keyword
MENU ▼
Read by QxMD icon Read
search

R leigh

keyword
https://www.readbyqxmd.com/read/29788345/the-sierra-leone-trial-to-introduce-a-vaccine-against-ebola-an-evaluation-of-rvsv%C3%A2-g-zebov-gp-vaccine-tolerability-and-safety-during-the-west-africa-ebola-outbreak
#1
Mohamed Samai, Jane F Seward, Susan T Goldstein, Barbara E Mahon, Durodami Radcliffe Lisk, Marc-Alain Widdowson, Mohamed I Jalloh, Stephanie J Schrag, Ayesha Idriss, Rosalind J Carter, Peter Dawson, S A S Kargbo, Bailah Leigh, Mohamed Bawoh, Jennifer Legardy-Williams, Gibrilla Deen, Wendy Carr, Amy Callis, Robert Lindblad, James B W Russell, Carey R Petrie, Augustin E Fombah, Brima Kargbo, Wendi McDonald, Olamide D Jarrett, Robert E Walker, Paul Gargiullo, Donald Bash-Taqi, Laura Gibson, Abu Bakarr Fofanah, Anne Schuchat
ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220].
May 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29787575/safety-of-intravenous-alteplase-within-4-5-hours-for-patients-awakening-with-stroke-symptoms
#2
Victor C Urrutia, Roland Faigle, Steven R Zeiler, Elisabeth B Marsh, Mona Bahouth, Mario Cerdan Trevino, Jennifer Dearborn, Richard Leigh, Susan Rice, Karen Lane, Mustapha Saheed, Peter Hill, Rafael H Llinas
BACKGROUND: Up to 25% of acute stroke patients first note symptoms upon awakening. We hypothesized that patients awaking with stroke symptoms may be safely treated with intravenous alteplase (IV tPA) using non-contrast head CT (NCHCT), if they meet all other standard criteria. METHODS: The SAfety of Intravenous thromboLytics in stroke ON awakening (SAIL ON) was a prospective, open-label, single treatment arm, pilot safety trial of standard dose IV tPA in patients who presented with stroke symptoms within 0-4...
2018: PloS One
https://www.readbyqxmd.com/read/29786935/evaluation-of-pcr-primers-targeting-the-groel-gene-for-the-specific-detection-of-streptococcus-agalactiae-in-the-context-of-aquaculture
#3
W J Leigh, R N Zadoks, A Jaglarz, J Z Costa, G Foster, K D Thompson
AIMS: The aim of this study was to design a set of primers for specific detection and identification of Streptococcus agalactiae in polymerase chain reaction (PCR) that can detect a diverse range of S. agalactiae isolates from different hosts and that it is capable of discriminating between S. agalactiae and other species that are closely related or potentially present in aquaculture environments, notably Streptococcus iniae. METHODS AND RESULTS: Primers, based on the groEL2 gene of S...
May 22, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29770924/roux-en-y-gastric-bypass-surgery-induced-weight-loss-and-metabolic-improvements-are-similar-in-tgr5-deficient-and-wildtype-mice
#4
Zheng Hao, R Leigh Townsend, Michael B Mumphrey, Thomas W Gettys, Sangho Yu, Heike Münzberg, Christopher D Morrison, Hans-Rudolf Berthoud
BACKGROUND AND PURPOSE: Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective treatments for obesity and type 2 diabetes. Despite this, the mechanisms through which it acts are still not well understood. Bile acid signaling through the transmembrane G-protein-coupled receptor TGR5 has been shown to have significant effects on metabolism and has recently been reported to be necessary for the full effects of vertical sleeve gastrectomy (VSG), a bariatric surgery with similar effects to RYGB...
