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https://www.readbyqxmd.com/read/28231510/lipopolyplex-potentiates-anti-tumor-immunity-of-mrna-based-vaccination
#1
Stefano Persano, Maria L Guevara, Zhaoqi Li, Junhua Mai, Mauro Ferrari, Pier Paolo Pompa, Haifa Shen
mRNA-based vaccines have the benefit of triggering robust anti-cancer immunity without the potential danger of genome integration from DNA vaccines or the limitation of antigen selection from peptide vaccines. Yet, a conventional mRNA vaccine comprising of condensed mRNA molecules in a positively charged protein core structure is not effectively internalized by the antigen-presenting cells. It cannot offer sufficient protection for mRNA molecules from degradation by plasma and tissue enzymes either. Here, we have developed a lipopolyplex mRNA vaccine that consists of a poly-(β-amino ester) polymer mRNA core encapsulated into a 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine/1,2-dioleoyl-sn-glycero-3-phosphatidyl-ethanolamine/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000 (EDOPC/DOPE/DSPE-PEG) lipid shell...
February 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28231432/dismantling-the-red-wall-of-colloidal-perovskites-highly-luminescent-formamidinium-and-formamidinium-cesium-lead-iodide-nanocrystals
#2
Loredana Protesescu, Sergii Yakunin, Sudhir Kumar, Janine Bär, Federica Bertolotti, Norberto Masciocchi, Antonietta Guagliardi, Matthias Grotevent, Ivan Shorubalko, Maryna I Bodnarchuk, Chih-Jen Shih, Maksym V Kovalenko
Colloidal nanocrystals (NCs) of APbX3-type lead halide perovskites [A=Cs+, CH3NH3+ (methylammonium or MA+) or CH(NH2)2+ (formamidinium or FA+); X=Cl-, Br-, I-] have recently emerged as highly versatile photonic sources for applications ranging from simple photoluminescence down-conversion (e.g., for display backlighting) to light emitting diodes. From the perspective of spectral coverage, a formidable challenge facing the use of these materials is how to obtain stable emissions in the red and infrared spectral regions covered by the iodide-based compositions...
February 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28231002/mid-infrared-photoluminescence-up-to-290-k-reveals-radiative-mechanisms-and-substrate-doping-type-effects-of-inas-nanowires
#3
Xiren Chen, Qiandong Zhuang, Hayfaa Alradhi, ZhiMing Jin, Liangqing Zhu, Xin Chen, Jun Shao
Photoluminescence (PL) as a conventional yet powerful optical spectroscopy may provide crucial insight into the mechanism of carrier recombination and bandedge structure in semiconductors. In this study, mid-infrared PL measurements on vertically aligned InAs nanowires (NWs) are realized for the first time in a wide temperature range of up to 290 K, by which the radiative recombinations are clarified in the NWs grown on n- and p-type Si substrates, respectively. A dominant PL feature is identified to be from the type-II optical transition across the interfaces between the zinc-blend (ZB) and the wurtzite (WZ) InAs, a lower-energy feature at low temperatures is ascribed to impurity-related transition, and a higher-energy feature at high temperatures originates in the interband transition of the WZ InAs being activated by thermal-induced electron transfer...
February 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28230973/unique-opto-electronic-structure-and-photo-reduction-properties-of-sulfur-doped-lead-chromates-explaining-their-instability-in-paintings
#4
Vanousheh Rahemi, Nasrin Sarmadian, Willemien Anaf, Koen Janssens, Dirk Lamoen, Bart Partoens, Karolien De Wael
Chrome yellow refers to a group of synthetic inorganic pigments that became popular as an artist's material from the second quarter of the 19th century. The color of the pigment, in which the chromate ion acts as a chromophore, is related to its chemical composition (PbCr1-xSxO4, with 0≤x≤0.8) and crystalline structure (monoclinic/orthorhombic). Their shades range from the yellow-orange to the paler yellow tones with increasing sulfate amount. These pigments show remarkable signs of degradation after limited time periods...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230930/in-silico-design-of-optimal-dissolution-kinetics-of-fe-doped-zno-nanoparticles-results-in-cancer-specific-toxicity-in-a-preclinical-rodent-model
#5
Bella B Manshian, Suman Pokhrel, Uwe Himmelreich, Kaido Tämm, Lauri Sikk, Alberto Fernández, Robert Rallo, Tarmo Tamm, Lutz Mädler, Stefaan J Soenen
Cancer cells have unique but widely varying characteristics that have proven them difficult to be treated by classical therapeutics and calls for novel and selective treatment options. Nanomaterials (NMs) have been shown to display biological effects as a function of their chemical composition, and the extent and exact nature of these effects can vary between different biological environments. Here, ZnO NMs are doped with increasing levels of Fe, which allows to finely tune their dissolution rate resulting in significant differences in their biological behavior on cancer or normal cells...
