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https://www.readbyqxmd.com/read/30552416/bevacizumab-associated-glomerular-microangiopathy
#1
Fermin Person, Markus M Rinschen, Silke R Brix, Sonia Wulf, Maria de Las Mercedes Noriega, Wilfried Fehrle, Jessica Schmitz, Anke Schwarz, Philipp Ivanyi, Oliver M Steinmetz, Linda Reinhard, Elion Hoxha, Peter F Zipfel, Jan Hinrich Bräsen, Thorsten Wiech
Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. We observed a distinctive histopathological pseudothrombotic pattern different from the previously reported thrombotic microangiopathy...
December 14, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/30552300/multiple-biomarkers-covering-distinct-pathways-for-predicting-outcomes-after-ischemic-stroke
#2
Chongke Zhong, Zhengbao Zhu, Aili Wang, Tan Xu, Xiaoqing Bu, Hao Peng, Jingyuan Yang, Liyuan Han, Jing Chen, Tian Xu, Yanbo Peng, Jinchao Wang, Qunwei Li, Zhong Ju, Deqin Geng, Jiang He, Yonghong Zhang
OBJECTIVE: To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke. METHODS: We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events...
December 14, 2018: Neurology
https://www.readbyqxmd.com/read/30551923/cold-evoked-potentials-acquisition-from-cervical-dermatomes
#3
Jan Rosner, Janosch Rinert, Mario Ernst, Armin Curt, Michèle Hubli
INTRODUCTION: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. OBJECTIVE: To test feasibility and test-retest reliability of CEPs within two cervical dermatomes, including recording sites in glabrous and hairy skin, in order to facilitate the transition into clinical practice...
December 11, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/30550590/glandular-defects-in-the-mouse-uterus-with-sustained-activation-of-tgf-beta-signaling-is-associated-with-altered-differentiation-of-endometrial-stromal-cells-and-formation-of-stromal-compartment
#4
Nan Ni, Yang Gao, Xin Fang, Maria Melgar, David F Vincent, John P Lydon, Laurent Bartholin, Qinglei Li
Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice...
2018: PloS One
https://www.readbyqxmd.com/read/30550266/diastereoselective-photooxidation-and-reduction-of-chiral-iridium-iii-complexes
#5
Li-Ping Li, He-Long Peng, Lian-Qiang Wei, Bao-Hui Ye
A diastereoselective photooxidation of α-amino acid (AA) complexes into imino acid complexes using a chiral iridium(III) complex as a photosensitizer and stereo-controller under visible light irradiation and oxygen was developed. It was found that the oxidative rate of Δ-[Ir(pq)2 ( L-AA)] (pq is 2-phenylquinoline) diastereomer is significantly higher than that of the corresponding Δ-[Ir(pq)2 ( D-AA)] diastereomer, providing a new protocol for kinetic resolution of AAs via a nonenzymatic pathway. Moreover, the thermodynamic controlled strategy offered a complemental method for the diastereoselective hydrogenation of imine bonds using NaBH4 as a reductant under the chiral Ir(III) complex as a stereo-controller...
December 14, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/30548312/trem2-triggers-microglial-density-and-age-related-neuronal-loss
#6
Bettina Linnartz-Gerlach, Liviu-Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neumann
The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with aging. The typical aging process goes along with microglial changes and mild neuronal loss, but the exact contribution of TREM2 is still unclear. Aged TREM2 knock-out mice showed decreased age-related neuronal loss in the substantia nigra and the hippocampus...
December 11, 2018: Glia
https://www.readbyqxmd.com/read/30546393/pvt1-regulates-inflammation-and-cardiac-function-via-the-mapk-nf-%C3%AE%C2%BAb-pathway-in-a-sepsis-model
#7
Fang Feng, Yan Qi, Chenming Dong, Chaohui Yang
The aim of the present study was to investigate the role of plasmacytoma variant translocation gene 1 (PVT1) in the occurrence and development of sepsis-induced inflammation and cardiac dysfunction and its underlying mechanism. A sepsis rat model was first established by cecal ligation and puncture. The mRNA levels of PVT1 and microRNA-143 in the myocardial tissues of rats were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. Cardiac function, levels of myocardial injury markers and inflammatory indicators were detected following PVT1 knockdown...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30542810/post-translational-and-transcriptional-regulation-of-phenylpropanoid-biosynthesis-pathway-by-kelch-repeat-f-box-protein-sagl1
#8
Si-In Yu, Hyojin Kim, Dae-Jin Yun, Mi Chung Suh, Byeong-Ha Lee
A Kelch repeat F-box containing protein, SMALL AND GLOSSY LEAVES1 (SAGL1) regulates phenylpropanoid biosynthesis as a post-translational regulator for PAL1 (phenylalanine ammonia-lyase) and an indirect transcriptional regulator for ANTHOCYANIDIN SYNTHASE. Phenylpropanoid biosynthesis in plants produces diverse aromatic metabolites with important biological functions. Phenylalanine ammonia-lyase (PAL) catalyzes the first step in phenylpropanoid biosynthesis by converting L-phenylalanine to trans-cinnamic acid...
