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Chronic central pain

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https://www.readbyqxmd.com/read/30549193/synthesis-and-biological-evaluation-of-%C3%AF-1-receptor-ligands-based-on-phenyl-1-2-4-oxadiazole-derivatives
#1
Xudong Cao, Zhongyuan Yao, Fei Dou, Yifang Zhang, Yinli Qiu, Song Zhao, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Yin Chen, Guisen Zhang
In this study, a series of phenyl-1,2,4-oxadiazole derivatives was synthesized and evaluated for anti-allodynic activity. Structure activity relationship studies identified compound 39 with excellent affinity for the σ1 receptor and selectivity for the σ2 receptor, with poor activity to other central nervous system neurotransmitter receptors and transporters associated with pain. Compound 39 exhibited dose-dependent efficacy in suppressing the formalin-induced flinching and attenuating mechanical allodynia in chronic constriction injury-induced neuropathic rats...
December 13, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/30545263/-irritable-bowel-syndrome-comorbid-psychiatric-disorders-and-psychological-treatment-options
#2
Panna Gajdos, Adrien Rigó
Irritable bowel syndrome is a chronic functional gastrointestinal disorder with a prevalence of 7-21%. It has a negative impact on health-related quality of life and work productivity and it is associated with increased psychological distress and mental comorbidity, like major depression disorder and generalised anxiety disorder. Due to biopsychosocial factors and the brain-gut axis playing a key role in the aetiology of the disease, the use of psychological treatments has great importance in the therapy of irritable bowel syndrome...
December 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30544081/emerging-neurotechnology-for-antinoceptive-mechanisms-and-therapeutics-discovery
#3
REVIEW
Bryan J Black, Rahul Atmaramani, Sarah Plagens, Zachary T Campbell, Gregory Dussor, Theodore J Price, Joseph J Pancrazio
The tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to traditional target-based drug discovery. Profiling cellular phenotypes enables quantification of physiologically relevant traits central to a disease pathology without prior identification of a specific drug target. For complex disorders such as chronic pain, which likely involves many molecular targets, this approach may identify novel treatments...
November 13, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30542905/the-role-of-the-peripheral-nerve-surgeon-in-the-treatment-of-pain
#4
REVIEW
Louis H Poppler, Susan E Mackinnon
Pain is a frequent cause of physician visits. Many physicians find these patients challenging because they often have complicated histories, emotional comorbidities, confusing examinations, difficult problems to fix, and the possibility of factitious complaints for attention or narcotic pain medications. As a result, many patients are lumped into the category of chronic, centralized pain and relegated to pain management. However, recent literature suggests that surgical management of carefully diagnosed generators of pain can greatly reduce patients' pain and narcotic requirements...
December 12, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/30541586/central-mechanisms-of-real-and-sham-electroacupuncture-in-the-treatment-of-chronic-low-back-pain-study-protocol-for-a-randomized-placebo-controlled-clinical-trial
#5
Jiang-Ti Kong, Brandon MacIsaac, Ruti Cogan, Amanda Ng, Christine Sze Wan Law, Joseph Helms, Rosa Schnyer, Nicholas Vasilis Karayannis, Ming-Chih Kao, Lu Tian, Beth D Darnall, James J Gross, Sean Mackey, Rachel Manber
BACKGROUND: Chronic low back pain (CLBP) is the most common chronic pain condition and is often resistant to conventional treatments. Acupuncture is a popular alternative for treating CLBP but its mechanisms of action remain poorly understood. Evidence suggests that pain regulatory mechanisms (particularly the ascending and secondarily the descending pain modulatory pathways) and psychological mechanisms (e.g., expectations, pain catastrophizing and self-efficacy) may be involved in the pathogenesis of CLBP and its response to treatments...