May 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29768316/evaluation-of-compliance-with-a-weight-based-nurse-driven-heparin-nomogram-in-a-tertiary-academic-medical-center
#5
James W Schurr, Craig A Stevens, Anne Bane, Sarah E Culbreth, Amy Leigh Miller, Jean M Connors, Katelyn W Sylvester
BACKGROUND: Recently, our institution adopted a weight-based nurse-driven heparin titration protocol that relies on nurses ordering laboratories, adjusting doses, and initiating boluses. Numerous institutions have implemented similar protocols with reported success. METHODS: A single-center retrospective analysis was conducted at the Brigham and Women's Hospital in Boston, Massachusetts that included all patients who were initiated on the weight-based nurse-driven heparin nomogram during a 30-day period...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29762926/genetic-complexity-of-mitral-valve-prolapse-revealed-by-clinical-and-genetic-evaluation-of-a-large-family
#6
Gloria T Haskell, Brian C Jensen, Cecile Skrzynia, Thelsa Pulikkotil, Christian R Tilley, Yurong Lu, Daniel S Marchuk, Leigh Ann Samsa, Kirk C Wilhelmsen, Ethan Lange, Cam Patterson, James P Evans, Jonathan S Berg
BACKGROUND: A genetic component to familial mitral valve prolapse (MVP) has been proposed for decades. Despite this, very few genes have been linked to MVP. Herein is described a four-generation pedigree with numerous individuals affected with severe MVP, some at strikingly young ages. METHODS: A detailed clinical evaluation performed on all affected family members demonstrated a spectrum of MVP morphologies and associated phenotypes. RESULTS: Linkage analysis failed to identify strong candidate loci, but revealed significant regions, which were investigated further using whole-exome sequencing of one of the severely affected family members...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29759009/implementation-of-policy-systems-and-environmental-community-based-interventions-for-cardiovascular-health-through-a-national-not-for-profit-a-multiple-case-study
#7
Whitney R Garney, Leigh E Szucs, Kristin Primm, Laura King Hahn, Kristen M Garcia, Emily Martin, Kenneth McLeroy
INTRODUCTION: In 2014, the Centers for Disease Control and Prevention funded the American Heart Association to implement policy, systems, and environment-focused strategies targeting access to healthy food and beverages, physical activity, and smoke-free environments. METHOD: To understand factors affecting implementation and variations in success across sites, evaluators conducted a multiple case study. Based on past literature, community sites were categorized as capacity-building or implementation-ready, for comparison...
May 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29751762/hiv-latency-reversing-agents-act-through-tat-post-translational-modifications
#8
Georges Khoury, Talia M Mota, Shuang Li, Carolin Tumpach, Michelle Y Lee, Jonathan Jacobson, Leigh Harty, Jenny L Anderson, Sharon R Lewin, Damian F J Purcell
BACKGROUND: Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells. A limited number of studies have demonstrated additive effects of LRAs with the viral protein Tat in initiating transcription, but less is known about how LRAs interact with Tat, particularly through basic residues that may be post-translationally modified to alter the behaviour of Tat for processive transcription and co-transcriptional RNA processing...
May 11, 2018: Retrovirology
https://www.readbyqxmd.com/read/29745870/isolation-antigenicity-and-immunogenicity-of-lleida-bat-lyssavirus
#9
Ashley C Banyard, David Selden, Guanghui Wu, Leigh Thorne, Daisy Jennings, Denise Marston, Stefan Finke, Conrad M Freuling, Thomas Müller, Juan E Echevarría, Anthony R Fooks
The lyssaviruses are an important group of viruses that cause a fatal encephalitis termed rabies. The prototypic lyssavirus, rabies virus, is predicted to cause more than 60 000 human fatalities annually. The burden of disease for the other lyssaviruses is undefined. The original reports for the recently described highly divergent Lleida bat lyssavirus were based on the detection of virus sequence alone. The successful isolation of live Lleida bat lyssavirus from the carcass of the original bat and in vitro characterization of this novel lyssavirus are described here...
May 10, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29744630/novel-wine-yeast-with-aro4-and-tyr1-mutations-that-overproduce-floral-aroma-compounds-2-phenylethanol-and-2-phenylethyl-acetate
#10
Antonio G Cordente, Mark Solomon, Alex Schulkin, I Leigh Francis, Alice Barker, Anthony R Borneman, Christopher D Curtin
It is well established that the choice of yeast used to perform wine fermentation significantly influences the sensory attributes of wines; different yeast species and strains impart different profiles of esters, volatile fatty acids, higher alcohols, and volatile sulphur compounds. Indeed, choice of yeast remains one of the simplest means by which winemakers can modulate the sensory characteristics of wine. Consequently, there are more than 100 commercially available Saccharomyces cerevisiae wine yeast strains available, mostly derived by isolation from vineyards and successful fermentations...
May 9, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29742745/validity-and-reliability-of-a-wearable-inertial-sensor-to-measure-velocity-and-power-in-the-back-squat-and-bench-press
#11
Samuel T Orange, James W Metcalfe, Andreas Liefeith, Phil Marshall, Leigh A Madden, Connor R Fewster, Rebecca V Vince
Orange, ST, Metcalfe, JW, Liefeith, A, Marshall, P, Madden, LA, Fewster, CR, and Vince, RV. Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press. J Strength Cond Res XX(X): 000-000, 2018-This study examined the validity and reliability of a wearable inertial sensor to measure velocity and power in the free-weight back squat and bench press. Twenty-nine youth rugby league players (18 ± 1 years) completed 2 test-retest sessions for the back squat followed by 2 test-retest sessions for the bench press...