December 12, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/30542003/comparative-transcriptome-analysis-revealed-the-improved-%C3%AE-carotene-production-in-sporidiobolus-pararoseus-yellow-mutant-muy9
#9
Chunji Li, Bingxue Li, Ning Zhang, Qifan Wang, Wenjing Wang, Hongtao Zou
Carotenoids are ubiquitous constituents of living organisms. These structurally diverse pigments have received considerable attention due to their biotechnological applications and potential beneficial effects on human health. In this study, we characterized an over-producing β-carotene mutant of Sporidiobolus pararoseus, obtained by ultraviolet mutagenesis, named MuY9. We compared the transcriptome between the wild-type and MuY9. A total of 348 differential expressed genes (DEGs) were found, and only one DEG crtYB is involved in carotenoid biosynthesis...
December 13, 2018: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/30541525/evaluation-of-a-local-government-shelter-and-van-intervention-to-improve-safety-and-reduce-alcohol-related-harm
#10
Bernadette M Ward, Belinda O'Sullivan, Penny Buykx
BACKGROUND: The entertainment precincts of cities, while contributing to local economies, need to be carefully managed to mitigate harms. Individual behaviours and government regulation have typically been the foci of interventions aimed at reducing alcohol-related harm. Little is known about how changes to the built environment might influence alcohol-related harms in these settings. The aim of this study was to explore how a public shelter and a volunteer-funded and staffed mobile van in a regional city influenced perceptions of safety and reduction in alcohol-related harm...
December 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/30541482/a-rare-case-of-alport-syndrome-atypical-hemolytic-uremic-syndrome-and-pauci-immune-crescentic-glomerulonephritis
#11
Jianling Tao, Jonathan Lieberman, Richard A Lafayette, Neeraja Kambham
BACKGROUND: Renal thrombotic microangiopathy (TMA) is occasionally seen in biopsies with pauci-immune necrotizing crescentic glomerulonephritis (PCGN). Recent study indicated that the complement activation is more prominent in the ANCA-negative glomerulonephritis. CASE PRESENTATION: We report a case of concurrent TMA and PCGN without ANCA positivity. Interestingly, our patient also had biopsy features supportive of Alport syndrome (AS). Genetic studies identified variants and polymorphisms in alternative complement pathway genes that confer substantial risk of developing atypical hemolytic uremic syndrome (aHUS)...
December 12, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30541078/health-burden-instrumental-and-emotional-support-adequacy-and-depressive-symptoms-in-older-men-with-hiv
#12
Aaron M Ogletree, Mark Brennan-Ing, Rosemary Blieszner, Stephen E Karpiak, Laura P Sands
Background and Objectives: Older adults with HIV face greater health burden than HIV-uninfected counterparts. Little is known about resources that might mediate the influence of physiological health burden on psychological well-being. Informed by the stress process model, we assessed the influence of multifaceted health burden indicators on depressive symptoms and evaluated the mediating effects of social support adequacy. Research Design and Methods: This cross-sectional study used structural equation modeling with data from 640 older men who participated in the Research on Older Adults with HIV study in the United States...
December 12, 2018: Gerontologist
https://www.readbyqxmd.com/read/30539587/detection-of-autoantibodies-to-complement-components-by-surface-plasmon-resonance-based-technology
#13
Remi Noe, Sophie Chauvet, Shambhuprasad K Togarsimalemath, Maria Chiara Marinozzi, Maria Radanova, Vasil V Vasilev, Veronique Fremeaux-Bacchi, Marie-Agnes Dragon-Durey, Lubka T Roumenina
The innate immune complement system is a powerful defense cascade against pathogens, but can induce host tissue damage when overactivated. In pathological conditions, mainly but not restricted to renal diseases, such as lupus nephritis, atypical hemolytic uremic syndrome, and C3 glomerulopathies, complement is overactivated or dysregulated by autoantibodies directed against its components and regulators. Among the key autoantibody targets are the initiator of the classical complement pathway C1q, the alternative pathway regulator Factor H, the components of the alternative pathway C3 convertase complex C3 and Factor B and the convertase complex itself...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30539576/analysis-of-c3-nephritic-factors-by-elisa
#14
Lillemor Skattum
Autoantibodies to the C3 convertase of the alternative pathway of complement, called C3 nephritic factors (C3NeF), cause persistently low C3 in the circulation and production of C3 degradation fragments due to prolonged stabilization of the C3 convertase. C3NeF are associated with glomerulopathy, acquired partial lipodystrophy, and less frequently with increased susceptibility to meningococcal infection. Analysis of C3NeF is an important part of the diagnostic workup of C3 glomerulopathy, but their identification is difficult presumably due to considerable heterogeneity...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30537355/engineering-controlled-peritumoral-inflammation-to-constrain-brain-tumor-growth
#15
Tarun Saxena, Johnathan G Lyon, S Balakrishna Pai, Daniel Pare, Jessica Amero, Lohitash Karumbaiah, Sheridan L Carroll, Eric Gaupp, Ravi V Bellamkonda
Brain tumors remain a great clinical challenge, in part due to their capacity to invade into eloquent, inoperable regions of the brain. In contrast, inflammation in the central nervous system (CNS) due to injuries activates microglia and astrocytes culminating in an astroglial scar that typically "walls-off" the injury site. Here, the hypothesis is tested that targeting peritumoral cells surrounding tumors to activate them via an inflammatory stimulus that recapitulates the sequelae of a traumatic CNS injury, could generate an environment that would wall-off and contain invasive tumors in the brain...
