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https://www.readbyqxmd.com/read/30530993/transactivation-of-rage-mediates-angiotensin-induced-inflammation-and-atherogenesis
#1
Raelene J Pickering, Christos Tikellis, Carlos J Rosado, Despina Tsorotes, Alexandra Dimitropoulos, Monique Smith, Olivier Huet, Ruth M Seeber, Rekhati Abhayawardana, Elizabeth Km Johnstone, Jonathan Golledge, Yutang Wang, Karin A Jandeleit-Dahm, Mark E Cooper, Kevin Dg Pfleger, Merlin C Thomas
Activation of the type 1 angiotensin II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glycation endproducts (RAGE). Activation of the AT1 receptor by angiotensin II (Ang II) triggered transactivation of the cytosolic tail of RAGE and NF-κB-driven proinflammatory gene expression independently of the liberation of RAGE ligands or the ligand-binding ectodomain of RAGE...
December 10, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30521799/vascular-and-metabolic-profiles-in-offspring-born-to-pregnant-mice-with-metabolic-syndrome-treated-with-inositols
#2
Monica Longo, Mesk Alrais, Esther H Tamayo, Francesca Ferrari, Fabio Facchinetti, Jerrie S Refuerzo, Sean C Blackwell, Baha M Sibai
BACKGROUND: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype. OBJECTIVE: Our aim was to evaluate if INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS...
December 3, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30503839/resveratrol-ameliorates-endothelial-dysfunction-in-diabetic-and-obese-mice-through-sirtuin-1-and-peroxisome-proliferator-activated-receptor-%C3%AE
#3
Wai San Cheang, Wing Tak Wong, Li Wang, Chak Kwong Cheng, Chi Wai Lau, Ronald Chin Wan Ma, Aimin Xu, Nanping Wang, Yu Huang, Xiao Yu Tian
Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells in mouse models of diabetes. However, whether SIRT1 also plays a protective role in vascular dysfunction of diabetic and obese mice is not fully characterized. Previous work showed that peroxisome proliferator-activated receptor δ (PPARδ) is beneficial in diabetic vascular dysfunction. Whether PPARδ is involved in the beneficial effect of SIRT1 on vascular endothelial function is unknown...
November 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30495987/elevating-atp-binding-cassette-transporter-g1-improves-re-endothelialization-function-of-endothelial-progenitor-cells-via-lyn-akt-enos-in-diabetic-mice
#4
Ying Shi, Xue Lv, Yanan Liu, Bochuan Li, Mingming Liu, Meng Yan, Yajin Liu, Qi Li, Xuejiao Zhang, Shuang He, Mason Zhu, Jinlong He, Yan Zhu, Yi Zhu, Ding Ai
Endothelial progenitor cell (EPC) dysfunction contributes to diabetes-induced delay in endothelium repair after vessel injury, prominently associated with diabetic cardiovascular complications such as neointima formation. ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux to HDL, which may favorably affect EPC function. However, whether ABCG1 improves EPC function, especially in diabetes, remains unknown. Here we investigated the role of ABCG1 in EPCs by using Tie2-mediated ABCG1 transgenic (Tie2- ABCG1Tg ) mice...
December 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30477148/vascular-plant-one-zinc-finger-voz-transcription-factors-are-positive-regulators-of-salt-tolerance-in-arabidopsis
#5
Kasavajhala V S K Prasad, Denghui Xing, Anireddy S N Reddy
Soil salinity, a significant problem in agriculture, severely limits the productivity of crop plants. Plants respond to and cope with salt stress by reprogramming gene expression via multiple signaling pathways that converge on transcription factors. To develop strategies to generate salt-tolerant crops, it is necessary to identify transcription factors that modulate salt stress responses in plants. In this study, we investigated the role of VOZ (VASCULAR PLANT ONE-ZINC FINGER PROTEIN) transcription factors (VOZs) in salt stress response...
November 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30470918/lack-of-thiazide-diuretic-inhibition-of-agonist-constriction-of-mouse-mesenteric-arterioles-ex-vivo
#6
Robert M Rapoport, Amanda J LeBlanc, Jason E Beare, Manoocher Soleimani
The chronic reduction of arterial blood pressure by thiazide diuretics (TZD) in hypertensive patients is mediated through an extra-renal mechanism. It is widely held that this extra-renal mechanism is a direct TZD inhibition of vasoconstriction. This study tested whether the TZD, hydrochlorothiazide (HCTZ), inhibited agonist constriction of mesenteric arterioles ex vivo. Mice deficient in the kidney distal convoluted tubule Na+ /Cl- cotransporter (NCC), i.e., the target of thiazide inhibition-mediated diuresis, and wild type (WT), were subjected to Na+ -restricted diet...
