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"neisseria meningitidis"

Gabriela Trzewikoswki de Lima, Elizabeth De Gaspari
No abstract text is available yet for this article.
August 9, 2018: Biologicals: Journal of the International Association of Biological Standardization
Alcides Moniz Munguambe, António Eugénio Castro Cardoso de Almeida, Aquino Albino Nhantumbo, Charlotte Elizabeth Come, Tomás Francisco Zimba, José Paulo Langa, Ivano de Filippis, Eduardo Samo Gudo
INTRODUCTION: In sub Saharan Africa, the epidemiology, including the distribution of serogroups of strains of N. meningitidis is poorly investigated in countries outside "the meningitis belt". This study was conducted with the aim to determine the distribution of serogroups of strains of N. meningitidis causing meningococcal meningitis in children and adults in Mozambique. METHODS: A total of 106 PCR confirmed Neisseria meningitidis Cerebrospinal Fluid (CSF) samples or isolates were obtained from the biobank of acute bacterial meningitis (ABM) surveillance being implemented by the National Institute of Health, at three central hospitals in Mozambique, from January to December 2014...
2018: PloS One
Tuuli Ahlstrand, Annamari Torittu, Heli Elovaara, Hannamari Välimaa, Marja T Pöllänen, Sergo Kasvandik, Martin Högbom, Riikka Ihalin
Naturally competent bacteria acquire DNA from their surroundings to survive in nutrient-poor environments and incorporate DNA into their genomes as new genes for improved survival. The secretin HofQ from the oral pathogen Aggregatibacter actinomycetemcomitans has been associated with DNA uptake. Cytokine sequestering is a potential virulence mechanism in various bacteria and may modulate both host defense and bacterial physiology. The objective of this study was to elucidate a possible connection between natural competence and cytokine uptake in A...
2018: Virulence
Crista B Wadsworth, Brian J Arnold, Mohamad R Abdul Sater, Yonatan H Grad
Mosaic interspecifically acquired alleles of the multiple transferable resistance ( mtr ) efflux pump operon correlate with increased resistance to azithromycin in Neisseria gonorrhoeae in epidemiological studies. However, whether and how these alleles cause resistance is unclear. Here, we use population genomics, transformations, and transcriptional analyses to dissect the relationship between variant mtr alleles and azithromycin resistance. We find that the locus encompassing the mtrR transcriptional repressor and the mtrCDE pump is a hot spot of interspecific recombination introducing alleles from Neisseria meningitidis and Neisseria lactamica into N...
August 7, 2018: MBio
A Bechini, M Chellini, E Pellegrino, E Tiscione, C Lorini, G Bonaccorsi, P Bonanni, S Boccalini
The World Health Organization (WHO) has established specific targets for control, elimination or eradication of some vaccine preventable infectious diseases, which were periodically updated. In Italy, WHO recommendations have been endorsed and implemented over time, through the national and regional health prevention plans. The aim of the study was to assess the impact of the immunization practices against measles, varicella and Neisseria meningitidis type C (Men C) in Italy and in Tuscany Region, during the last decades, by analyzing national and regional surveillance databases...
June 2018: Journal of Preventive Medicine and Hygiene
Osman A Dufailu, Jafar Mahdavi, Dlawer A A Ala'Aldeen, Karl G Wooldridge, Neil J Oldfield
Neisseria meningitidis is normally a human nasopharyngeal commensal but is also capable of causing life-threatening sepsis and meningitis. N. meningitidis secretes several virulence-associated proteins including Neisserial autotransporter lipoprotein (NalP), an immunogenic, type Va autotransporter harboring an S8-family serine endopeptidase domain. NalP has been previously characterized as a cell-surface maturation protease which processes other virulence-associated meningococcal surface proteins, and as a factor contributing to the survival of meningococci in human serum due to its ability to cleave complement factor C3...
August 3, 2018: Microbial Pathogenesis
Marianne Elizabeth Alexandra Clemence, Martin Christopher James Maiden, Odile Barbara Harrison
The genus Neisseria comprises a diverse group of commensal bacteria, which typically colonize the mucosal surfaces of humans and other animals. Neisseria meningitidis, the meningococcus, is notable for its potential to cause invasive meningococcal disease (IMD) in humans; however, IMD is comparatively rare, and meningococci normally colonize the nasopharynx asymptomatically. Possession of a polysaccharide capsule has been shown to be a prerequisite for disease in almost all IMD cases, and was previously considered unique to N...
