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Normal hemoglobin with low ferritin

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https://www.readbyqxmd.com/read/30499881/changing-epidemiology-of-liver-involvement-in-children-with-celiac-disease
#1
Elisa Benelli, Samuele Naviglio, Luigina De Leo, Giacomo Stera, Manuela Giangreco, Luca Ronfani, Vincenzo Villanacci, Stefano Martelossi, Alessandro Ventura, Tarcisio Not
OBJECTIVES: Available data indicate that liver involvement is present in a significant proportion of children with celiac disease (CD) at the diagnosis (elevated transaminases 15-57%, autoimmune liver disease 1-2%). We sought to evaluate prevalence, clinical course, and risk factors for liver involvement in a large cohort of children with CD. METHODS: Children (age 0-18 years) diagnosed with CD from March 2010 to April 2016 were enrolled. Liver involvement was considered to be present when ALT levels were >40 U/L (hypertransaminasemia, HTS)...
November 27, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30291758/repeat-whole-blood-donors-with-a-ferritin-level-of-30-%C3%AE-g-l-or-less-show-functional-iron-depletion
#2
Angelique Dijkstra, Katja van den Hurk, Henk J G Bilo, Robbert J Slingerland, Michel J Vos
BACKGROUND: Whole blood donors are screened for iron depletion through hemoglobin measurement alone or in combination with ferritin. Ferritin measurement gives the advantage of earlier detection of iron depletion. In a previous study we identified a ferritin level of 30 μg/L or less as a possible indicator of suboptimal erythropoiesis. In this study, erythropoietic parameters were measured to determine if a ferritin level of 30 μg/L or less is indicative of iron-deficient erythropoiesis in repeat whole blood donors...
October 6, 2018: Transfusion
https://www.readbyqxmd.com/read/30252420/anemia-in-older-adults
#3
J Brian Lanier, James J Park, Robert C Callahan
Anemia is associated with increased morbidity and mortality in older adults. Diagnostic cutoff values for defining anemia vary with age, sex, and possibly race. Anemia is often asymptomatic and discovered incidentally on laboratory testing. Patients may present with symptoms related to associated conditions, such as blood loss, or related to decreased oxygen-carrying capacity, such as weakness, fatigue, and shortness of breath. Causes of anemia in older adults include nutritional deficiency, chronic kidney disease, chronic inflammation, and occult blood loss from gastrointestinal malignancy, although in many patients the etiology is unknown...
October 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/30142801/bilateral-thalamic-and-mesencephalic-infarctions-with-hypopituitarism-as-long-term-complications-postradiotherapy-a-case-report
#4
Liang Hui, Hu Shijun, Liu Tao, Wen Guoqiang, Huang Shixiong
BACKGROUND: Radiation is widely used as the first-line treatment for nasopharyngeal carcinoma (NPC) and improves survival. Nevertheless, radiation also places the patients at risk of radiation-induced adverse effects, such as transient ischemic attack, ischemic stroke, hypopituitarism, and cranial nerve and temporal lobe dysfunction. CASE REPORT: A 54-year-old woman who had undergone radiation treatment for NPC 14 years earlier and had no cerebrovascular risk factors, visited our department 4 days after sudden onset of consciousness disturbance...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29761147/efficacy-of-long-term-oral-vitamin-b12-supplementation-after-total-gastrectomy-results-from-a-prospective-study
#5
Joana Moleiro, Susana Mão de Ferro, Sara Ferreira, Miguel Serrano, Margarida Silveira, António Dias Pereira
Background/Objectives: Vitamin B12 (VB12) deficiency is a common complication after total gastrectomy which may be associated with megaloblastic anemia and potentially irreversible neurologic symptoms. Intramuscular supplementation of VB12 has been considered the standard treatment, although it is associated with high costs and patient discomfort. Patients/Methods: We performed a prospective uncontrolled study (ACTRN12614000107628) in order to evaluate the clinical and laboratory efficacy of long-term oral VB12 supplementation in patients submitted to total gastrectomy...
