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(Intracranial OR brain) AND aneurysm

Christoph J Griessenauer, Ajith J Thomas, Alejandro Enriquez-Marulanda, Aviraj Deshmukh, Abhi Jain, Christopher S Ogilvy, Naci Kocer, Tobias Engelhorn, Markus Möhlenbruch, Markus Holtmannspötter, Hendrik Janssen, Thomas Finkenzeller, Wolfgang Reith, Michael Sonnberger, Jan-Hendrik Buhk, Clemens M Schirmer, Monika Killer-Oberpfalzer
BACKGROUND: Flow diversion has become an accepted endovascular treatment modality for intracranial aneurysms. Studies comparing different types of flow diverters are currently lacking. OBJECTIVE: To perform a propensity score-matched cohort study comparing the Pipeline Embolization Device (PED; Medtronic, Dublin, Ireland) and Flow Redirection Endoluminal Device (FRED; MicroVention, Aliso Viejo, California). METHODS: Aneurysms of the internal carotid artery proximal to the communicating segment treated with PED at 2 neurovascular centers in the United States were matched with aneurysms treated in the European FRED study using propensity scoring...
December 12, 2018: Neurosurgery
Kristine Ravina, Ben A Strickland, Ian A Buchanan, Robert C Rennert, Paul E Kim, Vance L Fredrickson, Jonathan J Russin
Large, broad-based basilar artery (BA) apex aneurysms involving multiple arterial origins are complex lesions commonly not amenable to direct clipping or endovascular management. BA proximal (Hunterian) occlusion with extracranial-to-intracranial bypass is a supported strategy if one or both posterior communicating arteries are small. Hunterian ligation risks sudden aneurysm thrombosis and thromboembolism in the perforator rich BA apex. There currently exists no guidelines for antiplatelet and anticoagulant therapy following Hunterian ligation for complex BA apex aneurysm treatment...
December 8, 2018: World Neurosurgery
Qiang Liu, Peng Shan, Haibin Li
Gamboge is the dry resin secreted by Garcinia hanbaryi Hook.f, with the function of promoting blood circulation and anti‑cancer effects, detoxification, hemostasis and killing insects. It is also used for the treatment of cancer, brain edema and other diseases. Gambogic acid is the main effective constituent of Gamboge. The present study tested the hypothesis that the effect of Gambogic acid prevents angiotensin II‑induced abdominal aortic aneurysm (AAA), and explored its underlying mechanism. It was demonstrated that gambogic acid significantly inhibited AAA incidence rate, and reduced edge leading aortic diameter and aortic wall thickness in AAA mice...
December 4, 2018: Molecular Medicine Reports
Serge Marbacher, Alexander Spiessberger, Michael Diepers, Luca Remonda, Javier Fandino
Microsurgical clip ligation is considered a definitive treatment for intracranial aneurysms (IAs), resulting in low rates of local recurrence that range from 0.2 to 0.5% and a latency period that averages about a decade. Our case report describes an early asymptomatic recurrence (i.e., without sentinel headache or seizure) less than 1 year after this 20-year-old woman underwent clip ligation of a ruptured anterior communicating artery (AComA) aneurysm. At recurrence, the patient underwent coiling of the regrowth; follow-up imaging at 6 and 18 months demonstrated complete IA occlusion...
October 2018: Journal of Neurological Surgery Reports
Domenico Policicchio, Giampiero Muggianu, Giosuè Dipellegrini, Riccardo Boccaletti
Background: Traumatic intracranial aneurysms (TICA) are often associated with poor prognosis and should be diagnosed as soon as possible to prevent delayed intracranial hemorrhage and high rates of morbidity/mortality related to bleeding. Diagnosis requires a high index of suspicion. The goal of treatment is to exclude the aneurysm issue with surgical or endovascular methods. Case Description: We report the case of a 19-year-old boy who suffered a cranio-orbital trauma; 2 weeks after initial trauma he deteriorates with a new intracranial bleeding...
2018: Surgical Neurology International
Chao Jiang, Haibin Lu, Yaoqiang Guo, Li Zhu, Tianqi Luo, Wendy Ziai, Jian Wang
Blood culture-negative endocarditis is often severe and difficult to diagnose. It is necessary to emphasize the importance for the early diagnosis and accurate treatment of blood culture-negative endocarditis. Here, we described the relevant clinical information of a blood culture-negative but clinically diagnosed infective endocarditis complicated by intracranial mycotic aneurysm, brain abscess, and posterior tibial artery pseudoaneurysm. This patient was a 65-year-old man with a 9-month history of intermittent fever and died in the end for the progressive neurological deterioration...
