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https://www.readbyqxmd.com/read/28350790/use-of-common-analgesic-medications-and-ovarian-cancer-survival-results-from-a-pooled-analysis-in-the-ovarian-cancer-association-consortium
#1
Suzanne C Dixon, Christina M Nagle, Nicolas Wentzensen, Britton Trabert, Alicia Beeghly-Fadiel, Joellen M Schildkraut, Kirsten B Moysich, Anna deFazio, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Marc T Goodman, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Allan Jensen, Susanne K Kjær, Estrid Høgdall, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Elizabeth M Poole, Elisa V Bandera, Lisa E Paddock, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Celeste Leigh Pearce, Anna H Wu, Malcolm C Pike, Penelope M Webb
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths)...
March 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28342541/continuous-gradient-temperature-raman-spectroscopy-and-differential-scanning-calorimetry-of-n-3dpa-and-dha-from-100-to-10%C3%A2-c
#2
C Leigh Broadhurst, Walter F Schmidt, Julie K Nguyen, Jianwei Qin, Kuanglin Chao, Steven R Aubuchon, Moon S Kim
Docosahexaenoic acid (DHA, 22:6n-3) is exclusively utilized in fast signal processing tissues such as retinal, neural and cardiac. N-3 docosapentaenoic acid (n-3DPA, 22:5n-3), with just one less double bond, is also found in the marine food chain yet cannot substitute for DHA. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions...
March 22, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28339721/analysis-of-professional-competencies-for-the-clinical-research-data-management-profession-implications-for-training-and-professional-certification
#3
Meredith N Zozus, Angel Lazarov, Leigh R Smith, Tim E Breen, Susan L Krikorian, Patrick S Zbyszewski, Shelly K Knoll, Debra A Jendrasek, Derek C Perrin, Demetris N Zambas, Tremaine B Williams, Carl F Pieper
Objective: : To assess and refine competencies for the clinical research data management profession. Materials and Methods: : Based on prior work developing and maintaining a practice standard and professional certification exam, a survey was administered to a captive group of clinical research data managers to assess professional competencies, types of data managed, types of studies supported, and necessary foundational knowledge. Results: : Respondents confirmed a set of 91 professional competencies...
February 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28336097/ranking-current-and-prospective-no2-pollution-mitigation-strategies-an-environmental-and-economic-modelling-investigation-in-oxford-street-london
#4
A P R Jeanjean, J Gallagher, P S Monks, R J Leigh
Air pollution continues to be a problem in the urban environment. A range of different pollutant mitigation strategies that promote dispersion and deposition exist, but there is little evidence with respect to their comparative performance from both an environmental and economic perspective. This paper focuses on examining different NO2 mitigation strategies such as trees, buildings facades coated with photocatalytic paint and solid barriers in Oxford Street in London. The case study findings will support ranking the environmental and economic impacts of these different strategies to improve personal exposure conditions on the footpath and on the road in a real urban street canyon...
March 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28291497/variation-in-postinjury-antibiotic-prophylaxis-patterns-over-five-years-in-a-combat-zone
#5
Bradley A Lloyd, Clinton K Murray, William Bradley, Faraz Shaikh, Deepak Aggarwal, M Leigh Carson, David R Tribble
In 2008, a clinical practice guideline (CPG) was developed for the prevention of infections among combat casualties and was later revised in 2011. We evaluated utilization of antimicrobials within 48 hours following injury in the combat zone over a 5-year period (June 2009 through May 2014) with regard to number of regimens, type of antimicrobial, and adherence to the 2011 CPG. The study population consisted of 5,196 wounded military personnel. Open fractures and skin and soft-tissue injuries were the most frequent injuries...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28286237/retrospectively-supervised-click-decoder-calibration-for-self-calibrating-point-and-click-brain-computer-interfaces
#6
Beata Jarosiewicz, Anish A Sarma, Jad Saab, Brian Franco, Sydney S Cash, Emad N Eskandar, Leigh R Hochberg
Brain-computer interfaces (BCIs) aim to restore independence to people with severe motor disabilities by allowing control of acursor on a computer screen or other effectors with neural activity. However, physiological and/or recording-related nonstationarities in neural signals can limit long-term decoding stability, and it would be tedious for users to pause use of the BCI whenever neural control degrades to perform decoder recalibration routines. We recently demonstrated that a kinematic decoder (i.e. a decoder that controls cursor movement) can be recalibrated using data acquired during practical point-and-click control of the BCI by retrospectively inferring users' intended movement directions based on their subsequent selections...
