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https://www.readbyqxmd.com/read/28095528/the-role-of-cutaneous-microbiota-harmony-in-maintaining-a-functional-skin-barrier
#1
Hilary E Baldwin, Neal D Bhatia, Adam Friedman, Richard Martin Eng, Sophie Seite
The skin is constantly exposed to various endogenous and exogenous factors that may impact its barrier function at the physical, mechanical, immunological, and microbial levels. These factors have the potential to initiate or exacerbate a variety of inflammatory skin conditions, especially those associated with barrier dysfunction. The barrier function of the skin depends upon a symbiotic relationship between resident microbial communities and host tissue. This symbiosis results from complex signals involved in both the innate and adaptive immune responses...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28087237/what-is-the-real-impact-of-urinary-incontinence-on-female-sexual-dysfunction-a-case-control-study
#2
Mariana Rhein Felippe, Joao Paulo Zambon, Marcia Eli Girotti, Juliana Schulze Burti, Claudia Rosenblatt Hacad, Lina Cadamuro, Fernando Almeida
INTRODUCTION: Urinary incontinence (UI) has been associated with negative effects on women's sexuality. Women's sexuality and sexual function are a complex issue, and the role of UI is not completely clear. AIM: To assess the impact of UI on female sexual function by comparing this population with a control group of continent women. METHODS: We performed a case-control study from August 2012 to September 2013. We evaluated continent and incontinent women (age range = 30-70 years) for their sexuality...
January 10, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28074589/on-patient-well-being-and-professional-authority
#3
Mildred Z Solomon
Two papers in this issue address the limits of surrogates' authority when making life-and-death decisions for dying family members or friends. Using palliative sedation as an example, Jeffrey Berger offers a conceptual argument for bounding surrogate authority. Since freedom from pain is an essential interest, when imminently dying, cognitively incapacitated patients are in duress and their symptoms are not manageable in any other way, clinicians should be free to offer palliative sedation without surrogate consent, although assent should be sought and every effort made to work with surrogates as harmoniously as possible...
January 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28062927/a-sensory-driven-controller-for-quadruped-locomotion
#4
César Ferreira, Cristina P Santos
Locomotion of quadruped robots has not yet achieved the harmony, flexibility, efficiency and robustness of its biological counterparts. Biological research showed that spinal reflexes are crucial for a successful locomotion in the most varied terrains. In this context, the development of bio-inspired controllers seems to be a good way to move toward an efficient and robust robotic locomotion, by mimicking their biological counterparts. This contribution presents a sensory-driven controller designed for the simulated Oncilla quadruped robot...
January 7, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/28054792/minimally-invasive-dentistry-a-conservative-approach-to-smile-makeover
#5
Jeffrey M Rosenberg
The concept of minimally invasive dentistry is based on preserving tooth structure, especially enamel. A conservative method to treat discolored teeth that have diastemas is a freehand additive technique using composite resin. While selecting the correct shade of resin can be challenging, newer composite resin formulations are being developed with optical properties that enable the material to more effectively blend into the dentition. This case report describes the use of conservative approaches and materials to treat discolored, unevenly spaced teeth and restore harmony and balance to a patient's smile...
January 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28054503/inhibition-of-telomerase-using-bibr1532-enhances-doxorubicin-induced-apoptosis-in-pre-b-acute-lymphoblastic-leukemia-cells
#6
Davood Bashash, Mohadeseh Zareii, Ava Safaroghli-Azar, Mir Davood Omrani, Seyed H Ghaffari
OBJECTIVES: Interest into targeting telomerase in cancer has increased by the recent disclosure that elevated telomerase activity is associated with disease recurrence and poor outcome in cancers. In addition, cellular acquisition of unlimited replicative potential, which is closely related to the maintenance of telomeres mostly via the reactivation of telomerase, has been shown to confer loss of sensitivity to a wide range of anti-neoplastic agents. METHODS: To evaluate whether telomerase inhibition using non-nucleosidic inhibitor of telomerase BIBR1532 could enhance cytotoxic effect of doxorubicin in acute lymphoblastic leukemia, Nalm-6 pre-B ALL cells were subjected to combination treatment and subsequent cell viability, growth kinetics, caspase-3 activity, and transcriptional alteration of p73, p21, FOXO3a, c-Myc, hTERT, and other apoptosis-related target genes were investigated...
January 5, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28050889/clinical-pharmacokinetics-and-pharmacodynamics-of-albiglutide
#7
REVIEW
Andreas Brønden, Filip K Knop, Mikkel B Christensen
Albiglutide is a long-acting, glucagon-like peptide-1 receptor agonist for subcutaneous administration with a recommended dose of 30-50 mg once weekly. The aim of this article is to outline the pharmacokinetic and pharmacodynamic properties of albiglutide including the clinical efficacy and safety data underlying the approval of albiglutide for the treatment of type 2 diabetes mellitus in both Europe and USA. Albiglutide is cleared from the circulation (by a mechanism partially dependent on renal function) with an elimination half-life of 5 days, allowing once-weekly administration...
