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Ji Won Kim, JaeSang Ko, JinJoo Kim, Jin Sook Yoon
PURPOSE: Early detection and control of inflammation are important to manage Graves' orbitopathy (GO). We investigated the effects of calprotectin (S100A8/A9) on orbital fibroblast inflammation and GO pathogenesis. METHODS: We measured serum calprotectin, S100A8 and S100A9 mRNA expression in orbital fat/connective tissue from GO patients and healthy controls, and proinflammatory cytokines in primary cultured orbital fibroblasts. RESULTS: The serum levels of S100A8/A9 and the expression of S100A8/A9 mRNA in orbital tissue were higher in the GO patients than in the healthy controls...
November 19, 2018: Ocular Immunology and Inflammation
Xiaonan Chen, Ting Tao, Hongyan Wang, Hongyu Zhao, Lin Lu, Fang Wu
BACKGROUND The aim of this study was to determine the involvement of S100A8/A9 in the development of arterial thrombosis. MATERIAL AND METHODS A total of 303 patients were enrolled in this study, with 110 having acute coronary syndrome (ACS) and 110 having coronary heart disease (CHD), and 83 subjects served as healthy blood donors. The concentrations of Toll-like receptor 4 (TLR-4), cyclooxygenase-2 (COX-2), and S100A8/A9 protein were determined in the sera of the participants and in peripheral blood mononuclear cells (PBMCs) derived from a rat carotid artery thrombosis model and in human aortic endothelial cells (HAECs)...
October 27, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Rie Kinoshita, Hiroki Sato, Akira Yamauchi, Yuta Takahashi, Yusuke Inoue, I Wayan Sumardika, Youyi Chen, Nahoko Tomonobu, Kota Araki, Kazuhiko Shien, Shuta Tomida, Hidejiro Torigoe, Kei Namba, Eisuke Kurihara, Yusuke Ogoshi, Hitoshi Murata, Ken-Ichi Yamamoto, Junichiro Futami, Endy Widya Putranto, I Made Winarsa Ruma, Hiromasa Yamamoto, Junichi Soh, Toshihiko Hibino, Masahiro Nishibori, Eisaku Kondo, Shinichi Toyooka, Masakiyo Sakaguchi
Within the "seed and soil" theory of organ tropic cancer metastasis is a growing compilation of evidence that S100A8/A9 functions as a soil signal that attracts cancer cells to certain organs, which prove beneficial to their growth. S100A8/A9-sensing receptors including Toll-like receptor 4 (TLR4), advanced glycation end products (RAGE), and also important receptors we recently succeeded in identifying (EMMPRIN, NPTNβ, ΜCAM, and ALCAM) have the potential to become promising therapeutic targets. In our study, we prepared extracellular regions of these novel molecules and fused them to human IgG2-Fc to extend half-life expectancy, and we evaluated the anti-metastatic effects of the purified decoy proteins on metastatic cancer cells...
October 26, 2018: International Journal of Cancer. Journal International du Cancer
Meili Wu, Lu Xu, Yu Wang, Ning Zhou, Fei Zhen, Ying Zhang, Xuebin Qu, Hongbin Fan, Sihan Liu, Yan Chen, Ruiqin Yao
S100A8/A9, a heterodimer complex composed of calcium-binding proteins S100A8 and S100A9, is significantly increased in the serum of multiple sclerosis (MS) patients. Relevant reports have revealed that MS pathology is commonly associated with the activation of microglial cells and the damage of oligodendrocyte precursor cells (OPCs). Moreover, microglia activation following stimulation increases the expression of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), which further exacerbate the damage to OPCs...
September 25, 2018: Brain Research Bulletin
Dirk Holzinger, Dirk Foell, Christoph Kessel
S100A8/A9 and S100A12 are released from activated monocytes and granulocytes and act as proinflammatory endogenous toll-like receptor (TLR)4-ligands. S100 serum concentrations correlate with disease activity, both during local and systemic inflammatory processes. In some autoinflammatory diseases such as familial Mediterranean fever (FMF) or systemic juvenile idiopathic arthritis (SJIA), dysregulation of S100 release may be involved in the pathogenesis. Moreover, S100 serum levels are a valuable supportive tool in the diagnosis of SJIA in fever of unknown origin...