August 3, 2018: Microbial Genomics
Emma Ispasanie, Francesca Micoli, Araceli Lamelas, Dominique Keller, Francesco Berti, Riccardo De Riccio, Roberta Di Benedettoi, Simona Rondini, Gerd Pluschke
Whole genome sequencing analysis of 100 Neisseria meningitidis serogroup A isolates has revealed that the csaABCD-ctrABCD-ctrEF capsule polysaccharide synthesis locus represents a spontaneous point mutation hotspot. Structural and functional properties of the capsule of 11 carriage and two disease isolates with non-synonymous point mutations or stop codons in capsule synthesis genes were analyzed for their capsular polysaccharide expression, recognition by antibodies and sensitivity to bactericidal killing...
2018: Virulence
Jo Anne Welsch, Shelly Senders, Brandon Essink, Thomas Klein, Igor Smolenov, Paola Pedotti, Silvia Barbi, Bikash Verma, Daniela Toneatto
BACKGROUND: Neisseria meningitidis serogroups A, B, C, W and Y cause most meningococcal disease worldwide. An investigational MenABCWY vaccine combining serogroup B antigens and a meningococcal ACWY CRM197 -glycoconjugate vaccine (MenACWY-CRM) could provide protection against all 5 serogroups. Complement mediated bactericidal activity induced by MenABCWY was tested against a panel of 110 randomly-selected serogroup B strains causing invasive disease in the US to evaluate the vaccine's breadth of coverage (BoC)...
July 27, 2018: Vaccine
Thomas Waterfield, Mark D Lyttle, Derek Fairley, James Mckenna, Kerry Woolfall, Fiona Lynn, Julie-Ann Maney, Damian Roland, Aoife Weir, Michael D Shields
BACKGROUND: Children commonly present to Emergency Departments (ED) with a non-blanching rash in the context of a feverish illness. While most have a self-limiting viral illness, this combination of features potentially represents invasive serious bacterial infection, including meningococcal septicaemia. A paucity of definitive diagnostic testing creates diagnostic uncertainty for clinicians; a safe approach mandates children without invasive disease are often admitted and treated with broad-spectrum antibiotics...
July 30, 2018: BMC Pediatrics
Araceli Lamelas, Abdul-Wahab M Hamid, Jean-Pierre Dangy, Julia Hauser, Maja Jud, Katharina Röltgen, Abraham Hodgson, Thomas Junghanss, Simon R Harris, Julian Parkhill, Stephen D Bentley, Gerd Pluschke
Neisseria meningitidis is the leading cause of epidemic meningitis in the 'meningitis belt' of Africa, where clonal waves of colonization and disease are observed. Point mutations and horizontal gene exchange lead to constant diversification of meningococcal populations during clonal spread. Maintaining a high genomic diversity may be an evolutionary strategy of meningococci that increases chances of fixing occasionally new highly successful 'fit genotypes'. We have performed a longitudinal study of meningococcal carriage and disease in northern Ghana by analysing cerebrospinal fluid samples from all suspected meningitis cases and monitoring carriage of meningococci by twice yearly colonization surveys...
July 27, 2018: Genome Biology and Evolution
Nadja Heidrich, Antony Hagmann, Saskia Bauriedl, Jörg Vogel, Christoph Schoen
Neisseria meningitidis, a commensal β-proteobacterium of the human nasopharynx, constitutes a worldwide leading cause of sepsis and epidemic meningitis. A recent genome-wide association study suggested an association of its type II-C CRISPR/Cas system with carriage and thus less invasive lineages. Here, we show that knock-out strains lacking the Cas9 protein are impaired in the adhesion to human nasopharyngeal cells which constitutes a central step in the pathogenesis of invasive meningococcal disease. Transcriptome sequencing data further suggest that meningococcal Cas9 does not affect the expression of surface adhesins but rather exerts its effect on cell adhesion in an indirect manner...
July 30, 2018: RNA Biology
Fernanda Ayane de Oliveira Santos, Nilton Lincopan, Elizabeth De Gaspari
BACKGROUND: The Neisseria meningitidis bacterium is a Gram-negative diplococcus that can be classified into different serogroups according to the capsular structure. Six of them (A, B, C, W, X, Y) are responsible for causing Invasive Meningococcal Disease (IMD). The strategies for the development of a vaccine for serogroup B have been directed to the use of outer membrane vesicles (OMVs). The aim of this study was to evaluate the immunogenicity of antigenic determinants from OMVs of N...
