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Cortisol Immunity

Helge Hasselmann, Stefanie Gamradt, Aline Taenzer, Jan Nowacki, Rami Zain, Kostas Patas, Caren Ramien, Friedemann Paul, Katja Wingenfeld, Dominique Piber, Stefan M Gold, Christian Otte
Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of major depressive disorder (MDD). However, the cellular origin of inflammatory signals and their specificity remain unclear. We examined the phenotype and glucocorticoid signaling in key cell populations of the innate immune system (monocytes) vs. adaptive immunity (T cells) in a sample of 35 well-characterized, antidepressant-free patients with MDD and 35 healthy controls individually matched for age, sex, smoking status and body mass index...
2018: Frontiers in Immunology
Mohanned Naif Alhussien, Ajay Kumar Dang
The present study was undertaken to compare the effect of different seasons on the mammary immunity of three Indian native breeds of cows (Tharparkar, Gir and Sahiwal) well adapted to the tropical region. For this milk samples were collected from cows in winter (THI=57, comfortable zone), hot-dry (HD; THI=76, heat stressful zone) and hot-humid (HH; THI = 82, severe heat stress) and estimated for milk somatic cell counts (SCC), phagocytic activity (PA) of milk neutrophils, milk cortisol and heat shock proteins and function associated genes in milk neutrophils...
December 2018: Journal of Thermal Biology
Ali Reza Khansari, Joan Carles Balasch, Eva Vallejos-Vidal, Mariana Teles, Camino Fierro-Castro, Lluis Tort, Felipe E Reyes-López
The stress and immune-related effects of short-term (1, 6 and 24 h) air exposure stress (1 min), bath vaccination with Vibrio anguillarum bacterin, and both stressors combined were evaluated in liver and spleen of Sparus aurata, Danio rerio and Onchorhynchus mykiss. Expression profiles of immune (interleukin 1 beta: il1β; tumor necrosis factor alpha: tnfα; interleukin 10: il10; tumor growth factor beta: tgfβ1; immunoglobulin M: igm; lysozyme: lys; complement protein c3: c3) and stress-related genes (glucocorticoid receptor: gr; heat shock protein 70: hsp70; and enolase) were analysed by RT-qPCR...
November 28, 2018: Fish & Shellfish Immunology
S Nazzari, P Fearon, F Rice, N Dottori, F Ciceri, M Molteni, A Frigerio
Accumulating evidence suggests that antenatal maternal stress is associated with altered behavioral and physiological outcomes in the offspring, however, whether this association is causal and the underlying biological mechanisms remain largely unknown. While the most studied mediator of maternal stress influences on the fetus has generally been cortisol, alternative novel markers of stress or inflammation warrant further consideration. The current investigation explored the influence of variations in self-reported symptoms of distress, stress hormones and inflammatory markers on infant birth outcomes and early stress regulation...
November 14, 2018: Psychoneuroendocrinology
W C Kayser, G E Carstens, I L Parsons, T H Welsh, K E Washburn, S D Lawhon, W E Pinchak, J T Richeson, E Chevaux, A L Skidmore
Objectives of this experiment were to examine the effects of live yeast (LY) supplementation on immunological, physiological and behavioral responses in steers experimentally challenged with Mannheimia haemolytica (MH). Thirty-six crossbred Angus steers (BW = 352 ± 23 kg) seronegative for MH were allocated within a 2 x 2 factorial arrangement: Factor 1= roughage-based diet with LY (Saccharomyces cerevisiae boulardii CNCM I-1079, 25 g·per steer daily) or negative control (CON). Factor 2 = bronchoselective endoscopic inoculation with MH or phosphate buffer solution (PBS)...
November 28, 2018: Journal of Animal Science
R Vargas, J C Balasch, I Brandts, F Reyes-López, L Tort, M Teles
Environmental insults, such as exposure to pathogens, modulate the behavioural coping style of animals to stressors, and repeated exposure to stressful environments may lead to species-specific infection phenotypes. To analyse the influence of stress behavioural phenotypes on immune and metabolic performance, gilthead sea bream (Sparus aurata L.) were first screened for proactive and reactive coping styles. Once characterized, both behavioural phenotypes fish groups were bath vaccinated with bacterin from Vibrio anguillarum, an opportunistic widespread pathogen of fish...