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29759803/reticulocyte-hemoglobin-content-mchr-in-the-assessment-of-iron-deficient-erythropoiesis-in-inflammatory-bowel-disease
#6
Eloísa Urrechaga, Johannes J M L Hoffmann, Antonio Bernal, Juan A Arévalo, José L Cabriada
BACKGROUND: In conditions associated with inflammation, biochemical parameters alone could be inadequate for assessing iron status. We investigated the potential utility of mean reticulocyte hemoglobin content (MCHr) in the assessment of the erythropoiesis status in inflammatory bowel disease (IBD). METHODS: We recruited 124 anemic outpatients with IBD. Serum iron, transferrin and ferritin were tested. Complete blood counts were performed on a CELL-DYN Sapphire analyzer (Abbott Diagnostics)...
November 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29655636/reticulocyte-hemoglobin-content-in-a-large-sample-of-the-general-dutch-population-and-its-relation-to-conventional-iron-status-parameters
#7
A Mireille Baart, Michiel G J Balvers, Maria T E Hopman, Thijs M H Eijsvogels, Jacqueline M T Klein Gunnewiek, Corine A van Kampen
BACKGROUND: No full consensus exists on which iron status parameters to use for iron status assessment. In this study, we assessed the usefulness of measurement of the hemoglobin content of reticulocytes (CHr) in the general population. METHODS: The following iron status parameters were assessed in 1024 adults: CHr, reticulocytes, hemoglobin (Hb), ferritin, serum iron, transferrin, transferrin saturation and mean corpuscular volume (MCV). Mean parameter values and correlation coefficients for CHr and other parameters were calculated...
August 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29652073/the-iron-regulatory-proteins-are-defective-in-repressing-translation-via-exogenous-5-iron-responsive-elements-despite-their-relative-abundance-in-leukemic-cellular-models
#8
Emmanuel Pourcelot, Marine Lénon, Peggy Charbonnier, Fiona Louis, Pascal Mossuz, Jean-Marc Moulis
In animal cells the specific translational control of proteins contributing to iron homeostasis is mediated by the interaction between the Iron Regulatory Proteins (IRP1 and IRP2) and the Iron Responsive Elements (IRE) located in the untranslated regions (UTR) of regulated messengers, such as those encoding ferritin or the transferrin receptor. The absolute concentrations of the components of this regulatory system in hematopoietic cells and the ability of the endogenous IRP to regulate exogenous IRE have been measured...
April 25, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29649107/impaired-hematologic-status-in-relation-to-clinical-outcomes-among-hiv-infected-adults-from-uganda-a-prospective-cohort-study
#9
Amara E Ezeamama, David Guwatudde, Alla Sikorskii, Edmond K Kabagambe, Raybun Spelts, Grace Vahey, Jenifer I Fenton, Wafaie W Fawzi
Impaired hematologic status (IHS) was investigated as a determinant of immune function defined as cluster of differentiation 4 (CD4) T-helper cell count, quality of life (QOL) weight and hospitalization/mortality over 18-months among 398 adult persons living with HIV/AIDS (PLWHA) on anti-retroviral therapy. IHS was defined as having anemia at baseline (Hemoglobin: <12 g/dL for women and <13 g/dL for men), time-updated anemia or having low (<30 μg/L) or high (>200 μg/L for men and >150 μg/L for women) ferritin levels at baseline...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29465053/erythropoietic-response-to-anaemia-of-dialysis-na%C3%A3-ve-patients-with-chronic-kidney-disease-in-zaria-north-west-nigeria
#10
L G Dogara, A Hassan, S Awwalu, L Okpetu, A D Waziri, A A Babadoko, I B Bosan, H M Muktar
Introduction: Chronic kidney disease (CKD) is a global health problem with an increasing prevalence worldwide. Anemia is one of its consistent and severe hematological complications although its mechanism is not fully elucidated. The primary defect could manifest as serum erythropoietin (sEPO) deficiency or EPO resistance. We set out to determine the erythropoietic response to anemia of patients with CKD and its relationship with their iron status in a cross-sectional descriptive study of 91 patients in various stages of CKD...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29075065/relationship-between-the-levels-of-holotranscobalamin-and-vitamin-b12-in-children