July 19, 2018: Immunobiology
Rania Bouneb, Manel Mellouli, Haifa Regaieg, Senda Majdoub, Imed Chouchène, Mohamed Boussarsar
Fulminant meningococcemia is a relatively rare life-threatening disease caused by Neisseria meningitidis. The clinical presentation is varied, but, when associated with myocarditis, it carries a particularly poor prognosis. We report a case of a patient with fulminant meningococcemia who subsequently developed severe myocardial dysfunction and successfully recovered within a period of 7 days of hospitalization. A 15-year-old girl presented with headache, fever, body ache for 1 day and few ecchymotic rash over her body for 3 hours...
2018: Pan African Medical Journal
Stefanie A Krumm, Katie J Doores
Glycosylation is an important post-translational modification that is required for structural and stability purposes and functional roles such as signalling, attachment and shielding. Many human pathogens such as bacteria display an array of carbohydrates on their surface that are non-self to the host; others such as viruses highjack the host-cell machinery and present self-carbohydrates sometimes arranged in a non-self more immunogenic manner. In combination with carrier proteins, these glycan structures can be highly immunogenic...
July 26, 2018: Current Topics in Microbiology and Immunology
Bingbing Sun, Junjie Yang, Sheng Yang, Richard D Ye, Daijie Chen, Yu Jiang
Mycobacterium smegmatis is an important model strain of Mycobacterium for scientific study because it is non-pathogenic and grows rapidly. However, research is limited by the low efficiency and time-consuming nature of existing genome editing tools. Although the Streptococcus pyogenes CRISPR-Cas9 system is widely used in bacterial genome editing, it cannot be introduced into M. smegmatis because of its toxicity. The authors test 14 different Cas effector proteins in M. smegmatis. Cas9 (TdCas9_m) from Treponema denticola, Cas9 (NmCas9) from Neisseria meningitidis, and Corynebacterium glutamicum codon-optimized Cpf1 (FnCpf1_cg) from Francisella tularensis do not affect cell growth...
July 24, 2018: Biotechnology Journal
Divya Chauhan, Kiran Mokta, Anil Kanga, Neelam Grover
Objectives: To study the epidemiology, clinical profile, and the role of rapid tests in the diagnosis of acute bacterial meningitis (ABM) in children (1-59 months). Materials and Methods: A total of 250 cerebrospinal fluid (CSF) and 187 blood samples received from clinically suspected cases of ABM were processed based on standard microbiological protocols. CSF samples were also subjected to antigen and nucleic acid detection. Antibiotic susceptibility testing was done according to the Clinical Laboratory Standards Institute guidelines...
July 2018: Neurology India
Paola Stefanelli, Cecilia Fazio, Paola Vacca, Annapina Palmieri, Luigina Ambrosio, Arianna Neri, Andrea Piana, Paolo Castiglia, Federico Argiolas, Simonetta Santus, Laura Masala, Giorgio Steri, Flavia Riccardo, Stefania Iannazzo, Francesco Paolo Maraglino, Claudio D'Amario, Giovanni Rezza
OBJECTIVES: To investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia. METHODS: An epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole genome sequencing (WGS). RESULTS: Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the 7 cases (5 males; mean age 19 years; range 18 to 21 years; CFR 40%) were due to a unique strain B:P1...
July 20, 2018: Clinical Microbiology and Infection
Adam C Retchless, Malika Congo-Ouédraogo, Dinanibè Kambiré, Jeni Vuong, Alex Chen, Fang Hu, Absetou Ky Ba, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Jaymin C Patel, Rasmata Ouédraogo Traoré, Lassana Sangaré, Xin Wang
BACKGROUND: Neisseria meningitidis serogroup A disease in Burkina Faso has greatly decreased following introduction of a meningococcal A conjugate vaccine in 2010, yet other serogroups continue to pose a risk of life-threatening disease. Capsule switching among epidemic-associated serogroup A N. meningitidis strains could allow these lineages to persist despite vaccination. The introduction of new strains at the national or sub-national levels could affect the epidemiology of disease...
July 18, 2018: BMC Infectious Diseases
Esayas Kebede Gudina, Markos Tesfaye, Andreas Wieser, Hans-Walter Pfister, Matthias Klein
BACKGROUND: The mortality and neurologic sequelae associated with acute bacterial meningitis (ABM) remain high despite advances in medical care. The main aim of this study was to evaluate short-term outcome in patients treated as bacterial meningitis at a teaching hospital in Ethiopia to identify factors that could be focused on to improve outcome in this setting. METHODS: A hospital based longitudinal study was conducted at Jimma University Hospital in southwest Ethiopia from March 1, 2013 to December 31, 2015...
2018: PloS One
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