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https://www.readbyqxmd.com/read/30120516/new-generation-hydrogel-endovascular-aneurysm-treatment-trial-heat-a-study-protocol-for-a-multicenter-randomized-controlled-trial
#1
Karl R Abi-Aad, Rami James N Aoun, Rudy J Rahme, Jennifer D Ward, Jason Kniss, Mary Jeanne Kwasny, Mithun G Sattur, Matthew E Welz, Bernard R Bendok
PURPOSE: Aneurysm recanalization constitutes a limitation in the endovascular treatment of intracranial aneurysms using conventional bare platinum coils. The development of platinum coils coupled with hydrogel polymers aimed at decreasing the rates of recurrence by way of enhanced coil packing density and biological healing within the aneurysm. While enhanced occlusion and durability has been shown for the first generation hydrogel coils, their use was limited by technical challenges...
August 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/30120370/impact-of-comorbidities-and-smoking-on-the-outcome-in-aneurysmal-subarachnoid-hemorrhage
#2
Alexander Hammer, Anahi Steiner, Gholamreza Ranaie, Eduard Yakubov, Frank Erbguth, Christian M Hammer, Monika Killer-Oberpfalzer, Hans Steiner, Hendrik Janssen
The intention of this observational study is to show the significant impact of comorbidities and smoking on the outcome in aneurysmal subarachnoid hemorrhage (SAH). During this observational study 203 cases of treatment of ruptured intracranial aneurysms were analyzed. We examined and classified prospectively the 12 month outcome according to the modified Rankin Scale (mRS) considering retrospectively a history of smoking and investigated prospectively the occurrence of early and delayed cerebral ischemia between 2012 and 2017...
August 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30117764/safety-of-coiling-with-stent-placement-for-the-treatment-of-ruptured-wide-necked-intracranial-aneurysms-a-contemporary-cohort-study-in-a-high-volume-center-after-improvement-of-skills-and-strategy
#3
Qiao Zuo, Pengfei Yang, Nan Lv, Qinghai Huang, Yu Zhou, Xiaoxi Zhang, Guoli Duan, Yina Wu, Yi Xu, Bo Hong, Rui Zhao, Qiang Li, Yibin Fang, Kaijun Zhao, Dongwei Dai, Jianmin Liu
OBJECTIVE The authors compared the contemporary perioperative procedure-related complications between coiling with stent placement and coiling without stent placement for acutely ruptured aneurysms treated in a single center after improvement of interventional skills and strategy. METHODS In an institutional review board-approved protocol, 133 patients who underwent coiling with stent placement and 289 patients who underwent coiling without stent placement from January 2012 to December 2014 were consecutively reviewed retrospectively...
August 17, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30117729/resident-microglia-activate-before-peripheral-monocyte-infiltration-and-p75ntr-blockade-reduces-microglial-activation-and-early-brain-injury-after-sah
#4
Zhen Xu, Wei-Hua Shi, Longbiao Xu, Min-Feng Shao, Zu-Peng Chen, Guo-Chong Zhu, Qun Hou
Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (SAH) contributes to high morbidity and mortality. Although it is well recognized that acute neuroinflammation reaction is one of the most important triggers of EBI, pharmacotherapy proved to be clinically effective against the initiating of neuroinflammation after SAH is lacking. The resident microglia and infiltrated peripheral monocyte are two main types of immune cells in central nervous system (CNS) and control the inflammation process in brain after SAH...
