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https://www.readbyqxmd.com/read/30551148/the-serogroup-b-meningococcal-vaccine-bexsero-elicits-antibodies-to-neisseria-gonorrhoeae
#1
Evgeny A Semchenko, Aimee Tan, Ray Borrow, Kate L Seib
Background: Neisseria gonorrhoeae and Neisseria meningitidis are closely related bacteria that cause a significant global burden of disease. Control of gonorrhoea is becoming increasingly difficult due to widespread antibiotic resistance. While vaccines are routinely used for N.meningitidis, no vaccine is available for N.gonorrhoeae. Recently, the outer membrane vesicle (OMV) meningococcal B vaccine, MeNZB, was reported to be associated with reduced rates of gonorrhoea following a mass vaccination campaign in New Zealand...
December 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30550236/evaluation-of-neisseria-meningitidis-carriage-with-the-analysis-of-serogroups-genogroups-and-clonal-complexes-among-polish-soldiers
#2
Krzysztof Korzeniewski, Monika Konior
Neisseria meningitidis is an etiological factor of invasive meningococcal disease (IMD). This Gram-negative diplococcus is transmitted from person to person via droplets or through a direct physical contact with secretions of infected patients or asymptomatic carriers. The latter account for 5-10% of the general population. The aim of the study was to estimate the actual N. meningitidis carriage rate in the military environment with identification of serogroups, genogroups, sequence types and clonal complexes of the isolates detected among Polish soldiers...
2018: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/30548358/bacteremia-and-meningitis-caused-by-a-novel-clone-of-neisseria-meningitidis-serogroup-b
#3
Jun Shinozuka, Hideyuki Takahashi, Mori Masahiro, Hitoshi Awaguni, Shinsaku Imashuku
No abstract text is available yet for this article.
December 11, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/30538184/the-meningococcal-cysteine-transport-system-plays-a-crucial-role-in-neisseria-meningitidis-survival-in-human-brain-microvascular-endothelial-cells
#4
Hideyuki Takahashi, Haruo Watanabe, Kwang Sik Kim, Shigeyuki Yokoyama, Tatsuo Yanagisawa
While Neisseria meningitidis typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of human cells are not always conducive to meningococci, N. meningitidis needs to exploit nutrients from host environments. In the present study, the utilization of cysteine by the meningococcal cysteine transport system (CTS) was analyzed for the pathogenesis of meningococcal infections...
December 11, 2018: MBio
https://www.readbyqxmd.com/read/30517103/development-of-a-pcr-algorithm-to-detect-and-characterize-neisseria-meningitidis-carriage-isolates-in-the-african-meningitis-belt
#5
Kanny Diallo, Mamadou D Coulibaly, Lisa S Rebbetts, Odile B Harrison, Jay Lucidarme, Kadidja Gamougam, Yenenesh K Tekletsion, Akalifa Bugri, Aliou Toure, Bassira Issaka, Marietou Dieng, Caroline Trotter, Jean-Marc Collard, Samba O Sow, Xin Wang, Leonard W Mayer, Ray Borrow, Brian M Greenwood, Martin C J Maiden, Olivier Manigart
Improved methods for the detection and characterization of carried Neisseria meningitidis isolates are needed. We evaluated a multiplex PCR algorithm for the detection of a variety of carriage strains in the meningitis belt. To further improve the sensitivity and specificity of the existing PCR assays, primers for gel-based PCR assays (sodC, H, Z) and primers/probe for real-time quantitative PCR (qPCR) assays (porA, cnl, sodC, H, E, Z) were modified or created using Primer Express software. Optimized multiplex PCR assays were tested on 247 well-characterised carriage isolates from six countries of the African meningitis belt...
2018: PloS One
https://www.readbyqxmd.com/read/30514786/potent-cas9-inhibition-in-bacterial-and-human-cells-by-acriic4-and-acriic5-anti-crispr-proteins
#6
Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D Gao, Pengpeng Liu, Alan R Davidson, Karen L Maxwell, Erik J Sontheimer
In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previously we discovered bacteriophage-encoded Cas9-specific anti-CRISPR (Acr) proteins that serve as countermeasures against host bacterial immunity by inactivating their CRISPR-Cas systems (A. Pawluk, N. Amrani, Y. Zhang, B. Garcia, et al., Cell 167:1829-1838.e9, 2016, https://doi...
December 4, 2018: MBio
https://www.readbyqxmd.com/read/30513251/b-part-of-it-study-a-longitudinal-study-to-assess-carriage-of-neisseria-meningitidis-in-first-year-university-students-in-south-australia
#7
Mark McMillan, Luke Walters, Mark Turra, Andrew Lawrence, Lex E X Leong, Thomas Sullivan, Geraint B Rogers, Ross M Andrews, Helen S Marshall
OBJECTIVES: N. meningitidis carriage in Australia is poorly understood. This study aimed to estimate prevalence and risk factors for carriage of N. meningitidis in South Australian university students. We also sought to identify whether delayed freezing of oro-pharyngeal samples altered PCR positivity, cycle threshold, or culture positivity. METHODS: Oro-pharyngeal swabs were taken from first year university students and repeated after 3 months, with risk factor questionnaires completed at both visits...