December 13, 2018: Trials
https://www.readbyqxmd.com/read/30541348/intermittent-blockade-of-ogfr-and-treatment-of-autoimmune-disorders
#6
Ian S Zagon, Patricia J McLaughlin
This mini-review presents information on the intermittent blockade of the opioid growth factor (OGF)-OGF receptor (OGFr) axis by low-dose naltrexone (LDN), and the role of enkephalin (i.e. OGF) in autoimmune disorders, specifically multiple sclerosis, Crohn's, and fibromyalgia. Clinical reports on subjects taking LDN have documented reduced fatigue, few side-effects, and improved overall health. Preclinical studies on mice with experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, revealed that immunization for EAE reduces serum OGF...
December 12, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30540222/the-treatment-of-central-sensitization-in-an-adolescent-using-pain-neuroscience-education-and-graded-exposure-to-activity-a-case-report
#7
Roger Pack, Randy Gilliland, Alisha Mecham
Chronic pain affects 1.7 million children in the United States, and its effects often linger into adulthood. Unfortunately, chronic pediatric pain is often undertreated. The current case report discusses the use of pain neuroscience education (PNE) combined with progressive exposure to activity to treat persistent pain in a 13-year-old female diagnosed with central sensitization syndrome. Prior to the diagnosis, the patient underwent two unsuccessful episodes of physical therapy that focused on musculoskeletal sources of pain...
December 12, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/30537935/single-dose-baclofen-induced-neurotoxicity-in-a-patient-with-end-stage-renal-disease-case-report
#8
Emad Khazneh, Alaa Shamlawi, Kamel Jebrin, Zakaria Hamdan, Osama Sawalmeh
BACKGROUND: Baclofen is a centrally acting GABAB receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function are prone to baclofen intoxication. Multiple doses of baclofen have been associated with toxicity, but it is very unusual that single dose can do so. CASE PRESENTATION: A 47 year old female patient with end stage renal disease (ESRD) presented with a sudden onset of altered mental status and state of unconsciousness after the ingestion of one tablet of baclofen 25 mg...
December 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30536919/angioplasty-versus-stenting-for-infrapopliteal-arterial-lesions-in-chronic-limb-threatening-ischaemia
#9
REVIEW
Charlie C-T Hsu, Gigi Nc Kwan, Dalveer Singh, John A Rophael, Chris Anthony, Mieke L van Driel
BACKGROUND: Chronic limb-threatening ischaemia (CLTI) is a manifestation of peripheral arterial disease (PAD) that includes chronic ischaemic rest pain or ischaemic skin lesions, ulcers, or gangrene for longer than two weeks. The severity of the disease depends on the extent of arterial stenosis and the availability of collateral circulation. Treatment for CLTI aims to relieve ischaemic pain, heal ischaemic ulcers, prevent limb loss, improve quality of life, and prolong survival. CLTI due to occlusive disease in the infrapopliteal arterial circulation (below-knee circulation) can be treated via an endovascular technique by a balloon opening the narrowed vessel, so called angioplasty, with or without the additional deployment of a scaffold made of metal alloy or other material, so called stenting...
December 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30536363/-pathophysiology-of-the-glutamate-and-the-glycine-transporters-new-therapeutic-targets
#10
REVIEW
C Gimenez, F Zafra, C Aragon
INTRODUCTION: The amino acids glutamate and glycine, apart from their role in protein synthesis, are two fundamental neurotransmitters in the central nervous system of mammals. The first one is ubiquitous and is involved in excitatory pathways of the neocortex, the retina and the cerebellum, and the second is involved in inhibitory pathways of brain caudal areas. However, both share their way of acting by integrating into the functioning of glutamate receptors of the NMDA type fundamentals in the regulation of motor, sensory and cognitive systems...
December 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/30535301/resident-challenges-with-pain-and-functional-limitations-in-chinese-residential-care-facilities
#11
Yuting Song, Ruth A Anderson, Bei Wu, Kezia Scales, Eleanor McConnell, Angela Y M Leung, Kirsten N Corazzini
Background and Objectives: Pain and functional limitations can severely impede older adults' quality of life. In Chinese residential care facilities, limited research suggests that residents potentially have significant unmet care needs with pain and related functional limitations. Therefore, we aimed to explore residents' challenges and self-management strategies in these two areas. This knowledge is essential to developing care interventions to improve quality of care and quality of life in Chinese residential care facilities...
