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Neuropsychological Examination

Colin Groot, Carole H Sudre, Frederik Barkhof, Charlotte E Teunissen, Bart N M van Berckel, Sang Won Seo, Sébastien Ourselin, Philip Scheltens, M Jorge Cardoso, Wiesje M van der Flier, Rik Ossenkoppele
OBJECTIVE: To examine the clinical phenotype, gray matter atrophy patterns, and small vessel disease in patients who developed prodromal or probable Alzheimer disease dementia, despite carrying the protective APOE ε2 allele. METHODS: We included 36 β-amyloid-positive (by CSF or PET) APOE ε2 carriers (all ε2/ε3) with mild cognitive impairment or dementia due to Alzheimer disease who were matched for age and diagnosis (ratio 1:2) to APOE ε3 homozygotes and APOE ε4 carriers (70% ε3/ε4 and 30% ε4/ε4)...
October 19, 2018: Neurology
Fabio Fierini, Anna Poggesi, Emilia Salvadori, Manlio Acquafresca, Enrico Fainardi, Marco Moretti, Leonardo Pantoni
OBJECTIVES: To investigate clinical and demographic characteristics of patients with intracranial arterial dolichoectasia (IADE) and describe the possible coexistence of cerebral small vessel disease (SVD) and systemic arteriopathy. MATERIAL AND METHODS: From January 2015 to March 2016, all the patients attending an out-patient service for chronic cerebrovascular diseases were screened for suspected IADE. Identified patients underwent a predefined protocol including: brain MR angiography for the diagnosis of IADE; brain MRI with visual rating of SVD features; whole-body CT angiography to assess signs of systemic arteriopathy; neuropsychological examination...
October 18, 2018: Acta Neurologica Scandinavica
Rivka Green, Christine Till, Hiba Al-Hakeem, Rob Cribbie, Martha M Téllez-Rojo, Erika Osorio, Howard Hu, Lourdes Schnaas
BACKGROUND: The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized tool used to measure cognitive function in diverse populations and is sensitive for assessing developmental changes in children. Although CANTAB has been used in several countries, its applicability in a Mexican child population is unknown. This study examined developmental trends on CANTAB in a large sample of urban Mexico City youth and tested the hypothesis that their performance would be similar to a large US normative sample...
October 18, 2018: Journal of Clinical and Experimental Neuropsychology
Irene C Mammarella, Ramona Cardillo, Leonardo Zoccante
OBJECTIVE: Although previous reports produced converging empirical evidence of a core deficit on visuospatial processing in children with a nonverbal learning disability (NLD), few studies compared the visuospatial profile of individuals with an autism spectrum disorder (ASD) or NLD in visuoconstructive and visuospatial working memory tasks. Nor did any of these studies investigate the role of the local bias, typically observed in ASD, when comparing these clinical groups. The present study aimed to analyze whether NLD and ASD share any characteristics...
October 18, 2018: Neuropsychology
Saida R Sharapova, Elyse Phillips, Karen Sirocco, Jennifer W Kaminski, Rebecca T Leeb, Italia Rolle
BACKGROUND: Normalisation of medicinal and recreational marijuana use has increased the importance of fully understanding effects of marijuana use on individual-and population-level health, including prenatal exposure effects on child development. We undertook a systematic review of the literature to examine the long-term effects of prenatal marijuana exposure on neuropsychological function in children aged 1-11 years. METHODS: Primary research publications were searched from Medline, Embase, PsychInfo, CINAHL EbscoHost, Cochrane Library, Global Health and ERIC (1980-2018)...
October 18, 2018: Paediatric and Perinatal Epidemiology
Tuukka O Piiponniemi, Teija Parkkari, Taneli Heikkinen, Jukka Puoliväli, Larry C Park, Roger Cachope, Maksym V Kopanitsa
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington's disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder. Therefore, application of maximally translational cognitive tests to animal models of HD is imperative for the development of treatments that could alleviate cognitive decline in human patients. Here, we examined the performance of the Q175 mouse knock-in model of HD in the touch screen version of the paired associates learning (PAL) task...
2018: Frontiers in Behavioral Neuroscience
Brandon J Lew, Timothy J McDermott, Alex I Wiesman, Jennifer O'Neill, Mackenzie S Mills, Kevin R Robertson, Howard S Fox, Susan Swindells, Tony W Wilson
OBJECTIVE: To identify the neural markers of attention dysfunction in patients with HIV-associated neurocognitive disorder (HAND). METHODS: Sixty participants, including 40 HIV-infected adults (half with HAND) and 20 demographically matched controls performed a visual selective attention task while undergoing high-density magnetoencephalography. Neuronal activity related to selective attention processing was quantified and compared across the 3 groups, and correlated with neuropsychological measures of attention and executive function...