March 8, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28285121/a-novel-rehabilitation-intervention-for%C3%A2-older-patients-with-acute-decompensated%C3%A2-heart-failure-the-rehab-hf-pilot-study
#7
Gordon R Reeves, David J Whellan, Christopher M O'Connor, Pamela Duncan, Joel D Eggebeen, Timothy M Morgan, Leigh Ann Hewston, Amy Pastva, Mahesh J Patel, Dalane W Kitzman
OBJECTIVES: This study sought to assess a novel physical rehabilitation intervention in older patients hospitalized for acute decompensated heart failure (ADHF). BACKGROUND: After ADHF, older patients, who are frequently frail with multiple comorbidities, have prolonged and incomplete recovery of physical function and remain at high risk for poor outcomes. METHODS: The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) pilot study was a 3-site, randomized, attention-controlled pilot study of a tailored, progressive, multidomain physical rehabilitation intervention beginning in the hospital and continuing for 12 weeks post-discharge in patients ≥60 years hospitalized with ADHF...
March 5, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28278476/review-human-intracortical-recording-and-neural-decoding-for-brain-computer-interfaces
#8
David M Brandman, Sydney S Cash, Leigh R Hochberg
Brain Computer Interfaces (BCIs) use neural information recorded from the brain for voluntary control of external devices. The development of BCI systems has largely focused on improving functional independence for individuals with severe motor impairments, including providing tools for communication and mobility. In this review, we describe recent advances in intracortical BCI technology and provide potential directions for further research.
March 2, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28269702/predicting-seizures-from-local-field-potentials-recorded-via-intracortical-microelectrode-arrays
#9
Mehdi Aghagolzadeh, Leigh R Hochberg, Sydney S Cash, Wilson Truccolo
The need for new therapeutic interventions to treat pharmacologically resistant focal epileptic seizures has led recently to the development of closed-loop systems for seizure control. Once a seizure is predicted/detected by the system, electrical stimulation is delivered to prevent seizure initiation or spread. So far, seizure prediction/detection has been limited to tracking non-invasive electroencephalogram (EEG) or intracranial EEG (iEEG) signals. Here, we examine seizure prediction based on local field potentials (LFPs) from a small neocortical patch recorded via a 10×10 microelectrode array implanted in a patient with focal seizures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267466/rehabilitation-therapy-in-older-acute-heart-failure-patients-rehab-hf-trial-design-and-rationale
#10
Gordon R Reeves, David J Whellan, Pamela Duncan, Christopher M O'Connor, Amy M Pastva, Joel D Eggebeen, Leigh Ann Hewston, Timothy M Morgan, Shelby D Reed, W Jack Rejeski, Robert J Mentz, Paul B Rosenberg, Dalane W Kitzman
BACKGROUND: Acute decompensated heart failure (ADHF) is a leading cause of hospitalization in older persons in the United States. Reduced physical function and frailty are major determinants of adverse outcomes in older patients with hospitalized ADHF. However, these are not addressed by current heart failure (HF) management strategies and there has been little study of exercise training in older, frail HF patients with recent ADHF. HYPOTHESIS: Targeting physical frailty with a multi-domain structured physical rehabilitation intervention will improve physical function and reduce adverse outcomes among older patients experiencing a HF hospitalization...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28246220/validation-of-a-health-related-quality-of-life-instrument-for-primary-ciliary-dyskinesia-qol-pcd
#11
Laura Behan, Margaret W Leigh, Sharon D Dell, Audrey Dunn Galvin, Alexandra L Quittner, Jane S Lucas
BACKGROUND: Quality of life (QOL)-primary ciliary dyskinesia (PCD) is the first disease-specific, health-related QOL instrument for PCD. Psychometric validation of QOL-PCD assesses the performance of this measure in adults, including its reliability, validity and responsiveness to change. METHODS: Seventy-two adults (mean (range) age: 33 years (18-79 years); mean (range) FEV1% predicted: 68 (26-115)) with PCD completed the 49-item QOL-PCD and generic QOL measures: Short-Form 36 Health Survey, Sino-Nasal Outcome Test 20 (SNOT-20) and St George Respiratory Questionnaire (SGRQ)-C...