2018: Case Reports in Neurological Medicine
Cong-Hui Li, Bu-Lang Gao, Ji-Wei Wang, Jian-Feng Liu, Hui Li, Song-Tao Yang
PURPOSE: To investigate construction of an aneurysm on a curved vascular segment of a carotid siphon model for testing endovascular devices. MATERIALS AND METHODS: Pre-shaped carotid siphon models of polytetrafluoroethylene were constructed from a human cadaver for confining canine common carotid artery (CCA). The canine right external jugular vein was isolated and harvested to make a venous pouch by suturing one end. The right CCA was isolated and the venous pouch was sutured onto the right CCA to make an aneurysm...
December 6, 2018: World Neurosurgery
Shafqat Rasul Chaudhry, Stilla Frede, Gerald Seifert, Thomas Mehari Kinfe, Mika Niemelä, Alf Lamprecht, Sajjad Muhammad
Aneurysmal subarachnoid hemorrhage (aSAH) is a highly complex disease. Majority of aSAH survivors confront post-SAH complications including cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) that mainly influence the clinical outcome. Tissue damage during early brain injury may lead to release of damage associated molecular pattern molecules (DAMPs) that may initiate and sustain inflammation during the course of aSAH through activation of pattern recognition receptors. Mitochondrial DNA (mtDNA) due to unmethylated CpG motifs acts as a DAMP via binding to toll-like receptor-9...
December 5, 2018: Mitochondrion
Haiyuan Shi, Chee Keong Wee, Sindhu John
The 2018 American Heart Association/American Stroke Association (AHA/ASA) guidelines stated that the administration of intravenous recombinant tissue-type plasminogen activator (rTPA) for acute ischaemic stroke is probably safe for patients with small (i.e. <10 mm) unruptured intracranial aneurysms. We present 2 cases of small (2 and 5 mm) lenticulostriate artery (LSA) aneurysms which ruptured immediately following rtPA infusion. The ensuing acute intracranial haemorrhages resulted in the death of one patient and severe functional impairment for the other...
October 24, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Kei Woldendorp, Christopher N Selvaraj, Paul G Bannon, Steven Dubenec
No abstract text is available yet for this article.
October 23, 2018: Journal of Thoracic and Cardiovascular Surgery
Raoul Julio Mascarenhas, Narada Dhitimantha Hapangama, Peter James Mews, Arjun Burlakoti, Sarbin Ranjitkar
Chronic orofacial pain of neuropathic origin can present diagnostic and management dilemmas to dental practitioners and also affect the patient's quality of life. Intracranial aneurysms are a potential cause of stroke, with associated sub-arachnoid haemorrhage leading to high rates of mortality and morbidity. A patient who had been previously managed for symptoms of temporomandibular joint disorder (TMD) presented with sharp, shooting pain of moderate intensity. It was precipitated by swallowing, and radiated to the right throat, posterior border of the mandible, ear and temporomandibular joint...
December 7, 2018: Australian Dental Journal
Selma Sijercic, Alisa Krdzalic, Harun Avdagic, Goran Krdzalic
Introduction: Cardiovascular complications in patients with subarachnoid hemorrhage are considered to be a neurally mediated process rather than a manifestation of coronary artery disease. Aim: The aim of study is to show the incidence and type cardiac complications after traumatic and spontaneous SAH. Patients and methods: The study had prospective character in which included 104 patients, with diagnosed subarachnoid hemorrhage (SAH), in the period from 2014 to 2017...
November 2018: Medical Archives
F Cagnazzo, N Limbucci, S Nappini, L Renieri, A Rosi, A Laiso, D Tiziano di Carlo, P Perrini, S Mangiafico
BACKGROUND: Y-stent-assisted coiling for wide-neck intracranial aneurysms required further investigation. PURPOSE: Our aim was to analyze outcomes after Y-stent placement in wide-neck aneurysms. DATA SOURCES: We performed a systematic search of 3 data bases for studies published from 2000 to 2018. STUDY SELECTION: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we included studies reporting Y-stent-assisted coiling of wide-neck aneurysms...