February 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28230153/unconventional-high-performance-laser-protection-system-based-on-dichroic-dye-doped-cholesteric-liquid-crystals
#6
Wanshu Zhang, Lanying Zhang, Xiao Liang, Le Zhou, Jiumei Xiao, Li Yu, Fasheng Li, Hui Cao, Kexuan Li, Zhou Yang, Huai Yang
High-performance and cost-effective laser protection system is of crucial importance for the rapid advance of lasers in military and civilian fields leading to severe damages of human eyes and sensitive optical devices. However, it is crucially hindered by the angle-dependent protective effect and the complex preparation process. Here we demonstrate that angle-independence, good processibility, wavelength tunability, high optical density and good visibility can be effectuated simultaneously, by embedding dichroic anthraquinone dyes in a cholesteric liquid crystal matrix...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230152/simultaneous-enhancement-of-magnetic-and-mechanical-properties-in-ni-mn-sn-alloy-by-fe-doping
#7
Changlong Tan, Zhipeng Tai, Kun Zhang, Xiaohua Tian, Wei Cai
Both magnetic-field-induced reverse martensitic transformation (MFIRMT) and mechanical properties are crucial for application of Ni-Mn-Sn magnetic shape memory alloys. Here, we demonstrate that substitution of Fe for Ni can simultaneously enhance the MFIRMT and mechanical properties of Ni-Mn-Sn, which are advantageous for its applications. The austenite in Ni44Fe6Mn39Sn11 shows the typical ferromagnetic magnetization with the highest saturation magnetization of 69 emu/g at 223 K. The result shows that an appropriate amount of Fe substitution can really enhance the ferromagnetism of Ni50Mn39Sn11 alloy in austenite, which directly leads to the enhancement of MFIRMT...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230083/lanthanide-doped-klu2f7-nanoparticles-with-high-upconversion-luminescence-performance-a-comparative-study-by-judd-ofelt-analysis-and-energy-transfer-mechanistic-investigation
#8
Dekang Xu, Anming Li, Lu Yao, Hao Lin, Shenghong Yang, Yueli Zhang
The development, design and the performance evaluation of rare-earth doped host materials is important for further optical investigation and industrial applications. Herein, we successfully fabricate KLu2F7 upconversion nanoparticles (UCNPs) through hydrothermal synthesis by controlling the fluorine-to-lanthanide-ion molar ratio. The structural and morphological results show that the samples are orthorhombic-phase hexagonal-prisms UCNPs, with average side length of 80 nm and average thickness of 110 nm...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230080/demonstrating-the-potential-of-yttrium-doped-barium-zirconate-electrolyte-for-high-performance-fuel-cells
#9
Kiho Bae, Dong Young Jang, Hyung Jong Choi, Donghwan Kim, Jongsup Hong, Byung-Kook Kim, Jong-Ho Lee, Ji-Won Son, Joon Hyung Shim
In reducing the high operating temperatures (≥800 °C) of solid-oxide fuel cells, use of protonic ceramics as an alternative electrolyte material is attractive due to their high conductivity and low activation energy in a low-temperature regime (≤600 °C). Among many protonic ceramics, yttrium-doped barium zirconate has attracted attention due to its excellent chemical stability, which is the main issue in protonic-ceramic fuel cells. However, poor sinterability of yttrium-doped barium zirconate discourages its fabrication as a thin-film electrolyte and integration on porous anode supports, both of which are essential to achieve high performance...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28230059/synergistic-effects-of-dimethyloxallyl-glycine-and-recombinant-human-bone-morphogenetic-protein-2-on-repair-of-critical-sized-bone-defects-in-rats
#10
Xin Qi, Yang Liu, Zhen-Yu Ding, Jia-Qing Cao, Jing-Huan Huang, Jie-Yuan Zhang, Wei-Tao Jia, Jing Wang, Chang-Sheng Liu, Xiao-Lin Li