November 23, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/30463256/endothelial-microsomal-prostaglandin-e-synthetase-1-upregulates-vascularity-and-endothelial-interleukin-1%C3%AE-in-deteriorative-progression-of-experimental-autoimmune-encephalomyelitis
#7
Takako Takemiya, Marumi Kawakami, Chisen Takeuchi
Microsomal prostaglandin E synthetase-1 (mPGES-1) is an inducible terminal enzyme for the production of prostaglandin E₂ (PGE₂). In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, mPGES-1 is induced in vascular endothelial cells (VECs) around inflammatory foci and facilitates inflammation, demyelination, and paralysis. Therefore, we investigated the role of CD31-positive VECs in mPGES-1-mediated EAE aggravation using immunohistochemical analysis and imaging of wild-type (wt) and mPGES - 1 -deficient ( mPGES-1 -/- ) mice...
November 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30452888/small-molecule-inhibition-of-dipeptidyl-peptidase-4-enhances-bone-marrow-progenitor-cell-function-and-angiogenesis-in-diabetic-wounds
#8
Alexander J Whittam, Zeshaan N Maan, Dominik Duscher, Janos A Barrera, Michael S Hu, Lauren H Fischer, Sacha Khong, Sun Hyung Kwon, Victor W Wong, Graham G Walmsley, Ferdinando Giacco, Michael Januszyk, Michael Brownlee, Michael T Longaker, Geoffrey C Gurtner
In diabetes, stromal cell-derived factor-1 (SDF-1) expression and progenitor cell recruitment are reduced. Dipeptidyl peptidase-4 (DPP-4) inhibits SDF-1 expression and progenitor cell recruitment. Here we examined the impact of the DPP-4 inhibitor, MK0626, on progenitor cell kinetics in the context of wound healing. Wildtype (WT) murine fibroblasts cultured under high-glucose to reproduce a diabetic microenvironment were exposed to MK0626, glipizide, or no treatment, and SDF-1 expression was measured with ELISA...
November 2, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/30381843/validation-of-chemical-genetics-for-the-study-of-zipper-interacting-protein-kinase-signaling
#9
Abdulhameed Al-Ghabkari, Lori D Moffat, Michael P Walsh, Justin A MacDonald
Zipper-interacting protein kinase (ZIPK) is a Ser/Thr kinase that mediates a variety of cellular functions. Analogue-sensitive kinase technology was applied to the study of ZIPK signaling in coronary artery smooth muscle cells. ZIPK was engineered in the ATP-binding pocket by substitution of a bulky gatekeeper amino acid (Leu93) with glycine. Cell-permeable derivatives of pyrazolo[3,4-d]pyrimidine provided effective inhibition of L93G-ZIPK (1NM-PP1, IC50 , 1.0 μM; 3MB-PP1, IC50 , 2.0 μM; and 1NA-PP1, IC50 , 8...
November 1, 2018: Proteins
https://www.readbyqxmd.com/read/30375081/organ-blood-flow-and-o-2-transport-during-hypothermia-27%C3%A2-c-and-rewarming-in-a-pig-model
#10
Sergei Valkov, Rizwan Mohyuddin, Jan Harald Nilsen, Torstein Schanche, Timofey Kondratiev, Gary C Sieck, Torkjel Tveita
NEW FINDINGS: What is the central question of this study? Absence of hypothermia-induced cardiac arrest is a strong predictor for a favorable outcome after rewarming. Nevertheless, detailed knowledge of preferences in organ blood flow during rewarming with spontaneous circulation is largely unknown. What is the main finding and its importance? In a porcine model of accidental hypothermia, we find, despite a significantly reduced cardiac output during rewarming, normal blood flow and O2 supply in vital organs due to patency of adequate physiologic compensatory responses...