January 3, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28050503/the-oro-facial-investment-scale-ofis-a-novel-outcomes-and-evaluation-measure-for-self-appraised-oro-facial-behavioural-and-aesthetic-constructs-among-professional-healthcare-students-of-belagavi-a-cross-sectional-study
#8
Vaibhav Kumar, Anil V Ankola, Sagar G Jalihal
INTRODUCTION: Several studies have shown that self perceived dental appearance is an important determinant in the decision to seek treatment. AIM: The aim of the present study was to assess the self-perceived oral health knowledge, attitude, practice, behaviour and perception among 18-20 year old students of professional healthcare institutions in Belagavi city, Karnataka. MATERIALS AND METHODS: The novel 21 item Oro-Facial Investment Scale (OFIS) formulated for this study was distributed to 600 students of professional healthcare institutions (200 each from Medical, Physiotherapy and Ayurveda specialties respectively)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28047624/su-g-jep3-07-real-time-image-guided-radiation-therapy-for-heterotopic-ossification-in-patients-after-hip-replacement
#9
A Le, S Jiang, R Timmerman, H Choy, A Pompos
PURPOSE: To demonstrate the feasibility of using CBCT in a real-time image guided radiation therapy (IGRT) for single fraction heterotopic ossification (HO) in patients after hip replacement. In this real-time procedure, all steps, from simulation, imaging, planning to treatment delivery, are performed at the treatment unit in one appointment time slot. This work promotes real-time treatment to create a paradigm shift in the single fraction radiation therapy. METHODS: An integrated real-time IGRT for HO was developed and tested for radiation treatment of heterotopic ossification for patient after hip replacement...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045830/advancing-and-lengthening-genioplasty-in-contouring-of-the-receding-and-short-chin
#10
Ce Zhang, Luyi Zhao, Chao-Ran Li, Yoong-Hoon Shim, Dejun Cao
BACKGROUND: In East Asia, receding and short chin are common complaints of patients who do not have satisfied lower face. In most former studies, receding and short chin are considered and treated separately. But during the clinical work, the authors found that, in many patients, neither vertical elongation nor horizontal advancement of the chin is sufficient to achieve a harmonious result. In regards of this problem, the authors performed an advancing and lengthening genioplasty and the results were aesthetically satisfactory...
December 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28044242/on-the-development-of-harmony-turbulence-and-independence-in-parent-adolescent-relationships-a-five-wave-longitudinal-study
#11
Hana Hadiwijaya, Theo A Klimstra, Jeroen K Vermunt, Susan J T Branje, Wim H J Meeus
The separation-individuation, evolutionary, maturational, and expectancy violation-realignment perspectives propose that the relationship between parents and adolescents deteriorate as adolescents become independent. This study examines the extent to which the development of adolescents' perceived relationship with their parents is consistent with the four perspectives. A latent transition analysis was performed in a two-cohort five-wave longitudinal study design covering ages 12-16 (n = 919, 49.2% female) and 16-20 (n = 392, 56...
January 2, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28033634/how-to-harmonize-the-ethnic-nose
#12
Artur Grinfeld, Rodrigo Betelli, Guilherme Arruda, Washington Almeida
The demand for cosmetic surgery has significantly increased in the past few years mainly due to economic rise witnessed in Brazil. The state of Bahia has predominately Afro-descendant population with the same countrywide scenario, where the surgeon must be able to face challenges such as the specifics demands of rhinoplasty in an ethnic nose. It represents not only a different nasal variety from the Caucasoid, but also a complex anatomical feature, with its own peculiarities, as thicker and oilier skin, with bulky fibrous fatty tissue with numerous sebaceous glands...
December 2016: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28031617/knowledge-awareness-and-practice-of-ethics-among-doctors-in-tertiary-care-hospital
#13
Surjit Singh, Pramod Kumar Sharma, Bharti Bhandari, Rimplejeet Kaur
INTRODUCTION: With the advancement of healthcare and medical research, doctors need to be aware of the basic ethical principles. This cross-sectional study is an attempt to assess the knowledge, awareness, and practice of health-care ethics among health-care professionals. MATERIALS AND METHODS: After taking written informed consent, a standard questionnaire was administered to 117 doctors. No personal information was recorded on the questionnaire so as to ensure the confidentiality and anonymity of participants...
