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https://www.readbyqxmd.com/read/30537081/grim-19-repressed-hypoxia-induced-invasion-and-emt-of-colorectal-cancer-by-repressing-autophagy-through-inactivation-of-stat3-hif-1%C3%AE-signaling-axis
#1
Juan Zhang, Dake Chu, Takuji Kawamura, Kiyohito Tanaka, Shuixiang He
Hypoxia leads to cancer progression and promotes the metastatic potential of cancer cells. Thereby, the aim of the present study was to investigate the detailed effects of gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) in colorectal cancer (CRC) cell lines under hypoxia conditions and explore the potential molecular mechanisms. Here, we observed that GRIM-19 expression was downregulated in several CRC cell lines as well as in HCT116 and Caco-2 cells under a hypoxic microenvironment...
December 7, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30536712/modeling-and-multi-scale-characterization-of-the-quantitative-imaging-based-fibrosis-index-reveals-pathophysiological-transcriptome-and-proteomic-correlates-of-lung-fibrosis-induced-by-fractionated-irradiation
#2
Cheng Zhou, Mahmoud R Moustafa, Liji Cao, Mark Kriegsmann, Martin Winter, Christian Schwager, Bleddyn Jones, Shijun Wang, Tobias Bäuerle, Ping-Kun Zhou, Martina Schnölzer, Wilko Weichert, Juergen Debus, Amir Abdollahi
Pulmonary fibrosis represents a leading cause of morbidity and mortality worldwide. Therapy induced lung fibrosis constitutes a pivotal dose-limiting side effect of radiotherapy and other anticancer agents. We aimed to develop objective criteria for assessment of fibrosis and discover pathophysiological and molecular correlates of lung fibrosis as a function of fractionated whole thoracic irradiation. Dose-response series of fractionated irradiation was utilized to develop a non-invasive and quantitative measure for the degree of fibrosis - the fibrosis index (FI)...
December 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30536541/down-regulation-of-lncrna-ogfrp1-induces-autophagy-and-growth-inhibition-by-akt-mtor-signaling-pathway-in-hcaecs
#3
Xiaolu Zhang, Jing Liu, Yufeng Gu, Chengming Sun, Fuzheng Qu
Long noncoding RNAs (lncRNAs) have been found to play important roles in nearly all biological processes. However, the functions of the majority of LncRNAs are not fully clear. Here we evaluated the function of lncRNA OGFRP1, which has not been previously annotated, in human coronary artery endothelial cells (HCAECs). First, we knocked down lncRNA OGFRP1 in HCAECs by using siRNA transfection. qRT-PCR results indicated that siRNA1 and siRNA3 both had potent interference efficiencies. Next, by using CCK8 assay and clone formation assay, we found that siRNA3 transfection induced growth inhibition in HCAECs...
December 11, 2018: Cell Biology International
https://www.readbyqxmd.com/read/30536263/expression-of-nitric-oxide-synthase-interacting-protein-nosip-is-decreased-in-the-pulmonary-vasculature-of-nitrofen-induced-congenital-diaphragmatic-hernia
#4
Hiroki Nakamura, Julia Zimmer, Florian Friedmacher, Prem Puri
INTRODUCTION:  Persistent pulmonary hypertension (PPH) is a major cause of morbidity and mortality in newborns with congenital diaphragmatic hernia (CDH). PPH is characterized by increased vascular resistance and smooth muscle cell (SMC) proliferation, leading to obstructive changes in the pulmonary vasculature. Nitric oxide (NO), generated by endothelial NO synthase (eNOS), is an important regulator of vascular tone and plays a key role in pulmonary vasodilatation. NO synthase interacting protein (NOSIP), which is strongly expressed by pulmonary SMCs, has recently been identified to reduce the endogenous NO production by interacting with eNOS...