August 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30116219/bilateral-cavernous-carotid-aneurysms-atypical-presentation-of-a-rare-cause-of-mass-effect-a-case-report-and-a-review-of-the-literature
#5
Delia Gagliardi, Irene Faravelli, Luisa Villa, Guglielmo Pero, Claudia Cinnante, Roberta Brusa, Eleonora Mauri, Laura Tresoldi, Francesca Magri, Alessandra Govoni, Nereo Bresolin, Giacomo P Comi, Stefania Corti
Bilateral cavernous carotid aneurysms (CCAs) represent a rare medical condition that can mimic other disorders. We present a rare case of bilateral CCAs simulating an ocular myasthenia. A 76-year-old woman presented with a history of fluctuating bilateral diplopia and unilateral ptosis, which led to the suspicion of ocular myasthenia. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) of the brain showed the presence of large bilateral aneurysms of the carotid cavernous tract. After an unsuccessful attempt with steroid therapy, the patient underwent endovascular treatment, with mild improvement...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30115675/feasibility-safety-and-periprocedural-complications-associated-with-endovascular-treatment-of-ruptured-intracranial-aneurysms-according-to-the-depth-of-anesthesia
#6
J Song, C-Y Lee, H-W Kim
BACKGROUND AND PURPOSE: The aim of the present study was to report the feasibility, safety, and periprocedural complications associated with EVT of ruptured intracranial aneurysms according to the depth of anesthesia. In most centers, endovascular treatment of intracranial aneurysm is performed under general anesthesia. MATERIALS AND METHODS: Between March 2011 and December 2016, a total of 183 consecutive patients with 183 aneurysms were treated endovascularly at the authors' center...
August 16, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/30113674/impact-of-aneurysm-multiplicity-on-treatment-and-outcome-after-aneurysmal-subarachnoid-hemorrhage
#7
Michel Roethlisberger, Rita Achermann, Schatlo Bawarjan, Martin N Stienen, Christian Fung, Donato D'Alonzo, Nicolai Maldaner, Andrea Ferrari, Marco V Corniola, Daniel Schöni, Johannes Goldberg, Daniele Valsecchi, Thomas Robert, Rodolfo Maduri, Martin A Seule, Jan-Karl Burkhardt, Serge Marbacher, Philippe Bijlenga, Kristine A Blackham, Heiner C Bucher, Luigi Mariani, Raphael Guzman, Daniel W Zumofen
BACKGROUND: One-third of patients with aneurysmal subarachnoid hemorrhage (aSAH) have multiple intracranial aneurysms (MIA). OBJECTIVE: To determine the predictors of outcome in aSAH patients with MIA compared to aSAH patients with a single intracranial aneurysm (SIA). METHODS: The Swiss Study of Subarachnoid Hemorrhage dataset 2009-2014 was used to evaluate outcome in aSAH patients with MIA compared to patients with SIA with the aid of descriptive and multivariate regression analysis...
August 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30113655/macrophage-infiltration-in-the-saccular-intracranial-aneurysm-wall-as-a-response-to-locally-lysed-erythrocytes-that-promote-degeneration
#8
Eliisa Ollikainen, Riikka Tulamo, Salla Kaitainen, Petri Honkanen, Satu Lehti, Timo Liimatainen, Juha Hernesniemi, Mika Niemelä, Petri T Kovanen, Juhana Frösen
Saccular intracranial aneurysm (sIA) rupture is often fatal. Rupture-prone sIA walls are infiltrated by macrophages expressing hemoglobin-receptor CD163, suggesting a role for erythrocyte lysis in the degenerative remodeling predisposing to rupture. We therefore studied erythrocyte remnants in 16 unruptured and 20 ruptured sIA walls using histology and immunohistochemistry. Glycophorin A (GPA), an erythrocyte membrane protein, was present in 34/36 (94%) sIA walls and correlated with loss of αSMA+ cells, reflecting loss of mural smooth muscle cells ([SMCs]; r = -0...
July 17, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/30107689/-paired-comparative-study-of-risk-factors-related-to-aneurysm-rupture-during-hospitalization
#9
X W Song, M Z Wang, J Z Zhao
Objective: Aneurysm rupture during in-hospital period contributes to the exceedingly high morbidity and mortality of inpatients with untreated aneurysm. However, risk factors for aneurysm rupture during hospitalization were scarcely focused in previous reports. The aim of this study was to investigate the risk factors of aneurysm rupture during hospitalization and to propose clinical strategies improving prognosis. Methods: Patients with intracranial aneurysm (lA) rupture during hospitalization were identified in our prospective cohort of consecutive patients admitted to Beijing Tiantan Hospital between Jan 2014 to Dec 2017...
