James K Romine, Huashi Li, Melissa M Coughlin, Jefferson M Jones, Amadea Britton, Harmony L Tyner, Sammantha B Fuller, Robin Bloodworth, Laura J Edwards, Jini N Etoule, Tyler C Morrill, Gabriella Newes-Adeyi, Lauren E W Olsho, Manjusha Gaglani, Ashley Fowlkes, James Hollister, Edward J Bedrick, Jennifer L Uhrlaub, Shawn Beitel, Ryan S Sprissler, Zoe Lyski, Cynthia J Porter, Patrick Rivers, Karen Lutrick, Alberto J Caban-Martinez, Sarang K Yoon, Andrew L Phillips, Allison L Naleway, Jefferey L Burgess, Katherine D Ellingson
BACKGROUND: There are limited data on whether hybrid immunity differs by count and order of immunity-conferring events (SARS-CoV-2 infection or COVID-19 vaccination). From a cohort of health care personnel, first responders, and other frontline workers in six US states, we examined heterogeneity of the effect of hybrid immunity on SARS-CoV-2 antibody levels. METHODS: Exposures included event-count (sum of infections and vaccine doses) and event-order, categorized into seven permutations of vaccination and/or infection...
March 11, 2024: Clinical Infectious Diseases