September 25, 2018: Molecular and Cellular Pediatrics
Claas H Hinze, Dirk Foell, Anne L Johnson, Steven J Spalding, Beth S Gottlieb, Paula W Morris, Yukiko Kimura, Karen Onel, Suzanne C Li, Alexei A Grom, Janalee Taylor, Hermine I Brunner, Jennifer L Huggins, James J Nocton, Kathleen A Haines, Barbara S Edelheit, Michael Shishov, Lawrence K Jung, Calvin B Williams, Melissa S Tesher, Denise M Costanzo, Lawrence S Zemel, Jason A Dare, Murray H Passo, Kaleo C Ede, Judyann C Olson, Elaine A Cassidy, Thomas A Griffin, Linda Wagner-Weiner, Jennifer E Weiss, Larry B Vogler, Kelly A Rouster-Stevens, Timothy Beukelman, Randy Q Cron, Daniel Kietz, Kenneth Schikler, Jay Mehta, Tracy V Ting, James W Verbsky, Anne B Eberhard, Bin Huang, Edward H Giannini, Daniel J Lovell
OBJECTIVE: To determine the relationship between serum S100A8/A9 and S100A12 and the maintenance of clinical inactive disease (CID) in patients with polyarticular forms of juvenile idiopathic arthritis (PF-JIA) while on anti-tumor necrosis factor therapy (anti-TNF) and disease flare following withdrawal of anti-TNF. METHODS: In this prospective, multicenter study, 137 patients with PF-JIA were enrolled while in CID on anti-TNF. Patients were observed for the initial 6 months...
September 18, 2018: Arthritis & Rheumatology
S C M van Dalen, N N L Kruisbergen, B Walgreen, M M A Helsen, A W Slöetjes, N A J Cremers, M I Koenders, F A J van de Loo, J Roth, T Vogl, A B Blom, P M van der Kraan, P L E M van Lent, M H J van den Bosch
OBJECTIVE: Synovitis in collagenase-induced osteoarthritis (CiOA) is driven by locally released S100A8/A9 proteins and enhances joint destruction. S100A8/A9 can induce reactive oxygen species (ROS) release by phagocytes in OA synovium via neutrophil cytosolic factor-1 (Ncf1)-regulated NOX2 activation. In the present study we investigated whether NOX2-derived ROS affect joint pathology during CiOA. METHODS: CiOA was induced in knee joints of wild type (WT) and Ncf1-deficient (Ncf1**) mice...
September 5, 2018: Osteoarthritis and Cartilage
Ibon Eguíluz-Gracia, Kristiina Malmstrom, Sinan Ahmed Dheyauldeen, Jouko Lohi, Antti Sajantila, Ragnhild Aaløkken, Arvind Y M Sundaram, Gregor D Gilfillan, Mika Makela, Espen S Baekkevold, Frode L Jahnsen
BACKGROUND: Activated T helper type 2 (Th2) cells are believed to play a pivotal role in allergic airway inflammation, but which cells attract and activate Th2 cells locally have not been fully determined. Recently, it was shown in an experimental human model of allergic rhinitis (AR) that activated monocytes rapidly accumulate in the nasal mucosa after local allergen challenge, where they promote recruitment of Th2 cells and eosinophils. OBJECTIVE: To investigate whether monocytes are recruited to the lungs in paediatric asthma...
September 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Kazufumi Nakamura, Masakiyo Sakaguchi, Hiromi Matsubara, Satoshi Akagi, Toshihiro Sarashina, Kentaro Ejiri, Kaoru Akazawa, Megumi Kondo, Koji Nakagawa, Masashi Yoshida, Toru Miyoshi, Takeshi Ogo, Takahiro Oto, Shinichi Toyooka, Yuichiro Higashimoto, Kei Fukami, Hiroshi Ito
BACKGROUND: Pulmonary vascular remodeling of pulmonary arterial hypertension (PAH) is characterized by an inappropriate increase of vascular cells. The receptor for advanced glycation end products (RAGE) is a type I single-pass transmembrane protein belonging to the immunoglobulin superfamily and is involved in a broad range of hyperproliferative diseases. RAGE is also implicated in the etiology of PAH and is overexpressed in pulmonary artery smooth muscle cells (PASMCs) in patients with PAH...
