keyword
Keywords (Epigen* OR (Methyla* OR Methy...

(Epigen* OR (Methyla* OR Methylo*)) AND ((TBI OR Traumatic Brain Injur* OR Concuss*) OR (MDD OR Depress* OR Mood))

https://read.qxmd.com/read/38546891/an-emerging-role-for-enhancer-rnas-in-brain-disorders
#1
REVIEW
Ankit Patel, Ashutosh Dharap
Noncoding DNA undergoes widespread context-dependent transcription to produce noncoding RNAs. In recent decades, tremendous advances in genomics and transcriptomics have revealed important regulatory roles for noncoding DNA elements and the RNAs that they produce. Enhancers are one such element that are well-established drivers of gene expression changes in response to a variety of factors such as external stimuli, cellular responses, developmental cues, and disease states. They are known to act at long distances, interact with multiple target gene loci simultaneously, synergize with other enhancers, and associate with dynamic chromatin architectures to form a complex regulatory network...
March 28, 2024: Neuromolecular Medicine
https://read.qxmd.com/read/38542252/biomarkers-of-depression-among-adolescent-girls-bdnf-and-epigenetics
#2
JOURNAL ARTICLE
Weronika Zwolińska, Karolina Bilska, Kateryna Tarhonska, Edyta Reszka, Maria Skibińska, Natalia Pytlińska, Agnieszka Słopień, Monika Dmitrzak-Węglarz
Alterations in brain-derived neurotrophic factor (BDNF) expression have been suggested to mediate the influence of environmental factors on the emergence of depression through epigenetic modifications. However, research on this subject in the developmental population is lacking and the pathophysiology of adolescent depression remains unclear. We aimed to investigate the alterations in BDNF expression and global DNA methylation in depression among adolescent girls. Thirty female inpatients with the initial diagnosis of depression were assessed before and after the period of antidepressant treatment and compared with thirty age-matched healthy controls...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38536869/study-protocol-identifying-transcriptional-regulatory-alterations-of-chronic-effects-of-blast-and-disturbed-sleep-in-united-states-veterans
#3
JOURNAL ARTICLE
Molly J Sullan, Kelly A Stearns-Yoder, Zhaoyu Wang, Andrew J Hoisington, Adam D Bramoweth, Walter Carr, Yongchao Ge, Hanga Galfalvy, Fatemah Haghighi, Lisa A Brenner
Injury related to blast exposure dramatically rose during post-911 era military conflicts in Iraq and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries following blast, an exposure that may not result in a definitive physiologic marker (e.g., loss of consciousness). Recent research suggests that exposure to low level blasts and, more specifically repetitive blast exposure (RBE), which may be subconcussive in nature, may also impact long term physiologic and psychological outcomes, though findings have been mixed...
2024: PloS One
https://read.qxmd.com/read/38532543/rack1-promotes-autophagy-via-the-perk-signaling-pathway-to-protect-against-traumatic-brain-injury-in-rats
#4
JOURNAL ARTICLE
Haibo Ni, Xugang Kan, Qin Rui, Yang Zhang, Weiwei Zhai, Baole Zhang, Zhengquan Yu
AIMS: Neuronal cell death is a primary factor that determines the outcome after traumatic brain injury (TBI). We previously revealed the importance of receptor for activated C kinase (RACK1), a multifunctional scaffold protein, in maintaining neuronal survival after TBI, but the specific mechanism remains unclear. The aim of this study was to explore the mechanism underlying RACK1-mediated neuroprotection in TBI. METHODS: TBI model was established using controlled cortical impact injury in Sprague-Dawley rats...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38529858/-gender-characteristics-of-depressive-disorders-clinical-psychological-neurobiological-and-translational-aspects
#5
JOURNAL ARTICLE
A G Gersamia, K I Pochigaeva, Yu E Less, R G Akzhigitov, A B Guekht, N V Gulyaeva
Various studies have indicated that the prevalence of depression is almost twice as high among women as among men. A major factor associated with the development of depression and other affective disorders are adverse and psychologically traumatic life events that contribute to changes in the neuroendocrine system, altering the capacity to adapt to stress. These changes are involved in the pathogenesis of mental disorders, along with genetic and other factors, and are to a significant degree regulated by gender dependent mechanisms...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38523595/alcohol-drinking-dna-methylation-and-psychiatric-disorders-a-multi-omics-mendelian-randomization-study-to-investigate-causal-pathways
#6
JOURNAL ARTICLE
Xiaoqiang Shi, Meng Li, Jianhua Yao, Ming D Li, Zhongli Yang
BACKGROUND AND AIMS: Whether alcohol-related DNA methylation has a causal effect on psychiatric disorders has not been investigated. Furthermore, a comprehensive investigation into the causal relationship and underlying mechanisms linking alcohol consumption and psychiatric disorders has been lacking. This study aimed to evaluate the causal effect of general alcohol intake and pathological drinking behaviors on psychiatric disorders, alcohol-associated DNA methylation on gene expression and psychiatric disorders, and gene expression on psychiatric disorders...