December 4, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30510007/polysaccharide-structure-dictates-mechanism-of-adaptive-immune-response-to-glycoconjugate-vaccines
#8
Ximei Sun, Giuseppe Stefanetti, Francesco Berti, Dennis L Kasper
Glycoconjugate vaccines are among the most effective interventions for preventing several serious infectious diseases. Covalent linkage of the bacterial capsular polysaccharide to a carrier protein provides CD4+ T cells with epitopes that facilitate a memory response to the polysaccharide. Classically, the mechanism responsible for antigen processing was thought to be similar to what was known for hapten-carrier conjugates: protease digestion of the carrier protein in the endosome and presentation of a resulting peptide to the T cell receptor on classical peptide-recognizing CD4+ T cells...
December 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30501091/improved-biosafety-and-biosecurity-measures-and-or-strategies-to-tackle-laboratory-acquired-infections-and-related-risks
#9
REVIEW
Huasong Peng, Muhammad Bilal, Hafiz M N Iqbal
Herein, we reviewed laboratory-acquired infections (LAIs) along with their health-related biological risks to provide an evidence base to tackle biosafety/biosecurity and biocontainment issues. Over the past years, a broad spectrum of pathogenic agents, such as bacteria, fungi, viruses, parasites, or genetically modified organisms, have been described and gained a substantial concern due to their profound biological as well as ecological risks. Furthermore, the emergence and/or re-emergence of life-threatening diseases are of supreme concern and come under the biosafety and biosecurity agenda to circumvent LAIs...
November 29, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30496490/managing-the-risk-of-bacterial-meningitis-among-healthcare-workers
#10
M Ferraro, L Morucci, L Coppeta, G De Carolis, A Pietroiusti, E Franco, A Magrini
Background: Meningococcal disease is generally caused by A, B, C, W and Y subgroups of Neisseria meningitidis. In 2015, the Italian mass media focused on this disease due to the death of two nurses. This generated alarm in the general population, especially in healthcare workers (HCWs). The Occupational Medicine department of the Foundation PTV Polyclinic Tor Vergata (PTV) offered free MenACWY vaccine to HCWs and to students of the University of Rome Tor Vergata. Aims: To analyse the prevalence of N...
November 29, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/30485280/tracking-a-serial-killer-integrating-phylogenetic-relationships-epidemiology-and-geography-for-two-invasive-meningococcal-disease-outbreaks
#11
Ifeoma Ezeoke, Madeline R Galac, Ying Lin, Alvin T Liem, Pierce A Roth, Andrew Kilianski, Henry S Gibbons, Danielle Bloch, John Kornblum, Paula Del Rosso, Daniel A Janies, Don Weiss
BACKGROUND: While overall rates of meningococcal disease have been declining in the United States for the past several decades, New York City (NYC) has experienced two serogroup C meningococcal disease outbreaks in 2005-2006 and in 2010-2013. The outbreaks were centered within drug use and sexual networks, were difficult to control, and required vaccine campaigns. METHODS: Whole Genome Sequencing (WGS) was used to analyze preserved meningococcal isolates collected before and during the two outbreaks...
2018: PloS One
https://www.readbyqxmd.com/read/30479961/a-case-report-of-serotype-w135-neisseria-meningitidis-epiglottitis-in-the-united-states-and-review-of-twelve-adult-cases-of-meningococcal-epiglottitis
#12
Sommer D Zarbock, Kirk L DePriest, Brandi M Koepp
No abstract text is available yet for this article.
2018: IDCases
https://www.readbyqxmd.com/read/30479393/emergence-and-spread-of-resistant-n-meningitidis-implicated-in-invasive-meningococcal-diseases-during-the-past-decade-2008-2017
#13
Yassine Zouheir, Taha Atany, Najma Boudebouch
Neisseria meningitidis is one of the most crucial causes of bacterial meningitis worldwide. The incidence of meningitis due to N. meningitidis greatly changes from one geographical area to the other: 500,000-1,200,000 invasive meningococcal diseases occur each year, with 50,000-135,000 deaths. Once the diagnosis of bacterial meningitis is made, parenteral antibiotic treatment is started as soon as possible. A preventive treatment can also be proposed for those subjects at risk of exposure. Globally, resistance to antibiotics used in the treatment of prophylaxis of meningococcal disease is relatively rare...
November 27, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/30478004/vaccine-preventable-invasive-bacterial-diseases-in-italy-a-comparison-between-the-national-surveillance-system-and-recorded-hospitalizations-2007-2016
#14
Patrizio Pezzotti, Stefania Bellino, Flavia Riccardo, Francesca Lucaroni, Marina Cerquetti, Annalisa Pantosti, Giovanni Rezza, Paola Stefanelli
BACKGROUND: Vaccine-preventable invasive bacterial diseases (IBDs) caused by Neisseria meningitidis (Nm), Streptococcus pneumoniae (Sp), and Haemophilus influenzae (Hi) have been notified in Italy since 2007 without assessing reporting completeness. METHODS: Our study compared the number of cases of IBDs identified from the Italian Hospital Discharge Records (HDRs), using specific diagnostic ICD-9-CM codes, with those notified to the National Surveillance System (NSS) from 2007 to 2016...