October 17, 2018: Neurology
Vera Zietemann, Marios K Georgakis, Thibaut Dondaine, Claudia Müller, Anne-Marie Mendyk, Anna Kopczak, Hilde Hénon, Stéphanie Bombois, Frank Arne Wollenweber, Régis Bordet, Martin Dichgans
OBJECTIVE: To examine whether the Montreal Cognitive Assessment (MoCA) administered within 7 days after stroke predicts long-term cognitive impairment, functional impairment, and mortality. METHODS: MoCA was administered to 274 patients from 2 prospective hospital-based cohort studies in Germany (n = 125) and France (n = 149). Cognitive and functional outcomes were assessed at 6, 12, and 36 months after stroke by comprehensive neuropsychological testing, the Clinical Dementia Rating (CDR) scale, the modified Rankin Scale (mRS), and Instrumental Activities of Daily Living (IADL) and analyzed with generalized estimating equations...
October 17, 2018: Neurology
Ingvar Bergman, Kurt Johansson, Catarina Lundberg
INTRODUCTION: Neuropsychological assessment of cognitive change over time is often conducted in clinical settings, but whether neuropsychological change scores are influenced by physical health has, as far as we know, not been examined previously. METHOD: In a sample of 153 older Swedish adults (age range, 72-86 years), we evaluated the influence of common age-related diseases, terminal decline pathology, age, education, and gender, to provide (a) preliminary test-specific regression weights and 90% confidence intervals to assess significant change in performance after five years on tests of visual scanning, mental shifting, visual spatial ability, memory, reaction time, and selective attention, and (b) normative data for the Useful Field of View test (UFOV) from a single testing occasion...
October 18, 2018: Journal of Clinical and Experimental Neuropsychology
Su Mi Park, Jung-Seok Choi, Ji Sun Lee, Jun-Young Lee, Saerom Lee, Hee Yeon Jung
This study aimed to examine the executive functioning of survivors exposed to recent sexual assaults. Twenty-seven female rape survivors who met the criterion for acute stress disorder (ASD) were enrolled and completed the assessment within 4 weeks after the traumatic experience. Additionally, 25 age-matched female health controls (HC) never exposed to such a traumatic event were enrolled. The assessments evaluated psychiatric symptoms including post-traumatic stress symptoms, depression, anxiety, and trait and state anger; general intelligence indexed by intellectual quotient (IQ); and executive functioning including set-shift/attention, planning, spatial working memory, and inhibition using the Cambridge Neuropsychological Test Automated Battery...
October 16, 2018: Journal of Clinical Medicine
Nergiz Turgut, Lisa Möller, Kerstin Dengler, Katrin Steinberg, Andreas Sprenger, Paul Eling, Andreas Kastrup, Helmut Hildebrandt
BACKGROUND: Visuospatial neglect is a disabling syndrome with serious consequences for activities in daily life. This study investigated the effect of adaptive cueing during a reading task as a possible treatment for neglect by including (1) a task relevant for the patient's daily life, (2) a fading out procedure to stimulate independent orientation to the left by self-cueing, and (3) a clear definition of neglect severity for the adaptive treatment protocol. METHODS: A randomized controlled crossover design was used, including 26 patients from an early rehabilitation unit with left-sided visuospatial neglect after stroke or hemorrhage...
October 17, 2018: Neurorehabilitation and Neural Repair
Sarah Pillemer, Emmeline Ayers, Roee Holtzer
OBJECTIVES: Research has extensively examined the relationship between social support and health outcomes in older adults. Little is known, however, about the longitudinal associations between distinct dimensions of perceived social support and incident cognitive decline. The current longitudinal study examined whether dimensions of perceived social support were associated with increased risk of cognitive decline, and if the relationship differed by gender. METHODS: 493 community-residing non-demented older adults were assessed for baseline social support via the Medical Outcomes Study-Social Support Survey (MOS-SSS)...
October 17, 2018: Aging & Mental Health
Evelyn Berger-Sieczkowski, Bernadette Gruber, Elisabeth Stögmann, Johann Lehrner
Personality and dementia are connected in different ways. A broad knowledge about personality and prodromal stages of dementia might be helpful to identify dementia as early as possible. Hence, personality differences between three cognitively impaired groups on the basis of patients' self-assessments of personality traits and connections between personality and cognitive functioning were examined via a cross-sectional study. The sample consisted of cognitively impaired patients (N = 133), aged 50 and older, who came to a memory clinic due to cognitive complaints...
October 17, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
Simona Mrakic-Sposta, Simona G Di Santo, Flaminia Franchini, Sara Arlati, Andrea Zangiacomi, Luca Greci, Sarah Moretti, Nithiya Jesuthasan, Mauro Marzorati, Giovanna Rizzo, Marco Sacco, Alessandra Vezzoli
The growing elderly population and the increased incidence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) call for the improvement of the quality and the efficacy of the healthcare and social support services. Exercise and cognitive stimulation have been demonstrated to mitigate cognitive impairment and oxidative stress (OxS) has been recognized as a factor that contributes to the advancement of neurodegenerative diseases. Taking these aspects into account, the impact of a novel virtual reality (VR)-based program combining aerobic exercise and cognitive training has been evaluated in the pilot study proposed here...