August 7, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/30107479/the-effect-of-flow-related-aneurysms-on-hemorrhagic-risk-of-intracranial-arteriovenous-malformations
#10
Alice L Hung, Wuyang Yang, Bowen Jiang, Tomas Garzon-Muvdi, Justin M Caplan, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Judy Huang
BACKGROUND: Previous reports indicated an association between hemorrhagic presentation and flow-related aneurysms in arteriovenous malformation (AVM) patients. However, it remains unclear whether these flow-related aneurysms result in the hemorrhage of AVM. OBJECTIVE: To characterize this hemorrhage risk using our institutional experience over 25 yr. METHODS: We retrospectively reviewed records of patients at our institution diagnosed with AVM from 1990 to 2015...
August 9, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30107354/therapeutic-strategies-for-residual-or-recurrent-intracranial-aneurysms-after-microsurgical-clipping
#11
Jung Hoon Kim, Joonho Chung, Seung Kon Huh, Keun Young Park, Dong Joon Kim, Byung Moon Kim, Jae Whan Lee
OBJECTIVES: Therapeutic strategies for residual or recurrent aneurysm (RRA) after microsurgical clipping have not been well established. The purpose of this study was to report our retreatment experiences with previously clipped aneurysms and to demonstrate retreatment strategies for these RRAs. PATIENTS AND METHODS: From 1996-2016, we treated 68 RRAs after previous clipping. Among them, 34 patients underwent microsurgical retreatment, and the other 34 underwent endovascular retreatment...
August 6, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30107248/management-of-concomitant-moyamoya-disease-arterial-venous-malformation-and-intracranial-aneurysm-case-illustration-literature-review-and-management-algorithm
#12
Mark T Mills, Arif Zafar, Kishor A Choudhari, Austen Smith, Stewart Coley, Stefan Jankowski, Marc Randall, Umang J Patel
BACKGROUND: Moyamoya disease (MMD), arterial venous malformations (AVMs), and intracranial aneurysms are distinct cerebrovascular disease processes that most commonly occur in isolation. The literature on the treatment algorithm of each individual condition is well established. An association between MMD and intracranial aneurysms is also known; but MMD in association with AVM is rare. CASE DESCRIPTION: The authors discuss various dilemmas in the multi-modality management of these conditions when they coexist with an illustrative case of a 46-year-old woman who presented following a stroke, with 1) left-sided MMD, 2) left-sided frontal AVM, and 3) an aneurysm arising from A1 segment of right anterior cerebral artery...
August 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30105144/the-role-of-inflammation-and-potential-use-of-sex-steroids-in-intracranial-aneurysms-and-subarachnoid-hemorrhage
#13
REVIEW
Jack W Barrow, Nefize Turan, Pasang Wangmo, Anil K Roy, Gustavo Pradilla
Background: Aneurysmal subarachnoid hemorrhage (aSAH) continues to be a devastating neurological condition with a high risk of associated morbidity and mortality. Inflammation has been shown to increase the risk of complications associated with aSAH such as vasospasm and brain injury in animal models and humans. The goal of this review is to discuss the inflammatory mechanisms of aneurysm formation, rupture and vasospasm and explore the role of sex hormones in the inflammatory response to aSAH...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30105133/a-giant-partially-thrombosed-partially-filling-and-partially-calcified-intracranial-aneurysm
#14
Navneet Singla, Ashish Aggarwal
No abstract text is available yet for this article.
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30103059/morphological-feature-elongation-can-predict-occlusion-status-following-pipeline-embolization-of-intracranial-aneurysms
#15
Yupeng Zhang, Chao Ma, Shikai Liang, Peng Yan, Fei Liang, Feng Guo, Chuhan Jiang
OBJECTIVE: To explore whether computed morphological features can be used as independent predictors of incomplete occlusion of aneurysms treated with pipeline embolization device. METHODS: From January 2016 to September 2017, 58 patients with 58 aneurysms were treated with pipeline embolization device in our center. Aneurysms were manually segmented from the DICOM file and we calculated 16 shape features voxel by voxel on the segmented aneurysm image. Along with other 13 clinical and radiographic variables, we performed univariate and multivariate analysis to explore predictors of incomplete occlusion...
