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https://www.readbyqxmd.com/read/28539510/sexual-conflict-and-correlated-evolution-between-male-persistence-and-female-resistance-traits-in-the-seed-beetle-callosobruchus-maculatus
#1
Liam R Dougherty, Emile van Lieshout, Kathryn B McNamara, Joe A Moschilla, Göran Arnqvist, Leigh W Simmons
Traumatic mating (or copulatory wounding) is an extreme form of sexual conflict whereby male genitalia physically harm females during mating. In such species females are expected to evolve counter-adaptations to reduce male-induced harm. Importantly, female counter-adaptations may include both genital and non-genital traits. In this study, we examine evolutionary associations between harmful male genital morphology and female reproductive tract morphology and immune function across 13 populations of the seed beetle Callosobruchus maculatus We detected positive correlated evolution between the injuriousness of male genitalia and putative female resistance adaptations across populations...
May 31, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28539185/frequency-of-untreated-hypogammaglobulinemia-in-bronchiectasis
#2
Melanie A Ruffner, Timothy R Aksamit, Byron Thomashow, Radmila Choate, Angela DiMango, Gerard M Turino, Anne E O'Donnell, Margaret M Johnson, Kenneth N Olivier, Kevin Fennelly, Charles L Daley, Kevin L Winthrop, Mark L Metersky, Matthias A Salathe, Michael R Knowles, M Leigh Anne Daniels, Peadar G Noone, Gregory Tino, David E Griffith, Kathleen E Sullivan
No abstract text is available yet for this article.
May 20, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28517366/genie-in-a-blotter-a-comparative-study-of-lsd-and-lsd-analogues-effects-and-user-profile
#3
Leigh D Coney, Larissa J Maier, Jason A Ferris, Adam R Winstock, Monica J Barratt
OBJECTIVE: This study aimed to describe self-reported patterns of use and effects of lysergic acid diethylamide (LSD) analogues (AL-LAD, 1P-LSD, and ETH-LAD) and the characteristics of those who use them. METHODS: An anonymous self-selected online survey of people who use drugs (Global Drug Survey 2016; N = 96,894), which measured perceived drug effects of LSD and its analogues. RESULTS: Most LSD analogue users (91%) had also tried LSD. The proportion of U...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28505188/early-childhood-lung-function-is-a-stronger-predictor-of-adolescent-lung-function-in-cystic-fibrosis-than-early-pseudomonas-aeruginosa-infection
#4
Jessica E Pittman, Hannah Noah, Hollin E Calloway, Stephanie D Davis, Margaret W Leigh, Mitchell Drumm, Scott D Sagel, Frank J Accurso, Michael R Knowles, Marci K Sontag
OBJECTIVE: Pseudomonas aeruginosa has been suggested as a major determinant of poor pulmonary outcomes in cystic fibrosis (CF), although other factors play a role. Our objective was to investigate the association of early childhood Pseudomonas infection on differences in lung function in adolescence with CF. METHODS: Two populations of subjects with CF were studied: from the Gene Modifier Study (GMS), 346 F508del homozygotes with severe vs. mild adolescent lung disease, and from the Colorado Newborn Screen Study (NBS) 172 subjects diagnosed with CF by newborn screening...
2017: PloS One
https://www.readbyqxmd.com/read/28502406/steering-the-conversation-a-linguistic-exploration-of-natural-language-interactions-with-a-digital-assistant-during-simulated-driving
#5
David R Large, Leigh Clark, Annie Quandt, Gary Burnett, Lee Skrypchuk
Given the proliferation of 'intelligent' and 'socially-aware' digital assistants embodying everyday mobile technology - and the undeniable logic that utilising voice-activated controls and interfaces in cars reduces the visual and manual distraction of interacting with in-vehicle devices - it appears inevitable that next generation vehicles will be embodied by digital assistants and utilise spoken language as a method of interaction. From a design perspective, defining the language and interaction style that a digital driving assistant should adopt is contingent on the role that they play within the social fabric and context in which they are situated...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28497696/chemical-imaging-by-dissolution-analysis-localized-kinetics-of-dissolution-behavior-to-provide-two-dimensional-chemical-mapping-and-tomographic-imaging-on-a-nanoscale
#6
Michael Reading, Muhammad U Ghori, D Robert Brown, Leigh T Fleming, Milan D Antonijevic, David B Grandy, Douglas J Hourston, Mo Song, Barbara R Conway
A new approach to achieving chemical mapping on a nanoscale is described that can provide 2D and tomographic images of surface and near-surface structure. The method comprises dissolving material from the surface of the sample by applying a series of aliquots of solvent, then analyzing their contents after removing them; in between exposures, the surface is imaged with atomic force microscopy. This technique relies on being able to compensate for any drift between images by use of software. It was applied to a blend of two polymers, PMMA and PS...