December 8, 2018: Gerontologist
https://www.readbyqxmd.com/read/30535165/primary-motor-cortex-transcranial-direct-current-stimulation-modulates-temporal-summation-of-the-nociceptive-withdrawal-reflex-in-healthy-subjects
#12
Sam Hughes, Sybil Grimsey, Paul H Strutton
Objective: Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has shown efficacy in a number of chronic pain conditions. Despite attempts to dissect the analgesic mechanisms, it is unknown whether M1 tDCS modulates the central integration of spinal nociception. To test this, we investigated the top-down modulation of spinal excitability using temporal summation (TS) of the nociceptive withdrawal reflex (NWR). Methods: In this randomized, blinded, cross-over study, eight healthy subjects received electrically evoked TS of the NWR, which was delivered at 5 Hz at a threshold and a suprathreshold (1...
December 7, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/30534805/diagnostic-and-therapeutic-approaches-in-oral-cavity-granulomas-based-on-new-data-concerning-their-origin-and-pathogenesis
#13
Adina Bianca Boşca, Alina Simona Şovrea, Viorel Miclăuş, Flavia Ruxanda, Carmen Mihaela Mihu, Carmen Stanca Melincovici, Anne Marie Constantin, Bianca Nausica Petrescu, Radu Septimiu Câmpian, Alina Elena Pârvu, Aranka Ilea
Giant cell granulomas in the oral cavity are reactive hyperplastic lesions that arise either peripherally in the mucoperiosteum or centrally in the bone. The peripheral giant cell granuloma (PGCG) is a benign lesion induced by local chronic irritation. It may develop at any age, and tends to be more frequent in females. Central giant cell granuloma (CGCG) is a reactive lesion of unknown etiology. It commonly occurs in children and young adults. It is also predominant in females and frequently located in the anterior part of the mandible...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/30534627/granulocyte-macrophage-colony-stimulating-factor-receptor-expression-in-clinical-pain-disorder-tissues-and-role-in-neuronal-sensitization
#14
Philippe Donatien, Uma Anand, Yiangos Yiangou, Marco Sinisi, Michael Fox, Anthony MacQuillan, Tom Quick, Yuri E Korchev, Praveen Anand
Introduction: Granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is highly expressed in peripheral macrophages and microglia, and is involved in arthritis and cancer pain in animal models. However, there is limited information on GM-CSFR expression in human central nervous system (CNS), peripheral nerves, or dorsal root ganglia (DRG), particularly in chronic pain conditions. Objectives: Immunohistochemistry was used to quantify GM-CSFR expression levels in human tissues, and functional sensory effects of GM-CSF were studied in cultured DRG neurons...
September 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/30531308/the-relationship-between-catastrophizing-and-altered-pain-sensitivity-in-patients-with-chronic-low-back-pain
#15
Samantha M Meints, Ishtiaq Mawla, Vitaly Napadow, Jian Kong, Jessica Gerber, Suk-Tak Chan, Ajay D Wasan, Ted J Kaptchuk, Christina McDonnell, Junie Carriere, Bruce Rosen, Randy L Gollub, Robert R Edwards
Changes in central pain processing have been shown in patients with chronic low back pain (cLBP). We used quantitative sensory testing (QST) methods to identify differences in pain sensitization between patients with cLBP (N=167) and healthy controls (N=33). Results indicated that, compared to healthy pain-free controls, cLBP patients showed increased sensitivity and greater painful aftersensations for mechanical pressure and pin prick stimuli and lower tactile spatial acuity in the two-point discrimination task (ps<...