March 25, 2024: Addiction
https://read.qxmd.com/read/38522151/group-differences-in-oxt-methylation-between-patients-with-major-depressive-disorder-and-healthy-controls-a-pre-registered-replication-study
#7
JOURNAL ARTICLE
Simon Sanwald, Christian Montag, Markus Kiefer
Depression is linked to stress which leaves traces in the epigenetic signature of genes. The oxytocin system is implicated in allostatic processes promoting adaption to environmental stressors. Interactions of the oxytocin system with the environment, e.g., methylation of the gene coding for oxytocin (OXT), are candidates for the investigation of the biological underpinnings of depression. Recently, we found hypomethylation of OXT in patients with Major Depressive Disorder (MDD) compared to healthy controls (HC)...
March 16, 2024: Psychiatry Research
https://read.qxmd.com/read/38519174/unlocking-the-power-of-lactoferrin-exploring-its-role-in-early-life-and-its-preventive-potential-for-adult-chronic-diseases
#8
REVIEW
Wenli Wang, Qin An, Kunlun Huang, Yunping Dai, Qingyong Meng, Yali Zhang
Nutrition during the early postnatal period exerts a profound impact on both infant development and later-life health. Breast milk, which contains lactoferrin, a dynamic protein, plays a crucial role in the growth of various biological systems and in preventing numerous chronic diseases. Based on the relationship between early infant development and chronic diseases later in life, this paper presents a review of the effects of lactoferrin in early life on neonates intestinal tract, immune system, nervous system, adipocyte development, and early intestinal microflora establishment, as well as the preventive and potential mechanisms of early postnatal lactoferrin against adult allergy, inflammatory bowel disease, depression, cancer, and obesity...
April 2024: Food Research International
https://read.qxmd.com/read/38519010/early-developmental-changes-in-a-rat-model-of-malformations-of-cortical-development-abnormal-neuronal-migration-and-altered-response-to-nmda-induced-excitotoxic-injury
#9
JOURNAL ARTICLE
Minyoung Lee, Eun-Jin Kim, Mi-Sun Yum
Malformations of cortical development (MCDs) are caused by abnormal neuronal migration processes during the fetal period and are a major cause of intractable epilepsy in infancy. However, the timing of hyperexcitability or epileptogenesis in MCDs remains unclear. To identify the early developmental changes in the brain of the MCD rat model, which exhibits increased seizure susceptibility during infancy (P12-15), we analyzed the pathological changes in the brains of MCD model rats during the neonatal period and tested NMDA-induced seizure susceptibility...