December 10, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30535534/the-effects-of-probiotic-supplementation-on-genetic-and-metabolic-profiles-in-patients-with-gestational-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#5
Mahtab Babadi, Ahmad Khorshidi, Esmat Aghadavood, Mansooreh Samimi, Elham Kavossian, Fereshteh Bahmani, Alireza Mafi, Rana Shafabakhsh, Mahbobeh Satari, Zatollah Asemi
This study was carried out to evaluate the effects of probiotic supplementation on genetic and metabolic profiles in patients with gestational diabetes mellitus (GDM) who were not on oral hypoglycemic agents. This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 patients with GDM. Participants were randomly divided into two groups to intake either probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, Lactobacillus fermentum (2 × 109  CFU/g each) (n = 24) or placebo (n = 24) for 6 weeks...
December 8, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/30534803/transdifferentiations-and-heterogeneity-in-the-stromal-niches-of-uterine-leiomyomas
#6
Mugurel Constantin Rusu, Florinel Pop, Sorin Hostiuc, Livia Manta, Nicoleta Măru, Mihai Grigoriu
Uterine leiomyomas, also known as uterine fibroids (UFs), are benign smooth muscle cells tumors, the most frequent tumors in women. Even though UFs are monoclonal tumors, they contain a heterogeneous and versatile cells population. There are scarce proofs about the processes of transdifferentiation that might occur in UFs, modify the tumor microenvironment and support blood and lymph vessels formation. The stromal niches of the UFs harbor cells with angiogenic∕lymphangiogenic, as well as with vasculogenic∕lymphvasculogenic potential, which belong to a phenotypic continuum between the endothelial and mesenchymal lineages...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/30531786/-objective-assessment-of-the-degree-of-ischaemia-and-efficacy-of-treatment-in-chronic-arterial-insufficiency-of-lower-limbs
#7
A V Shabunin, D V Matveev, M R Kuznetsov, E E Fedorov, A D Matveev
Presented in the review is the data concerning contemporary criteria for assessing the degree of chronic lower limb ischaemia and quality of the treatment performed. Problems regarding objectivization of the degree of an ischaemic lesion of an extremity and assessment of quality of conservative treatment still remain unresolved. Currently, in the world practice along with instrumental methods (assessment of the ankle-brachial index) subjective criteria are mainly employed: assessment of pain-free walking distance or maximum distance walked...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/30531772/-endotheliotropic-effects-of-venotonic-drugs-in-treatment-of-patients-with-varicose-veins
#8
R E Kalinin, I A Suchkov, A A Kamaev, V I Zvyagina, A A Krylov
The authors analysed the effect of Venarus on the endothelial function in patients suffering from lower limb varicose veins. Our open-label prospective study included a total of 100 patients diagnosed as having CEAP class C1-C2 varicose veins and divided into two equal groups. Dynamic assessment of the clinical course of the disease in Group One patients was carried out on the background of taking Venarus and compression therapy, with Group Two patients evaluated without taking Venarus. At defined stages we determined the level of biochemical markers of endothelial function...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/30531158/vascularization-via-activation-of-vegf-vegfr-signaling-is-essential-for-peripheral-nerve-regeneration
#9
Yohei Nishida, Yurie Yamada, Hiroko Kanemaru, Atsushi Ohazama, Takeyasu Maeda, Kenji Seo
Peripheral nerve injury has been suggested to up-regulate mRNA for the vascular endothelial growth factor (VEGF) which enhances nerve regeneration. VEGF is known to regulate angiogenesis by binding with a specific receptor, the vascular endothelial growth factor receptor (VEGFR). However, little is known about the involvement of VEGF-VEGFR signaling in the nerve regeneration at early stages though previous studies contained a lengthy observation. The present study examined that relationship between angiogenesis and peripheral nerve regeneration at the early stage after nerve transection by focusing on the chronological changes in the expression patterns of VEGF-VEGFR signaling...
2018: Biomedical Research
https://www.readbyqxmd.com/read/30530197/fractionation-of-embryonic-cardiac-progenitor-cells-and-evaluation-of-their-differentiation-potential
#10
Tiam Feridooni, Kishore B S Pasumarthi
Mid-gestation mouse ventricles (E11.5) contain a larger number of Nkx2.5+ cardiac progenitor cells (CPCs). The proliferation rates are consistently higher in CPCs compared to myocyte population of developing ventricles. Recent studies suggested that CPCs are an ideal donor cell type for replacing damaged tissue in diseased hearts. Thus, the ability to isolate and expand CPCs from embryos or stem cell cultures could be useful for cell fate studies and regenerative therapies. Since embryonic CPCs possess fewer mitochondria compared to cardiomyocytes, we reasoned that CPCs can be fractionated using a fluorescent mitochondrial membrane potential dye (TMRM) and these cells may retain cardiomyogenic potential even in the absence of cardiomyocytes (CMs)...