October 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28028126/susan-lindquist-visionary-scientist-and-peerless-mentor
#14
Brooke J Bevis
The science universe is dimmer after one of our brightest stars, Susan Lee Lindquist, was taken by cancer on October 27, 2016. Sue was an innovative, creative, out-of-the-box scientific thinker. She had unique biological intuition-an instinct for both the way things worked and the right questions to ask to uncover new research insights. Her wide-ranging career began with the study of protein folding and molecular chaperones, and she went on to show that protein folding can have profound and unexpected biological effects on such diverse processes as cancer, evolution, and neurodegenerative disease...
January 2, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28025255/representations-of-pitch-and-timbre-variation-in-human-auditory-cortex
#15
Emily J Allen, Philip C Burton, Cheryl A Olman, Andrew J Oxenham
: Pitch and timbre are two primary dimensions of auditory perception, but how they are represented in the human brain remains a matter of contention. Some animal studies of auditory cortical processing have suggested modular processing, with different brain regions preferentially coding for pitch or timbre, whereas other studies have suggested a distributed code for different attributes across the same population of neurons. This study tested whether variations in pitch and timbre elicit activity in distinct regions of the human temporal lobes...
December 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28017556/bilateral-globus-pallidus-internus-deep-brain-stimulation-for-dyskinetic-cerebral-palsy-supports-success-of-cochlear-implantation-in-a-5-year-old-ex-24%C3%A2-week-preterm-twin-with-absent-cerebellar-hemispheres
#16
Jean-Pierre Lin, Margaret Kaminska, Sarah Perides, Hortensia Gimeno, Lesley Baker, Daniel E Lumsden, Anzell Britz, Sandra Driver, Alec Fitzgerald-O'Connor, Richard Selway
BACKGROUND: Early onset dystonia (dyskinesia) and deafness in childhood pose significant challenges for children and carers and are the cause of multiple disability. It is particularly tragic when the child cannot make use of early cochlear implantation (CI) technology to relieve deafness and improve language and communication, because severe cervical and truncal dystonia brushes off the magnetic amplifier behind the ears. Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) neuromodulation can reduce dyskinesia, thus supporting CI neuromodulation success...
December 10, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28007115/comparison-of-stability-between-a-modular-intraocular-lens-system-and-a-single-piece-hydrophobic-acrylic-intraocular-lens
#17
Jeffrey R SooHoo, Stephen S Lane, Robert J Cionni, John P Berdahl, Glenn R Sussman, Malik Y Kahook
PURPOSE: To compare the movement of a modular intraocular lens (IOL) with that of a standard single-piece hydrophobic acrylic IOL in a human cadaver eye perfusion model. SETTING: Department of Ophthalmology, University of Colorado, Aurora, Colorado, USA. DESIGN: Experimental study. METHODS: Eight phakic human donor eyes of 4 patients had standard phacoemulsification with lens removal. One of 2 IOLs was then implanted in the capsular bag: a modular IOL (Harmoni) or a standard single-piece IOL (Acrysof SN60)...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28006965/nucleolus-like-compartmentalization-of-the-transcription-machinery-in-fast-growing-bacterial-cells
#18
Ding Jun Jin, Carmen Mata Martin, Zhe Sun, Cedric Cagliero, Yan Ning Zhou
We have learned a great deal about RNA polymerase (RNA Pol), transcription factors, and the transcriptional regulation mechanisms in prokaryotes for specific genes, operons, or transcriptomes. However, we have only begun to understand how the transcription machinery is three-dimensionally (3D) organized into bacterial chromosome territories to orchestrate the transcription process and to maintain harmony with the replication machinery in the cell. Much progress has been made recently in our understanding of the spatial organization of the transcription machinery in fast-growing Escherichia coli cells using state-of-the-art superresolution imaging techniques...
December 23, 2016: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27994250/thermal-transport-harmony-with-superatoms
#19
Longji Cui, Edgar Meyhofer, Pramod Reddy
No abstract text is available yet for this article.
December 20, 2016: Nature Materials
https://www.readbyqxmd.com/read/27990158/chronic-functional-constipation-and-encopresis-in-children-in-relationship-with-the-psychosocial-environment
#20
Claudia Olaru, Smaranda Diaconescu, Laura Trandafir, Nicoleta Gimiga, Radian A Olaru, Gabriela Stefanescu, Gabriela Ciubotariu, Marin Burlea, Magdalena Iorga
Functional constipation is an issue for both the patient and his/her family, affecting the patient's psychoemotional balance, social relations, and their harmonious integration in the school environment. We aimed to highlight the connection between chronic constipation and encopresis and the patient's psychosocial and family-related situation. Material and Method. 57 patients with ages spanning from 6 to 15 were assessed within the pediatric gastroenterology ward. Sociodemographic, medical, and psychological data was recorded...
2016: Gastroenterology Research and Practice
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