinical cases treated with an innovative technique called hemolasertherapy, which stimulates growth of gingival papilla and thus permanently fills in the black spaces...
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29652568/photons-harmony-for-cell-communication
#8
Reza Fekrazad
No abstract text is available yet for this article.
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29649022/effectiveness-of-chinese-martial-arts-and-philosophy-to-reduce-reactive-and-proactive-aggression-in-schoolchildren
#9
Annis Lai Chu Fung, Toney Ka Hung Lee
OBJECTIVE: This study examined the effectiveness of Chinese martial arts in reducing reactive and proactive aggressive behavior among schoolchildren with a cluster-randomized trial. METHODS: A screening questionnaire was completed by 3511 schoolchildren of Grades 2 to 5 from 13 sites in Hong Kong. We shortlisted 298 children who scored z ≥ 1 on the total score of the Reactive-Proactive Aggression Questionnaire in their respective sites to participate in the experiment...
April 10, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29628291/citri-reticulatae-pericarpium-chenpi-botany-ethnopharmacology-phytochemistry-and-pharmacology-of-a-frequently-used-traditional-chinese-medicine
#10
REVIEW
Xin Yu, Shuang Sun, Yuyan Guo, Yan Liu, Dayu Yang, Guoyu Li, Shaowa Lü
ETHNOPHARMACOLOGICAL RELEVANCE: Citri Reticulatae Pericarpium (Rutaceae, CRP), commonly called as Chenpi () in Chinese, is most frequently used as a qi-regulating drug in thousands of Chinese medicine prescriptions. CRP is found mainly in major citrus-producing areas such as the Guangdong, Guangxi, Sichuan, Fujian, and Zhejiang Provinces of China. Since thousands of years in China, CRP has been used widely in clinical practice to treat nausea, vomiting, indigestion, anepithymia, diarrhea, cough, expectoration, and so on...
April 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29623722/new-visual-field-indices-of-disharmony-for-early-diagnosis-of-glaucoma-alone-or-associated-with-conventional-parameters
#11
Rodrigo Abreu-Gonzalez, Marta Gonzalez-Hernandez, Cristina Pena-Betancor, Paloma Rodriguez-Esteve, Manuel Gonzalez De La Rosa
PURPOSE: To evaluate the specificity of new perimetric indices based on harmony, alone and in combination with structural data, for glaucoma detection. METHODS: In this prospective observational cross-sectional study, one eye of 105 healthy subjects and 97 early and suspect glaucomas were sequentially included and examined with Cirrus optical coherence tomography, twice with OCULUS Smartfield perimeter (SPARK strategy) and twice with Humphrey Analyzer (24-2 SITA-Fast) at the Ophthalmology Department from the University Hospital La Candelaria...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29623419/axial-plane-dissimilarities-of-two-identical-lenke-type-6c-scoliosis-cases-visualized-and-analyzed-by-vertebral-vectors
#12
Tamás S Illés, Máté Burkus, Szabolcs Somoskeőy, Fabien Lauer, Francois Lavaste, Jean F Dubousset
PURPOSE: The global appearance of scoliosis in the horizontal plane is not really known. Therefore, the aims of this study were to analyze scoliosis in the horizontal plane using vertebral vectors in two patients classified with the same Lenke group, and to highlight the importance of the information obtained from these vertebral vector-based top-view images in clinical practice. METHODS: Two identical cases of scoliosis were selected, based on preoperative full-body standing anteroposterior and lateral radiographs obtained by the EOS™ 2D/3D system...
April 6, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29620094/an-integrated-experimental-and-theoretical-reaction-path-search-analyses-of-the-multistage-reaction-of-an-ionized-diethylether-dimer-involving-isomerization-proton-transfer-and-dissociation
#13
Yoshiyuki Matsuda, Min Xie, Asuka Fujii
An ionization-induced multistage reaction of an ionized diethylether (DEE) dimer involving isomerization, proton transfer, and dissociation is investigated by combining infrared (IR) spectroscopy, tandem mass spectrometry, and a theoretical reaction path search. The vertically-ionized DEE dimer isomerizes to a hydrogen-bonded cluster of protonated DEE and the [DEE-H] radical through barrierless intermolecular proton transfer from the CH bond of the ionized moiety. This isomerization process is confirmed by IR spectroscopy and the theoretical reaction path search...
April 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29616742/coordination-between-body-growth-and-tissue-growth-wolffian-duct-elongation-and-somitogenesis-proceed-in-harmony-with-axial-growth
#14
Yoshiko Takahashi, Ryo Kudo, Ryosuke Tadokoro, Yuji Atsuta
During embryogenesis, different tissues develop coordinately, and this coordination is often in harmony with body growth. Recent studies allow us to understand how this harmonious regulation is achieved at the levels of inter-cellular, inter-tissue, and tissue-body relationships. Here, we present an overview of recently revealed mechanisms by which axial growth (tail growth) drives a variety of morphogenetic events, with a focus on the coordinated progression between Wolffian (nephric) duct elongation and somitogenesis...