May 8, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29739492/change-in-distribution-of-cytoskeleton-associated-proteins-lasp-1-and-palladin-during-uterine-receptivity-in-the-rat-endometrium
#12
Leigh Nicholson, Laura Lindsay, Christopher R Murphy
The epithelium of the uterine lumen is the first point of contact with the blastocyst before implantation. To facilitate pregnancy, these uterine epithelial cells (UECs) undergo morphological changes specific to the receptive uterus. These changes include basal, lateral and apical alterations in the plasma membrane of UECs. This study looked at the cytoskeletal and focal adhesion-associated proteins, lasp-1 and palladin, in the uterus during early pregnancy in the rat. Two palladin isoforms, 140 kDa and 90 kDa, were analysed, with the migration-associated 140-kDa isoform increasing significantly at the time of implantation when compared with the time of fertilisation...
May 9, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29727447/early-warning-and-response-system-ewars-for-dengue-outbreaks-recent-advancements-towards-widespread-applications-in-critical-settings
#13
Laith Hussain-Alkhateeb, Axel Kroeger, Piero Olliaro, Joacim Rocklöv, Maquins Odhiambo Sewe, Gustavo Tejeda, David Benitez, Balvinder Gill, S Lokman Hakim, Roberta Gomes Carvalho, Leigh Bowman, Max Petzold
BACKGROUND: Dengue outbreaks are increasing in frequency over space and time, affecting people's health and burdening resource-constrained health systems. The ability to detect early emerging outbreaks is key to mounting an effective response. The early warning and response system (EWARS) is a toolkit that provides countries with early-warning systems for efficient and cost-effective local responses. EWARS uses outbreak and alarm indicators to derive prediction models that can be used prospectively to predict a forthcoming dengue outbreak at district level...
2018: PloS One
https://www.readbyqxmd.com/read/29717911/epidemiology-of-trauma-related-infections-among-a-combat-casualty-cohort-after-initial-hospitalization-the-trauma-infectious-disease-outcomes-study
#14
David R Tribble, Margot R Krauss, Clinton K Murray, Tyler E Warkentien, Bradley A Lloyd, Anuradha Ganesan, Lauren Greenberg, Jiahong Xu, Ping Li, M Leigh Carson, William Bradley, Amy C Weintrob
BACKGROUND: The Trauma Infectious Disease Outcomes Study (TIDOS) cohort follows military personnel with deployment-related injuries in order to evaluate short- and long-term infectious complications. High rates of infectious complications have been observed in more than 30% of injured patients during initial hospitalization. We present data on infectious complications related to combat trauma after the initial period of hospitalization. PATIENTS AND METHODS: Data related to patient care for military personnel injured during combat operations between June 2009 and May 2012 were collected...
May 2, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29694279/stable-long-term-bci-enabled-communication-in-als-and-locked-in-syndrome-using-lfp-signals
#15
Tomislav Milekovic, Anish A Sarma, Daniel Bacher, John D Simeral, Jad Saab, Chethan Pandarinath, Brittany L Sorice, Christine Blabe, Erin M Oakley, Kathryn R Tringale, Emad Eskandar, Sydney S Cash, Jaimie M Henderson, Krishna V Shenoy, John P Donoghue, Leigh R Hochberg
Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain-computer interfaces (BCIs) based on intracortical spiking activity to efficiently type messages. However, due to neuronal signal instability, most intracortical BCIs have required frequent calibration and continuous assistance of skilled engineers to maintain performance. Here, an individual with locked-in syndrome due to brainstem stroke and an individual with tetraplegia secondary to amyotrophic lateral sclerosis (ALS) used a simple communication BCI based on intracortical local field potentials (LFPs) for 76 and 138 days, respectively, without recalibration and without significant loss of performance...
April 25, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29691892/congenital-titinopathy-comprehensive-characterisation-and-pathogenic-insights
#16
Emily C Oates, Kristi J Jones, Sandra Donkervoort, Amanda Charlton, Susan Brammah, John E Smith, James S Ware, Kyle S Yau, Lindsay C Swanson, Nicola Whiffin, Anthony J Peduto, Adam Bournazos, Leigh B Waddell, Michelle A Farrar, Hugo A Sampaio, Hooi Ling Teoh, Phillipa J Lamont, David Mowat, Robin B Fitzsimons, Alastair J Corbett, Monique M Ryan, Gina L O'Grady, Sarah A Sandaradura, Roula Ghaoui, Himanshu B Joshi, Jamie L Marshall, Melinda A Nolan, Simranpreet Kaur, Jaya Punetha, Ana Töpf, Elizabeth Harris, Madhura Bakshi, Casie A Genetti, Minttu Marttila, Ulla Werlauff, Nathalie Streichenberger, Alan Pestronk, Ingrid Mazanti, Jason R Pinner, Carole Vuillerot, Carla Grosmann, Ana Camacho, Payam Mohassel, Meganne E Leach, A Reghan Foley, Diana Bharucha-Goebel, James Collins, Anne M Connolly, Heather R Gilbreath, Susan T Iannaccone, Diana Castro, Beryl B Cummings, Richard I Webster, Leïla Lazaro, John Vissing, Sandra Coppens, Nicolas Deconinck, Ho-Ming Luk, Neil H Thomas, Nicola C Foulds, Marjorie A Illingworth, Sian Ellard, Catriona A McLean, Rahul Phadke, Gianina Ravenscroft, Nanna Witting, Peter Hackman, Isabelle Richard, Sandra T Cooper, Erik-Jan Kamsteeg, Eric P Hoffman, Kate Bushby, Volker Straub, Bjarne Udd, Ana Ferreiro, Kathryn N North, Nigel F Clarke, Monkol Lek, Alan H Beggs, Carsten G Bönnemann, Daniel G MacArthur, Henk Granzier, Mark R Davis, Nigel G Laing
OBJECTIVE: Comprehensive clinical characterisation of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. METHODS: Using massively parallel sequencing we identified 30 patients from 27 families with two pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathology and imaging features of these patients. RESULTS: All patients had prenatal- or early-onset hypotonia and/or congenital contractures...