December 7, 2018: Pain
https://www.readbyqxmd.com/read/30526011/effects-of-kinesiotape-on-pain-and-disability-in-individuals-with-chronic-low-back-pain-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Yuejie Li, Ying Yin, Gongwei Jia, Hong Chen, Lehua Yu, Dandong Wu
OBJECTIVE: To explore the effects of kinesiotape on pain and disability in individuals with chronic low back pain. DATA SOURCES: PubMed, Embase and the Cochrane Central Register of Controlled Trials were searched for English language publications from inception to 13 February 2018. REVIEW METHODS: This study was registered in PROSPERO (CRD42018089831). Our key search terms were ((kinesio taping) OR (kinesiotaping) OR (kinesiotape)) AND (low back pain)...
December 11, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/30521948/the-involvement-of-iron-responsive-element-divalent-metal-transporter-1-mediated-the-spinal-iron-overload-via-cxcl10-cxcr3-pathway-in-neuropathic-pain-in-rats
#17
Weituan Xu, Weihua Liu, Wenli Yu
BACKGROUND: Iron is pivotal for life, but it is toxic if in excess. Iron overload mediated by divalent metal transporter 1 (DMT1) in the central nervous system has participated in various neuroinflammatory diseases. Chemokine-induced neuroinflammation involves the development of pathological pain. Recently, chemokine CXCL10 is implicated in the pathogenesis of chronic pain, however, little is known about the potential link between iron accumulation and CXCL10 in pain condition. Here, we examined whether iron accumulation regulated neuropathic pain via CXCL10...
December 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30510445/efficacy-of-isothiocyanate-based-compounds-on-different-forms-of-persistent-pain
#18
Elena Lucarini, Laura Micheli, Alma Martelli, Lara Testai, Vincenzo Calderone, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Purpose: Current pharmacotherapy for persistent pain related to neuropathy or articular diseases is unsatisfactory, due to the large number of unresponsive patients and side effects. Isothiocyanates (ITCs) are a class of natural or synthetic compounds characterized by the general formula R-NCS. ITCs show antihyperalgesic effects in models of central and peripheral nervous tissue injury and anti-inflammatory properties. The pharmacodynamics are strictly related to the release of the gasotransmitter hydrogen sulfide (H2 S) from their moiety...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/30508987/percutaneous-epidural-adhesiolysis-using-inflatable-balloon-catheter-and-balloon-less-catheter-in-central-lumbar-spinal-stenosis-with-neurogenic-claudication-a-randomized-controlled-trial
#19
Myong-Hwan Karm, Seong-Soo Choi, Doo-Hwan Kim, Jun-Young Park, Sukyung Lee, Jin Kyu Park, Young Joong Suh, Jeong-Gil Leem, Jin Woo Shin
BACKGROUND: When conventional interventional procedures fail, percutaneous epidural adhesiolysis (PEA), which has moderate evidence for successful treatment of lumbar spinal stenosis (LSS), has been recommended over surgical treatments. In a previous study, we demonstrated the efficacy of a newly developed inflatable balloon catheter for overcoming the access limitations of pre-existing catheters for patients with severe stenosis or adhesions. OBJECTIVES: This study compared the treatment response of combined PEA with balloon decompression and PEA only in patients with central LSS over 6 months of follow-up...
November 2018: Pain Physician
https://www.readbyqxmd.com/read/30506913/what-do-you-expect-catastrophizing-mediates-associations-between-expectancies-and-pain-facilitatory-processes
#20
Junie S Carriere, Marc Olivier Martel, Samantha M Meints, Marise C Cornelius, Robert R Edwards
BACKGROUND: Pain expectancies are associated with altered pain sensitivity in individuals with chronic pain. However, little is known about the processes by which pain expectancies impact pain processing. This study assessed the association between pain expectancies and temporal summation (TS) of pain, and examined whether pain catastrophizing mediated this association. METHODS: In this cross-sectional study, participants (437 chronic low back pain (CLBP) patients, 115 controls) completed self-report measures of pain intensity, pain expectancies and pain catastrophizing before undergoing psychophysical pain-testing procedures designed to assess mechanical TS of mechanical pain...
December 3, 2018: European Journal of Pain: EJP
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