#11
Ikbal Ok Bozkaya, Nese Yarali, Murat Kizilgün, Secil Ozkan, Bahattin Tunc
The purpose of this study was to evaluate the relationship between the plasma holoTC and serum vitamin B12 in children and to identify a cutoff cobalamin values according to holoTC. One hundred and fifty-five children were enrolled into the study. All children were evaluated for hemoglobin, vitamin B12, folate, ferritin and holoTC levels. Children were grouped as with low vitamin B12 level (≤200 pg/mL, group I) and normal vitamin B12 (>200 pg/mL, group II). Serum vitamin B12, and holoTC levels were performed in each patient in the study...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29070754/-a-70-year-old-woman-presenting-with-restless-shoulder-following-posterior-internal-capsule-infarction
#12
REVIEW
Takeo Matsubara, Keisuke Suzuki, Madoka Okamura, Tomohiko Shiina, Masayuki Miyamoto, Toshiki Nakamura, Koichi Hirata
A 70-year-old woman noticed difficulty in speech and weakness of the left upper and lower limb upon awakening. Neurological examination showed dysarthria and left hemiparesis. No sensory disturbance was observed. Brain MRI revealed acute infarction in the right posterior limb of the internal capsule. On the hospital day 1, she developed the abnormal sensations restricted to the bilateral shoulders, resulting in difficulty initiating sleep. On laboratory data, renal function and serum hemoglobin and ferritin levels were normal...
November 25, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28994539/-siwu-decoction-improves-iron-deficiency-anemia-in-infant-rats-and-regulates-iron-metabolism
#13
Ran He, Hong-Jin Wang, Ying Zhou, Jing-Jing Li, Xiao-Yu Xu
To investigate the effect of Siwu decoction on improving iron deficiency anemia in infant rats and observe its regulatory effects on iron metabolism. SD rats were fed with low iron fodder for 2 weeks, and then the rats with hemoglobin level less than 75 g•L ⁻¹ were screened out and randomly divided into model group, Ferrous succinate 50 mg•kg ⁻¹ group, Siwu decoction 4 g•kg ⁻¹, 8 g•kg ⁻¹ and 16 g•kg ⁻¹ groups. After 4 weeks' gavage administration, Wright-Giemsa's staining of blood smear and HE staining of the livers were conducted, and all rats were tested for blood routine, serum iron, total iron binding capacity, serum ferritin, serum hepcidin and liver hepcidin...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28955692/association-between-hemoglobin-level-and-bone-mineral-density-in-korean-adults
#14
Yun Hwan Oh, Ji Hyun Moon, Belong Cho
BACKGROUND: Low bone mineral density (BMD) increases fracture risk. Anemia is highly prevalent. Some studies suggested that anemia is an independent risk factor for osteoporosis. The aim of this study was to evaluate the association between hemoglobin (Hb) level and BMD in Korean adults. METHODS: This study was based on data from the Korea National Health and Nutrition Examination Survey 2008 to 2011. Propensity score-matching was performed to establish a dataset for analysis...
August 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28824243/effect-of-intravenous-iron-supplementation-on-hepcidin-levels-in-iron-deficient-pregnant-females-in-second-and-third-trimester
#15
Amtuz Zehra, Saleh Mohammed Saleh Abdullah, Muhammad Saboor, Moinuddin
Objective of the study was to assess effect of iron therapy on serum hepcidin levels in iron deficient pregnant women and its correlation with hemoglobin, serum iron profile and C-reactive protein (CRP). A total of 100 pregnant women were enrolled in the study; 25 were included in the "control group" having normal hematological and biochemical parameters while 75 iron deficient pregnant women were enrolled in the "patient group" with low hematological and biochemical parameters. CRP was done to rule out inflammation and to observe its association with hepcidin...