November 26, 2018: Scientific Reports
Qian Zhang, Chong Li, Xiaolin Niu, Zhian Zhang, Fadi Li, Fei Li
BACKGROUND: Pre-weaning milk replacer (MR) feeding program is a key factor affecting the health and welfare of lambs during their weaning. Weaning stress is well known as an inducement that negatively impacts the immune system of young ruminants, whose physiological and immune state is closely linked to the community of microbiota in their intestines. This study had two objectives: 1) To evaluate the innate immune response to weaning stress at both the physiological and molecular level; 2) To investigate changes to the jejunal chyme and mucosal adhesive microbiota between the control and high plane of MR groups...
November 26, 2018: BMC Veterinary Research
Robert-Paul Juster, Marc Sasseville, Charles-Édouard Giguère, Signature Consortium, Sonia J Lupien
OBJECTIVE: Individuals requiring psychiatric emergency services are often highly distressed and intoxicated. To provide an objective and comprehensive measure of their stress-related physiological dysregulations, we indexed allostatic load with 14 biomarkers collected within 24 h of patients' admission to the largest psychiatric hospital in the Canadian province of Quebec. METHODS: This study (N = 278) combines data for emergency patients (n = 76; 65.8% women; M age = 44...
December 2018: Journal of Psychosomatic Research
E Merlot, H Pastorelli, A Prunier, M-C Père, I Louveau, L Lefaucheur, M-H Perruchot, M C Meunier-Salaün, D Gardan-Salmon, F Gondret, H Quesnel
In pig husbandry, pregnant females are often exposed to stressful conditions, and their outcomes on maternal and offspring health have not been well evaluated. The present study aimed at testing whether improving the welfare of gestating sows could be associated with a better maternal health during gestation, changes in the composition of lacteal secretions and improvement in piglet survival. Two contrasted group-housing systems for gestating sows were used, that is, a French conventional system on slatted floor (C, 49 sows) and an enriched system using larger pens on deep straw (E, 57 sows)...
November 23, 2018: Animal: An International Journal of Animal Bioscience
Alejandro Morales-Jinez, Francisco J López-Rincón, Alicia Ugarte-Esquivel, Irma Andrade-Valles, Luz Elena Rodríguez-Mejía, José Luis Hernández-Torres
OBJECTIVE: to compare the biomarkers and the allostatic load levels in a sample of older persons with and without canine companionship. METHOD: descriptive and comparative study. Data were collected using a sociodemographic questionnaire and a fasting blood sample. The allostatic load comprised 11 biomarkers that are primary and secondary stress mediators, which arise from the following systems: neuroendocrine, immune, metabolic, cardiovascular and anthropometric...
November 14, 2018: Revista Latino-americana de Enfermagem
Maude Lambert, Marie-Ève Couture-Lalande, Kelly Brennan, Aldin Basic, Sophie Lebel, Catherine Bielajew
Introduction: One way to examine the extent to which the stress associated with a breast cancer experience (BC) impacts stress-related physiological mechanisms is to study the secretion patterns of associated biomarkers. Unlike cortisol and α-amylase (sAA), biomarkers of immune functioning such as secretory immunoglobulin A (SIgA) have rarely been examined in BC survivors. Aim of the study: This study had two principal aims: the first was to evaluate the basal secretion profiles of SIgA as well as its response to an acute stressor as a marker of immune health in BC survivors and women with no history of BC, and the second was to determine how SIgA stress-related patterns compare to published cortisol and sAA patterns in the same women...
2018: Contemporary Oncology Współczesna Onkologia
Ulrik Stervbo, Toralf Roch, Tina Kornprobst, Birgit Sawitzki, Gerald Grütz, Andreas Wilhelm, Francis Lacombe, Kaoutar Allou, Markus Kaymer, Antoine Pacheco, Jacques Vigne, Timm H Westhoff, Felix S Seibert, Nina Babel
Gravitational stress occurs during space flights or certain physical activities including extreme sports, where the change in experienced gravitational acceleration can reach large magnitudes. These changes include reduction and increase in the physical forces experienced by the body and may potentially induce pathogenic alterations of physiological processes. The immune system is known to regulate most functions in the human organism and previous studies suggest an impairment of the immune function under gravitational stress...
2018: PloS One
Simone Brixius-Anderko, Emily E Scott
Human cytochrome P450 11B1 (CYP11B1) is responsible for the final step generating the steroid hormone cortisol, which controls stress and immune responses and glucose homeostasis. CYP11B1 is a promising drug target to manage Cushing's disease, a disorder arising from excessive cortisol production. However, the design of selective inhibitors has been hampered because structural information for CYP11B1 is unavailable and the enzyme has high amino acid sequence identity (93%) to a closely related enzyme, the aldosterone-producing CYP11B2...