March 20, 2024: Experimental Neurology
https://read.qxmd.com/read/38500994/electroacupuncture-regulates-histone-acetylation-of-bcl-2-and-caspase-3-genes-to-improve-ischemic-stroke-injury
#10
JOURNAL ARTICLE
Lingling Meng, Bufan Wu, Ling OuYang, Rou Peng, Yonglin Chen, Zhijuan Tang, Min Zhang, Tanqing Xu, Yaling Wang, Shengfeng Lu, Xinyue Jing, Shuping Fu
BACKGROUND: Imbalances between Bcl-2 and caspase-3 are significant evidence of apoptosis, which is considered an influential factor in rapidly occurring neuronal cell death and the decline of neurological function after stroke. Studies have shown that acupuncture can reduce poststroke brain cell damage via either an increase in Bcl-2 or a reduction in caspase-3 exposure. The current study aimed to investigate whether acupuncture could modulate Bcl-2 and caspase-3 expression through histone acetylation modifications, which could potentially serve as a neuroprotective mechanism...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496252/wonder-symphony-epigenetics-and-the-enchantment-of-the-arts
#11
REVIEW
Marta Gallazzi, Marta Pizzolante, Elia Mario Biganzoli, Valentina Bollati
Epigenetics, the study of heritable changes in gene expression without altering the DNA sequence, has gained significant attention due to its implications for gene regulation and chromatin stability. Epigenetic mechanisms play a fundamental role in gene-environment interactions, shaping individual development and adaptation. DNA methylation, histone modifications, and non-coding RNAs are key epigenetic regulators. Epigenetic changes can be triggered by environmental factors, including stress, toxins, and social interactions, influencing health and well-being...
2024: Environmental Epigenetics
https://read.qxmd.com/read/38492365/total-paeony-glycoside-relieves-neuroinflammation-to-exert-antidepressant-effect-via-the-interplay-between-nlrp3-inflammasome-pyroptosis-and-autophagy
#12
JOURNAL ARTICLE
Lili Su, Haoyu Lu, Dongxue Zhang, Xiaoying Zhu, Jianming Li, Ying Zong, Yan Zhao, Zhongmei He, Weijia Chen, Rui Du
BACKGROUND: Depression is a common mental illness characterised by abnormal and depressed emotions. Total paeony glycoside (TPG) is a naturally active saponin extracted from the traditional Chinese medicine Radix Paeoniae rubra. However, the antidepressant and neuroinflammatory effects of TPG have not been thoroughly studied. PURPOSE: To study the therapeutic potential of TGP in depression caused by neuronal injury and neuroinflammation and to explore the mechanism of TGP and the relationship between the NLRP3 inflammasome, pyroptosis, and autophagy...
March 8, 2024: Phytomedicine
https://read.qxmd.com/read/38486962/brain-behavior-and-physiological-changes-associated-with-predator-stress-an-animal-model-for-trauma-exposure-in-adult-and-neonatal-rats
#13
JOURNAL ARTICLE
Stacey L Kigar, Amelia Cuarenta, Carla L Zuniga, Liza Chang, Anthony P Auger, Vaishali P Bakshi
The use of predators and predator odor as stressors is an important and ecologically relevant model for studying the impact of behavioral responses to threat. Here we summarize neural substrates and behavioral changes in rats resulting from predator exposure. We briefly define the impact predator exposure has on neural targets throughout development (neonatal, juvenile, and adulthood). These findings allow us to conceptualize the impact of predator exposure in the brain, which in turn may have broader implications for human disorders such as PTSD...
2024: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/38481632/reactive-gliosis-in-traumatic-brain-injury-a-comprehensive-review
#14
REVIEW
Zuzana Amlerova, Martina Chmelova, Miroslava Anderova, Lydia Vargova
Traumatic brain injury (TBI) is one of the most common pathological conditions impacting the central nervous system (CNS). A neurological deficit associated with TBI results from a complex of pathogenetic mechanisms including glutamate excitotoxicity, inflammation, demyelination, programmed cell death, or the development of edema. The critical components contributing to CNS response, damage control, and regeneration after TBI are glial cells-in reaction to tissue damage, their activation, hypertrophy, and proliferation occur, followed by the formation of a glial scar...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38479709/association-between-maternal-prenatal-depressive-symptoms-and-offspring-epigenetic-aging-at-3-5-weeks
#15
JOURNAL ARTICLE
Alonzo T Folger, Lili Ding, Kimberly Yolton, Robert T Ammerman, Hong Ji, Jennifer R Frey, Katherine A Bowers
Epigenetic clocks are emerging as tools for assessing acceleration and deceleration of biological age during childhood. Maternal depression during pregnancy may affect the biological aging of offspring and related development. In a low-income cohort of mother-child dyads, we investigated the relationship between prenatal maternal depressive symptoms and infant epigenetic age residuals, which represent the deviation (acceleration or deceleration) that exists between predicted biological age and chronological age...