2018: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29606693/canadian-alliance-for-healthy-hearts-and-minds-first-nations-cohort-study-rationale-and-design
#15
Sonia S Anand, Sylvia Abonyi, Laura Arbour, Jeff Brook, Sharon Bruce, Heather Castleden, Dipika Desai, Russell J de Souza, Stewart Harris, James Irvine, Christopher Lai, Diana Lewis, Richard T Oster, Paul Poirier, Ellen L Toth, Karen Bannon, Vicky Chrisjohn, Albertha D Davis, Jean L'Hommecourt, Randy Littlechild, Kathleen McMullin, Sarah McIntosh, Julie Morrison, Manon Picard, Pictou Landing First Nation, Melissa M Thomas, Natasa Tusevljak, Matthias G Friedrich, Jack V Tu
BACKGROUND: This is the first national indigenous cohort study in which a common, in-depth protocol with a common set of objectives has been adopted by several indigenous communities across Canada. OBJECTIVES: The overarching objective of the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort is to investigate how the community-level environment is associated with individual health behaviors and the presence and progression of chronic disease risk factors and chronic diseases such as cardiovascular disease (CVD) and cancer...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29603525/the-engineering-of-chemical-synthesis-humans-and-machines-working-in-harmony
#16
EDITORIAL
Steven V Ley
"Chemical synthesis has previously tended to rely heavily on robust labour-intensive processes. We have been advocating a machine-assisted approach to synthesis for many years. To replace a bench chemist with a machine is not only unrealistic but impossible. What is realistic is to use this rapidly developing array of equipment and novel concepts to take us way beyond where we are today …". Read more in the Guest Editorial by Steven V. Ley.
March 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29599735/on-the-determinants-and-outcomes-of-passion-for-playing-pok%C3%A3-mon-go
#17
Gábor Orosz, Ágnes Zsila, Robert J Vallerand, Beáta Böthe
In 2016, Pokémon Go became the most popular smartphone game. Despite the increasing popularity of this augmented reality game, to date, no studies have investigated passion for playing Pokémon Go. On the theoretical basis of the Dualistic Model of Passion (DMP), our goal was to investigate the associations between Pokémon Go playing motives, passion, and impulsivity. A total of 621 Pokémon Go players participated in the study (54.9% female; M age = 22.6 years, SD age = 4.4). It was found that impulsivity was more strongly associated with obsessive passion (OP) than with harmonious passion (HP)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29599599/diagnosis-treatment-planning-and-full-mouth-rehabilitation-in-a-case-of-amelogenesis-imperfecta
#18
Mayuri Naik, Siddharth Bansal
Amelogenesis imperfecta is a genetic condition affecting the teeth resulting in aberrations of the structure and clinical appearance of enamel. The treatment of amelogenesis imperfecta involves a multidisciplinary treatment approach requiring a comprehensive examination, diagnosis, and effective treatment planning strategy along with satisfaction of patient-related factors. The clinical case described here involves judicious involvement of different disciplines to formulate a treatment plan best suitable to confirm with the patient's needs and expectations, at the same time maintaining the integrity and harmony of associated hard and soft tissues...
January 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29589566/constraints-on-signaling-network-logic-reveal-functional-subgraphs-on-multiple-myeloma-omic-data
#19
Bertrand Miannay, Stéphane Minvielle, Florence Magrangeas, Carito Guziolowski
BACKGROUND: The integration of gene expression profiles (GEPs) and large-scale biological networks derived from pathways databases is a subject which is being widely explored. Existing methods are based on network distance measures among significantly measured species. Only a small number of them include the directionality and underlying logic existing in biological networks. In this study we approach the GEP-networks integration problem by considering the network logic, however our approach does not require a prior species selection according to their gene expression level...
March 21, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29583082/test-selection-for-women-with-suspected-stable-ischemic-heart-disease
#20
Harmony R Reynolds, Anais Hausvater, Kerrilynn Carney
Ischemic heart disease (IHD) is the leading cause of death and disability among women in the United States. Identifying IHD in women presenting with stable symptoms and stratifying their risk for an IHD event can be challenging for providers, with several different tests available. This article is meant to serve as a practical guide for clinicians treating women with potentially ischemic symptoms. Evidence and American Heart Association (AHA) recommendations regarding test selection are reviewed, with a focus on the information to be gained from each test...
March 27, 2018: Journal of Women's Health
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