May 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28483130/assessment-of-ciliary-beat-pattern-variability-in-healthy-control-subjects-has-implications-for-use-as-test-for-primary-ciliary-dyskinesia
#7
EDITORIAL
Margaret W Leigh, Michael R Knowles
No abstract text is available yet for this article.
May 2017: Chest
https://www.readbyqxmd.com/read/28473263/differences-in-white-matter-structure-between-seizure-prone-fast-and-seizure-resistant-slow-rat-strains
#8
Pragati Sharma, David K Wright, Leigh A Johnston, Kim L Powell, Mary E Wlodek, Sandy R Shultz, Terence J O'Brien, Krista L Gilby
Alterations in white matter integrity have been well documented in chronic epilepsy and during epileptogenesis. However, the relationship between white matter integrity and a predisposition towards epileptogenesis has been understudied. The FAST rat strain exhibit heightened susceptibility towards kindling epileptogenesis whereas SLOW rats are highly resistant. FAST rats also display behavioral phenotypes reminiscent of those observed in neurodevelopmental disorders that commonly comorbid with epilepsy. In this study, we aim to identify differences in white matter integrity that may contribute to a predisposition towards epileptogenesis and its associated comorbidities in 6month old FAST (n=10) and SLOW (n=10) male rats...
May 1, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28469040/mutations-in-the-vesicular-trafficking-protein-annexin-a11-are-associated-with-amyotrophic-lateral-sclerosis
#9
Bradley N Smith, Simon D Topp, Claudia Fallini, Hideki Shibata, Han-Jou Chen, Claire Troakes, Andrew King, Nicola Ticozzi, Kevin P Kenna, Athina Soragia-Gkazi, Jack W Miller, Akane Sato, Diana Marques Dias, Maryangel Jeon, Caroline Vance, Chun Hao Wong, Martina de Majo, Wejdan Kattuah, Jacqueline C Mitchell, Emma L Scotter, Nicholas W Parkin, Peter C Sapp, Matthew Nolan, Peter J Nestor, Michael Simpson, Michael Weale, Monkel Lek, Frank Baas, J M Vianney de Jong, Anneloor L M A Ten Asbroek, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Nigel Leigh, Hardev Pall, Karen E Morrison, Ammar Al-Chalabi, Pamela J Shaw, Janine Kirby, Martin R Turner, Kevin Talbot, Orla Hardiman, Jonathan D Glass, Jacqueline De Belleroche, Masatoshi Maki, Stephen E Moss, Christopher Miller, Cinzia Gellera, Antonia Ratti, Safa Al-Sarraj, Robert H Brown, Vincenzo Silani, John E Landers, Christopher E Shaw
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. We screened 751 familial ALS patient whole-exome sequences and identified six mutations including p.D40G in the ANXA11 gene in 13 individuals. The p.D40G mutation was absent from 70,000 control whole-exome sequences. This mutation segregated with disease in two kindreds and was present in another two unrelated cases (P = 0.0102), and all mutation carriers shared a common founder haplotype. Annexin A11-positive protein aggregates were abundant in spinal cord motor neurons and hippocampal neuronal axons in an ALS patient carrying the p...
May 3, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28452711/office-based-rhinologic-surgery-a-modern-experience-with-operative-techniques-under-local-anesthetic
#10
John R Scott, Leigh J Sowerby, Brian W Rotenberg
BACKGROUND: Office-based rhinologic procedures have become popularized in recent years with the advent of several minimally invasive techniques. There is a paucity of literature, however, that supports more robust in-clinic procedures, e.g., true endoscopic sinus surgery (ESS). There is a high volume of this work being done at our center, and the objective of this article was to review the safety and tolerability of in-clinic surgeries. METHODS: A retrospective chart review was conducted...