2018: Frontiers in Aging Neuroscience
Burcu Zeydan, Nirubol Tosakulwong, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Robert I Reid, Liliana Gazzuola Rocca, Timothy G Lesnick, Carin Y Smith, Kent R Bailey, Val J Lowe, Rosebud O Roberts, Clifford R Jack, Ronald C Petersen, Virginia M Miller, Michelle M Mielke, Walter A Rocca, Kejal Kantarci
Importance: There is an increased risk of cognitive impairment or dementia in women who undergo bilateral salpingo-oophorectomy (BSO) before menopause. However, data are lacking on the association of BSO before menopause with imaging biomarkers that indicate medial temporal lobe neurodegeneration and Alzheimer disease pathophysiology. Objective: To investigate medial temporal lobe structure, white matter lesion load, and β-amyloid deposition in women who underwent BSO before age 50 years and before reaching natural menopause...
October 15, 2018: JAMA Neurology
Robyn Westmacott, Kyla P McDonald, Samantha D Roberts, Gabrielle deVeber, Daune MacGregor, Mahendranath Moharir, Nomazulu Dlamini, Tricia S Williams
Childhood arterial ischemic stroke often involves basal ganglia and thalamus but little is known about neuropsychological outcomes in this group. We examined intellectual ability, academics, attention, executive function, and psychological diagnoses in children and adolescents (6-20 years of age) with childhood stroke involving the basal ganglia (n = 32) or thalamus (n = 12). Intellectual ability was age-appropriate but working memory was significantly lower than expected. Compared to the normative mean, the stroke group exhibited significantly weaker performance in reading comprehension, math fluency, attention, and greater challenges with executive function...
October 15, 2018: Developmental Neuropsychology
Natacha Akshoomoff, Timothy T Brown, Roger Bakeman, Donald J Hagler
OBJECTIVE: The NIH Toolbox Cognition Battery (NTCB) is a brief computerized method for evaluating neuropsychological functions in children, adolescents, and adults. We examined how performance on the 2 executive function measures of cognitive flexibility and inhibitory control was related to performance on the other NTCB measures across development. METHOD: Participants were 1,020 typically developing individuals between the ages of 3 and 21 from the Pediatric Imaging, Neurocognition, and Genetics Study who were divided into 5 age groups (3-6, 7-9, 10-13, 14-17, and 18-21)...
October 2018: Neuropsychology
Yiming Deng, Luyao Wang, Xuan Sun, Lian Liu, Meifang Zhu, Chunxue Wang, Binbin Sui, Mi Shen, Weibin Gu, Dapeng Mo, Ning Ma, Ligang Song, Xiaoqing Li, Xiaochuan Huo, Zhongrong Miao, Duanduan Chen, Feng Gao
Objective: This study aimed to investigate the association between cognitive impairment and cerebral haemodynamic changes in patients with chronic vertebra-basilar (VB) stenosis. Methods: Patients with severe posterior circulation VB stenosis and infarction or a history of infarction for more than 2 weeks from January 2014 to January 2015 were enrolled ( n = 96). They were divided into three groups, namely, the computed tomography perfusion (CTP) normal group, the CTP compensated group, and the CTP decompensated group...
2018: Frontiers in Psychiatry
Meng-Tien Wu, Pei-Fang Tang, Joshua O S Goh, Tai-Li Chou, Yu-Kai Chang, Yung-Chin Hsu, Yu-Jen Chen, Nai-Chi Chen, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau, Ming-Jang Chiu, Ching Lan
Studies have shown that Tai Chi Chuan (TCC) training has benefits on task-switching ability. However, the neural correlates underlying the effects of TCC training on task-switching ability remain unclear. Using task-related functional magnetic resonance imaging (fMRI) with a numerical Stroop paradigm, we investigated changes of prefrontal brain activation and behavioral performance during task-switching before and after TCC training and examined the relationships between changes in brain activation and task-switching behavioral performance...
2018: Frontiers in Aging Neuroscience
Simona Portaro, Antonino Naro, Vincenzo Cimino, Giuseppa Maresca, Francesco Corallo, Rosa Morabito, Rocco Salvatore Calabrò
INTRODUCTION: Transient global amnesia (TGA) is characterized by a sudden onset of anterograde and retrograde amnesia, sometimes associated with mild subclinical neuropsychological deficits and vegetative symptoms, lasting for days after the episode. Migraine history, cardiovascular risk factors, and emotional stress are considered possible risk factors. TGA usually occurs during the seventh decade of life, that is, when risk factors and concomitant pathologies have a higher incidence...
October 2018: Medicine (Baltimore)
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