2018: PloS One
Morichika Takita, Fujiko Tsukahara, Taishi Mishima, Katsuaki Ieguchi, Masayuki Yamada, Hiroaki Honda, Yoshiro Maru
Chronic myeloid leukemia (CML) is believed to be caused by the tyrosine kinase p210BCR-ABL, which exhibits growth-promoting and anti-apoptotic activities. However, mechanisms that allow cell differentiation in CML still remain elusive. Here we established tetracycline (Tet)-regulatable p210BCR-ABL-expressing murine 32D myeloid progenitor (32D/TetOff-p210) cells to explore p210BCR-ABL-induced cell death and differentiation. Tet-regulatable overexpression of p210BCR-ABL induced cell death due to the activation of both caspase-1 and caspase-3, coincident with the differentiation from myeloid progenitors into CD11b+ Ly6C+ Ly6G+ cells with segmented nuclei, exemplified as granulocytic myeloid-derived suppressor cells (G-MDSC), and the ability to secrete IL-1β, TNF-α, and S100A8/A9 into the culture supernatant...
August 3, 2018: Oncotarget
Xuemei Jiang, Xiaohui Hao, Tao Wen, Yang Jin, Meng Sun, Hua Yang, Zongmei Wen
BACKGROUND Extracellular histones have recently been suggested as critical mediators in many inflammatory diseases. However, the role of extracellular histones in tuberculous pleural effusion (TPE) is unclear. The goal of this study was to explore the potential involvement of extracellular histones in patients with TPE. MATERIAL AND METHODS Samples of pleural effusion and peripheral blood were obtained from 58 patients with tuberculosis. Extracellular histones were determined in both TPE and serum samples. Moreover, the biomarkers for cellular damage, inflammatory cell activation, and systemic inflammation including lactate dehydrogenase (LDH), myeloperoxidase (MPO), S100A8/A9, as well as multiple inflammatory cytokines were measured...
August 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Maren Kasper, Karoline Walscheid, Björn Laffer, Dirk Bauer, Martin Busch, Lena Wildschütz, Bo Wang, Karin Loser, Thomas Vogl, Rafael S Grajewski, Thomas Langmann, Arnd Heiligenhaus
HLA-B27 is the allele most frequently associated with human anterior uveitis. The majority of HLA-B27-positive [acute anterior uveitis (AAU)] patients develop clinically distinct symptoms with acute symptomatic onset of flare and a recurrent disease course characterized by a massive cellular ocular infiltrate during uveitis relapse. By contrast, uveitis in HLA-B27-negative [idiopathic anterior uveitis (IAU)] patients tends to develop a clinically less fulminant, more chronic, and typically asymptomatic disease course...
2018: Frontiers in Immunology
Arash Forouzan, Kambiz Masoumi, Fakher Rahim, Meisam Moezzi, Ali Khavanin, Nastaran Ranjbari, Malehi Amal Saki, Amirali Fallah Amoli, Niloofar Akhiani, Fatemeh Ghourchian
Study Design: This study was performed to investigate the diagnostic values of some inflammatory biomarkers in abdominal pain. Methods: Patients over 18 years of age with acute recent abdominal pain who presented to the Emergency Department were evaluated. Serum and urinary samples were taken and evaluated for serum and urine S100A8/A9 and serum amyloid A. All patients were referred to a surgeon and were followed up until the final diagnosis. In the end, the final diagnosis was compared with the levels of biomarkers...
2018: Disease Markers
Hannah Trøstrup, Christian Johann Lerche, Lars Jackie Christophersen, Kim Thomsen, Peter Østrup Jensen, Hans Petter Hougen, Niels Høiby, Claus Moser
No abstract text is available yet for this article.