February 28, 2017: Thorax
https://www.readbyqxmd.com/read/28244437/a-novel-molten-salt-electrochemical-cell-for-investigating%C3%A2-the-reduction-of-uranium-dioxide-to-uranium-metal-by-lithium-using-in-situ-synchrotron-radiation
#12
Leon D Brown, Rema Abdulaziz, Rhodri Jervis, Vidal Bharath, Thomas J Mason, Robert C Atwood, Christina Reinhard, Leigh D Connor, Douglas Inman, Daniel J L Brett, Paul R Shearing
A novel electrochemical cell has been designed and built to allow for in situ energy-dispersive X-ray diffraction measurements to be made during reduction of UO2 to U metal in LiCl-KCl at 500°C. The electrochemical cell contains a recessed well at the bottom of the cell into which the working electrode sits, reducing the beam path for the X-rays through the molten-salt and maximizing the signal-to-noise ratio from the sample. Lithium metal was electrodeposited onto the UO2 working electrode by exposing the working electrode to more negative potentials than the Li deposition potential of the LiCl-KCl eutectic electrolyte...
March 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28242733/ocular-stability-and-set-point-adaptation
#13
REVIEW
D S Zee, P Jareonsettasin, R J Leigh
A fundamental challenge to the brain is how to prevent intrusive movements when quiet is needed. Unwanted limb movements such as tremor impair fine motor control and unwanted eye drifts such as nystagmus impair vision. A stable platform is also necessary to launch accurate movements. Accordingly, nature has designed control systems with agonist (excitation) and antagonist (inhibition) muscle pairs functioning in push-pull, around a steady level of balanced tonic activity, the set-point Sensory information can be organized similarly, as in the vestibulo-ocular reflex, which generates eye movements that compensate for head movements...
April 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28227963/predicting-seizures-from-local-field-potentials-recorded-via-intracortical-microelectrode-arrays
#14
Mehdi Aghagolzadeh, Leigh R Hochberg, Sydney S Cash, Wilson Truccolo, Mehdi Aghagolzadeh, Leigh R Hochberg, Sydney S Cash, Wilson Truccolo, Sydney S Cash, Wilson Truccolo, Mehdi Aghagolzadeh, Leigh R Hochberg
The need for new therapeutic interventions to treat pharmacologically resistant focal epileptic seizures has led recently to the development of closed-loop systems for seizure control. Once a seizure is predicted/detected by the system, electrical stimulation is delivered to prevent seizure initiation or spread. So far, seizure prediction/detection has been limited to tracking non-invasive electroencephalogram (EEG) or intracranial EEG (iEEG) signals. Here, we examine seizure prediction based on local field potentials (LFPs) from a small neocortical patch recorded via a 10×10 microelectrode array implanted in a patient with focal seizures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220753/high-performance-communication-by-people-with-paralysis-using-an-intracortical-brain-computer-interface
#15
Chethan Pandarinath, Paul Nuyujukian, Christine H Blabe, Brittany L Sorice, Jad Saab, Francis R Willett, Leigh R Hochberg, Krishna V Shenoy, Jaimie M Henderson
Brain-computer interfaces (BCIs) have the potential to restore communication for people with tetraplegia and anarthria by translating neural activity into control signals for assistive communication devices. While previous pre-clinical and clinical studies have demonstrated promising proofs-of-concept (Serruya et al., 2002; Simeral et al., 2011; Bacher et al., 2015; Nuyujukian et al., 2015; Aflalo et al., 2015; Gilja et al., 2015; Jarosiewicz et al., 2015; Wolpaw et al., 1998; Hwang et al., 2012; Spüler et al...