March 11, 2024: Annals of Epidemiology
https://read.qxmd.com/read/38470558/sex-differences-in-stress-susceptibility-as-a-key-mechanism-underlying-depression-risk
#16
REVIEW
Summer Mengelkoch, George M Slavich
PURPOSE OF REVIEW: Although females are at relatively greater risk for a variety of disorders, including depression, the biological mechanisms underlying this striking health disparity remain unclear. To address this issue, we highlight sex differences in stress susceptibility as a key mechanism potentially driving this effect and describe the interacting inflammatory, hormonal, epigenomic, and social-environmental mechanisms involved. RECENT FINDINGS: Using the Social Signal Transduction Theory of Depression as a theoretical framework, women's elevated risk for depression may stem from a tight link between life stress, inflammation, and depression in women...
March 12, 2024: Current Psychiatry Reports
https://read.qxmd.com/read/38465865/m6a-reader-ythdc2-mediates-ncoa4-mrna-stability-affecting-ferritinophagy-to-alleviate-secondary-injury-after-intracerebral-haemorrhage
#17
JOURNAL ARTICLE
Fengfeng Li, Fang Wang, Lei Wang, Jianhua Wang, Shanshan Wei, Junjun Meng, Yanan Li, Lei Feng, Pei Jiang
Oxidative stress and neuronal dysfunction caused by intracerebral haemorrhage (ICH) can lead to secondary injury. The m6A modification has been implicated in the progression of ICH. This study aimed to investigate the role of the m6A reader YTHDC2 in ICH-induced secondary injury. ICH models were established in rats using autologous blood injection, and neuronal cell models were induced with Hemin. Experiments were conducted to overexpress YTH domain containing 2 (YTHDC2) and examine its effects on neuronal dysfunction, brain injury, and neuronal ferritinophagy...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/38453794/m6a-m1a-m5c-associated-methylation-alterations-and-immune-profile-in-mdd
#18
JOURNAL ARTICLE
Xin Ren, Zhuxiao Feng, Xiaodong Ma, Lijuan Huo, Huiying Zhou, Ayu Bai, Shujie Feng, Ying Zhou, Xuchu Weng, Changhe Fan
Major depressive disorder (MDD) is a prevalent psychiatric condition often accompanied by severe impairments in cognitive and functional capacities. This research was conducted to identify RNA modification-related gene signatures and associated functional pathways in MDD. Differentially expressed RNA modification-related genes in MDD were first identified. And a random forest model was developed and distinct RNA modification patterns were discerned based on signature genes. Then, comprehensive analyses of RNA modification-associated genes in MDD were performed, including functional analyses and immune cell infiltration...
March 8, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38446350/therapeutic-potential-of-saffron-in-brain-disorders-from-bench-to-bedside
#19
REVIEW
Erjola Bej, Anna Rita Volpe, Patrizia Cesare, Annamaria Cimini, Michele d'Angelo, Vanessa Castelli
Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders...
March 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38438062/sulforaphane-s-role-in-redefining-autophagic-responses-in-depression-associated-with-polycystic-ovarian-syndrome-unveiling-the-sirt1-ampk-lkb1-pathway-connection
#20
JOURNAL ARTICLE
Ahmed S Kamel, Sarah S El-Sayed, Nesrine S El Sayed
Polycystic ovarian syndrome (PCOS) has been associated with depression and suicidal ideations in females. Studies have highlighted the role of autophagic deficiency in depression pathogenesis. Sulforaphane (SFN) is a natural product that improved autophagic deficiency and showed antidepressant activity in depressed patients. Herein, the study aimed to evaluate the impact of using SFN on depression-associated with PCOS via hippocampal energy sensors and cellular bioenergetics. PCOS was induced by administering letrozole (1 mg/kg, p...
March 2, 2024: European Journal of Pharmacology
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