October 29, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30372741/spontaneous-posterior-segment-vascular-disease-phenotype-of-a-mouse-model-rnv3-is-dependent-on-the-crb1rd8-allele
#11
Bo Chang, Bernard FitzMaurice, Jieping Wang, Benjamin E Low, Michael V Wiles, Patsy M Nishina
Purpose: To determine the molecular basis of lesion development in a murine model of spontaneous retinal vascularization, rnv3 (retinal vascularization 3, aka JR5558). Methods: Disease progression of rnv3 was examined in longitudinal studies by clinical evaluation, electroretinography (ERG) and light microscopy analyses. The chromosomal position for the recessive rnv3 mutation was determined by DNA pooling and genome-wide linkage analysis. The causative mutation was discovered by comparison of whole exome sequences of rnv3 mutant and wild-type (WT) controls...
October 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30355234/generation-of-cardiomyocytes-from-vascular-adventitia-resident-stem-cells
#12
Subba Rao Mekala, Philipp Wörsdörfer, Jochen Bauer, Olga Stoll, Nicole Wagner, Laurens Reeh, Kornelia Loew, Georg Eckner, Chee Keong Kwok, Erhard Wischmeyer, Mary Eleanor Dickinson, Harald Schulze, David Stegner, Ralf A Benndorf, Frank Edenhofer, Verena Pfeiffer, Stefanie Kuerten, Stefan Frantz, Süleyman Ergün
RATIONALE: Regeneration of lost cardiomyocytes is a fundamental unresolved problem leading to heart failure. Despite several strategies developed from intensive studies performed in the past decades, endogenous regeneration of heart tissue is still limited and presents a big challenge that needs to be overcome to serve as a successful therapeutic option for myocardial infarction. OBJECTIVE: One of the essential prerequisites for cardiac regeneration is the identification of endogenous cardiomyocyte progenitors and their niche that can be targeted by new therapeutic approaches...
August 31, 2018: Circulation Research
https://www.readbyqxmd.com/read/30355157/response-gene-to-complement-32-maintains-blood-pressure-homeostasis-by-regulating-%C3%AE-adrenergic-receptor-expression
#13
Jun-Ming Tang, Ning Shi, Kun Dong, Scott A Brown, Amanda E Coleman, Matthew A Boegehold, Shi-You Chen
RATIONALE: Hypertension prevalence is much higher among children and adolescents with low birth weight and greater postnatal weight gain than in individuals with normal birth weight. However, the cause and molecular mechanisms underlying this complication remain largely unknown. Our previous studies have shown that RGC-32 (response gene to complement 32)-deficient (RGC-32-/- ) mice are born significantly smaller but grow faster than their WT (wild type) controls, which allows adult RGC-32-/- mice to attain body weights similar to those of control mice...
October 12, 2018: Circulation Research
https://www.readbyqxmd.com/read/30347179/a-long-term-treatment-with-taurine-prevents-cardiac-dysfunction-in-mdx-mice
#14
Antonietta Mele, Paola Mantuano, Michela De Bellis, Francesco Rana, Francesca Sanarica, Elena Conte, Maria Grazia Morgese, Maria Bove, Jean-Francois Rolland, Roberta Francesca Capogrosso, Sabata Pierno, Giulia Maria Camerino, Luigia Trabace, Annamaria De Luca
Taurine is an amino acid abundantly present in heart and skeletal muscle. Duchenne muscular dystrophy (DMD) is a genetic disorder in which the absence of dystrophin leads to skeletal muscle wasting and heart failure. An altered taurine metabolism has been described in dystrophic animals and short-term taurine administration exerts promising amelioration of early muscular alterations in the mdx mouse model of DMD. To reinforce the therapeutic and nutraceutical taurine potential in DMD, we evaluated the effects of a long-term treatment on cardiac and skeletal muscle function of mdx mice in a later disease stage...
September 28, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/30343562/the-kv7-channel-activator-retigabine-induces-vasorelaxation-via-an-endothelial-independent-pathway-in-male-mouse-aorta
#15
Hyun Namgoong, Chaeeun Cho, Sewon Lee
PURPOSE: Previous studies have indicated that Kv7 channels have an important role in the regulation of blood vessel reactivity, including in the coronary, renal, and cerebral arteries. The present studies examined whether Kv7 channels regulated vascular reactivity in the mouse aorta and investigated the mechanisms involved in the reactivity. METHODS: Wild-type (WT) male C57BL/6 mice, between 10 and 15 weeks old, were used in this study. The vascular function of the aorta in WT male mice was assessed by using a pin myography system (Model 620; DMT, Denmark)...