August 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30101479/srpk1-gene-silencing-promotes-vascular-smooth-muscle-cell-proliferation-and-vascular-remodeling-via-inhibition-of-the-pi3k-akt-signaling-pathway-in-a-rat-model-of-intracranial-aneurysms
#16
Xin-Guo Li, Yi-Bao Wang
OBJECTIVE: Intracranial aneurysm (IA) is a life threatening cerebrovascular disease characterized by phenotypic modulation of vascular smooth muscle cells (VSMCs) and loss of vessel cells. In addition to environmental factors, genetic factors have been proposed to be a critical factor in the onset and progression of IA. The present study investigates the effects of serine-arginine protein kinase 1 (SRPK1) on VSMC proliferation and apoptosis both in vivo and in vitro, as well as its role in vascular remodeling in vivo through PI3 K/Akt signaling in IA...
August 12, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/30101391/vascular-responses-to-abrupt-blood-flow-change-after-bypass-surgery-for-complex-intracranial-aneurysms
#17
Hiroharu Kataoka, Yasuhide Makino, Kiyofumi Takanishi, Yohei Kimura, Kenji Takamura, Takanobu Yagi, Satoshi Iguchi, Akihide Yamamoto, Hidehiro Iida, Soshiro Ogata, Kunihiro Nishimura, Masanori Nakamura, Mitsuo Umezu, Koji Iihara, Jun C Takahashi
BACKGROUND: Bypass surgery for complex intracranial aneurysms (IAs) results in drastic blood flow changes in intracranial arteries. The aim of the study was to elucidate how vessels adapt to blood flow changes after bypass surgery with phase-contrast magnetic resonance imaging (PC-MRI). METHODS: This is a prospective observational study to assess changes of the blood flow in intracranial arteries after bypass surgery for IAs. Flow rates and vessel diameters were measured with PC-MRI in 52 intracranial arteries of 7 healthy volunteers and 31 arteries of 8 IA patients who underwent bypass surgery...
August 13, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/30101354/multiple-aneurysms-clipping-through-the-eyebrow-approach-2-dimensional-operative-video
#18
Sorin Aldea, Stephan Gaillard
The eyebrow approach is a versatile technique that may apply to various vascular and tumoral pathologies of the anterior skull base. We present a case of multiple aneurysms clipping through the eyebrow approach and we discuss the nuances of this technique. A 44-yr-old patient presented with incidentally found aneurysms. Angiography showed 2 4.5-mm aneurysms on the left middle cerebral artery (MCA) and internal carotid artery (ICA) bifurcations. At surgery, the patient is positioned supine with the head elevated, slightly rotated, and extended in order to obtain good access and gravity retraction of the brain...
August 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30101327/microsurgical-clip-placement-for-a-giant-anterior-communicating-artery-aneurysm-with-intraluminal-thrombus-2-dimensional-operative-video
#19
Guilherme Salemi Riechelmann, Marcos Devanir Silva da Costa, Ricardo Lourenço Caramanti, Marcelo Augusto Acosta Goiri, Bruno Lourenço Costa, Kléber González-Echeverría, Feres Chaddad-Neto
Giant brain aneurysms account for approximately 5% of all intracranial aneurysms. Although treatment modalities can vary widely, none is ideal for every patient. Endovascular treatment is usually preferred, especially when the large size of the aneurysm limits visualization of the brain parenchyma and parent vessels that arise from the aneurysm, making surgical clip placement across the neck a difficult task. However, despite the higher chances of morbidity, microsurgery is an effective treatment modality due to lower recurrence rates...
August 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30101005/aneurysm-wall-enhancement-in-black-blood-mri-correlates-with-aneurysm-size-black-blood-mri-could-serve-as-an-objective-criterion-of-aneurysm-stability-in-near-future
#20
Athanasios K Petridis, Andreas Filis, Elias Chasoglou, Igor Fischer, Maxine Dibué-Adjei, Richard Bostelmann, Hans Jakob Steiger, Bernd Turowski, Rebecca May
The increasing number of incidental intracranial aneurysms creates a dilemma of which aneurysms to treat and which to observe. Clinical scoring systems consider risk factors for aneurysm rupture however objective parameters for assessment of aneurysms stability are needed. We retrospectively analysed contrast enhancing behaviour of un-ruptured aneurysms in the black blood magnetic resonance imaging (MRI) in N=71 patients with 90 aneurysms and assessed correlation between aneurysm wall contrast enhancement (AWCE) and aneurysm anatomy and clinical scoring systems...
July 10, 2018: Clinics and Practice
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