Caitríona Grönberg, Sara Rattik, Cuong Tran-Manh, Xiang Zhou, Aleix Rius Rigau, Yi-Nan Li, Andrea-Hermina Györfi, Nicholas Dickel, Meik Kunz, Alexander Kreuter, Emil-Alexandru Matei, Honglin Zhu, Petter Skoog, David Liberg, Jörg Hw Distler, Thuong Trinh-Minh
BACKGROUND: The interleukin (IL)-1 receptor accessory protein (IL1RAP) is an essential coreceptor required for signalling through the IL-1, IL-33 and IL-36 receptors. Here, we investigate the antifibrotic potential of the combined inhibition of these cytokines by an anti-IL1RAP antibody to provide a scientific background for clinical development in systemic sclerosis (SSc). METHODS: The expression of IL1RAP-associated signalling molecules was determined by data mining of publicly available RNA sequencing (RNAseq) data as well as by imaging mass cytometry...
April 9, 2024: Annals of the Rheumatic Diseases