March 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28449327/skeletal-muscle-il-15-il-15r%C3%AE-and-myofibrillar-protein-synthesis-after-resistance-exercise
#11
Alberto Pérez-López, James McKendry, Marcos Martin-Rincon, David Morales-Alamo, Bárbara Pérez-Köhler, David Valadés, Julia Buján, Jose A L Calbet, Leigh Breen
In vitro and in vivo studies described the myokine IL-15 and its receptor IL-15Rα as anabolic/anti-atrophy agents, however the protein expression of IL-15Rα has not been measured in human skeletal muscle and data regarding IL-15 expression remain inconclusive. The purpose of the study was to determine serum and skeletal muscle IL-15 and IL-15Rα responses to resistance exercise session and to analyse their association with myofibrillar protein synthesis (MPS). Fourteen participants performed a bilateral leg resistance exercise composed of 4 sets of leg press and 4 sets of knee extension at 75% 1RM to task failure...
April 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28441394/maternal-obese-type-gut-microbiota-differentially-impact-cognition-anxiety-and-compulsive-behavior-in-male-and-female-offspring-in-mice
#12
Annadora J Bruce-Keller, Sun-Ok Fernandez-Kim, R Leigh Townsend, Claudia Kruger, Richard Carmouche, Susan Newman, J Michael Salbaum, Hans-Rudolf Berthoud
Maternal obesity is known to predispose offspring to metabolic and neurodevelopmental abnormalities. While the mechanisms underlying these phenomena are unclear, high fat diets dramatically alter intestinal microbiota, and gut microbiota can impact physiological function. To determine if maternal diet-induced gut dysbiosis can disrupt offspring neurobehavioral function, we transplanted high fat diet- (HFD) or control low fat diet-associated (CD) gut microbiota to conventionally-housed female mice. Recipient mice were then bred and the behavioral phenotype of male and female offspring was tracked...
2017: PloS One
https://www.readbyqxmd.com/read/28426052/artificial-molecular-motors
#13
REVIEW
Salma Kassem, Thomas van Leeuwen, Anouk S Lubbe, Miriam R Wilson, Ben L Feringa, David A Leigh
Motor proteins are nature's solution for directing movement at the molecular level. The field of artificial molecular motors takes inspiration from these tiny but powerful machines. Although directional motion on the nanoscale performed by synthetic molecular machines is a relatively new development, significant advances have been made. In this review an overview is given of the principal designs of artificial molecular motors and their modes of operation. Although synthetic molecular motors have also found widespread application as (multistate) switches, we focus on the control of directional movement, both at the molecular scale and at larger magnitudes...
May 9, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28425186/association-studies-of-low-frequency-coding-variants-in-nonsyndromic-cleft-lip-with-or-without-cleft-palate
#14
Elizabeth J Leslie, Jenna C Carlson, John R Shaffer, Carmen J Buxó, Eduardo E Castilla, Kaare Christensen, Frederic W B Deleyiannis, Leigh L Field, Jacqueline T Hecht, Lina Moreno, Ieda M Orioli, Carmencita Padilla, Alexandre R Vieira, George L Wehby, Eleanor Feingold, Seth M Weinberg, Jeffrey C Murray, Mary L Marazita
Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a group of common human birth defects with complex etiology. Although genome-wide association studies have successfully identified a number of risk loci, these loci only account for about 20% of the heritability of orofacial clefts. The "missing" heritability may be found in rare variants, copy number variants, or interactions. In this study, we investigated the role of low-frequency variants genotyped in 1995 cases and 1626 controls on the Illumina HumanCore + Exome chip...
June 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28424332/improving-genetic-diagnosis-in-mendelian-disease-with-transcriptome-sequencing
#15
Beryl B Cummings, Jamie L Marshall, Taru Tukiainen, Monkol Lek, Sandra Donkervoort, A Reghan Foley, Veronique Bolduc, Leigh B Waddell, Sarah A Sandaradura, Gina L O'Grady, Elicia Estrella, Hemakumar M Reddy, Fengmei Zhao, Ben Weisburd, Konrad J Karczewski, Anne H O'Donnell-Luria, Daniel Birnbaum, Anna Sarkozy, Ying Hu, Hernan Gonorazky, Kristl Claeys, Himanshu Joshi, Adam Bournazos, Emily C Oates, Roula Ghaoui, Mark R Davis, Nigel G Laing, Ana Topf, Peter B Kang, Alan H Beggs, Kathryn N North, Volker Straub, James J Dowling, Francesco Muntoni, Nigel F Clarke, Sandra T Cooper, Carsten G Bönnemann, Daniel G MacArthur
Exome and whole-genome sequencing are becoming increasingly routine approaches in Mendelian disease diagnosis. Despite their success, the current diagnostic rate for genomic analyses across a variety of rare diseases is approximately 25 to 50%. We explore the utility of transcriptome sequencing [RNA sequencing (RNA-seq)] as a complementary diagnostic tool in a cohort of 50 patients with genetically undiagnosed rare muscle disorders. We describe an integrated approach to analyze patient muscle RNA-seq, leveraging an analysis framework focused on the detection of transcript-level changes that are unique to the patient compared to more than 180 control skeletal muscle samples...