In bone remodeling, osteogenesis is closely coupled to angiogenesis. Bone tissue engineering using multifunctional bioactive materials is a promising technique which has the ability to simultaneously stimulate osteogenesis and angiogenesis for repair of bone defects. We developed mesoporous bioactive glass (MBG)-doped poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) composite scaffolds as delivery vehicle. Two bioactive molecules, dimethyloxalylglycine (DMOG), a small-molecule angiogenic drug, and recombinant human bone morphogenetic protein-2 (rhBMP-2), an osteoinductive growth factor, were co-incorporated into the scaffold...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229601/enhanced-magnetization-of-cobalt-defect-clusters-embedded-in-tio2-%C3%AE-films
#11
David L Cortie, Yury Khaydukov, Thomas Keller, David John Sprouster, Jacob S Hughes, James P Sullivan, Xiaolin Wang, Anton P Le Brun, Joel Bertinshaw, Sara J Callori, Robert D Aughterson, Michael James, Peter J Evans, Gerry Triani, Frank Klose
High magnetizations are desirable for spintronic devices that operate by manipulating electronic states using built-in magnetic fields. However, the magnetic moment in promising dilute magnetic oxide nanocomposites is very low, typically corresponding to only fractions of a Bohr magneton for each dopant atom. In this study we report a large magnetization formed by ion implantation of Co into amorphous TiO2-δ films producing an inhomogenous magnetic moment, with certain regions producing over 2.5 µB per Co, depending on the local dopant concentration...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229595/stabilization-of-the-perovskite-phase-of-formamidinium-lead-triiodide-by-methylammonium-cs-and-or-rb-doping
#12
Olga A Syzgantseva, Michael Saliba, Michael Grätzel, Ursula Rothlisberger
In this work we perform a computational study comparing the influence of monovalent cation substitution by methylammonium (MA+), cesium (Cs+) and rubidium (Rb+) on the properties of formamidinium lead triiodide (FAPbI3)-based perovskites. The relative stability of the desired, photoactive perovskite α phase ("black phase") and the non-photoactive, non-perovskite δ phase ("yellow phase") is studied as a function of dopant nature, concentration and temperature. Cs+ and Rb+ are shown to be more efficient in the stabilization of the perovskite α phase than MA+...
February 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28228121/bleb-failure-and-intraocular-pressure-rise-following-nd-yag-laser-capsulotomy
#13
Andreas Diagourtas, Petros Petrou, Ilias Georgalas, Kostantinos Oikonomakis, Panagiotis Giannakouras, Athanasios Vergados, Dimitrios Papaconstantinou
BACKGROUND: To report the negative effect of Nd: Yag (Neodymium-doped: Yttrium Aluminium Garnet) laser capsulotomy on the intraocular pressure (IOP) and the trabeculectomy bleb integrity, in a small series of eyes, both trabeculectomised and pseudophakic, following the laser application for the management of posterior capsular opacification (PCO). METHODS: This is a retrospective, non-comparative interventional case series study, in which 20 trabeculectomised and pseudophakic eyes from 15 patients, with otherwise well functioning blebs, were presented with uncontrolled IOP, in a variable distance of time following the application of YAG laser capsulotomy...
February 22, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28228032/structure-and-mechanisms-underlying-ion-transport-in-ternary-polymer-electrolytes-containing-ionic-liquids
#14
Santosh Mogurampelly, Venkat Ganesan
We use all atom molecular dynamics simulations to investigate the influence of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) ionic liquid on the structure and transport properties of poly(ethylene oxide) (PEO) polymer electrolytes doped with LiPF6 salt. We observe enhanced diffusivities of the Li(+), PF6(-), and BMIM(+) ions with increasing loading of the ionic liquid. Interplay between the different ion-ion and ion-polymer interactions is seen to lead to a destabilization of the Li-PF6 coordination and increase in the strength of association between the Li(+) cations and the polymer backbone...