November 23, 2018: Vaccine
https://www.readbyqxmd.com/read/30476070/differential-influences-of-complement-on-neutrophil-responses-to-n-meningitidis-infection
#15
Sören Krüger, Emma Eichler, Lea Strobel, Alexandra Schubert-Unkmeir, Kay O Johswich
The complement system is the primary innate immune determinant protecting against invasive diseases caused by the Gram-negative bacterium Neisseria meningitidis (Nme, meningococcus), as evidenced by the extreme susceptibility of individuals with complement deficiencies. In contrast, the role of phagocytes such as neutrophils is much less well understood, although they are recruited in great numbers to the cerebrospinal fluid during meningococcal meningitis. Here, we consider the interaction of Nme with primary human neutrophils using either purified cells or a whole blood model of infection...
November 21, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/30475234/neisseria-meningitidis-isolated-in-vitreous-humor-in-a-5-month-old-infant-death-from-meningococcal-sepsis
#16
Jack Garland, Winston Philcox, Kilak Kesha, Veronica Playle, Shanika Perera, Toni OʼRegan, Simon Stables, Rexson Tse
Diagnosing sepsis at postmortem is challenging. With respect to meningococcal sepsis, the postmortem microbiological identification of Neisseria meningitidis is nearly always due to true infection, including in cases of decomposition. Previous case series and case reports were able to isolate N. meningitidis in vitreous humor in adult deaths from meningococcal sepsis when blood and/or cerebrospinal fluid was unavailable. It was suggested that vitreous humor polymerase chain reaction (PCR) may be useful in the diagnosis of meningococcal sepsis...
November 20, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/30471953/concomitant-administration-of-a-fully-liquid-ready-to-use-dtap-ipv-hb-prp-t-hexavalent-vaccine-with-a-meningococcal-acwy-conjugate-vaccine-in-toddlers
#17
Timo Vesikari, Ray Borrow, Xavier Da Costa, Stéphane Thomas, Cécile Eymin, Florence Boisnard, Stephen Lockhart
Invasive meningococcal disease caused by Neisseria meningitidis is a life-threatening disease. Several countries now include meningococcal serogroup C (MenC) conjugate and, more recently, a meningococcal serogroup ACWY conjugate (MenACWY) vaccination in their national immunization schedules. DTaP-IPV-HB-PRP-T is a hexavalent vaccine that provides protection against six diseases. The phase III, open-label, randomised, multicentre study enrolled healthy toddlers who received the DTaP-IPV-HB-PRP-T vaccine (at 2, 3 and 4 months) with or without a MenC vaccine (at 2 and 4 months) in the primary series study...
November 21, 2018: Vaccine
https://www.readbyqxmd.com/read/30471022/simple-way-to-detect-trp-to-tb-3-resonance-energy-transfer-in-calcium-binding-peptides-using-excitation-spectrum
#18
Petra Lišková, Ivo Konopásek, Radovan Fišer
The sensitized phosphorescence of Tb3+ is often used for the assessment of the ion binding to various chelating agents or natural Ca2+ -binding proteins. The detailed structure of the Tb3+ excitation spectrum gives a special advantage for analysis; any extra absorption peak can be easily detected which provides simple and direct evidence that resonance energy transfer occurs. By employing the Tb3+ phosphorescence, we characterized the Ca2+ -binding sites of two related peptides - self-processing module of the FrpC protein produced by bacterium Neisseria meningitidis and the shorter peptide derived from FrpC...
November 23, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/30463732/splenic-embolization-after-trauma-an-opportunity-to-improve-best-immunization-practices
#19
Kyle G Crooker, James M Howard, Aaron R Alvarado, Tracy J McDonald, Stepheny D Berry, Justin L Green, Robert D Winfield
BACKGROUND: The spleen is the second most commonly injured solid organ during blunt abdominal trauma. Although total splenectomy is frequently performed for injury, splenic rupture can also be managed by splenic embolization. For these patients, current Advisory Committee on Immunization Practices (ACIP) recommendations indicate that if 50% or more of the splenic mass is lost, patients should be treated as though they are asplenic. We have previously demonstrated that compliance with ACIP guidelines regarding immunization after splenectomy is poor...
December 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/30462563/experience-implementing-a-university-based-mass-immunization-program-in-response-to-a-meningococcal-b-outbreak
#20
Blair Capitano, Krista Dillon, Andre LeDuc, Bruce Atkinson, Cynthia Burman
Neisseria meningitidis serogroup B (MenB) has caused several recent outbreaks of meningococcal disease on US college campuses. In January 2015, a case of MenB was reported at a university in Oregon, culminating in an outbreak with a total of 7 cases (including 1 fatality) identified over a 5-month period. In response to the outbreak, the university organized a mass immunization campaign with 4 "opt-in" immunization clinics. The preparation, challenges, and resources required for organization and implementation of a mass immunization program in response to an outbreak at a large public university are discussed herein...
November 21, 2018: Human Vaccines & Immunotherapeutics
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