September 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28811791/differentiation-of-beta-thalassemia-trait-from-iron-deficiency-anemia-by-hematological-indices
#16
Tahir Jameel, Mukhtiar Baig, Ijaz Ahmed, Muhammad Barakat Hussain, Motlag Bin Doghaim Alkhamaly
OBJECTIVE: We aimed at finding out reliable parameter in the differentiation of iron deficiency anemia (IDA) and beta-thalassemia trait (β-TT) in the adult population subjected to Saudi Arabian Premarital Screening Program. METHODS: A total of 620 adults (age range 21-36 years) reported during February 2012 to November 2012. Tests for serum iron and ferritin were carried out in individuals showing low hemoglobin (Hb). All the selected subjects' samples were subjected to blood morphology, comparison of MCV, RBC count...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28608655/do-patients-with-iron-deficiency-without-anemia-benefit-from-an-endoscopic-examination
#17
Ana García García de Paredes, Carlos Teruel Sánchez-Vegazo, Nerea Hernanz Ruiz, Carlos Ferre Aracil, Enrique Rodríguez de Santiago, Lara Aguilera Castro, María Sierra Morales, Agustín Albillos
OBJECTIVE: The need for endoscopic investigation in patients with iron deficiency without anemia (ID) is not established. METHODS: Data from patients with ID (serum ferritin ≤20 ng/mL, normal hemoglobin) studied with upper and lower endoscopies were retrospectively analyzed. Patients evaluated for iron deficiency anemia (IDA) served as controls, matched by sex and age in the proportion of 2:1. The groups were compared for the presence, type, location and age distribution of endoscopic findings...
July 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27900761/the-effect-of-iron-balance-on-platelet-counts-in-blood-donors
#18
Anne F Eder, Yu Ying Yau, Kamille West
BACKGROUND: Thrombocytosis (or, less commonly, thrombocytopenia) is associated with iron-deficiency anemia and resolves with iron therapy. Many volunteer blood donors have low iron stores, with or without anemia. Iron balance could affect platelet counts in blood donors. STUDY DESIGN AND METHODS: Whole blood donors deferred for finger-stick hemoglobin levels less than 12.5 g/dL were evaluated by complete blood count and serum iron panel before and after oral iron treatment...
February 2017: Transfusion
https://www.readbyqxmd.com/read/27836440/reticulocyte-hemoglobin-content-mchr-in-the-detection-of-iron-deficiency
#19
Eloísa Urrechaga Igartua, Johannes J M L Hoffmann, Silvia Izquierdo-Álvarez, Jesús F Escanero
BACKGROUND: Blood hemoglobin (Hb) concentration within the reference interval does not exclude iron deficiency (ID): individuals with normal stores lose iron during a long period before their Hb falls below of the level that is defined as anemia. The process entails a decrease of storage iron, shown by serum ferritin below reference range, followed by iron depletion, eventually leading to iron restricted erythropoiesis; consequence of an imbalance between erythropoietic iron requirements and too low supply is a reduction of Hb synthesis in reticulocytes...
September 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27811439/rates-and-determinants-of-peripartum-and-puerperal-anemia-in-enugu-nigeria
#20
C F Emegoakor, C A Iyoke, H U Ezegwui, O U Umeora, L O Lawani, A J Madu
BACKGROUND: Anemia in the peripartum or postpartum period could pose a significant risk for maternal morbidity and mortality during and after delivery. AIMS: To determine the rates of anemia at term and in the puerperium and describe the determinants of puerperal anemia among a cohort of women with both normal and cesarean deliveries, following uncomplicated term singleton pregnancies in Enugu, Nigeria. METHODS: A prospective longitudinal study involving women with uncomplicated singleton pregnancies who were recruited at term at two tertiary maternity centers and were followed up with the determination of hemoglobin and ferritin concentrations till 6 weeks after delivery...
November 2016: Nigerian Journal of Clinical Practice
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