December 6, 2018: AJNR. American Journal of Neuroradiology
Edgar A Samaniego, Jorge A Roa, Braulio Martinez-Burbano, Santiago Ortega-Gutierrez, David M Hasan, Manuel Jibaja, James C Torner, Nelson Maldonado
BACKGROUND: Most of the literature describing morphological features of intracranial aneurysms (IAs) is from North-America, East-Asia, and Europe. There is limited data from South-America. We describe the epidemiologic and angiographic features of ruptured and unruptured IAs in a cohort of patients from Ecuador. METHODS: We conducted a retrospective analysis of prospectively acquired databases from 3 different tertiary hospitals over a 3-year period (2014-2017)...
December 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Vera Vigo, Flavia Dones, Rina Di Bonaventura, Dania Barakat, Michael W McDermott, Adib A Abla, Roberto Rodriguez Rubio
INTRODUCTION: Anterior-inferior cerebellar artery (AICA) aneurysms are rare with no optimal consensus on management strategies. When the treatment requires parent artery occlusion post-operative ischemic or neuropathic, complications can occur. OBJECTIVE: To evaluate the feasibility of direct revascularization of premeatal AICA using the middle meningeal artery (MMA) as the donor through an anterior petrosectomy (APA) window. METHODS: Ten specimens were used for the surgical simulation of the MMA-AICA bypass...
December 3, 2018: World Neurosurgery
Yi-Chen Li, Rong Wang, Man-Man Xu, Xiang-Ru Jing, Jiye Aa, Run-Bin Sun, Shi-Jie Na, Tao Liu, Xuan-Sheng Ding, Cui-Yun Sun, Wei-Hong Ge
Cerebral metabolism alterations influence cerebrospinal fluid (CSF) composition, and is sensitive to brain injury. In subarachnoid hemorrhage (SAH) patients, Fisher scale, Hunt-Hess scale and World Federation of Neurological Societies (WFNS) grading scales evaluating SAH severity are inadequate to predict long-term outcome; therefore, in an effort to determine metabolite pattern disparity and discover corresponding biomarkers, we designed an untargeted CSF metabolomic research covering a board range of metabolites of SAH patients with different severity and outcome...
December 6, 2018: ACS Chemical Neuroscience
Monica Acciarresi, Riccardo Altavilla, Maria G Mosconi, Valeria Caso
PURPOSE OF REVIEW: The absolute risk of pregnancy-associated intracranial haemorrhage (ICH) has been reported to be relatively low and often associated with high risks of life-long disabilities and mortality. The aim of this narrative review was obtaining a better understanding of the current management practices for ICH, unruptured aneurysms and/or arteriovenous malformations during pregnancy, as well as the effects of future pregnancies, and the uses of oral contraceptive or HRT. RECENT FINDING: General guidelines for the management of ICH are used for pregnant women but additional expedient and thorough evaluation of foetal viability and its gestational age are requested...
November 30, 2018: Current Opinion in Neurology
Leanne Stunkel, Nancy J Newman, Valérie Biousse
PURPOSE OF REVIEW: This review summarizes the recent literature on diagnostic error relevant to the practice of neuro-ophthalmology, and evaluates the potential of increased access to neuro-ophthalmology as a means to decrease rates of diagnostic error, thereby reducing medical harm and spending on unnecessary tests and treatments. RECENT FINDINGS: Despite medical advances, current research continues to show alarmingly high rates of diagnostic error. Research into diagnostic error shows that many of these errors can be traced to cognitive errors...
December 3, 2018: Current Opinion in Neurology
Gabriel J E Rinkel
PURPOSE OF REVIEW: Intracranial aneurysms are frequent incidental findings on cranial imaging. The decision for preventive treatment depends on the presumed risk of rupture, the efficacy and risk of complications of preventive treatment, and the quality of life having to live with an unruptured aneurysms. Data on all these factors are still incomplete, and additional data are needed. RECENT FINDINGS: The current review describes advances of the last 2 years in assessment of risk of rupture, on risks of preventive aneurysms occlusion, on follow-up imaging and on medical management of patients with unruptured intracranial aneurysms...
December 3, 2018: Current Opinion in Neurology
Susanne Muehlschlegel
PURPOSE OF REVIEW: This article reviews the epidemiology, clinical presentation, diagnosis, and management of patients with aneurysmal subarachnoid hemorrhage (SAH). SAH is a type of hemorrhagic stroke and is a neurologic emergency with substantial morbidity and mortality. This article reviews the most common and potentially life-threatening neurologic and medical complications to promote their early recognition and prevent secondary brain injury. RECENT FINDINGS: Over the past 30 years, the incidence of SAH has remained stable; yet, likely because of improved care in specialized neurocritical care units, discharge mortality has considerably decreased...
December 2018: Continuum: Lifelong Learning in Neurology
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