November 23, 2018: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/30530048/dyslipidemia-induced-inflammatory-status-platelet-activation-and-endothelial-dysfunction-in-rabbits-protective-role-of-10-dehydrogingerdione
#11
Mohamed Mahmoud El-Seweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Reham Raafat El-Zeiky, Naif A Al-Gabri
10-Dehydrogingerdione is a novel cholesteryl ester transfer protein (CETP) inhibitor of natural origin. Some synthetic CETP inhibitors have recently been reported to suppress proprotein convertase subtilisin/kexin type 9 (PCSK9). Therefore, the present study aimed mainly to clarify the effect of 10-Dehydrogingerdione on cellular adhesion inflammatory molecules, platelet activation and endothelial dysfunction markers in addition to PCSK9 as compared to atorvastatin in dyslipidemic rabbits. Dyslipidemia was induced in 30 male rabbits, distributed in 3 equal groups through feeding dietary cholesterol (0...
December 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30530043/effect-of-antiepileptic-drug-topiramate-and-cold-pressed-ginger-oil-on-testicular-genes-expression-sexual-hormones-and-histopathological-alterations-in-mice
#12
Aida I El Makawy, Faten M Ibrahim, Dalia M Mabrouk, Kawkab A Ahmed, Mohamed Fawzy Ramadan
Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. The target of this work was to appraise the sexual dysfunction of antiepileptic Topiramate (TPM) and cold pressed ginger oil (CPGO) as antiepileptic alternative medicine in male mice. Fifty-four adult male albino mice were divided into nine groups (n = 6 mice)...
December 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30529828/the-relationship-between-endothelial-function-and-aortic-valve-calcification-multi-ethnic-study-of-atherosclerosis
#13
Moshrik Abd Alamir, Michael Goyfman, Dana Johnson, Yangyang Liu, Firas Dabbous, Adib Chaus, Mathew Budoff
BACKGROUND AND AIMS: Aortic valve calcification (AVC) may be associated with atherogenic processes arising from endothelial dysfunction (ED). Limited data is available about the relationship between ED, defined by flow mediated dilation (FMD%) and biomarkers, and the prevalence and progression of AVC in a multiethnic population. METHODS: A sample of 3475 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA), with both initial and repeat CT scans at a mean of 2...
November 28, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30527746/fibroblast-growth-factor-receptor-2-polymorphism-rs2981582-is-correlated-with-progression-free-survival-and-overall-survival-in-patients-with-metastatic-clear-cell-renal-cell-carcinoma-treated-with-sunitinib
#14
Maxime Vanmechelen, Diether Lambrechts, Thomas Van Brussel, Annelies Verbiest, Gabrielle Couchy, Patrick Schöffski, Herlinde Dumez, Philip R Debruyne, Evelyne Lerut, Jean-Pascal Machiels, Vincent Richard, Maarten Albersen, Vincent Verschaeve, Stéphane Oudard, Arnaud Méjean, Pascal Wolter, Jessica Zucman-Rossi, Benoit Beuselinck
BACKGROUND: There are no validated markers that predict response or resistance in patients with metastatic clear-cell renal cell carcinoma (mccRCC) treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors such as sunitinib and pazopanib. Recently, single nucleotide polymorphism (SNP) rs2981582 in Fibroblast Growth Factor Receptor 2 (FGFR2) was found to be associated with clinical outcome in patients with mccRCC treated with pazopanib and sunitinib. We aimed to validate these findings in patients treated with sunitinib...