November 30, 2017: Pathogens and Disease
Chonggao Yin, Guoxin Zhang, Ruimei Sun, Xinting Pan, Xuewen Wang, Hongli Li, Yunbo Sun
In our previous study, advanced glycosylation end‑product specific receptor (RAGE) was observed to bind to S100A8/A9 and cause epithelial mesenchymal transition (EMT). The results from target gene prediction revealed that microRNA (miR)‑185‑5p had a RAGE binding site. However, the function of miR‑185‑5p in the invasion and migration of breast cancer remains ambiguous. In the present study, the expression of miR‑185‑5p was examined in breast cancer tissues and cells. Clinical features revealed a negative correlation between miR‑185‑5p and tumor size, as well as in tumor differentiation and lymph node metastasis in breast cancer...
September 2018: Molecular Medicine Reports
Ahoud A Jazzar, Penelope J Shirlaw, Guy H Carpenter, Stephen J Challacombe, Gordon B Proctor
BACKGROUND: Sjögren's syndrome (SS) is an autoimmune inflammatory disease that affects the exocrine glands. The absence of early diagnostic markers contributes to delays in its diagnosis. Identification of changes in the protein profile of saliva is considered one of the promising strategies for the discovery of new biomarkers for SS. OBJECTIVE: To identify salivary protein biomarkers with potential for use in discriminating between different lymphoma risk subgroups of SS...
July 12, 2018: Journal of Oral Pathology & Medicine
Sofia Björnfot Holmström, Ronaldo Lira-Junior, Stephanie Zwicker, Mirjam Majster, Anders Gustafsson, Sigvard Åkerman, Björn Klinge, Mattias Svensson, Elisabeth A Boström
Matrix metalloproteinase (MMP)-12, S100A8/A9, and S100A12 are involved in innate immune responses. We addressed whether different aspects of oral health and non-disease-related covariates influence their levels in saliva. 436 participants were clinically examined, completed a health questionnaire, and provided stimulated saliva. Salivary levels of MMP-12, S100A8/A9, and S100A12 were determined by enzyme-linked immunosorbent assays. Lower MMP-12 levels were observed in individuals 40-64 years old (yo) compared to < 40 yo, and higher S100A8/A9 levels were found in individuals > 64 yo compared to 40-64 yo...
July 5, 2018: Cytokine
Abhijit Basu, Saira Munir, Medanie A Mulaw, Karmveer Singh, Diana Crisan, Anca Sindrilaru, Nicolai Treiber, Meinhard Wlaschek, Markus Huber-Lang, Florian Gebhard, Karin Scharffetter-Kochanek
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
July 2, 2018: Scientific Reports
Valentina Giudice, Zhijie Wu, Sachiko Kajigaya, Maria Del Pilar Fernandez Ibanez, Olga Rios, Foo Cheung, Sawa Ito, Neal S Young
The alarmin family members S100A8 and S100A9 are acute phase inflammation proteins, but they also have been proposed as biomarkers in many malignant and non-malignant diseases. In this study, circulating S100A8 and S100A9 homodimers and S100A8/A9 heterodimers in plasma were systematically investigated by ELISA in aplastic anemia (AA) and myelodysplastic syndromes (MDS). Plasma was obtained from 58 severe AA (SAA) and 30 MDS patients, and from 47 age- and sex-matched healthy donors. In 40 out of the 58 AA subjects, S100A protein levels were measured before and 6 months after immunosuppressive therapy (IST)...
June 26, 2018: Cytokine
S Shi, J-L Yi
OBJECTIVE: Inflammation and extracellular matrix degradation play a role in cardiac rupture (CR) after myocardial infarction (MI). It has been found that the expression of inflammatory cytokine S100A8/A9 was elevated in acute MI patients, whereas its impact in CR after infarction remains unclear. PATIENTS AND METHODS: Samples from cardiac tissue and peripheral blood of patients with CR after MI, MI, patients without CR, and healthy control (cardiotrauma) were collected to test the expressions of S100A8/A9, p-p65, and MMP-9...
June 2018: European Review for Medical and Pharmacological Sciences
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