November 13, 2018: Journal of Biological Chemistry
Rosaria Marino, Mariangela Caroprese, Giovanni Annicchiarico, Francesco Ciampi, Maria Giovanna Ciliberti, Antonella Della Malva, Antonella Santillo, Agostino Sevi, Marzia Albenzio
In the last years several studies have investigated the strong relation between nutrition and immune response in the livestock production, particularly in dairy cattle and sheep. The aim of this study was to evaluate the effects of supplementation based on linseed, quinoa seeds and their combination on welfare, productivity and quality of meat from merinos derived lambs. 32 weaned lambs were divided into 4 experimental groups: quinoa (Q), linseed (LS) and combination of quinoa and linseed (LS + Q) that received the respective supplementation and control group (C) without supplementation...
November 10, 2018: Animals: An Open Access Journal From MDPI
Diah Tri Widayati, Pradita Iustitia Sitaresmi, Sigit Bintara, Budi Prasetyo Widyobroto
BACKGROUND AND OBJECTIVE: In goats, weak estrus behavior is potentially caused by a decline in reproductive efficiency. In the present study, aim was to measure the vaginal pH to determine the accuracy of lust detection in Saanen Etawah crossbreed goats. MATERIALS AND METHODS: Thirteen Saanen Etawah crossbred does (Capra hircus) with body condition score of 2-3 were used. The dose were fed concentrate, provided forage and water ad libitum. The experiment was conducted during the natural estrous cycle...
January 2018: Pakistan Journal of Biological Sciences: PJBS
Kyung-Baeg Roh, Deokhoon Park, Eunsun Jung
Glucocorticoids are a risk factor for age-induced skin structure and function defects, and the glucocorticoid-activating enzyme, 11 β -hydroxysteroid dehydrogenase 1 (11 β -HSD1), represents a promising therapeutic target. Prunella vulgaris L. (PV) is a perennial and an edible herbaceous plant normally cultivated in Asia and Europe. A recent study demonstrated a broad range of biological activities of PV including immune modulatory, antiviral, antiallergic, anti-inflammatory, antioxidant, and antidiabetic...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Peter Ergang, Anna Mikulecka, Martin Vodicka, Karla Vagnerova, Ivan Miksik, Jiri Pacha
Stress is an important risk factors for human diseases. It activates the hypothalamic-pituitary-adrenal (HPA) axis and increases plasma glucocorticoids, which are powerful regulators of immune system. The response of the target cells to glucocorticoids depends not only on the plasma concentrations of cortisol and corticosterone but also on their local metabolism. This metabolism is catalysed by 11beta-hydroxysteroid dehydrogenases type 1 and 2, which interconvert glucocorticoid hormones cortisol and corticosterone and their 11-oxo metabolites cortisone and 11-dehydrocorticosterone...
November 1, 2018: Endocrine Connections
Liisa Hantsoo, Eldin Jašarević, Stephanie Criniti, Brendan McGeehan, Ceylan Tanes, Mary D Sammel, Michal A Elovitz, Charlene Compher, Gary Wu, C Neill Epperson
BACKGROUND: Adverse childhood experiences (ACEs), such as abuse or chronic stress, program an exaggerated adult inflammatory response to stress. Emerging rodent research suggests that the gut microbiome may be a key mediator in the association between early life stress and dysregulated glucocorticoid-immune response. However, ACE impact on inflammatory response to stress, or on the gut microbiome, have not been studied in human pregnancy, when inflammation increases risk of poor outcomes...
November 3, 2018: Brain, Behavior, and Immunity
F L Cheng, X P Qi, C Q Zhao, Y F An, J J Ren, C Li
Objective: To study the effect of dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis on the pathogenesis of allergic rhinitis (AR) by the mouse model of decreased endogenous glucocorticoid (GC) after adrenalectomy, and further explore the mechanism of neural-endocrine regulation. Methods: According to literatures, adrenalectomized (ADX) mice and AR model were established. Eighty mice were randomly divided into four groups ( n =20 per group) including control group, AR group of normal mice (AR group), AR group of bilateral ADX (bilateral ADX/AR group) and AR group of unilateral ADX (unilateral ADX/AR group)...
October 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Ana E Duran-Pinedo, Jose Solbiati, Jorge Frias-Lopez
Imbalances of the microbiome, also referred to as microbial dysbiosis, could lead to a series of different diseases. One factor that has been shown to lead to dysbiosis of the microbiome is exposure to psychological stressors. Throughout evolution microorganisms of the human microbiome have developed systems for sensing host-associated signals such as hormones associated with those stressors, enabling them to recognize essential changes in their environment, thus changing their expression gene profile to fit the needs of the new environment...
2018: NPJ Biofilms and Microbiomes
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