November 16, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/30526689/induced-pluripotent-stem-cell-derived-endothelial-progenitor-cells-attenuate-ischemic-acute-kidney-injury-and-cardiac-dysfunction
#15
Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung, Hsin-Fu Chen
BACKGROUND: Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy for AKI is an unmet clinical need, and molecular mechanisms underlying the interactions between an injured kidney and distant organs remain unclear. Therefore, novel therapeutic strategies should be developed. METHODS: We directed the differentiation of human induced pluripotent stem (iPS) cells into endothelial progenitor cells (iEPCs), which were then applied for treating mouse AKI...
December 10, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30525069/preparation-of-ips-cell-derived-cd31-endothelial-cells-using-three-dimensional-suspension-culture
#16
Shinako Masuda, Katsuhisa Matsuura, Tatsuya Shimizu
A well-organised vascular network is essential for metabolic exchange to maintain homoeostasis in the body. Therefore, for progress in regenerative medicine, it is particularly important to establish methods of vascularization in bioengineered three-dimensional (3D) functional tissues. In addition, it is necessary to develop methods to supply a large number of iPS cell-derived endothelial cells for fabricating the vascular network structure. There are already many reports on the method of inducing the differentiation of endothelial cells from iPS cells using 2D culture...
December 2018: Regenerative Therapy
https://www.readbyqxmd.com/read/30524661/the-possible-pathophysiological-outcomes-and-mechanisms-of-tourniquet-induced-ischemia-reperfusion-injury-during-total-knee-arthroplasty
#17
REVIEW
Prangmalee Leurcharusmee, Passakorn Sawaddiruk, Yodying Punjasawadwong, Nipon Chattipakorn, Siriporn C Chattipakorn
Ischemia and reperfusion (I/R) injury induced by tourniquet (TQ) application leads to the release of both oxygen free radicals and inflammatory cytokines. The skeletal muscle I/R may contribute to local skeletal muscle and remote organ damage affecting outcomes after total knee arthroplasty (TKA). The aim of the study is to summarize the current findings associated with I/R injury following TKA using a thigh TQ, which include cellular alterations and protective therapeutic interventions. The PubMed database was searched using the keywords "ischemia reperfusion injury," "oxidative stress," "tourniquet," and "knee arthroplasty...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30523755/tgf-%C3%AE-secreted-by-tumor-associated-macrophages-promotes-proliferation-and-invasion-of-colorectal-cancer-via-mir-34a-vegf-axis
#18
Danhua Zhang, Xinguang Qiu, Jianhua Li, Shouhua Zheng, Liwen Li, Hongchao Zhao
Tumor-associated macrophages (TAMs) were reported to be involved in colorectal cancer (CRC) progression. However, its biological role and underlying mechanism in CRC remained to be elucidated. In this study, the expressions of the macrophage marker CD68 and transforming growth factor β1 (TGF-β1) in CRC tumor tissues and adjacent tissues were detected by immunohistochemistry. The expression levels of miR-34a, TGF-β1 and vascular endothelial growth factor (VEGF) in CRC tumor tissues and peripheral blood macrophages were measured by quantitative real-time PCR (qRT-PCR) and western blot...
December 7, 2018: Cell Cycle
https://www.readbyqxmd.com/read/30523586/the-ng2-proteoglycan-in-pericyte-biology
#19
William B Stallcup
Studies of pericytes have been retarded by the lack of appropriate markers for identification of these perivascular mural cells. Use of antibodies against the NG2 proteoglycan as a pericyte marker has greatly facilitated recent studies of pericytes, emphasizing the intimate spatial relationship between pericytes and endothelial cells, allowing more accurate quantification of pericyte/endothelial cell ratios in different vascular beds, and revealing the participation of pericytes throughout all stages of blood vessel formation...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30523585/pericyte-biology-development-homeostasis-and-disease
#20
Alexander Birbrair
In the nineteenth century, a French researcher, Charles-Marie Benjamin Rouget, revealed a population of contractile cells associated with small blood vessels, which were initially named after him as the Rouget cells. In the twentieth century, a German scientist, Karl Wilhelm Zimmermann, called these cells "pericytes" due to their anatomical position located in a perivascular position. The word pericyte was derived from "peri" meaning "around" and "cyte" from the word "kytos" (cell), illustrating a cell encircling a blood vessel...
2018: Advances in Experimental Medicine and Biology
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