February 21, 2017: ELife
https://www.readbyqxmd.com/read/28207158/integration-of-chlorophyll-a-fluorescence-and-photorespirometry-techniques-to-understand-production-dynamics-in-macroaglal-communities
#16
REVIEW
Leigh W Tait, Ian Hawes, David R Schiel
Global declines of macroalgal beds in coastal waters have prompted a plethora of studies attempting to understand the drivers of change within dynamic nearshore ecosystems. Photosynthetic measurements are good tools for assessing the consequences of numerous stressors of macroalgae, but there is somewhat of a disconnection between studies that focus on organism-specific ecophysiological responses and those that address causes and consequences of shifts in macroalgal productivity. Our goal is to highlight the applications of two complementary tools for measuring photosynthesis-variable chlorophyll a fluorescence and photorespirometry-and provide guidance for the integration of physiology and ecology to understand the drivers of change in macroalgal communities...
February 16, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28178762/pet-trumps-surgical-staging-in-locally-advanced-cervical-cancer
#17
Leigh A Cantrell, Linda R Duska
Locally advanced cervical cancer (LACC) is a significant problem. The status of the para-aortic lymph nodes (PALN) in women with LACC is critical, as positive PALN dictate extended radiation fields and portend a dismal prognosis. Since 10-25% of women with LACC will have PALN metastases (S Gout, et al. Lancet Oncol 13(5) 2012), the ideal method to identify and treat them is paramount. This article is protected by copyright. All rights reserved.
February 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28177925/signal-independent-noise-in-intracortical-brain-computer-interfaces-causes-movement-time-properties-inconsistent-with-fitts-law
#18
Francis R Willett, Brian A Murphy, William D Memberg, Christine H Blabe, Chethan Pandarinath, Benjamin L Walter, Jennifer A Sweet, Jonathan P Miller, Jaimie M Henderson, Krishna V Shenoy, Leigh R Hochberg, Robert F Kirsch, A Bolu Ajiboye
OBJECTIVE: Do movements made with an intracortical BCI (iBCI) have the same movement time properties as able-bodied movements? Able-bodied movement times typically obey Fitts' law: [Formula: see text] (where MT is movement time, D is target distance, R is target radius, and [Formula: see text] are parameters). Fitts' law expresses two properties of natural movement that would be ideal for iBCIs to restore: (1) that movement times are insensitive to the absolute scale of the task (since movement time depends only on the ratio [Formula: see text]) and (2) that movements have a large dynamic range of accuracy (since movement time is logarithmically proportional to [Formula: see text])...
April 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28158489/validation-of-non-invasive-central-blood-pressure-devices-artery-society-task-force-consensus-statement-on-protocol-standardization
#19
James E Sharman, Alberto P Avolio, Johannes Baulmann, Athanase Benetos, Jacques Blacher, C Leigh Blizzard, Pierre Boutouyrie, Chen-Huan Chen, Phil Chowienczyk, John R Cockcroft, J Kennedy Cruickshank, Isabel Ferreira, Lorenzo Ghiadoni, Alun Hughes, Piotr Jankowski, Stephane Laurent, Barry J McDonnell, Carmel McEniery, Sandrine C Millasseau, Theodoros G Papaioannou, Gianfranco Parati, Jeong Bae Park, Athanase D Protogerou, Mary J Roman, Giuseppe Schillaci, Patrick Segers, George S Stergiou, Hirofumi Tomiyama, Raymond R Townsend, Luc M Van Bortel, Jiguang Wang, Siegfried Wassertheurer, Thomas Weber, Ian B Wilkinson, Charalambos Vlachopoulos
No abstract text is available yet for this article.
January 30, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28158183/beyond-the-mhc-a-canine-model-of-dermatomyositis-shows-a-complex-pattern-of-genetic-risk-involving-novel-loci
#20
Jacquelyn M Evans, Rooksana E Noorai, Kate L Tsai, Alison N Starr-Moss, Cody M Hill, Kendall J Anderson, Thomas R Famula, Leigh Anne Clark
Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression...
February 2017: PLoS Genetics
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