February 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28228008/integration-of-highly-strained-sige-in-source-and-drain-with-hk-and-mg-for-22%C3%A2-nm-bulk-pmos-transistors
#15
Guilei Wang, Jun Luo, Changliang Qin, Renrong Liang, Yefeng Xu, Jinbiao Liu, Junfeng Li, Huaxiang Yin, Jiang Yan, Huilong Zhu, Jun Xu, Chao Zhao, Henry H Radamson, Tianchun Ye
In this study, the integration of SiGe selective epitaxy on source/drain regions and high-k and metal gate for 22 nm node bulk pMOS transistors has been presented. Selective Si1-x Ge x growth (0.35 ≤ × ≤ 0.40) with boron concentration of 1-3 × 10(20) cm(-3) was used to elevate the source/drain. The main focus was optimization of the growth parameters to improve the epitaxial quality where the high-resolution x-ray diffraction (HRXRD) and energy dispersive spectrometer (EDS) measurement data provided the key information about Ge profile in the transistor structure...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28228003/electrochemical-formation-of-multilayer-sno2-sb-x-o-y-coating-in-complex-electrolyte
#16
Antonina Maizelis, Boris Bairachniy
The multilayer antimony-doped tin dioxide coating was obtained by cathodic deposition of multilayer metal-hydroxide coating with near 100-nm thickness layers on the alloy underlayer accompanied by the anodic oxidation of this coating. The potential regions of deposition of tin, antimony, tin-antimony alloy, and mixture of this metals and their hydroxides in the pyrophosphate-tartrate electrolyte were revealed by the cyclic voltammetric method. The possibility of oxidation of cathodic deposit consisting of tin and Sn(II) hydroxide compounds to the hydrated tin dioxide in the same electrolyte was demonstrated...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28227291/development-of-a-head-phantom-and-measurement-setup-for-lightning-effects
#17
Rene Machts, Alexander Hunold, Carsten Leu, Jens Haueisen, Michael Rock, Rene Machts, Alexander Hunold, Carsten Leu, Jens Haueisen, Michael Rock, Alexander Hunold, Carsten Leu, Jens Haueisen, Michael Rock, Rene Machts
Direct lightning strikes to human heads lead to various effects ranging from Lichtenberg figures, over loss of consciousness to death. The evolution of the induced current distribution in the head is of great interest to understand the effect mechanisms. This work describes a technique to model a simplified head-phantom to investigate effects during direct lightning strike. The head-phantom geometry, conductive and dielectric parameters were chosen similar to that of a human head. Three layers (brain, skull, and scalp) were created for the phantom using agarose hydrogel doped with sodium chloride and carbon...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226915/miniaturized-force-torque-sensor-for-in-vivo-measurements-of-tissue-characteristics
#18
M Hessinger, T Pilic, R Werthschutzky, P P Pott, M Hessinger, T Pilic, R Werthschutzky, P P Pott, R Werthschutzky, M Hessinger, T Pilic, P P Pott
This paper presents the development of a surgical instrument to measure interaction forces/torques with organic tissue during operation. The focus is on the design progress of the sensor element, consisting of a spoke wheel deformation element with a diameter of 12 mm and eight inhomogeneous doped piezoresistive silicon strain gauges on an integrated full-bridge assembly with an edge length of 500 μm. The silicon chips are contacted to flex-circuits via flip chip and bonded on the substrate with a single component adhesive...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226455/the-effect-of-multiple-thin-film-coatings-of-protein-loaded-sol-gel-on-total-multi-electrode-array-thickness
#19
Matthew D McDermott, Kevin J Otto, Matthew D McDermott, Kevin J Otto, Matthew D McDermott, Kevin J Otto
Tetramethyl orthosilicate shows promise as a thin-film delivery vehicle for multi-electrode arrays for drug release and electrical performance; however, its effect upon device footprint has yet to be assessed. Using a previously established silicon wafer chip model, the thickness of one, two, and four protein doped coatings of sol-gel were analyzed via profilometry. Coating thickness was found to be 0.4μm, 1.1μm and 2.2μm on each side of the device. This addition to a native MEA is minimal when compared to other drug delivery paradigms currently associated with neural implants...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226209/production-of-high-performance-bioinspired-silk-fibers-by-straining-flow-spinning
#20
Rodrigo Madurga, Alfonso M Ganan-Calvo, Gustavo Ramón Plaza, Gustavo V Guinea, Manuel Elices, José Pérez-Rigueiro
In the last years there has been an increasing interest on bioinspired approaches for different applications, including the spinning of high performance silk fibers. Bioinspired spinning is based on the natural spinning system of spiders and worms and requires combining changes in the chemical environment of the proteins with the application of mechanical stresses. Here we present the novel Straining Flow Spinning (SFS) process and prove its ability to produce high performance fibers under mild, environmentally friendly conditions, from aqueous protein dopes...
February 22, 2017: Biomacromolecules
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