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28421268/using-a-population-model-to-inform-the-management-of-river-flows-and-invasive-carp-cyprinus-carpio
#16
John D Koehn, Charles R Todd, Brenton P Zampatti, Ivor G Stuart, Anthony Conallin, Leigh Thwaites, Qifeng Ye
Carp are a highly successful invasive fish species, now widespread, abundant and considered a pest in south-eastern Australia. To date, most management effort has been directed at reducing abundances of adult fish, with little consideration of population growth through reproduction. Environmental water allocations are now an important option for the rehabilitation of aquatic ecosystems, particularly in the Murray-Darling Basin. As carp respond to flows, there is concern that environmental watering may cause floodplain inundation and provide access to spawning habitats subsequently causing unwanted population increase...
April 18, 2017: Environmental Management
https://www.readbyqxmd.com/read/28418211/cutting-costs-and-standardizing-care-once-per-cycle-complete-blood-count-monitoring-may-be-safe-for-patients-undergoing-platinum-based-chemotherapy
#17
Christine Garcia, Lauren Montemorano, Erin Saks, Linda R Duska, Leigh A Cantrell
AIM: The aim of this study was to evaluate whether frequency of complete blood count (CBC) testing during chemotherapy for gynecologic cancer impacts hospital admissions or rates of neutropenic fever. METHODS: A retrospective cohort study was performed at a single academic institution. Patients undergoing platinum-based chemotherapy for endometrial or ovarian cancer from January 2010 to December 2014 were identified from a clinical database. Patients receiving dose-dense chemotherapy or on a clinical trial were excluded...
April 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28412967/factors-associated-with-lingual-tonsil-hypertrophy-in-canadian-adults
#18
Matthew S Harris, Brian W Rotenberg, Kathryn Roth, Leigh J Sowerby
BACKGROUND: Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adult patient is unclear and likely multifactorial. Previous studies have suggested that the lingual tonsils may undergo compensatory hyperplasia post-tonsillectomy in children, although it is unknown if this occurs or persists into adulthood. The purpose of this study was to determine what factors are associated with LTH in a population of Canadian adults...
April 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28409623/a-combined-density-functional-theory-and-spectrophotometry-study-of-the-bonding-interactions-of-npo2%C3%A2-m-4-cation-cation-complexes
#19
John W Freiderich, Adam G Burn, Leigh R Martin, Kenneth L Nash, Aurora E Clark
The equilibrium constants for [NpO2·M](4+) (M = Al(3+), In(3+), Sc(3+), Fe(3+)) in μ = 10 M nitric acid and [NpO2·Ga](4+) in μ = 10 M hydrochloric acid media have been determined. The trend in the interaction strength follows: Fe(3+) > Sc(3+) ≥ In(3+) > Ga(3+) ≫ Al(3+). These equilibrium constants are compared to those of previously reported values for NpO2(+) complexes with Cr(3+) and Rh(3+) within the literature. Thermodynamic parameters and bonding modes are discussed, with density functional theory and natural bond orbital analysis indicating that the NpO2(+) dioxocation acts as a π-donor with transition-metal cations and a σ-donor with group 13 cations...
April 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28387485/plasma-insulin-level-correlation-to-metabolic-parameter-shifts-in-hospitalized-psychiatric-patients
#20
Andrew C Naglich, Leigh Anne Nelson, Courtney A Iuppa, Lauren A Diefenderfer, Ellie S R Elliott, Roger W Sommi
Objective: To identify potential correlations between baseline plasma insulin level and shifts in metabolic status in psychiatric inpatients. Methods: A population of 75 patients was identified for this single-center, retrospective study conducted at a state psychiatric hospital in Kansas City, Missouri. Patients were selected on the basis of presence of a baseline fasting plasma insulin level drawn at admission; duration of stay ≥ 12 weeks between August 1, 2013, and December 31, 2015; and presence of metabolic laboratory and weight measurements at baseline and 3 months...
April 6, 2017: Primary Care Companion to CNS Disorders
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