December 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30536348/c5ar-antagonist-inhibits-occurrence-and-progression-of-complement-c5a-induced-inflammatory-response-of-microglial-cells-through-activating-p38mapk-and-erk1-2-signaling-pathway
#16
Y Liu, S-Q Xu, W-J Long, X-Y Zhang, H-L Lu
OBJECTIVE: To discuss the effect of complement C52 (C5a) and complement C5a receptor (C5aR) antagonists on inflammatory status of mouse microglial cells. MATERIALS AND METHODS: Primary culture was performed on mouse microglial cells. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay was used to detect effect of C5a and C5aR antagonists on vitality of microglial cells. The effect of C5a and C5aR antagonists on mRNA expression of p38MAPK and ERK1/2 was determined using quantitative PCR (qPCR)...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30535813/periodontal-ehlers-danlos-syndrome-is-associated-with-leukoencephalopathy
#17
Ines Kapferer-Seebacher, Quinten Waisfisz, Sylvia Boesch, Marieke Bronk, Peter van Tintelen, Elke R Gizewski, Rebekka Groebner, Johannes Zschocke, Marjo S van der Knaap
Here, we report brain white matter alterations in individuals clinically and genetically diagnosed with periodontal Ehlers-Danlos syndrome, a rare disease characterized by premature loss of teeth and connective tissue abnormalities. Eight individuals of two families clinically diagnosed with periodontal Ehlers-Danlos syndrome were included in the present study and underwent general physical, dental, and neurological examination. Whole exome sequencing was performed, and all patients included in the study underwent MRI of the brain...
December 8, 2018: Neurogenetics
https://www.readbyqxmd.com/read/30535472/mir%C3%A2-138%C3%A2-5p-modulates-the-expression-of-excision-repair-cross%C3%A2-complementing-proteins-ercc1-and-ercc4-and-regulates-the-sensitivity-of-gastric-cancer-cells-to-cisplatin
#18
Jie Ning, Yang Jiao, Xiaoque Xie, Xuefei Deng, Yiyin Zhang, Yuexin Yang, Chenchen Zhao, Hua Wang, Kangsheng Gu
The microRNA (miR)‑138‑5p affects the chemotherapeutic sensitivity of several human cancer types. In the present study, the expression and regulatory mechanisms of miR‑138‑5p were investigated in the gastric cancer cell line SGC7901 and its cisplatin‑resistant derivative SGC7901/DDP. Gene microarray and reverse transcription‑quantitative polymerase chain reaction analyses revealed that miR‑138‑5p was expressed at significantly lower levels in SGC7901/DDP compared with SGC7901 cells. Using computational predictive algorithms, two proteins involved in the nuclear excision repair pathway were identified, excision repair cross‑complementing (ERCC)1 and ERCC4, as putative miR‑138‑5p target genes...
December 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30534891/-directed-acyclic-graphs-in-statistical-modelling-of-epidemiological-studies
#19
Fabiola Werlinger, Dante D Cáceres
BACKGROUND: Confusion in observational epidemiological studies distorts the relationship between exposure and event. "Step by step" regression models, diverts the decision to a statistical algorithm with little causal basis. Directed Acyclic Graphs (DAGs), qualitatively and visually assess the confusion. They can complement the decision on confounder control during statistical modeling. AIM: To evaluate the minimum set of confounders to be controlled in a cause-effect relationship with the use of "step-by-step regression" and DAGs, in a study of arsenic exposure...
July 2018: Revista Médica de Chile
https://www.readbyqxmd.com/read/30534386/auxin-regulates-anthocyanin-biosynthesis-through-the-aux-iaa-arf-signaling-pathway-in-apple
#20
Yi-Cheng Wang, Nan Wang, Hai-Feng Xu, Sheng-Hui Jiang, Hong-Cheng Fang, Meng-Yu Su, Zong-Ying Zhang, Tian-Liang Zhang, Xue-Sen Chen
Auxin signaling, which is crucial for normal plant growth and development, mainly depends on ARF-Aux/IAA interactions. However, little is known regarding the regulatory effects of auxin signaling on anthocyanin metabolism in apple ( Malus domestica ). We investigated the functions of MdARF13, which contains a repression domain and is localized to the nucleus. This protein was observed to interact with the Aux/IAA repressor, MdIAA121, through its C-terminal dimerization domain. Protein degradation experiments proved that MdIAA121 is an unstable protein that is degraded by the 26S proteasome...
2018: Horticulture Research
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