April 25, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29665506/intimate-partner-violence-victimization-and-parenting-a-systematic-review
#17
REVIEW
Antonia E Chiesa, Leigh Kallechey, Nicole Harlaar, C Rashaan Ford, Edward F Garrido, William R Betts, Sabine Maguire
Early studies examining parenting in the setting of intimate partner violence (IPV) often focus on abuse by the IPV perpetrator or effects of long term exposure. This review addresses how intimate partner violence impacts victim parenting. Seven databases were searched for the time period 1970-2015. Included were comparative studies involving children 11 years or younger. Quality ranking was based on: confirmation of victim status, consideration of co-perpetration, heterogeneity of the population, and standardization of measurements...
April 14, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29657419/giardiasis-serum-antibodies-and-coproantigens-in-brown-rats-rattus-norvegicus-from-grenada-west-indies
#18
Keshaw Tiwari, Camille Coomansingh Springer, Alfred Chikweto, Josephine Tang, Yvette Sepulveda, Amanda Leigh Smith, Nia Rametta, Ravindra Nath Sharma
Aim: Giardia is a serious zoonotic parasite, which causes diarrheal disease in humans and animals including rodents. The purpose of this study was to estimate the prevalence of Giardia spp. in brown rats ( Rattus norvegicus ) in Grenada. Materials and Methods: Intestinal contents from 99 and serum samples from 169 brown rats ( R. norvegicus ) from Grenada were collected. These samples were examined for the Giardia coproantigens using Cryptosporidium / Giardia Quik Chek assay (Tech lab® Inc...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29625026/biallelic-mutations-in-mrps34-lead-to-instability-of-the-small-mitoribosomal-subunit-and-leigh-syndrome
#19
Nicole J Lake, Bryn D Webb, David A Stroud, Tara R Richman, Benedetta Ruzzenente, Alison G Compton, Hayley S Mountford, Juliette Pulman, Coralie Zangarelli, Marlene Rio, Nathalie Boddaert, Zahra Assouline, Mingma D Sherpa, Eric E Schadt, Sander M Houten, James Byrnes, Elizabeth M McCormick, Zarazuela Zolkipli-Cunningham, Katrina Haude, Zhancheng Zhang, Kyle Retterer, Renkui Bai, Sarah E Calvo, Vamsi K Mootha, John Christodoulou, Agnes Rötig, Aleksandra Filipovska, Ingrid Cristian, Marni J Falk, Metodi D Metodiev, David R Thorburn
No abstract text is available yet for this article.
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29618003/cohort-profile-the-pregnancy-and-neonatal-diabetes-outcomes-in-remote-australia-pandora-study
#20
I-Lynn Lee, Brydie Purbrick, Federica Barzi, Alex Brown, Christine Connors, Cherie Whitbread, Elizabeth Moore, Marie Kirkwood, Alison Simmonds, Paula van Dokkum, Elizabeth Death, Stacey Svenson, Sian Graham, Vanya Hampton, Joanna Kelaart, Danielle Longmore, Angela Titmuss, Jacqueline Boyle, Julie Brimblecombe, Richard Saffery, Anita D'Aprano, Michael R Skilton, Leigh C Ward, Sumaria Corpus, Shridhar Chitturi, Sujatha Thomas, Sandra Eades, Chrissie Inglis, Karen Dempsey, Michelle Dowden, Michael Lynch, Jeremy Oats, Harold D McIntyre, Paul Zimmet, Kerin O'Dea, Jonathan E Shaw, Louise J Maple-Brown
No abstract text is available yet for this article.
March 29, 2018: International Journal of Epidemiology
keyword
keyword
16830
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"