September 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/30342159/methylglyoxal-accumulation-de-regulates-hoxa5-expression-thereby-impairing-angiogenesis-in-glyoxalase-1-knock-down-mouse-aortic-endothelial-cells
#16
Cecilia Nigro, Alessia Leone, Michele Longo, Immacolata Prevenzano, Thomas H Fleming, Antonella Nicolò, Luca Parrillo, Rosa Spinelli, Pietro Formisano, Peter P Nawroth, Francesco Beguinot, Claudia Miele
Impaired angiogenesis leads to long-term complications and is a major contributor of the high morbidity in patients with Diabetes Mellitus (DM). Methylglyoxal (MGO) is a glycolysis byproduct that accumulates in DM and is detoxified by the Glyoxalase 1 (Glo1). Several studies suggest that MGO contributes to vascular complications through mechanisms that remain to be elucidated. In this study we have clarified for the first time the molecular mechanism involved in the impairment of angiogenesis induced by MGO accumulation...
October 18, 2018: Biochimica et biophysica acta. Molecular basis of disease
https://www.readbyqxmd.com/read/30337301/infused-wild-type-macrophages-reside-and-self-renew-in-the-liver-to-rescue-the-hemolysis-and-anemia-of-hmox1-deficient-mice
#17
Ki Soon Kim, De-Liang Zhang, Gennadiy Kovtunovych, Manik C Ghosh, Hayden Ollivierre, Michael A Eckhaus, Tracey A Rouault
Heme oxygenase 1 (HMOX1), the inducible enzyme that catabolizes the degradation of heme into biliverdin, iron, and carbon monoxide, plays an essential role in the clearance of senescent and damaged red blood cells, systemic iron homeostasis, erythropoiesis, vascular hemostasis, and oxidative and inflammatory stress responses. In humans, HMOX1 deficiency causes a rare and lethal disease, characterized by severe anemia, intravascular hemolysis, as well as vascular and tissue damage. Hmox1 knockout (KO) mice recapitulated the phenotypes of HMOX1-deficiency patients and could be rescued by bone marrow (BM) transplantation that engrafted donor's hematopoietic stem cells into the recipient animals after myeloablation...
October 23, 2018: Blood Advances
https://www.readbyqxmd.com/read/30336142/brg1-trans-activates-endothelium-derived-colony-stimulating-factor-to-promote-calcium-chloride-induced-abdominal-aortic-aneurysm-in-mice
#18
Xinjian Zhang, Shuai Liu, Xinyu Weng, Teng Wu, Liming Yu, Yong Xu, Junli Guo
Endothelial cell derived secretive factors play pivotal roles maintaining the homeostasis by influencing the behaviors of other cells. When dysregulated, these factors may contribute to the disruption of physiological integrity and promote disease genesis in a number of different tissues and organs. In the present study we investigated how targeted deletion of brahma related gene 1 (Brg1), a chromatin remodeling protein, in endothelium might affect the pathogenesis of abdominal aortic aneurysm (AAA) induced by calcium chloride (CaCl2 )...
October 16, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/30327711/curcumin-inhibits-acute-vascular-inflammation-through-the-activation-of-heme-oxygenase-1
#19
Yunjun Xiao, Junjie Xia, Shuang Wu, Ziquan Lv, Suli Huang, Haiyan Huang, Xuefen Su, Jinquan Cheng, Yuebin Ke
Curcumin has several therapeutic properties such as anti-inflammatory effect. Heme oxygenase-1 (HO-1) has been showed to have cytoprotective effects in some pathological conditions. However, the role of HO-1 in anti-inflammatory effect of curcumin is unknown. In this study, we investigate whether the anti-inflammatory effect of curcumin in vascular may be involved in the activation of HO-1. New Zealand white rabbits were fed regular control diet or control diet added with 0.3% curcumin (wt/wt) for four weeks...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30296361/preparation-of-self-regulating-anti-adhesive-hydrogels-and-their-ability-to-promote-healing-in-burn-wounds
#20
Min Liang, Zhongmin Chen, Fuping Wang, Lan Liu, Runan Wei, Mei Zhang
Few burn dressings can self-regulate the optimal humidity levels that are required for wound healing, while also providing good anti-adhesive properties to prevent damage that can occur when wound dressings are changed. Consequently, a water-soluble carboxymethylcellulose sodium/sodium alginate/chitosan (CMC-Na/SA/CS) composite hydrogel has been developed as a potential burn wound dressing, with orthogonal testing revealing an optimal ratio of CMC-Na, SA, and CS as 2, 3, and 1 wt % for hydrogel preparation, respectively...
October 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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